iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-134273

Ensembl Protein ID

ENSXMAP00000018335.1

UniProt Accession

M4AV40; M4AV40_XIPMA

Genbank Protein ID

ENSXMAP00000018335

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGAJ01009555

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000018261.1	ENSXMAT00000018362.1	ENSXMAP00000018335.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-53	181.4	319	859
UBD/Alpha-Helix/UBA	1.40e-19	69.6	717	754

Active Site

Position(s)	Description	Evidence
328	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
822	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel.........................w.ks 63
           tG+kNlgN+CY+  vLQ+L++ip++++++   + +++ + +p +p+++++++++kl + l                         +  +
   Q: 319  TGIKNLGNSCYLSTVLQVLFSIPDFQRMYVG-NLQRIFDYSPLDPTQDFATQMAKLGHGLlsgqyskppmkselieqvmkeehkvLnGH 406
           7*****************************9.777777778999999999999999999977777777777777777666655542477 PP
   S: 64   kkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlks 152
           +++ +spr+l++ +++ ++efs+++qqD +Ef+ +l++ +e++                               +++  sd F++ +++
   Q: 407  QQRGISPRMLKALVSRGHPEFSSNRQQDGHEFFLHLINLVERNS-----------------------------AGSENPSDSFRFLVEE 466
           777**************************************999.............................6788899********* PP
   S: 153  qikclecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkk 214
           +++c + ++v  ++   + ++lp p +  t+ e                            ++ cL++ft++e++ +   ++++  ++k
   Q: 467  RVQCCQTRRVRYTQRVDYCIQLPAPIEAATNREellayearrkeaeentrappepvrariPFTACLQAFTEPENVPD---FWSSALQAK 552
           ****99999987777666666666666655555679***************************************97...********* PP
   S: 215  qeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.................................... 267
           +  +k+ ++ ++Pe+L++++k+f+f  + ++++k++  +++p+ Ldls+  ++                                    
   Q: 553  SAGVKTSRFASFPEYLVMQIKKFTFGVD-WVPKKLDLAIDVPDFLDLSRLRATglqageeelpdlmppivlpedtrdnsmsstdspeid 640
           *************************776.*******************98888899999999999999999888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 641  egavmqlaemgfpleacrkavyytgnmgpemafnwiiahmeepdfaepltlpsmmdplpstsdspmgatpldnlppeesiailtsmgfp 729
           88888888888777777777777777777777777777777777777777777777777777777777777777666666666666666 PP
   S: 268  .........................peekqke.............................................kkkYeLiavvvH 286
                                    p     e                                             + +YeL+a+++H
   Q: 730  rnhsiralkatnnnleraldwifshP-----EeeesdglsdmadtepndnafsnmnshsdstlspdretsgprvkdgPGRYELFAIISH 813
           66666666665555555555555551.....0555556666666666677777777777888888888888999999************ PP
   S: 287  sG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +G s+ sGHYv+++k+ +g+W+ ++D+kV  +  e+  +   + +Y++fY+r
   Q: 814  MGaSTMSGHYVCHIKK-EGRWVIYNDHKVCLS--ERPPK---DLGYIYFYRR 859
           ****************.9***********988..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ ++ l++MGF+r++ ++aL a+nnnle+A+++++++
   Q: 717  EESIAILTSMGFPRNHSIRALKATNNNLERALDWIFSH 754
           789*********************************97 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MAADLGELLV PFMPTIRVPK TGDRVYKSEC AFSFDSPESE GGLYVCMNTF LGFGREHVER 60
HYRKTGQSVY MHLKRHVKEK TTGAAGGAIP RRRNGKVFLD LELNRDFNGE EYEYEDEAKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAACAGCAGC GCTGTAATTT CTGCGCAGGT CCATGCTTCA GTAAGAAAAA AGAAAAAAAA 60
AAATCAACAA AAGCGCAGCT CTTTACCCTC CGTGCCCTTA CCCTCAGACT CAGAGGCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

xma:102233838

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	73.60	0.00e+00	1259.00
IUUC-Apl-003712	Anas platyrhynchos	74.15	0.00e+00	1238.00
IUUC-Aca-004634	Anolis carolinensis	74.62	0.00e+00	1288.00
IUUC-Ame-011470	Astyanax mexicanus	84.49	0.00e+00	1474.00
IUUC-Bta-013349	Bos taurus	74.39	0.00e+00	1276.00
IUUC-Cja-019021	Callithrix jacchus	73.78	0.00e+00	1256.00
IUUC-Cfa-020614	Canis familiaris	73.60	0.00e+00	1258.00
IUUC-Cpo-022484	Cavia porcellus	72.63	0.00e+00	1194.00
IUUC-Csa-024078	Chlorocebus sabaeus	73.67	0.00e+00	1259.00
IUUC-Cho-024522	Choloepus hoffmanni	61.33	0.00e+00	933.00
IUUC-Dre-027651	Danio rerio	84.38	0.00e+00	1527.00
IUUC-Dno-028975	Dasypus novemcinctus	73.61	0.00e+00	1257.00
IUUC-Dor-030130	Dipodomys ordii	54.97	0.00e+00	822.00
IUUC-Ete-032251	Echinops telfairi	62.95	0.00e+00	989.00
IUUC-Eca-033568	Equus caballus	73.58	0.00e+00	1200.00
IUUC-Fca-036280	Felis catus	73.39	0.00e+00	1194.00
IUUC-Fal-036610	Ficedula albicollis	74.21	0.00e+00	1214.00
IUUC-Gmo-038906	Gadus morhua	83.83	0.00e+00	1474.00
IUUC-Gga-041215	Gallus gallus	74.25	0.00e+00	1292.00
IUUC-Gac-042441	Gasterosteus aculeatus	88.70	0.00e+00	1578.00
IUUC-Ggo-044446	Gorilla gorilla	73.90	0.00e+00	1266.00
IUUC-Hsa-046546	Homo sapiens	73.67	0.00e+00	1259.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	68.39	0.00e+00	1148.00
IUUC-Kpa-049156	Komagataella pastoris	30.38	2.00e-102	367.00
IUUC-Lch-050425	Latimeria chalumnae	72.71	0.00e+00	1311.00
IUUC-Loc-052072	Lepisosteus oculatus	78.73	0.00e+00	1363.00
IUUC-Laf-053909	Loxodonta africana	72.65	0.00e+00	1244.00
IUUC-Mcc-054686	Macaca mulatta	73.55	0.00e+00	1260.00
IUUC-Meu-056361	Macropus eugenii	74.35	0.00e+00	964.00
IUUC-Mga-059972	Meleagris gallopavo	70.08	0.00e+00	1182.00
IUUC-Mmr-060916	Microcebus murinus	73.67	0.00e+00	1261.00
IUUC-Mdo-062302	Monodelphis domestica	75.29	0.00e+00	1334.00
IUUC-Mmu-063639	Mus musculus	73.54	0.00e+00	1259.00
IUUC-Mac-065634	Musa acuminata	39.37	4.00e-176	612.00
IUUC-Mpu-066533	Mustela putorius furo	73.49	0.00e+00	1257.00
IUUC-Mlu-067786	Myotis lucifugus	69.46	0.00e+00	1184.00
IUUC-Nle-069997	Nomascus leucogenys	73.32	0.00e+00	1189.00
IUUC-Ont-071859	Oreochromis niloticus	89.81	0.00e+00	1618.00
IUUC-Oan-072959	Ornithorhynchus anatinus	78.84	6.00e-114	403.00
IUUC-Ocu-074265	Oryctolagus cuniculus	73.20	0.00e+00	1255.00
IUUC-Ola-087344	Oryzias latipes	88.11	0.00e+00	1612.00
IUUC-Oga-088734	Otolemur garnettii	73.44	0.00e+00	1241.00
IUUC-Oar-089636	Ovis aries	74.33	0.00e+00	1242.00
IUUC-Ptr-090982	Pan troglodytes	73.78	0.00e+00	1264.00
IUUC-Pan-091991	Papio anubis	73.67	0.00e+00	1261.00
IUUC-Psi-093509	Pelodiscus sinensis	74.28	0.00e+00	1310.00
IUUC-Pfo-096029	Poecilia formosa	98.73	0.00e+00	1785.00
IUUC-Pab-098672	Pongo abelii	70.19	0.00e+00	1175.00
IUUC-Pva-102545	Pteropus vampyrus	73.65	0.00e+00	1060.00
IUUC-Rno-105210	Rattus norvegicus	73.31	0.00e+00	1245.00
IUUC-Sar-113733	Sorex araneus	76.28	0.00e+00	630.00
IUUC-Tgu-116591	Taeniopygia guttata	75.09	0.00e+00	1300.00
IUUC-Tru-118627	Takifugu rubripes	88.67	0.00e+00	1635.00
IUUC-Tsy-119278	Tarsius syrichta	66.55	0.00e+00	1070.00
IUUC-Tni-120804	Tetraodon nigroviridis	90.77	0.00e+00	1650.00
IUUC-Tbe-127699	Tupaia belangeri	61.73	0.00e+00	687.00
IUUC-Ttr-128295	Tursiops truncatus	67.32	0.00e+00	1139.00
IUUC-Vpa-130170	Vicugna pacos	65.62	0.00e+00	1025.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence