iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037387

Ensembl Protein ID

ENSFALP00000007208.1

UniProt Accession

U3JWQ4; U3JWQ4_FICAL

Genbank Protein ID

ENSFALP00000007208

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Genbank Nucleotide ID

AGTO01010686

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000006902.1	ENSFALT00000007240.1	ENSFALP00000007208.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-45	150.4	145	181
UBD/Beta-Prp	6.50e-66	222.2	9	229

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gHt+ v+cl+f +d + ++s++dD+t+k+WDl+ g+l
   Q: 145  GHTEAVRCLRFsPDgKWVASAADDHTVKLWDLTAGKL 181
           8***********999******************9986 PP

UBD/Beta-Prp

   S: 41   tgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqc 128
           t ++l+++  h++ v++v + + +  +l+tg++D  +++w++s++ c+++l+gh++ + sl+++p+ + +v+Gs+   irvwdle  ++
   Q: 9    TAWKLQEIMAHSSNVSSVVLGKGSGrMLATGGDDCRVNIWSVSKPNCIMSLTGHTSPIESLQVNPNEQLIVAGSRSGSIRVWDLEAAKV 97
           4455789999******9999766555*************************************************************** PP
   S: 129  leetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrt 217
           l+ tl gh++ ++++++hp+g  ++sGslD+ ++lWd++++ ++ t++g ht++v++l f+++gk ++s+++d tvklwdl +g+ + +
   Q: 98   LR-TLPGHKANICSLHFHPFGGFVASGSLDTNIKLWDVRRKGCIFTFKG-HTEAVRCLRFSPDGKWVASAADDHTVKLWDLTAGKLMFE 184
           **.*********************************************9.*************************************** PP
   S: 218  lnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlql 262
           ++ght +v++v+f+pn+ +l+sgssD+++r+Wdl++ +++++++ 
   Q: 185  FTGHTGPVNVVEFHPNEYLLASGSSDRTVRFWDLEKFQVVSCIEE 229
           **************************************9999876 PP

Organism

Ficedula albicollis

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Protein Sequence
(Fasta)

MAVAVTTKTA WKLQEIMAHS SNVSSVVLGK GSGRMLATGG DDCRVNIWSV SKPNCIMSLT 60
GHTSPIESLQ VNPNEQLIVA GSRSGSIRVW DLEAAKVLRT LPGHKANICS LHFHPFGGFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGTGGCGG CCGCGCCGCC GTCGCCGTGG CAACCGCCCC GCCCTCGCCT CCTATTGGCC 60
GAGCGGCGCG CGGAGCCCGG GCAACCGCCC GGCGCGGCGC GGGGTTGTTG TGAAGGGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007067--P:mitotic nuclear division
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

KEGG

fab:101817095

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	47.26	8.00e-85	308.00
IUUC-Aml-002187	Ailuropoda melanoleuca	73.74	0.00e+00	915.00
IUUC-Atr-002899	Amborella trichopoda	54.45	3.00e-102	365.00
IUUC-Apl-003305	Anas platyrhynchos	84.40	0.00e+00	1111.00
IUUC-Aca-004635	Anolis carolinensis	81.13	0.00e+00	988.00
IUUC-Aly-005711	Arabidopsis lyrata	52.82	3.00e-103	369.00
IUUC-Ath-007606	Arabidopsis thaliana	52.82	3.00e-103	369.00
IUUC-Ame-010870	Astyanax mexicanus	57.72	2.00e-97	348.00
IUUC-Bta-012527	Bos taurus	78.01	0.00e+00	990.00
IUUC-Bdi-014652	Brachypodium distachyon	52.15	4.00e-103	369.00
IUUC-Bol-015242	Brassica oleracea	51.50	4.00e-102	365.00
IUUC-Bra-017390	Brassica rapa	51.83	2.00e-102	367.00
IUUC-Cja-019706	Callithrix jacchus	76.60	0.00e+00	923.00
IUUC-Cfa-020139	Canis familiaris	63.81	1.00e-179	622.00
IUUC-Cpo-021710	Cavia porcellus	78.79	0.00e+00	981.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	43.46	4.00e-72	265.00
IUUC-Csa-023546	Chlorocebus sabaeus	79.06	0.00e+00	902.00
IUUC-Cin-025156	Ciona intestinalis	42.11	2.00e-153	536.00
IUUC-Csv-025962	Ciona savignyi	48.81	1.00e-89	322.00
IUUC-Dre-028215	Danio rerio	62.07	0.00e+00	836.00
IUUC-Dno-029314	Dasypus novemcinctus	78.37	0.00e+00	939.00
IUUC-Dor-030482	Dipodomys ordii	78.60	0.00e+00	1004.00
IUUC-Dme-032188	Drosophila melanogaster	38.76	3.00e-59	223.00
IUUC-Eca-034143	Equus caballus	78.18	0.00e+00	978.00
IUUC-Fca-035924	Felis catus	78.45	0.00e+00	964.00
IUUC-Gmo-038692	Gadus morhua	62.62	3.00e-149	521.00
IUUC-Gga-040597	Gallus gallus	85.87	0.00e+00	1136.00
IUUC-Gac-042004	Gasterosteus aculeatus	62.20	0.00e+00	833.00
IUUC-Gma-044134	Glycine max	53.82	1.00e-102	367.00
IUUC-Ggo-044761	Gorilla gorilla	78.91	0.00e+00	921.00
IUUC-Hsa-045698	Homo sapiens	79.21	0.00e+00	939.00
IUUC-Hvu-047649	Hordeum vulgare	51.49	2.00e-102	367.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	78.76	0.00e+00	958.00
IUUC-Lch-049674	Latimeria chalumnae	65.93	0.00e+00	917.00
IUUC-Lpe-051554	Leersia perrieri	52.81	6.00e-105	375.00
IUUC-Loc-052623	Lepisosteus oculatus	64.94	0.00e+00	885.00
IUUC-Laf-054587	Loxodonta africana	79.09	0.00e+00	990.00
IUUC-Mcc-055851	Macaca mulatta	78.91	0.00e+00	921.00
IUUC-Meu-056704	Macropus eugenii	80.40	0.00e+00	1060.00
IUUC-Mtr-058053	Medicago truncatula	53.49	1.00e-105	377.00
IUUC-Mga-059608	Meleagris gallopavo	86.02	0.00e+00	1132.00
IUUC-Mmr-061154	Microcebus murinus	76.70	0.00e+00	946.00
IUUC-Mdo-062365	Monodelphis domestica	76.33	0.00e+00	992.00
IUUC-Mmu-063754	Mus musculus	79.39	0.00e+00	967.00
IUUC-Mac-064439	Musa acuminata	48.12	5.00e-100	358.00
IUUC-Mpu-066245	Mustela putorius furo	78.15	0.00e+00	930.00
IUUC-Mlu-067692	Myotis lucifugus	79.29	0.00e+00	971.00
IUUC-Nle-070051	Nomascus leucogenys	76.32	0.00e+00	912.00
IUUC-Opr-070855	Ochotona princeps	78.64	0.00e+00	970.00
IUUC-Ont-071883	Oreochromis niloticus	58.82	0.00e+00	825.00
IUUC-Oan-073293	Ornithorhynchus anatinus	79.51	0.00e+00	927.00
IUUC-Ocu-074644	Oryctolagus cuniculus	79.55	0.00e+00	981.00
IUUC-Oba-075448	Oryza barthii	53.47	1.00e-105	377.00
IUUC-Obr-076385	Oryza brachyantha	52.48	7.00e-105	374.00
IUUC-Ogl-077427	Oryza glaberrima	53.47	3.00e-106	379.00
IUUC-Ogu-079022	Oryza glumaepatula	48.87	2.00e-95	343.00
IUUC-Oin-079811	Oryza indica	51.11	5.00e-103	368.00
IUUC-Olo-080245	Oryza longistaminata	51.11	6.00e-103	368.00
IUUC-Ome-081239	Oryza meridionalis	53.58	2.00e-102	366.00
IUUC-Oni-082640	Oryza nivara	53.47	1.00e-105	377.00
IUUC-Opu-083748	Oryza punctata	53.14	2.00e-105	376.00
IUUC-Oru-084609	Oryza rufipogon	53.47	1.00e-105	377.00
IUUC-Osa-085801	Oryza sativa	40.72	1.00e-95	344.00
IUUC-Ola-087483	Oryzias latipes	54.78	0.00e+00	630.00
IUUC-Oga-087964	Otolemur garnettii	79.09	0.00e+00	995.00
IUUC-Oar-089483	Ovis aries	76.54	0.00e+00	940.00
IUUC-Ptr-091387	Pan troglodytes	79.36	0.00e+00	941.00
IUUC-Pan-092623	Papio anubis	78.91	0.00e+00	921.00
IUUC-Psi-093830	Pelodiscus sinensis	85.02	0.00e+00	1091.00
IUUC-Pma-094135	Petromyzon marinus	43.56	2.00e-39	155.00
IUUC-Ppa-095379	Physcomitrella patens	55.14	1.00e-97	350.00
IUUC-Pfo-096755	Poecilia formosa	58.17	0.00e+00	817.00
IUUC-Pab-097564	Pongo abelii	76.66	0.00e+00	801.00
IUUC-Pop-099149	Populus trichocarpa	54.15	8.00e-107	381.00
IUUC-Pca-100357	Procavia capensis	83.33	3.00e-109	388.00
IUUC-Ppe-101237	Prunus persica	54.15	7.00e-106	378.00
IUUC-Pva-102397	Pteropus vampyrus	75.11	0.00e+00	910.00
IUUC-Rno-105349	Rattus norvegicus	79.51	0.00e+00	1007.00
IUUC-Smo-109409	Selaginella moellendorffii	53.61	1.00e-99	357.00
IUUC-Sit-110360	Setaria italica	53.47	1.00e-105	377.00
IUUC-Sly-111307	Solanum lycopersicum	53.67	2.00e-101	363.00
IUUC-Stu-112462	Solanum tuberosum	52.74	4.00e-97	348.00
IUUC-Sar-112953	Sorex araneus	67.98	4.00e-89	321.00
IUUC-Sbi-114389	Sorghum bicolor	44.07	5.00e-95	342.00
IUUC-Ssc-115949	Sus scrofa	75.48	0.00e+00	723.00
IUUC-Tgu-117461	Taeniopygia guttata	95.64	0.00e+00	1269.00
IUUC-Tru-117865	Takifugu rubripes	60.63	0.00e+00	823.00
IUUC-Tsy-119036	Tarsius syrichta	63.31	8.00e-60	224.00
IUUC-Tni-120903	Tetraodon nigroviridis	61.42	0.00e+00	799.00
IUUC-Tca-121185	Theobroma cacao	53.16	5.00e-104	372.00
IUUC-Tae-125307	Triticum aestivum	52.15	4.00e-103	369.00
IUUC-Tur-126181	Triticum urartu	43.10	3.00e-93	336.00
IUUC-Tbe-127518	Tupaia belangeri	66.96	1.00e-149	523.00
IUUC-Ttr-128172	Tursiops truncatus	77.69	0.00e+00	954.00
IUUC-Vvi-131489	Vitis vinifera	54.49	2.00e-106	380.00
IUUC-Xtr-132915	Xenopus tropicalis	70.90	0.00e+00	937.00
IUUC-Xma-134133	Xiphophorus maculatus	58.17	0.00e+00	811.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence