iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000003258.6	ENSPTRT00000006209.5	ENSPTRP00000005730.5
ENSPTRG00000003258.6	ENSPTRT00000064043.2	ENSPTRP00000055590.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.10e-09	36.0	15	59
E3 activity/RING/U-box	3.40e-06	27.0	9	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle + + pl+l+CgH f++ Cl + + ++ + ++e +CP+Cr
   Q: 15   CPICLELLTQ-PLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCR 59
           ********99.***************555457788**********8 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl.....asggktcPvtrqplteedlvPnltlrrliqa 67
           v ee  CpI lel ++P  l +G+++ ++++         ++g+++cPv+r + ++e++ Pn  + +++++
   Q: 9    VKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHkksmlDKGESSCPVCRISYQPENIRPNRHVANIVEK 79
           78999*************************975322223377777*****************998887776 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MASGILVNVK EEVTCPICLE LLTQPLSLDC GHSFCQACLT ANHKKSMLDK GESSCPVCRI 60
SYQPENIRPN RHVANIVEKL REVKLSPEGQ KVDHCAHHGE KLLLFCQEDG KVICWLCERS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTTATCTT TCACTTTCCT GCCCTGGCTG TGAGCAAGAA TTTGCTGCGG TTCCTCTAGG 60
AAAATTCCTT TGTGCAGATC AGGCCCGTGG ATTGGTGAGT GAATCCTAAC CACGTCTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR010908--Longin_dom
IPR003877--SPRY_dom
IPR032917--TRIM5
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:1990462--C:omegasome
GO:0000932--C:P-body
GO:0008329--F:signaling pattern recognition receptor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410--P:positive regulation of MAPK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0031664--P:regulation of lipopolysaccharide-mediated signaling pathway
GO:0032880--P:regulation of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013110	Bos taurus	57.79	1.00e-156	546.00
IUUC-Cja-019944	Callithrix jacchus	68.22	0.00e+00	647.00
IUUC-Csa-023609	Chlorocebus sabaeus	82.14	0.00e+00	856.00
IUUC-Dor-030700	Dipodomys ordii	53.04	6.00e-147	513.00
IUUC-Ete-033021	Echinops telfairi	54.33	5.00e-125	441.00
IUUC-Eeu-034968	Erinaceus europaeus	50.33	4.00e-114	404.00
IUUC-Ggo-044783	Gorilla gorilla	92.70	0.00e+00	897.00
IUUC-Hsa-046573	Homo sapiens	96.15	0.00e+00	955.00
IUUC-Mcc-055525	Macaca mulatta	85.71	0.00e+00	872.00
IUUC-Mmr-061336	Microcebus murinus	61.60	8.00e-147	513.00
IUUC-Mlu-067695	Myotis lucifugus	59.72	2.00e-154	538.00
IUUC-Nle-069081	Nomascus leucogenys	89.07	0.00e+00	868.00
IUUC-Opr-071057	Ochotona princeps	52.34	5.00e-130	457.00
IUUC-Ocu-073956	Oryctolagus cuniculus	56.16	7.00e-148	517.00
IUUC-Pan-092730	Papio anubis	85.71	0.00e+00	870.00
IUUC-Pab-098782	Pongo abelii	92.90	0.00e+00	923.00
IUUC-Pca-100502	Procavia capensis	51.92	3.00e-130	458.00
IUUC-Sar-113094	Sorex araneus	50.00	8.00e-113	400.00
IUUC-Ssc-115715	Sus scrofa	57.85	1.00e-144	506.00
IUUC-Tsy-119055	Tarsius syrichta	61.01	2.00e-164	571.00
IUUC-Tbe-127426	Tupaia belangeri	52.81	6.00e-129	454.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence