iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028263

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A

Genbank Nucleotide ID

BC071328

Gene Name

sae1; sae2a; uble1a; zgc:86633

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000010487.8	ENSDART00000011447.8	ENSDARP00000016138.8

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.40e-72	245.4	20	166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQirlwG +aq++l+ ++vllvG+ glG+E++KnL+laGv+ +t++D+++v+ +   +qFL+  +  g++ A++++e+++ lnp+v+
   Q: 20   YDRQIRLWGLDAQKRLRGSRVLLVGLRGLGAEVAKNLILAGVKGLTLLDHEQVTEESRRAQFLIPVDADGQNHAQASLERAQFLNPMVE 108
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeivFfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqv 149
           v+a++e+++ + ++  Ff +fd V+l+ ++r+ + +v++lc + +++ ++++++G+ G++
   Q: 109  VKADTEPVESKPDD--FFFQFDAVCLTRCSRDLMVRVDQLCASRNIKVFCGDVYGYNGYM 166
           **************..*******************************************9 PP

Organism

Danio rerio

Functional Description
(View)

The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).

Protein Sequence
(Fasta)

MIDTIEKEDT IISEEEAAQY DRQIRLWGLD AQKRLRGSRV LLVGLRGLGA EVAKNLILAG 60
VKGLTLLDHE QVTEESRRAQ FLIPVDADGQ NHAQASLERA QFLNPMVEVK ADTEPVESKP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATTGTCGAG CTCTGATTCT GGCACACATC TCCTGCGTCA TCATTGCGCG CCTTTACGAG 60
TTTCACTAAG CGGCACTTTT GTCCCATTGA ATGGGCAATA GAAAAAATAG AGCGTAGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR000011--UBQ/SUMO-activ_enz_E1-like

Pfam

PF00899--ThiF

PRINTS

PR01849--UBIQUITINACT

Gene Ontology

GO:0005634--C:nucleus
GO:0008022--F:protein C-terminus binding
GO:0008641--F:small protein activating enzyme activity
GO:0060216--P:definitive hemopoiesis
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0016925--P:protein sumoylation

KEGG

dre:415148

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000695	Aegilops tauschii	30.39	8.00e-40	157.00
IUUC-Aml-001477	Ailuropoda melanoleuca	69.39	3.00e-137	481.00
IUUC-Atr-002536	Amborella trichopoda	31.90	2.00e-43	169.00
IUUC-Apl-003982	Anas platyrhynchos	62.60	1.00e-83	302.00
IUUC-Aca-004868	Anolis carolinensis	66.03	4.00e-124	437.00
IUUC-Aly-005588	Arabidopsis lyrata	32.75	5.00e-44	171.00
IUUC-Ath-006677	Arabidopsis thaliana	33.33	3.00e-45	175.00
IUUC-Ago-007891	Ashbya gossypii	29.73	5.00e-36	145.00
IUUC-Acl-008197	Aspergillus clavatus	33.33	4.00e-41	162.00
IUUC-Afl-008520	Aspergillus flavus	34.22	5.00e-45	175.00
IUUC-Afu-009107	Aspergillus fumigatus	31.76	2.00e-34	140.00
IUUC-Ani-009143	Aspergillus nidulans	32.75	9.00e-39	154.00
IUUC-Ang-009804	Aspergillus niger	33.63	1.00e-42	167.00
IUUC-Aor-010190	Aspergillus oryzae	34.22	5.00e-45	175.00
IUUC-Ate-010519	Aspergillus terreus	27.95	2.00e-15	76.30
IUUC-Ame-011043	Astyanax mexicanus	87.36	2.00e-166	578.00
IUUC-Bgr-012084	Blumeria graminis	30.18	7.00e-36	144.00
IUUC-Bta-012723	Bos taurus	69.54	4.00e-136	477.00
IUUC-Bci-013809	Botrytis cinerea	31.36	5.00e-39	155.00
IUUC-Bdi-014800	Brachypodium distachyon	32.14	7.00e-43	167.00
IUUC-Bol-015744	Brassica oleracea	31.40	1.00e-41	163.00
IUUC-Bra-016683	Brassica rapa	31.98	1.00e-42	166.00
IUUC-Cel-018434	Caenorhabditis elegans	31.40	1.00e-39	157.00
IUUC-Cja-019815	Callithrix jacchus	68.79	2.00e-141	494.00
IUUC-Cfa-020329	Canis familiaris	68.18	2.00e-135	475.00
IUUC-Cpo-022208	Cavia porcellus	67.75	1.00e-136	479.00
IUUC-Csa-023592	Chlorocebus sabaeus	67.38	3.00e-111	394.00
IUUC-Cho-024345	Choloepus hoffmanni	58.12	2.00e-81	295.00
IUUC-Cin-025351	Ciona intestinalis	44.71	8.00e-80	290.00
IUUC-Cgl-026491	Colletotrichum gloeosporioides	32.46	1.00e-35	144.00
IUUC-Cne-026970	Cryptococcus neoformans	27.41	4.00e-21	95.50
IUUC-Dno-030055	Dasypus novemcinctus	68.48	5.00e-136	477.00
IUUC-Dor-030864	Dipodomys ordii	67.20	9.00e-124	436.00
IUUC-Dse-031565	Dothistroma septosporum	34.83	1.00e-42	167.00
IUUC-Dme-032011	Drosophila melanogaster	39.23	5.00e-56	211.00
IUUC-Ete-032982	Echinops telfairi	63.05	3.00e-120	424.00
IUUC-Eca-034164	Equus caballus	67.94	5.00e-128	450.00
IUUC-Eeu-035135	Erinaceus europaeus	57.08	8.00e-71	260.00
IUUC-Fca-035564	Felis catus	69.39	1.00e-137	482.00
IUUC-Fox-037928	Fusarium oxysporum	35.55	2.00e-42	167.00
IUUC-Fso-038404	Fusarium solani	34.19	2.00e-39	157.00
IUUC-Gmo-038867	Gadus morhua	81.16	1.00e-157	549.00
IUUC-Ggr-040068	Gaeumannomyces graminis	31.34	7.00e-39	155.00
IUUC-Gga-041197	Gallus gallus	66.77	6.00e-105	374.00
IUUC-Gac-042609	Gasterosteus aculeatus	80.29	3.00e-156	544.00
IUUC-Gma-044135	Glycine max	32.17	1.00e-44	173.00
IUUC-Ggo-044600	Gorilla gorilla	69.70	6.00e-138	483.00
IUUC-Hsa-046731	Homo sapiens	69.70	6.00e-138	483.00
IUUC-Itr-049038	Ictidomys tridecemlineatus	69.70	9.00e-139	486.00
IUUC-Kpa-049371	Komagataella pastoris	27.06	2.00e-30	126.00
IUUC-Lch-050045	Latimeria chalumnae	73.23	2.00e-144	505.00
IUUC-Lpe-051103	Leersia perrieri	30.88	3.00e-39	155.00
IUUC-Loc-051749	Lepisosteus oculatus	70.66	6.00e-138	483.00
IUUC-Lma-053150	Leptosphaeria maculans	31.71	3.00e-39	156.00
IUUC-Laf-053875	Loxodonta africana	68.48	2.00e-135	475.00
IUUC-Mcc-055107	Macaca mulatta	67.11	1.00e-122	432.00
IUUC-Meu-056076	Macropus eugenii	51.59	8.00e-95	340.00
IUUC-Mor-057029	Magnaporthe oryzae	30.79	2.00e-38	153.00
IUUC-Mtr-058633	Medicago truncatula	32.65	8.00e-44	171.00
IUUC-Mla-059040	Melampsora laricipopulina	26.89	1.00e-21	96.70
IUUC-Mvi-060367	Microbotryum violaceum	33.73	6.00e-48	184.00
IUUC-Mmr-061294	Microcebus murinus	66.45	3.00e-120	424.00
IUUC-Mdo-062827	Monodelphis domestica	68.79	2.00e-142	498.00
IUUC-Mmu-063568	Mus musculus	69.54	1.00e-128	452.00
IUUC-Mac-064495	Musa acuminata	31.50	3.00e-44	172.00
IUUC-Mpu-065826	Mustela putorius furo	69.09	2.00e-136	478.00
IUUC-Mlu-067751	Myotis lucifugus	67.94	1.00e-127	449.00
IUUC-Nfi-068597	Neosartorya fischeri	32.12	9.00e-44	171.00
IUUC-Ncr-068768	Neurospora crassa	31.05	6.00e-36	145.00
IUUC-Nle-069882	Nomascus leucogenys	71.25	6.00e-64	236.00
IUUC-Opr-071077	Ochotona princeps	52.00	2.00e-85	308.00
IUUC-Ont-072576	Oreochromis niloticus	82.99	3.00e-149	521.00
IUUC-Oan-073560	Ornithorhynchus anatinus	66.78	4.00e-122	431.00
IUUC-Ocu-074732	Oryctolagus cuniculus	61.79	7.00e-118	417.00
IUUC-Oba-075956	Oryza barthii	31.23	2.00e-40	159.00
IUUC-Obr-076004	Oryza brachyantha	31.83	3.00e-39	155.00
IUUC-Ogu-078335	Oryza glumaepatula	31.53	5.00e-41	161.00
IUUC-Oin-079177	Oryza indica	31.53	2.00e-41	162.00
IUUC-Olo-080537	Oryza longistaminata	28.70	2.00e-32	132.00
IUUC-Ome-081880	Oryza meridionalis	31.53	2.00e-41	162.00
IUUC-Oni-082688	Oryza nivara	31.83	3.00e-42	165.00
IUUC-Opu-083231	Oryza punctata	31.67	2.00e-43	169.00
IUUC-Oru-084759	Oryza rufipogon	31.53	2.00e-41	162.00
IUUC-Osa-085601	Oryza sativa	31.23	6.00e-41	161.00
IUUC-Ola-086496	Oryzias latipes	81.69	2.00e-149	521.00
IUUC-Oga-089005	Otolemur garnettii	65.06	3.00e-125	441.00
IUUC-Oar-089611	Ovis aries	69.54	6.00e-136	477.00
IUUC-Ptr-091337	Pan troglodytes	69.70	6.00e-138	483.00
IUUC-Pan-092401	Papio anubis	65.15	3.00e-127	447.00
IUUC-Pma-094210	Petromyzon marinus	59.24	5.00e-117	414.00
IUUC-Pno-094975	Phaeosphaeria nodorum	29.68	1.00e-35	144.00
IUUC-Ppa-095925	Physcomitrella patens	36.60	4.00e-53	201.00
IUUC-Pfo-096890	Poecilia formosa	82.11	1.00e-155	542.00
IUUC-Pab-098173	Pongo abelii	69.70	6.00e-138	483.00
IUUC-Pop-099424	Populus trichocarpa	32.36	4.00e-48	185.00
IUUC-Pca-100899	Procavia capensis	56.36	1.00e-103	369.00
IUUC-Ppe-101274	Prunus persica	28.94	2.00e-32	132.00
IUUC-Pva-102625	Pteropus vampyrus	67.88	9.00e-135	473.00
IUUC-Pgr-103426	Puccinia graminis	33.82	1.00e-44	173.00
IUUC-Pte-104082	Pyrenophora teres	32.00	3.00e-38	152.00
IUUC-Pyt-104818	Pyrenophora triticirepentis	32.37	4.00e-38	152.00
IUUC-Rno-106129	Rattus norvegicus	68.81	3.00e-136	478.00
IUUC-Sce-106370	Saccharomyces cerevisiae	30.97	1.00e-35	143.00
IUUC-Sha-107120	Sarcophilus harrisii	66.46	7.00e-120	423.00
IUUC-Sja-107996	Schizosaccharomyces japonicus	26.57	2.00e-28	119.00
IUUC-Spo-108321	Schizosaccharomyces pombe	30.49	5.00e-30	124.00
IUUC-Ssl-108608	Sclerotinia sclerotiorum	31.66	9.00e-41	160.00
IUUC-Smo-109539	Selaginella moellendorffii	30.70	5.00e-33	135.00
IUUC-Sit-110166	Setaria italica	33.14	2.00e-46	179.00
IUUC-Sly-111116	Solanum lycopersicum	33.73	7.00e-44	171.00
IUUC-Stu-112397	Solanum tuberosum	33.14	1.00e-43	169.00
IUUC-Sar-113506	Sorex araneus	61.29	6.00e-119	420.00
IUUC-Sbi-114548	Sorghum bicolor	34.31	2.00e-48	186.00
IUUC-Sre-115022	Sporisorium reilianum	27.79	2.00e-23	103.00
IUUC-Ssc-115891	Sus scrofa	69.39	4.00e-138	484.00
IUUC-Tru-118469	Takifugu rubripes	75.87	6.00e-145	506.00
IUUC-Tsy-119304	Tarsius syrichta	60.51	1.00e-107	382.00
IUUC-Tni-119803	Tetraodon nigroviridis	69.36	2.00e-139	488.00
IUUC-Tca-121747	Theobroma cacao	32.85	2.00e-47	182.00
IUUC-Tre-122060	Trichoderma reesei	31.16	1.00e-36	147.00
IUUC-Tvi-122324	Trichoderma virens	33.43	1.00e-38	153.00
IUUC-Tae-125474	Triticum aestivum	32.27	5.00e-45	174.00
IUUC-Tur-126224	Triticum urartu	31.95	7.00e-41	160.00
IUUC-Tme-126939	Tuber melanosporum	32.07	1.00e-44	174.00
IUUC-Tbe-127982	Tupaia belangeri	62.12	4.00e-120	424.00
IUUC-Ttr-128758	Tursiops truncatus	69.09	2.00e-137	482.00
IUUC-Uma-129422	Ustilago maydis	26.61	8.00e-26	111.00
IUUC-Vda-129664	Verticillium dahliae	32.65	1.00e-39	157.00
IUUC-Vpa-130778	Vicugna pacos	57.33	2.00e-95	342.00
IUUC-Vvi-131399	Vitis vinifera	31.98	6.00e-48	184.00
IUUC-Xtr-131919	Xenopus tropicalis	68.67	5.00e-134	470.00
IUUC-Xma-133482	Xiphophorus maculatus	82.70	1.00e-149	522.00
IUUC-Yli-134596	Yarrowia lipolytica	27.40	6.00e-32	131.00
IUUC-Zma-135688	Zea mays	34.30	4.00e-48	185.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence