iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000007510.2	ENSPPYT00000008827.2	ENSPPYP00000008481.2
ENSPPYG00000007510.2	ENSPPYT00000008826.2	ENSPPYP00000008480.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.10e-136	453.6	541	873

Active Site

Position(s)	Description	Evidence
842	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 541  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 628
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 629  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 714
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 715  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 802
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+l+ekLlyAieet+gF++
   Q: 803  TGTCRLPVGGFAELIgtngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQ 873
           *********************************************************************96 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

ASASSSRAGV GPCLFEKSQL TLESVVSAKP KVHNRQPRIN SYVEVAVDGL PSETKKTGKR 60
IGSSELLWNE IIILNVTAQS HLDLKVWSCH TLRNELLGTA SVNLSNVLKN NGGKMENTQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCTTCCGG GTCAGGTGAC CGCGCGCGGT CACGTGACCC GGTCCGAGTG CGGGCGGTGG 60
AAGGCGGAAG TAGGAGAGGA GTTCGGCGCC GCTTCTGTGG CCACGGCAGG TAGCGAGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	91.89	0.00e+00	1564.00
IUUC-Apl-003912	Anas platyrhynchos	75.87	0.00e+00	1205.00
IUUC-Aca-004291	Anolis carolinensis	79.33	0.00e+00	1391.00
IUUC-Bta-013231	Bos taurus	91.08	0.00e+00	1521.00
IUUC-Cel-018299	Caenorhabditis elegans	66.84	0.00e+00	827.00
IUUC-Cja-019455	Callithrix jacchus	94.51	0.00e+00	1634.00
IUUC-Cfa-021017	Canis familiaris	92.56	0.00e+00	1555.00
IUUC-Cpo-021988	Cavia porcellus	92.11	0.00e+00	1606.00
IUUC-Csa-023549	Chlorocebus sabaeus	94.39	0.00e+00	1639.00
IUUC-Dre-028513	Danio rerio	91.77	0.00e+00	1132.00
IUUC-Dno-028976	Dasypus novemcinctus	91.42	0.00e+00	1594.00
IUUC-Dor-030176	Dipodomys ordii	89.75	0.00e+00	1467.00
IUUC-Eca-033949	Equus caballus	92.22	0.00e+00	1572.00
IUUC-Eeu-034529	Erinaceus europaeus	83.69	0.00e+00	1293.00
IUUC-Fca-036236	Felis catus	91.88	0.00e+00	1597.00
IUUC-Fal-036948	Ficedula albicollis	77.65	0.00e+00	1311.00
IUUC-Gmo-038842	Gadus morhua	89.07	0.00e+00	1065.00
IUUC-Gga-040617	Gallus gallus	80.11	0.00e+00	1411.00
IUUC-Gac-041338	Gasterosteus aculeatus	89.88	0.00e+00	1077.00
IUUC-Ggo-045278	Gorilla gorilla	95.42	0.00e+00	1651.00
IUUC-Hsa-046148	Homo sapiens	95.42	0.00e+00	1652.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	97.94	0.00e+00	1116.00
IUUC-Lch-050663	Latimeria chalumnae	76.61	0.00e+00	1368.00
IUUC-Loc-052604	Lepisosteus oculatus	75.03	0.00e+00	1309.00
IUUC-Laf-053944	Loxodonta africana	91.88	0.00e+00	1592.00
IUUC-Mcc-055655	Macaca mulatta	94.51	0.00e+00	1639.00
IUUC-Meu-055953	Macropus eugenii	77.03	0.00e+00	1319.00
IUUC-Mga-060190	Meleagris gallopavo	80.43	0.00e+00	1418.00
IUUC-Mmr-060896	Microcebus murinus	92.87	0.00e+00	1569.00
IUUC-Mdo-062536	Monodelphis domestica	87.77	0.00e+00	1539.00
IUUC-Mmu-064017	Mus musculus	92.11	0.00e+00	1582.00
IUUC-Mpu-066608	Mustela putorius furo	89.71	0.00e+00	1519.00
IUUC-Mlu-067623	Myotis lucifugus	89.14	0.00e+00	1521.00
IUUC-Nle-069496	Nomascus leucogenys	93.14	0.00e+00	1600.00
IUUC-Opr-071054	Ochotona princeps	94.67	0.00e+00	1221.00
IUUC-Ont-071279	Oreochromis niloticus	72.89	0.00e+00	1253.00
IUUC-Oan-073512	Ornithorhynchus anatinus	84.36	0.00e+00	1455.00
IUUC-Ocu-074271	Oryctolagus cuniculus	91.63	0.00e+00	1557.00
IUUC-Ola-087237	Oryzias latipes	65.45	0.00e+00	1116.00
IUUC-Oga-088164	Otolemur garnettii	92.68	0.00e+00	1608.00
IUUC-Oar-089698	Ovis aries	91.42	0.00e+00	1533.00
IUUC-Ptr-091306	Pan troglodytes	94.16	0.00e+00	1621.00
IUUC-Pan-092814	Papio anubis	90.18	0.00e+00	1546.00
IUUC-Pfo-096709	Poecilia formosa	72.76	0.00e+00	1246.00
IUUC-Pca-100596	Procavia capensis	83.16	0.00e+00	1358.00
IUUC-Pva-103154	Pteropus vampyrus	90.30	0.00e+00	1538.00
IUUC-Rno-104954	Rattus norvegicus	91.58	0.00e+00	1362.00
IUUC-Sha-106781	Sarcophilus harrisii	88.57	0.00e+00	1581.00
IUUC-Sre-114929	Sporisorium reilianum	46.02	2.00e-150	526.00
IUUC-Ssc-116307	Sus scrofa	80.15	0.00e+00	1398.00
IUUC-Tgu-116530	Taeniopygia guttata	77.03	0.00e+00	1102.00
IUUC-Tru-118287	Takifugu rubripes	89.63	0.00e+00	1066.00
IUUC-Tsy-119097	Tarsius syrichta	82.68	0.00e+00	1206.00
IUUC-Tni-120801	Tetraodon nigroviridis	70.45	0.00e+00	1201.00
IUUC-Tbe-127793	Tupaia belangeri	81.58	0.00e+00	1370.00
IUUC-Ttr-128275	Tursiops truncatus	88.56	0.00e+00	1517.00
IUUC-Uma-129332	Ustilago maydis	46.53	7.00e-143	501.00
IUUC-Xtr-132866	Xenopus tropicalis	81.98	0.00e+00	1121.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence