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Tag Content
UUCD2 ID IUUC-Mga-059561
UUCD1 version UUC-MeG-00874
Ensembl Protein ID ENSMGAP00000004598.1
UniProt Accession G1MZU0; G1MZU0_MELGA
Protein Name Uncharacterized protein
Gene Name CYLD
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMGAG00000004739.1 ENSMGAT00000005318.1 ENSMGAP00000004598.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 8.60e-24 84.1 591 950
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 591  GIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 677
           999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  +k++k +  +i++l+++++ ++ +k    ++c  ++  r+ + +++ 
   Q: 678  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMDKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKMF 764
           ****************99..88999999999999**************************9854144444799****999********9 PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleL.. 259
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++++ +   k+k+++++   +           ++++ ++ +++p+ L  
   Q: 765  NKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYEDTDISAG-KIKQFCKTCNTQVHLH-----PRRQSHKFNPLSLPKDLpd 844
           999999988...***************987655**********85554.8888888655444333.....1223445778888866511 PP
   S: 260  .dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD................skVtevke.eevleetg. 327
            d ++ c+        ++k eL+av++ +      HYva+vk  +++  Wl fd                  +Vt+++e  e l+++  
   Q: 845  wDWRHGCIP-------YQKMELFAVLCIET----SHYVAFVKYGRDDsaWLFFDSmadrdgkkggqngfniPQVTPCPEvGEYLKMSVe 922
           133344444.......99*********999....9********6555669999988888899998888888555555543455554445 PP
   S: 328  ..................staYvlfYkr 337
                             ++aY+++Y++
   Q: 923  elhsldsrkiqgcarrllCDAYMCMYQS 950
           555666667777889***********85 PP
   
Organism Meleagris gallopavo
Protein Sequence
(Fasta)
MSSGLWSQEK GSSSYWEERI FYLLLQECSV VDKQTQKLLK VPKGSIGQFF QDRSSMGHSR 60
NIPCKGKKLQ IGLKILEQPH AILFVDEKDV IEINEKLAEL LLAITNCEER YSLFKSKSRL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mga-059561|DUB,USP|Meleagris gallopavo
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGCTGTATT TTTTTCTTGA AATCTTCTGT GCAGCTTCTG AAGTTTCAGT CACAATGAGT 60
TCAGGGTTAT GGAGTCAAGA AAAAGGAAGT TCATCCTATT GGGAAGAGCG CATCTTTTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mga-059561|DUB,USP|Meleagris gallopavo
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 86.88 0.00e+00 1724.00
IUUC-Apl-003356 Anas platyrhynchos 96.76 0.00e+00 1849.00
IUUC-Aca-004402 Anolis carolinensis 83.58 0.00e+00 1550.00
IUUC-Ame-011581 Astyanax mexicanus 68.98 0.00e+00 1229.00
IUUC-Bta-012359 Bos taurus 86.94 0.00e+00 1721.00
IUUC-Cel-018528 Caenorhabditis elegans 34.90 7.00e-56 212.00
IUUC-Cja-018797 Callithrix jacchus 86.56 0.00e+00 1721.00
IUUC-Cfa-020264 Canis familiaris 87.25 0.00e+00 1727.00
IUUC-Cpo-022057 Cavia porcellus 86.67 0.00e+00 1722.00
IUUC-Csa-023093 Chlorocebus sabaeus 87.36 0.00e+00 1730.00
IUUC-Cho-024486 Choloepus hoffmanni 72.89 1.00e-158 553.00
IUUC-Cin-025179 Ciona intestinalis 43.83 1.00e-117 416.00
IUUC-Dre-028233 Danio rerio 68.59 0.00e+00 1268.00
IUUC-Dno-029496 Dasypus novemcinctus 86.83 0.00e+00 1726.00
IUUC-Dor-030919 Dipodomys ordii 82.40 0.00e+00 1625.00
IUUC-Dme-032159 Drosophila melanogaster 46.06 1.00e-123 436.00
IUUC-Ete-032734 Echinops telfairi 82.08 0.00e+00 1602.00
IUUC-Eca-033350 Equus caballus 87.25 0.00e+00 1736.00
IUUC-Eeu-034566 Erinaceus europaeus 91.01 4.00e-107 382.00
IUUC-Fca-035632 Felis catus 84.07 0.00e+00 1165.00
IUUC-Fal-037313 Ficedula albicollis 90.39 0.00e+00 1705.00
IUUC-Gmo-039239 Gadus morhua 67.60 0.00e+00 1210.00
IUUC-Gga-040668 Gallus gallus 98.64 0.00e+00 1871.00
IUUC-Gac-042630 Gasterosteus aculeatus 68.08 0.00e+00 1212.00
IUUC-Ggo-044462 Gorilla gorilla 87.08 0.00e+00 1725.00
IUUC-Hsa-045846 Homo sapiens 87.08 0.00e+00 1726.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 85.15 0.00e+00 751.00
IUUC-Lch-050303 Latimeria chalumnae 70.97 0.00e+00 1303.00
IUUC-Loc-052190 Lepisosteus oculatus 70.29 0.00e+00 1276.00
IUUC-Laf-054480 Loxodonta africana 88.81 0.00e+00 735.00
IUUC-Mcc-055849 Macaca mulatta 87.29 0.00e+00 1729.00
IUUC-Meu-056755 Macropus eugenii 76.03 0.00e+00 800.00
IUUC-Mmr-060942 Microcebus murinus 86.88 0.00e+00 1714.00
IUUC-Mdo-062618 Monodelphis domestica 86.88 0.00e+00 1717.00
IUUC-Mmu-063843 Mus musculus 85.62 0.00e+00 1657.00
IUUC-Mpu-066919 Mustela putorius furo 87.15 0.00e+00 1729.00
IUUC-Mlu-066983 Myotis lucifugus 83.70 0.00e+00 1638.00
IUUC-Nle-069893 Nomascus leucogenys 86.98 0.00e+00 1724.00
IUUC-Opr-071181 Ochotona princeps 79.91 0.00e+00 1446.00
IUUC-Ont-071697 Oreochromis niloticus 67.45 0.00e+00 1205.00
IUUC-Oan-073658 Ornithorhynchus anatinus 86.73 0.00e+00 1693.00
IUUC-Ocu-074954 Oryctolagus cuniculus 87.19 0.00e+00 1730.00
IUUC-Ome-081687 Oryza meridionalis 27.27 5.50e-01 28.90
IUUC-Ola-086523 Oryzias latipes 66.06 0.00e+00 1177.00
IUUC-Oga-089003 Otolemur garnettii 87.19 0.00e+00 1736.00
IUUC-Oar-090376 Ovis aries 86.51 0.00e+00 1723.00
IUUC-Ptr-090520 Pan troglodytes 85.31 0.00e+00 1675.00
IUUC-Pan-092281 Papio anubis 87.36 0.00e+00 1730.00
IUUC-Psi-093047 Pelodiscus sinensis 93.48 0.00e+00 1680.00
IUUC-Pma-094575 Petromyzon marinus 55.25 9.00e-67 246.00
IUUC-Pfo-096358 Poecilia formosa 66.16 0.00e+00 1156.00
IUUC-Pab-097740 Pongo abelii 86.67 0.00e+00 1718.00
IUUC-Pca-100461 Procavia capensis 78.01 0.00e+00 1381.00
IUUC-Pva-102134 Pteropus vampyrus 77.81 0.00e+00 1513.00
IUUC-Rno-105807 Rattus norvegicus 84.54 0.00e+00 1628.00
IUUC-Sha-107236 Sarcophilus harrisii 87.23 0.00e+00 1669.00
IUUC-Sar-113366 Sorex araneus 94.26 0.00e+00 904.00
IUUC-Tgu-117201 Taeniopygia guttata 92.60 0.00e+00 1751.00
IUUC-Tru-117953 Takifugu rubripes 68.36 0.00e+00 1204.00
IUUC-Tsy-119610 Tarsius syrichta 84.90 0.00e+00 1681.00
IUUC-Tni-120743 Tetraodon nigroviridis 52.55 2.00e-136 479.00
IUUC-Tbe-128155 Tupaia belangeri 70.49 0.00e+00 666.00
IUUC-Ttr-128942 Tursiops truncatus 81.56 0.00e+00 1602.00
IUUC-Vpa-130281 Vicugna pacos 76.96 0.00e+00 1477.00
IUUC-Xtr-132627 Xenopus tropicalis 77.64 0.00e+00 1421.00
Created Date 25-Jun-2017

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