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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046696
Ensembl Protein ID ENSP00000427130.2
UniProt Accession Q6ZTN6; D6RCN6; Q0VAK0; Q0VGC3; Q6ZVD0; Q86SU1; AN13D_HUMAN
Genbank Protein ID BAC85932.1; BAC86550.1; AAH44239.1; AAI10420.1; AAI21025.1; AAI21026.1
Protein Name Ankyrin repeat domain-containing protein 13D
Genbank Nucleotide ID AK124721; AK126438; AP001885; BC110419; BC121024; BC121025
Gene Name ANKRD13D
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000172932.14 ENST00000506119.1 ENSP00000480227.1
ENSG00000172932.14 ENST00000515828.1 ENSP00000443977.1
ENSG00000172932.14 ENST00000511455.6 ENSP00000427130.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 22298428
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UIM 1.00e-06 29.7 565 583
UBD/Alpha-Helix/UIM 0.00027 13.1 482 499
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UIM
   S: 2    EdeeLqlAlalSlqEeees 20
            +e+L+lAl+lS+ E+ee+
   Q: 565  FEEQLRLALELSSREQEER 583
           79**************986 PP
   

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEee 18
           ++d++Lq A+++Sl E++
   Q: 482  EDDDLLQFAIQQSLLEAG 499
           69**************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
 Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Protein Sequence
(Fasta)
MAGPGPTFPL HRLVWANRHR ELEAALHSHQ HDIEQEDPRG RTPLELAVSL GNLESVRVLL 60
RHNANVGKEN RQGWAVLQEA VSTGDPEMVQ LVLQYRDYQR ATQRLAGIPE LLNKLRQAPD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046696|UBD,UIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACGCTGGCA GCCAACCGCA GCCTCTGCAA AAGGGACTCG TGCGGCGGGC GAAGGCAGCC 60
GTTCGCCGCG GGCGGTCCTC CGCCGGGACG GCTCTGCCGC TGCCTGGGCC TGCGCCCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046696|UBD,UIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR021832--ANKRD13
IPR003903--UIM_dom
PROSITE

PS50330--UIM
Pfam

PF11904--GPCR_chapero_1
SMART

SM00726--UIM
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005770--C:late endosome
GO:0005886--C:plasma membrane
KEGG hsa:338692
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001892 Ailuropoda melanoleuca 91.54 0.00e+00 937.00
IUUC-Aca-004711 Anolis carolinensis 74.71 0.00e+00 915.00
IUUC-Ame-011241 Astyanax mexicanus 63.18 0.00e+00 740.00
IUUC-Bta-013346 Bos taurus 93.64 0.00e+00 955.00
IUUC-Cel-018411 Caenorhabditis elegans 36.57 6.00e-96 345.00
IUUC-Cja-019755 Callithrix jacchus 97.05 0.00e+00 853.00
IUUC-Cfa-020633 Canis familiaris 93.74 0.00e+00 996.00
IUUC-Cpo-021676 Cavia porcellus 94.39 0.00e+00 1084.00
IUUC-Csa-023215 Chlorocebus sabaeus 98.18 0.00e+00 834.00
IUUC-Dre-027486 Danio rerio 69.43 0.00e+00 838.00
IUUC-Dno-030054 Dasypus novemcinctus 86.81 0.00e+00 761.00
IUUC-Dor-030688 Dipodomys ordii 89.41 0.00e+00 781.00
IUUC-Dme-031648 Drosophila melanogaster 41.64 2.00e-134 473.00
IUUC-Eca-033452 Equus caballus 93.37 0.00e+00 976.00
IUUC-Fca-036526 Felis catus 94.55 0.00e+00 975.00
IUUC-Fal-036633 Ficedula albicollis 81.57 0.00e+00 855.00
IUUC-Gmo-038939 Gadus morhua 73.24 0.00e+00 742.00
IUUC-Gga-041273 Gallus gallus 80.59 0.00e+00 799.00
IUUC-Gac-042062 Gasterosteus aculeatus 67.92 0.00e+00 803.00
IUUC-Ggo-044997 Gorilla gorilla 99.43 0.00e+00 1048.00
IUUC-Itr-048122 Ictidomys tridecemlineatus 96.20 0.00e+00 1028.00
IUUC-Lch-049628 Latimeria chalumnae 71.78 0.00e+00 786.00
IUUC-Laf-053963 Loxodonta africana 91.03 0.00e+00 1004.00
IUUC-Mcc-055559 Macaca mulatta 91.30 0.00e+00 900.00
IUUC-Meu-056015 Macropus eugenii 89.10 0.00e+00 770.00
IUUC-Mga-059736 Meleagris gallopavo 83.42 0.00e+00 635.00
IUUC-Mmr-060813 Microcebus murinus 94.31 0.00e+00 967.00
IUUC-Mmu-063277 Mus musculus 92.40 0.00e+00 974.00
IUUC-Mpu-065797 Mustela putorius furo 93.05 0.00e+00 857.00
IUUC-Mlu-066928 Myotis lucifugus 93.16 0.00e+00 830.00
IUUC-Nle-069938 Nomascus leucogenys 98.10 0.00e+00 1044.00
IUUC-Ont-071644 Oreochromis niloticus 71.79 0.00e+00 839.00
IUUC-Ola-087183 Oryzias latipes 71.10 0.00e+00 829.00
IUUC-Olu-087726 Ostreococcus lucimarinus 22.32 1.00e-12 67.40
IUUC-Oga-087944 Otolemur garnettii 93.14 0.00e+00 1049.00
IUUC-Oar-089889 Ovis aries 80.00 0.00e+00 894.00
IUUC-Ptr-091094 Pan troglodytes 99.24 0.00e+00 1047.00
IUUC-Pan-092736 Papio anubis 98.29 0.00e+00 1008.00
IUUC-Pma-094712 Petromyzon marinus 63.06 3.00e-120 425.00
IUUC-Pfo-096046 Poecilia formosa 67.25 0.00e+00 823.00
IUUC-Pab-097819 Pongo abelii 98.41 0.00e+00 835.00
IUUC-Pva-103123 Pteropus vampyrus 88.18 0.00e+00 821.00
IUUC-Rno-106043 Rattus norvegicus 93.06 0.00e+00 1003.00
IUUC-Ssc-115326 Sus scrofa 93.88 0.00e+00 976.00
IUUC-Tru-117688 Takifugu rubripes 70.38 0.00e+00 835.00
IUUC-Tni-120596 Tetraodon nigroviridis 70.38 0.00e+00 834.00
IUUC-Ttr-129074 Tursiops truncatus 92.07 0.00e+00 869.00
Created Date 25-Jun-2017

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