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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063993
Ensembl Protein ID ENSMUSP00000141731.1
UniProt Accession Q8N7N5; Q8CII7; Q8CIK6; DCAF8_MOUSE
Genbank Protein ID BAC05237.1; BAE27462.1; AAH23704.1; AAH23804.1
Protein Name DDB1- and CUL4-associated factor 8; WD repeat-containing protein 42A
Genbank Nucleotide ID AK098114; AK146825; BC023704; BC023804
Gene Name Dcaf8; D1Ucla4; H326; Wdr42a
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026554.15 ENSMUST00000193638.5 ENSMUSP00000141836.1
ENSMUSG00000026554.15 ENSMUST00000191689.5 ENSMUSP00000141731.1
ENSMUSG00000026554.15 ENSMUST00000195345.1 ENSMUSP00000141842.1
ENSMUSG00000026554.15 ENSMUST00000191891.1 ENSMUSP00000141751.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.30e-22 80.0 185 216
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gHt+ v+ l+f   +t l+sGsdD ++ vWD+
   Q: 185  GHTGCVNTLHFnqRGTWLASGSDDLKVVVWDW 216
           8**********86559***************7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Protein Sequence
(Fasta)
MSNKRPNTTD GRTDLANGSL SSSPEEMSGA EEGRETSSGI EVEASDLSLS LTGDDGGPNR 60
TSTESRGTDT ESSGEEKDSD SMEDTGHYSI NDESRGHGHS DEEDEEQPRH RGQRKRASRD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063993|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGTCGCAAA CCCCGCCGGA AAGCGTGACG GCGCAGGCGC AGGCGCGGAG ACCCGAGACG 60
GTGGTGGTGG CTGCCGCTGG CCAGTGTAAG ATGGCGGCGG CGTTGGTGGC GGCAGTGGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063993|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016567--P:protein ubiquitination
KEGG mmu:98193
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000985 Aegilops tauschii 41.19 1.00e-83 303.00
IUUC-Aml-001810 Ailuropoda melanoleuca 94.30 0.00e+00 1042.00
IUUC-Atr-002578 Amborella trichopoda 43.88 1.00e-82 300.00
IUUC-Apl-003872 Anas platyrhynchos 67.87 4.00e-159 554.00
IUUC-Aca-004853 Anolis carolinensis 81.31 0.00e+00 903.00
IUUC-Aly-005505 Arabidopsis lyrata 41.82 4.00e-80 291.00
IUUC-Ath-007629 Arabidopsis thaliana 42.09 8.00e-78 284.00
IUUC-Ame-011615 Astyanax mexicanus 63.27 0.00e+00 701.00
IUUC-Bta-013549 Bos taurus 96.28 0.00e+00 1056.00
IUUC-Bdi-014538 Brachypodium distachyon 39.95 3.00e-74 272.00
IUUC-Bol-015797 Brassica oleracea 41.53 1.00e-77 283.00
IUUC-Bra-017142 Brassica rapa 41.80 1.00e-77 283.00
IUUC-Cja-018802 Callithrix jacchus 95.14 0.00e+00 1052.00
IUUC-Cfa-020535 Canis familiaris 94.64 0.00e+00 1046.00
IUUC-Cpo-022216 Cavia porcellus 96.11 0.00e+00 1058.00
IUUC-Cre-022883 Chlamydomonas reinhardtii 63.22 9.00e-29 122.00
IUUC-Csa-023095 Chlorocebus sabaeus 95.32 0.00e+00 1053.00
IUUC-Cho-024446 Choloepus hoffmanni 85.15 1.00e-139 489.00
IUUC-Cin-025683 Ciona intestinalis 57.96 3.00e-144 504.00
IUUC-Csv-026331 Ciona savignyi 58.05 1.00e-126 446.00
IUUC-Dre-027731 Danio rerio 64.64 0.00e+00 680.00
IUUC-Dno-029192 Dasypus novemcinctus 92.98 0.00e+00 1022.00
IUUC-Dse-031250 Dothistroma septosporum 50.00 2.00e-23 105.00
IUUC-Dme-032115 Drosophila melanogaster 42.66 1.00e-83 304.00
IUUC-Ete-032932 Echinops telfairi 85.66 0.00e+00 881.00
IUUC-Eca-034100 Equus caballus 94.97 0.00e+00 1050.00
IUUC-Fca-036138 Felis catus 94.15 0.00e+00 1041.00
IUUC-Fal-037132 Ficedula albicollis 95.58 5.00e-55 205.00
IUUC-Gmo-038895 Gadus morhua 78.68 0.00e+00 634.00
IUUC-Gga-040447 Gallus gallus 87.15 0.00e+00 925.00
IUUC-Gac-041796 Gasterosteus aculeatus 78.00 0.00e+00 678.00
IUUC-Gma-044062 Glycine max 40.63 7.00e-75 275.00
IUUC-Ggo-045613 Gorilla gorilla 96.21 0.00e+00 1035.00
IUUC-Hsa-046377 Homo sapiens 95.48 0.00e+00 1055.00
IUUC-Hvu-047687 Hordeum vulgare 43.01 1.00e-85 310.00
IUUC-Itr-048599 Ictidomys tridecemlineatus 90.19 0.00e+00 959.00
IUUC-Lch-050050 Latimeria chalumnae 61.83 0.00e+00 656.00
IUUC-Lpe-051191 Leersia perrieri 42.12 8.00e-82 297.00
IUUC-Laf-053407 Loxodonta africana 95.94 0.00e+00 1016.00
IUUC-Mcc-055604 Macaca mulatta 95.32 0.00e+00 1055.00
IUUC-Meu-056043 Macropus eugenii 88.54 0.00e+00 850.00
IUUC-Mtr-057813 Medicago truncatula 41.38 6.00e-82 298.00
IUUC-Mga-059697 Meleagris gallopavo 84.85 2.00e-166 578.00
IUUC-Mmr-061338 Microcebus murinus 95.64 0.00e+00 1056.00
IUUC-Mdo-062689 Monodelphis domestica 94.01 0.00e+00 958.00
IUUC-Mac-064558 Musa acuminata 40.80 7.00e-83 301.00
IUUC-Mpu-066622 Mustela putorius furo 93.80 0.00e+00 1045.00
IUUC-Mlu-067235 Myotis lucifugus 94.29 0.00e+00 983.00
IUUC-Nle-069048 Nomascus leucogenys 95.32 0.00e+00 1053.00
IUUC-Opr-070489 Ochotona princeps 80.06 8.00e-141 493.00
IUUC-Ont-072060 Oreochromis niloticus 77.88 0.00e+00 693.00
IUUC-Ocu-074684 Oryctolagus cuniculus 94.93 0.00e+00 1029.00
IUUC-Oba-075746 Oryza barthii 41.65 1.00e-84 306.00
IUUC-Obr-076629 Oryza brachyantha 42.32 9.00e-87 314.00
IUUC-Ogl-077243 Oryza glaberrima 43.39 2.00e-86 313.00
IUUC-Ogu-078029 Oryza glumaepatula 43.39 2.00e-86 312.00
IUUC-Oin-080109 Oryza indica 39.34 7.00e-74 271.00
IUUC-Olo-080308 Oryza longistaminata 42.23 9.00e-84 303.00
IUUC-Ome-081126 Oryza meridionalis 43.32 6.00e-84 304.00
IUUC-Oni-083114 Oryza nivara 43.39 1.00e-86 313.00
IUUC-Opu-083288 Oryza punctata 42.51 4.00e-84 305.00
IUUC-Oru-084724 Oryza rufipogon 43.39 2.00e-86 312.00
IUUC-Osa-085895 Oryza sativa 43.39 2.00e-86 313.00
IUUC-Olu-087847 Ostreococcus lucimarinus 29.86 4.00e-35 142.00
IUUC-Oga-088849 Otolemur garnettii 95.97 0.00e+00 1058.00
IUUC-Oar-089474 Ovis aries 92.76 0.00e+00 1000.00
IUUC-Ptr-091235 Pan troglodytes 95.48 0.00e+00 1055.00
IUUC-Pan-092895 Papio anubis 95.32 0.00e+00 1053.00
IUUC-Psi-093973 Pelodiscus sinensis 88.15 0.00e+00 961.00
IUUC-Ppa-095764 Physcomitrella patens 42.68 2.00e-85 309.00
IUUC-Pfo-097275 Poecilia formosa 78.55 0.00e+00 692.00
IUUC-Pab-098299 Pongo abelii 95.65 0.00e+00 1057.00
IUUC-Pop-099784 Populus trichocarpa 41.23 2.00e-78 286.00
IUUC-Pca-100729 Procavia capensis 89.78 0.00e+00 970.00
IUUC-Ppe-101712 Prunus persica 40.47 6.00e-79 288.00
IUUC-Pva-103030 Pteropus vampyrus 95.31 0.00e+00 1053.00
IUUC-Rno-105416 Rattus norvegicus 98.14 0.00e+00 1078.00
IUUC-Sha-106545 Sarcophilus harrisii 94.62 0.00e+00 972.00
IUUC-Smo-109128 Selaginella moellendorffii 46.11 3.00e-90 325.00
IUUC-Sit-110823 Setaria italica 41.16 5.00e-85 308.00
IUUC-Sly-111605 Solanum lycopersicum 38.86 3.00e-76 279.00
IUUC-Stu-111978 Solanum tuberosum 40.90 7.00e-82 298.00
IUUC-Sbi-114455 Sorghum bicolor 41.01 5.00e-80 291.00
IUUC-Ssc-115612 Sus scrofa 95.14 0.00e+00 1050.00
IUUC-Tru-117708 Takifugu rubripes 78.12 0.00e+00 695.00
IUUC-Tsy-119579 Tarsius syrichta 88.55 0.00e+00 742.00
IUUC-Tni-120739 Tetraodon nigroviridis 71.91 0.00e+00 706.00
IUUC-Tca-121555 Theobroma cacao 42.03 4.00e-80 292.00
IUUC-Tae-125509 Triticum aestivum 44.51 5.00e-87 314.00
IUUC-Tur-126617 Triticum urartu 41.53 2.00e-73 269.00
IUUC-Tbe-128115 Tupaia belangeri 94.94 0.00e+00 712.00
IUUC-Ttr-128231 Tursiops truncatus 89.78 0.00e+00 972.00
IUUC-Vpa-130377 Vicugna pacos 78.06 0.00e+00 854.00
IUUC-Vvi-131540 Vitis vinifera 40.98 6.00e-80 291.00
IUUC-Xtr-131860 Xenopus tropicalis 77.64 0.00e+00 819.00
IUUC-Xma-133371 Xiphophorus maculatus 78.37 0.00e+00 693.00
Created Date 25-Jun-2017

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