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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108345
UUCD1 version UUC-ScP-00272
Ensembl Protein ID SPAC24H6.12c.1:pep
UniProt Accession Q09765; UBA3_SCHPO
Genbank Protein ID CAA90856.1
Protein Name NEDD8-activating enzyme E1 catalytic subunit; Ubiquitin-activating enzyme E1 3
Genbank Nucleotide ID CU329670
Gene Name uba3; SPAC24H6.12c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC24H6.12c SPAC24H6.12c.1 SPAC24H6.12c.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexMentha
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E1 7.20e-81 270.6 40 223
Active Site
Position(s) Description Evidence
205 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU10132}
Domain Profile

   E1
   S: 14   eklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesiteleeei 104
           ++  s+k+l++GagglGcE+lK L+l+G++ + v+Dmdt++++nlnrqFLf+++++  +KA+vaa  + ++ p+  v++   +i++++ e 
   Q: 40   KSAFSSKILIIGAGGLGCEILKDLALSGFRDLSVIDMDTIDITNLNRQFLFNESNIDEPKANVAASMIMKRIPSTVVTPFYGKIQDKTIE- 129
           556789*********************************************************************************999. PP
   S: 105  vFfkkfdvVvlaldnrearrkvnrlclna.....rvpliesgtlGllGqvrviikgltecyscsd..dppqktiPfctlketpnaaehtie 188
            F+k+f++++++ld++earr++n+ ++++      +pl+++g++Gl+Gq+rvii+ +t cy+cs     p+ ++P+ctl++tp+ +eh++e
   Q: 130  -FYKEFKLIICGLDSVEARRWINSTLVAIaktgdLIPLVDGGSEGLKGQARVIIPTITSCYECSLdmLTPKISYPICTLANTPRLPEHCVE 219
           .****************************************************************88889999****************** PP
   S: 189  wavl 192
           wa+l
   Q: 220  WAYL 223
           **33 PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Catalytic subunit of the dimeric uba3-ula1 E1 enzyme. E1 activates NEDD8/ubl1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-uba3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc12 (By similarity).
 Catalytic subunit of the dimeric uba3-ula1 E1 enzyme. E1 activates NEDD8/ubl1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-uba3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc12 (By similarity).
Protein Sequence
(Fasta)
MPSSDVCKAG SHRHSGWIQS LKKPGPFNLD APENPEETLK SAFSSKILII GAGGLGCEIL 60
KDLALSGFRD LSVIDMDTID ITNLNRQFLF NESNIDEPKA NVAASMIMKR IPSTVVTPFY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Spo-108345|E1,E1_ThiF|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CACATTATTA CATGTTAAAA AGTATCTTCC AACTTTCATA CTCCATTTCA TTATCCTCTT 60
ATTAAATGAG TAGCCATATT TCCTGACAGC ATTGGAGTAT TTTCATACAC AAATTCCTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108345|E1,E1_ThiF|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR014929--E2_binding
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR023318--Ub_act_enz_dom_a
IPR030468--Uba3
IPR033127--UBQ-activ_enz_E1_Cys_AS
PROSITE

PS00865--UBIQUITIN_ACTIVAT_2
Pfam

PF08825--E2_bind
PF00899--ThiF
SMART

SM01181--E2_bind
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0016881--F:acid-amino acid ligase activity
GO:0005524--F:ATP binding
GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation
KEGG spo:SPAC24H6.12c
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001124 Aegilops tauschii 38.24 5.00e-62 229.00
IUUC-Aml-001578 Ailuropoda melanoleuca 43.54 8.00e-98 348.00
IUUC-Atr-002591 Amborella trichopoda 39.95 6.00e-70 256.00
IUUC-Apl-003671 Anas platyrhynchos 43.51 2.00e-99 353.00
IUUC-Aca-004749 Anolis carolinensis 43.75 1.00e-99 354.00
IUUC-Aly-005747 Arabidopsis lyrata 41.56 2.00e-79 287.00
IUUC-Ath-006623 Arabidopsis thaliana 41.56 2.00e-79 287.00
IUUC-Ago-007934 Ashbya gossypii 42.06 5.00e-69 252.00
IUUC-Acl-008047 Aspergillus clavatus 46.84 3.00e-109 386.00
IUUC-Afl-008615 Aspergillus flavus 40.38 9.00e-69 251.00
IUUC-Afu-008996 Aspergillus fumigatus 47.89 4.00e-106 375.00
IUUC-Ani-009281 Aspergillus nidulans 44.08 8.00e-75 271.00
IUUC-Ang-009539 Aspergillus niger 48.19 4.00e-100 355.00
IUUC-Aor-010151 Aspergillus oryzae 43.20 6.00e-96 342.00
IUUC-Ate-010502 Aspergillus terreus 46.95 8.00e-102 361.00
IUUC-Ame-011837 Astyanax mexicanus 41.51 4.00e-88 316.00
IUUC-Bgr-012068 Blumeria graminis 45.41 9.00e-97 345.00
IUUC-Bta-013003 Bos taurus 43.54 2.00e-98 350.00
IUUC-Bci-013983 Botrytis cinerea 46.93 5.00e-103 365.00
IUUC-Bdi-014429 Brachypodium distachyon 40.00 3.00e-69 253.00
IUUC-Bol-015490 Brassica oleracea 40.32 2.00e-71 261.00
IUUC-Bra-018023 Brassica rapa 39.19 3.00e-70 257.00
IUUC-Cel-018684 Caenorhabditis elegans 40.33 1.00e-92 331.00
IUUC-Cja-019200 Callithrix jacchus 43.44 4.00e-97 346.00
IUUC-Cfa-021038 Canis familiaris 43.54 1.00e-98 351.00
IUUC-Cre-022778 Chlamydomonas reinhardtii 47.84 9.00e-87 311.00
IUUC-Csa-024079 Chlorocebus sabaeus 43.78 4.00e-99 352.00
IUUC-Cho-025052 Choloepus hoffmanni 38.76 7.00e-82 295.00
IUUC-Cin-025113 Ciona intestinalis 39.08 2.00e-82 297.00
IUUC-Csv-026231 Ciona savignyi 41.40 2.00e-91 327.00
IUUC-Cgl-026535 Colletotrichum gloeosporioides 43.93 4.00e-101 359.00
IUUC-Cne-026850 Cryptococcus neoformans 50.59 2.00e-112 397.00
IUUC-Cme-027275 Cyanidioschyzon merolae 32.04 2.00e-63 234.00
IUUC-Dre-028751 Danio rerio 41.32 9.00e-90 322.00
IUUC-Dno-029571 Dasypus novemcinctus 43.03 2.00e-98 350.00
IUUC-Dor-030395 Dipodomys ordii 43.90 2.00e-98 350.00
IUUC-Dse-031329 Dothistroma septosporum 41.76 4.00e-92 329.00
IUUC-Dme-031776 Drosophila melanogaster 41.65 2.00e-91 327.00
IUUC-Eca-034389 Equus caballus 43.54 2.00e-98 350.00
IUUC-Eeu-035152 Erinaceus europaeus 39.80 1.00e-80 291.00
IUUC-Fca-036032 Felis catus 43.54 1.00e-98 351.00
IUUC-Fal-037506 Ficedula albicollis 43.03 5.00e-99 352.00
IUUC-Fox-037871 Fusarium oxysporum 46.01 2.00e-86 310.00
IUUC-Fso-038350 Fusarium solani 47.51 2.00e-94 337.00
IUUC-Gmo-039647 Gadus morhua 44.36 4.00e-91 326.00
IUUC-Ggr-039859 Gaeumannomyces graminis 47.42 3.00e-97 346.00
IUUC-Gga-040843 Gallus gallus 42.07 1.00e-92 331.00
IUUC-Gac-042601 Gasterosteus aculeatus 41.48 2.00e-89 320.00
IUUC-Gma-043031 Glycine max 39.80 5.00e-74 269.00
IUUC-Ggo-044788 Gorilla gorilla 43.44 7.00e-98 348.00
IUUC-Hsa-045849 Homo sapiens 43.54 6.00e-99 352.00
IUUC-Hvu-047819 Hordeum vulgare 41.01 7.00e-64 235.00
IUUC-Itr-047863 Ictidomys tridecemlineatus 43.27 8.00e-99 352.00
IUUC-Kpa-049393 Komagataella pastoris 54.30 5.00e-102 362.00
IUUC-Lch-049471 Latimeria chalumnae 42.31 4.00e-88 316.00
IUUC-Lpe-051297 Leersia perrieri 38.69 1.00e-76 278.00
IUUC-Loc-052910 Lepisosteus oculatus 41.75 3.00e-88 317.00
IUUC-Lma-053181 Leptosphaeria maculans 43.98 6.00e-102 362.00
IUUC-Laf-054314 Loxodonta africana 43.03 5.00e-97 346.00
IUUC-Mcc-054870 Macaca mulatta 43.54 6.00e-99 352.00
IUUC-Meu-056574 Macropus eugenii 37.41 1.00e-45 174.00
IUUC-Mor-056919 Magnaporthe oryzae 43.87 1.00e-90 324.00
IUUC-Mpo-057614 Magnaporthe poae 47.13 1.00e-91 327.00
IUUC-Mtr-058110 Medicago truncatula 40.35 4.00e-73 266.00
IUUC-Mla-058949 Melampsora laricipopulina 51.24 1.00e-106 377.00
IUUC-Mga-059455 Meleagris gallopavo 43.27 7.00e-99 352.00
IUUC-Mvi-060270 Microbotryum violaceum 48.65 4.00e-109 386.00
IUUC-Mmr-061155 Microcebus murinus 43.06 3.00e-96 343.00
IUUC-Mdo-062037 Monodelphis domestica 42.82 3.00e-97 346.00
IUUC-Mmu-063670 Mus musculus 43.44 4.00e-99 352.00
IUUC-Mac-064711 Musa acuminata 40.33 1.00e-68 251.00
IUUC-Mpu-066734 Mustela putorius furo 43.75 1.00e-98 351.00
IUUC-Mlu-067068 Myotis lucifugus 43.68 3.00e-99 353.00
IUUC-Nfi-068349 Neosartorya fischeri 47.42 5.00e-105 372.00
IUUC-Ncr-068626 Neurospora crassa 48.94 1.00e-93 335.00
IUUC-Nle-069366 Nomascus leucogenys 45.41 4.00e-95 339.00
IUUC-Ont-072196 Oreochromis niloticus 43.49 8.00e-89 318.00
IUUC-Oan-073511 Ornithorhynchus anatinus 43.20 2.00e-98 350.00
IUUC-Ocu-073773 Oryctolagus cuniculus 43.54 4.00e-99 352.00
IUUC-Oba-075726 Oryza barthii 35.57 4.00e-67 246.00
IUUC-Obr-076286 Oryza brachyantha 39.13 1.00e-74 271.00
IUUC-Ogu-078473 Oryza glumaepatula 35.57 3.00e-67 246.00
IUUC-Oin-079393 Oryza indica 38.86 9.00e-77 278.00
IUUC-Olo-080446 Oryza longistaminata 37.50 2.00e-70 257.00
IUUC-Ome-081737 Oryza meridionalis 37.50 1.00e-70 258.00
IUUC-Oni-082853 Oryza nivara 35.57 4.00e-67 246.00
IUUC-Opu-083590 Oryza punctata 38.86 3.00e-76 276.00
IUUC-Oru-084184 Oryza rufipogon 35.57 4.00e-67 246.00
IUUC-Osa-085402 Oryza sativa 38.86 9.00e-77 278.00
IUUC-Ola-086671 Oryzias latipes 43.53 7.00e-81 292.00
IUUC-Olu-087738 Ostreococcus lucimarinus 37.66 2.00e-69 254.00
IUUC-Oga-088101 Otolemur garnettii 43.54 1.00e-98 351.00
IUUC-Oar-090293 Ovis aries 43.03 7.00e-97 345.00
IUUC-Ptr-090503 Pan troglodytes 43.54 6.00e-99 352.00
IUUC-Pan-092477 Papio anubis 42.09 2.00e-95 340.00
IUUC-Psi-093442 Pelodiscus sinensis 42.93 1.00e-95 341.00
IUUC-Pma-094247 Petromyzon marinus 43.78 2.00e-92 330.00
IUUC-Pno-094780 Phaeosphaeria nodorum 47.26 1.00e-105 374.00
IUUC-Ppa-095338 Physcomitrella patens 40.65 2.00e-90 323.00
IUUC-Pfo-096846 Poecilia formosa 40.88 4.00e-91 326.00
IUUC-Pab-098060 Pongo abelii 43.30 5.00e-90 322.00
IUUC-Pop-099914 Populus trichocarpa 41.46 1.00e-77 281.00
IUUC-Pca-100500 Procavia capensis 36.95 1.00e-66 245.00
IUUC-Ppe-102008 Prunus persica 40.37 1.00e-69 254.00
IUUC-Pva-103095 Pteropus vampyrus 50.27 3.00e-53 200.00
IUUC-Pgr-103666 Puccinia graminis 51.72 2.00e-109 387.00
IUUC-Ptt-103901 Puccinia triticina 49.09 2.00e-109 387.00
IUUC-Pte-104198 Pyrenophora teres 44.68 2.00e-102 363.00
IUUC-Pyt-104792 Pyrenophora triticirepentis 44.44 2.00e-100 357.00
IUUC-Rno-105446 Rattus norvegicus 43.20 6.00e-99 352.00
IUUC-Sce-106355 Saccharomyces cerevisiae 39.56 3.00e-66 243.00
IUUC-Sha-106664 Sarcophilus harrisii 42.79 4.00e-97 346.00
IUUC-Sja-107982 Schizosaccharomyces japonicus 49.42 2.00e-113 400.00
IUUC-Ssl-108540 Sclerotinia sclerotiorum 44.58 7.00e-91 325.00
IUUC-Smo-109098 Selaginella moellendorffii 46.34 2.00e-101 360.00
IUUC-Sit-109724 Setaria italica 39.24 1.00e-67 248.00
IUUC-Sly-110916 Solanum lycopersicum 41.30 4.00e-77 280.00
IUUC-Stu-112236 Solanum tuberosum 41.04 7.00e-77 279.00
IUUC-Sar-113044 Sorex araneus 44.42 2.00e-96 343.00
IUUC-Sbi-114276 Sorghum bicolor 39.40 1.00e-67 248.00
IUUC-Sre-114963 Sporisorium reilianum 50.94 7.00e-110 388.00
IUUC-Ssc-116301 Sus scrofa 43.03 4.00e-97 346.00
IUUC-Tgu-117265 Taeniopygia guttata 43.03 2.00e-98 350.00
IUUC-Tru-117526 Takifugu rubripes 42.23 8.00e-87 311.00
IUUC-Tsy-119483 Tarsius syrichta 43.10 9.00e-97 345.00
IUUC-Tni-120363 Tetraodon nigroviridis 42.82 3.00e-89 320.00
IUUC-Tca-121731 Theobroma cacao 40.86 1.00e-70 258.00
IUUC-Tre-122221 Trichoderma reesei 44.07 1.00e-83 300.00
IUUC-Tvi-122352 Trichoderma virens 47.42 8.00e-97 345.00
IUUC-Tae-123864 Triticum aestivum 39.95 1.00e-68 252.00
IUUC-Tur-126070 Triticum urartu 35.33 5.00e-53 199.00
IUUC-Tme-127199 Tuber melanosporum 51.01 4.00e-108 382.00
IUUC-Tbe-128076 Tupaia belangeri 43.30 8.00e-99 351.00
IUUC-Ttr-128695 Tursiops truncatus 54.81 1.00e-39 155.00
IUUC-Uma-129638 Ustilago maydis 49.43 3.00e-110 389.00
IUUC-Vda-129963 Verticillium dahliae 45.94 3.00e-91 326.00
IUUC-Vpa-130637 Vicugna pacos 38.85 5.00e-80 289.00
IUUC-Vvi-131613 Vitis vinifera 39.19 4.00e-69 253.00
IUUC-Xtr-132924 Xenopus tropicalis 43.77 5.00e-90 322.00
IUUC-Xma-134209 Xiphophorus maculatus 41.23 4.00e-91 326.00
IUUC-Yli-134365 Yarrowia lipolytica 50.50 4.00e-102 362.00
IUUC-Zma-135941 Zea mays 36.27 2.00e-64 237.00
Created Date 25-Jun-2017

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