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Tag Content
UUCD2 ID IUUC-Xtr-132397
UUCD1 version UUC-XeT-00860
Ensembl Protein ID ENSXETP00000021128.2
UniProt Accession Q08BU1; MED8_XENTR
Genbank Protein ID AAI24563.1
Protein Name Mediator of RNA polymerase II transcription subunit 8; Mediator complex subunit 8
Genbank Nucleotide ID BC124562
Gene Name med8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000009582.2 ENSXETT00000021128.2 ENSXETP00000021128.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 77.99 3.00e-113 405.00 IUUC-Hsa-046908
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Xenopus tropicalis
Functional Description
(View)

Functional Description



     Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Protein Sequence
(Fasta)
MQREEKQLEA CLDALISQVS DIKNSLVGFI HKLENEYDRL TWPSVLDSFA LLSGQLNTLN 60
KVLKNEKTPL LRNQVIIPLL LSPDRDEEIM RLTEGRVPVF SHEVVPDHLR TKPDPDVEEL 120
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Protein Fasta Sequence



>IUUC-Xtr-132397|E3,SOCS|Xenopus tropicalis
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Nucleotide Sequence
(Fasta)
GAAGAAGTGA CCGGAATCTT TATAGCCCTA AGGAGAGGGA TTTGGCGGAA AACGTGAAAA 60
TGCAGGTAAG ATTGACATAA GACGTGTTTC ATTAATGTTT ATGTTAGTGC AAAGGCGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Xtr-132397|E3,SOCS|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway

Interpro

IPR019364--Mediatior_Med8_fun/met

Pfam

PF10232--Med8

Gene Ontology

GO:0016592--C:mediator complex
GO:0001104--F:RNA polymerase II transcription cofactor activity
GO:0016567--P:protein ubiquitination
GO:0006351--P:transcription, DNA-templated

KEGG xtr:549368
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001562 Ailuropoda melanoleuca 77.99 3.00e-104 370.00
IUUC-Apl-004218 Anas platyrhynchos 77.44 7.00e-103 366.00
IUUC-Aca-005363 Anolis carolinensis 78.36 1.00e-111 395.00
IUUC-Ame-011384 Astyanax mexicanus 66.67 1.00e-98 352.00
IUUC-Bta-012751 Bos taurus 78.81 6.00e-104 369.00
IUUC-Cel-018292 Caenorhabditis elegans 25.74 2.00e-19 89.00
IUUC-Cja-019318 Callithrix jacchus 77.99 6.00e-103 366.00
IUUC-Cfa-020106 Canis familiaris 87.39 2.00e-54 205.00
IUUC-Cpo-022416 Cavia porcellus 77.24 2.00e-94 338.00
IUUC-Csa-023695 Chlorocebus sabaeus 77.99 1.00e-102 365.00
IUUC-Cin-025570 Ciona intestinalis 46.97 6.00e-45 173.00
IUUC-Csv-025808 Ciona savignyi 43.86 7.00e-47 180.00
IUUC-Dre-027606 Danio rerio 72.39 8.00e-68 248.00
IUUC-Dno-029924 Dasypus novemcinctus 78.73 5.00e-97 346.00
IUUC-Dor-030115 Dipodomys ordii 77.99 1.00e-103 369.00
IUUC-Dme-031887 Drosophila melanogaster 43.38 5.00e-54 203.00
IUUC-Eca-034101 Equus caballus 78.73 2.00e-105 375.00
IUUC-Eeu-034655 Erinaceus europaeus 72.39 1.00e-95 342.00
IUUC-Fca-036172 Felis catus 77.99 1.00e-103 368.00
IUUC-Fal-036877 Ficedula albicollis 77.53 2.00e-106 378.00
IUUC-Gmo-039244 Gadus morhua 63.33 3.00e-87 314.00
IUUC-Gga-040751 Gallus gallus 77.99 9.00e-105 372.00
IUUC-Gac-041885 Gasterosteus aculeatus 66.05 2.00e-91 328.00
IUUC-Ggo-045201 Gorilla gorilla 77.99 8.00e-103 366.00
IUUC-Hsa-046908 Homo sapiens 77.99 8.00e-103 366.00
IUUC-Itr-048814 Ictidomys tridecemlineatus 78.36 1.00e-104 372.00
IUUC-Lch-049994 Latimeria chalumnae 76.11 3.00e-67 247.00
IUUC-Loc-051765 Lepisosteus oculatus 69.89 1.00e-100 358.00
IUUC-Laf-053336 Loxodonta africana 77.24 1.00e-105 375.00
IUUC-Mcc-055259 Macaca mulatta 78.36 1.00e-103 368.00
IUUC-Meu-056166 Macropus eugenii 75.56 1.00e-94 339.00
IUUC-Mga-059317 Meleagris gallopavo 77.82 4.00e-103 367.00
IUUC-Mmr-061501 Microcebus murinus 78.36 2.00e-104 372.00
IUUC-Mdo-062026 Monodelphis domestica 78.73 9.00e-103 365.00
IUUC-Mmu-063469 Mus musculus 78.73 1.00e-104 372.00
IUUC-Mpu-065945 Mustela putorius furo 77.99 7.00e-104 369.00
IUUC-Mlu-067414 Myotis lucifugus 76.87 3.00e-103 367.00
IUUC-Nle-069411 Nomascus leucogenys 78.73 3.00e-103 367.00
IUUC-Opr-070733 Ochotona princeps 77.90 2.00e-103 368.00
IUUC-Ont-071344 Oreochromis niloticus 63.84 9.00e-91 326.00
IUUC-Oan-073366 Ornithorhynchus anatinus 71.59 6.00e-91 326.00
IUUC-Ocu-074762 Oryctolagus cuniculus 78.73 4.00e-101 360.00
IUUC-Ola-086874 Oryzias latipes 65.68 1.00e-89 322.00
IUUC-Oga-088187 Otolemur garnettii 77.24 4.00e-103 367.00
IUUC-Oar-089832 Ovis aries 78.36 2.00e-103 368.00
IUUC-Ptr-091178 Pan troglodytes 77.61 3.00e-102 364.00
IUUC-Pan-092520 Papio anubis 78.36 2.00e-103 368.00
IUUC-Psi-093517 Pelodiscus sinensis 74.44 1.00e-103 369.00
IUUC-Pma-094752 Petromyzon marinus 62.87 2.00e-88 318.00
IUUC-Pfo-096659 Poecilia formosa 63.84 6.00e-85 306.00
IUUC-Pca-101064 Procavia capensis 73.51 3.00e-93 334.00
IUUC-Pva-102173 Pteropus vampyrus 78.36 3.00e-106 377.00
IUUC-Spo-108036 Schizosaccharomyces pombe 28.12 5.00e-03 34.30
IUUC-Sar-113363 Sorex araneus 76.03 5.00e-100 357.00
IUUC-Ssc-115563 Sus scrofa 78.73 1.00e-115 408.00
IUUC-Tgu-116686 Taeniopygia guttata 78.20 4.00e-106 377.00
IUUC-Tru-118003 Takifugu rubripes 63.33 1.00e-88 319.00
IUUC-Tsy-118875 Tarsius syrichta 69.78 9.00e-93 332.00
IUUC-Tni-120624 Tetraodon nigroviridis 61.25 1.00e-80 292.00
IUUC-Tbe-127611 Tupaia belangeri 74.63 2.00e-77 281.00
IUUC-Ttr-129198 Tursiops truncatus 77.99 2.00e-114 405.00
IUUC-Vpa-130245 Vicugna pacos 71.54 2.00e-33 135.00
Created Date 25-Jun-2017

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