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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063836
Ensembl Protein ID ENSMUSP00000031542.9
UniProt Accession Q9Z2F2; Q9D6S2; OASL2_MOUSE
Genbank Protein ID AAD02818.1; BAB26655.1; BAE29608.1; ENSMUSP00000031542
Protein Name 2'-5'-oligoadenylate synthase-like protein 2; 54 kDa 2'-5'-oligoadenylate synthase-like protein; M1204
Genbank Nucleotide ID AF068835; AK010034; AK150492; AC116500
Gene Name Oasl2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029561.17 ENSMUST00000031542.12 ENSMUSP00000031542.9
ENSMUSG00000029561.17 ENSMUST00000144064.4 ENSMUSP00000117876.1
ENSMUSG00000029561.17 ENSMUST00000124716.2 ENSMUSP00000115070.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_Other UBQ_Other 10395668; 12799444
Classification
Family E-value Score Start End
ULD/UDP/UBQ/UBQ_Other 9.50e-25 87.4 435 505
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 1    vqvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihlle 71
           ++v+vk + g + ++ ++p+dt+++LKekie++ g  +e+q L++++++Ledd +L+++ +kd +ti+l++
   Q: 435  ILVFVKYPGGQSKPFTIDPDDTILDLKEKIEDAGGPCAEDQVLLLDDEELEDDESLKELEIKDCDTIILIR 505
           579********************************99********************************96 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
 Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
Protein Sequence
(Fasta)
MDPFPDLYAT PGDSLDHFLE HSLQPQRDWK EEGQDAWERI ERFFREQCFR DELLLDQEVR 60
VIKVVKGGSS GKGTTLNHRS DQDMILFLSC FSSFEEQARN REVVISFIKK RLIHCSRSLA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063836|ULD,UBQ_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
CTCACTGAAG ATAACTAGAC AGAAAACATC GTGAGACTAC CTCACGCTGT CCATTGACCA 60
GGAGCAATCC TTTGTGCCTC ACATCTTTGG GACTGCGGTA GGCATCAGAG AAATGTCACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063836|ULD,UBQ_Other|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0051--Antiviral defense
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0391--Immunity
KW-0399--Innate immunity
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0548--Nucleotidyltransferase
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0808--Transferase
Interpro

IPR006117--2-5-oligoadenylate_synth_CS
IPR006116--2-5-oligoadenylate_synth_N
IPR018952--2-5-oligoAdlate_synth_1_dom2/C
IPR026774--2-5A_synthase
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS00832--25A_SYNTH_1
PS00833--25A_SYNTH_2
PS50152--25A_SYNTH_3
PS50053--UBIQUITIN_2
Pfam

PF10421--OAS1_C
PF00240--ubiquitin
SMART

SM00213--UBQ
Gene Ontology

GO:0001730--F:2'-5'-oligoadenylate synthetase activity
GO:0005524--F:ATP binding
GO:0003725--F:double-stranded RNA binding
GO:0046872--F:metal ion binding
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0006164--P:purine nucleotide biosynthetic process
GO:0009615--P:response to virus
KEGG mmu:23962
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aca-004872 Anolis carolinensis 47.71 1.00e-91 329.00
IUUC-Cfa-021273 Canis familiaris 67.33 0.00e+00 638.00
IUUC-Dno-029752 Dasypus novemcinctus 61.11 2.00e-167 582.00
IUUC-Eca-033262 Equus caballus 66.73 0.00e+00 647.00
IUUC-Fal-036722 Ficedula albicollis 41.27 2.00e-98 353.00
IUUC-Gga-041271 Gallus gallus 42.60 6.00e-91 328.00
IUUC-Lch-050467 Latimeria chalumnae 44.73 7.00e-85 309.00
IUUC-Mpu-066277 Mustela putorius furo 66.13 1.00e-169 589.00
IUUC-Ocu-074374 Oryctolagus cuniculus 68.00 0.00e+00 656.00
IUUC-Oga-089012 Otolemur garnettii 59.83 3.00e-75 275.00
IUUC-Psi-093420 Pelodiscus sinensis 38.25 2.00e-88 320.00
IUUC-Rno-104847 Rattus norvegicus 78.66 0.00e+00 766.00
IUUC-Sha-106862 Sarcophilus harrisii 43.18 1.00e-111 397.00
Created Date 25-Jun-2017

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