iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040445

Ensembl Protein ID

ENSGALP00000009155.3

UniProt Accession

Q5F3E8; BACD2_CHICK

Genbank Protein ID

CAH65336.1

Protein Name

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1

Genbank Nucleotide ID

AJ851702

Gene Name

TNFAIP1; RCJMB04_19f9

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000005715.3	ENSGALT00000009169.3	ENSGALP00000009155.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	5.10e-08	33.5	33	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgklde 67
            v l+vgg+ + ++  vL+++  +++a+f++ +e  +++++ + i+ +  ++f ++l++l+ +++ +
   Q: 33   YVRLNVGGSLYYTTVQVLTRHDTMLKAMFSGRMEvLTDKEGWILID-RCGKHFGTILNYLRDDTIAL 98
           599********************************9999******9.**************998765 PP

Organism

Gallus gallus

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Protein Sequence
(Fasta)

MSGDTCLTTT LCPAVGPKPK TCSFKVGSLG NKYVRLNVGG SLYYTTVQVL TRHDTMLKAM 60
FSGRMEVLTD KEGWILIDRC GKHFGTILNY LRDDTIALPK HRQEIKELMA EAKYYLIQGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGTATTGC CGCGGGCCGC AGCTGTGGGG CGGTCGCAGG CGGTGAGTGA GCGCCGGGTT 60
CGGGTGCGGT CCTGAGAGGT GGCCGTGCGC GGGCGGGGTT GCGGACACGG AGCTTCGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

PROSITE

PS50097--BTB

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0005730--C:nucleolus
GO:0017049--F:GTP-Rho binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0016477--P:cell migration
GO:0006260--P:DNA replication
GO:0009790--P:embryo development
GO:0006955--P:immune response
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
GO:0016567--P:protein ubiquitination
GO:0043149--P:stress fiber assembly

KEGG

gga:417672

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001724	Ailuropoda melanoleuca	89.17	4.00e-166	576.00
IUUC-Apl-003702	Anas platyrhynchos	98.41	0.00e+00	643.00
IUUC-Aca-004408	Anolis carolinensis	85.17	4.00e-152	530.00
IUUC-Afu-008834	Aspergillus fumigatus	32.50	1.00e+00	26.90
IUUC-Ang-009546	Aspergillus niger	33.87	6.00e-03	34.30
IUUC-Ame-010738	Astyanax mexicanus	73.37	2.00e-127	447.00
IUUC-Bta-013551	Bos taurus	89.81	5.00e-159	553.00
IUUC-Cja-019122	Callithrix jacchus	90.76	6.00e-169	585.00
IUUC-Cfa-020193	Canis familiaris	90.76	5.00e-169	586.00
IUUC-Cpo-022024	Cavia porcellus	89.49	2.00e-167	580.00
IUUC-Csa-024138	Chlorocebus sabaeus	90.76	3.00e-169	587.00
IUUC-Cho-024629	Choloepus hoffmanni	55.90	1.00e-70	258.00
IUUC-Cin-025494	Ciona intestinalis	72.77	2.00e-105	375.00
IUUC-Csv-026325	Ciona savignyi	69.18	7.00e-109	386.00
IUUC-Cgl-026403	Colletotrichum gloeosporioides	34.55	5.50e+00	26.90
IUUC-Dno-029163	Dasypus novemcinctus	89.49	2.00e-168	584.00
IUUC-Dor-030970	Dipodomys ordii	89.49	7.00e-167	579.00
IUUC-Dse-031450	Dothistroma septosporum	29.23	3.70e+00	25.80
IUUC-Dme-031829	Drosophila melanogaster	68.80	4.00e-99	353.00
IUUC-Ete-032820	Echinops telfairi	60.16	1.00e-84	305.00
IUUC-Eca-034114	Equus caballus	90.45	8.00e-169	585.00
IUUC-Eeu-034709	Erinaceus europaeus	90.45	3.00e-168	583.00
IUUC-Fca-036397	Felis catus	90.45	2.00e-160	558.00
IUUC-Fal-037588	Ficedula albicollis	95.54	0.00e+00	625.00
IUUC-Ggo-045312	Gorilla gorilla	90.76	2.00e-169	587.00
IUUC-Hsa-046091	Homo sapiens	90.76	3.00e-169	587.00
IUUC-Itr-048608	Ictidomys tridecemlineatus	89.81	3.00e-168	583.00
IUUC-Lch-049970	Latimeria chalumnae	92.04	6.00e-173	599.00
IUUC-Laf-054286	Loxodonta africana	90.13	9.00e-169	585.00
IUUC-Meu-056850	Macropus eugenii	84.39	5.00e-148	516.00
IUUC-Mga-060119	Meleagris gallopavo	99.17	4.00e-143	499.00
IUUC-Mdo-061847	Monodelphis domestica	90.45	4.00e-161	560.00
IUUC-Mmu-063130	Mus musculus	89.81	1.00e-167	581.00
IUUC-Mpu-066060	Mustela putorius furo	90.45	2.00e-168	584.00
IUUC-Mlu-067951	Myotis lucifugus	90.76	2.00e-169	587.00
IUUC-Nle-069523	Nomascus leucogenys	90.76	3.00e-169	587.00
IUUC-Opr-070426	Ochotona princeps	90.45	8.00e-169	585.00
IUUC-Ont-072156	Oreochromis niloticus	71.65	6.00e-132	462.00
IUUC-Oan-073164	Ornithorhynchus anatinus	84.28	2.00e-68	251.00
IUUC-Ocu-074319	Oryctolagus cuniculus	90.13	1.00e-168	584.00
IUUC-Oga-088279	Otolemur garnettii	89.81	1.00e-168	585.00
IUUC-Oar-089368	Ovis aries	89.81	4.00e-168	583.00
IUUC-Ptr-091204	Pan troglodytes	90.45	3.00e-162	563.00
IUUC-Pan-092880	Papio anubis	90.76	2.00e-169	588.00
IUUC-Psi-093768	Pelodiscus sinensis	93.63	1.00e-176	611.00
IUUC-Pma-094524	Petromyzon marinus	72.40	2.00e-96	345.00
IUUC-Pab-098414	Pongo abelii	89.17	2.00e-164	570.00
IUUC-Pca-100380	Procavia capensis	84.71	6.00e-156	543.00
IUUC-Pva-102366	Pteropus vampyrus	91.08	9.00e-170	588.00
IUUC-Ptt-103935	Puccinia triticina	28.57	1.30e-01	30.00
IUUC-Rno-104902	Rattus norvegicus	89.49	1.00e-167	582.00
IUUC-Sha-106996	Sarcophilus harrisii	89.81	4.00e-161	560.00
IUUC-Ssc-116300	Sus scrofa	90.45	1.00e-168	585.00
IUUC-Tgu-116738	Taeniopygia guttata	95.22	5.00e-180	622.00
IUUC-Tru-117840	Takifugu rubripes	73.94	1.00e-115	408.00
IUUC-Tsy-119370	Tarsius syrichta	76.35	6.00e-102	363.00
IUUC-Tni-119857	Tetraodon nigroviridis	72.39	3.00e-130	457.00
IUUC-Tbe-127709	Tupaia belangeri	89.49	2.00e-166	577.00
IUUC-Ttr-129110	Tursiops truncatus	89.81	3.00e-168	583.00
IUUC-Vpa-130528	Vicugna pacos	73.74	7.00e-90	323.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence