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Tag Content
iUUCD ID IUUC-Cne-026953
Ensembl Protein ID AAW46554
UniProt Accession Q5K8K6; Q55M64; Q5K8K6_CRYNJ
Genbank Protein ID AAW46554.1
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID AE017352
Gene Name URM1; CNL05330
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CNL05330 AAW46554 AAW46554
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 42.72 1.00e-14 73.20 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Cryptococcus neoformans
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MATTDDFVIN SNGLGYMAPS SEKITGGVQT DAGVKGDDTM EVRFEFGGGL HLLFSSQPKH 60
VAHLPRFVPG TTPPEPLNMR YVVKWMKENL LSEREEMFGE GDGVRPGILV LINDADWELE 120
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Protein Fasta Sequence


>IUUC-Cne-026953|ULD,UBQ_Other|Cryptococcus neoformans
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Nucleotide Sequence
(Fasta)
ATGGCAACTA CTGACGACTT TGTCATCAAC TCCAACGGAT TGGGCTACAT GGCGCCTTCG 60
TCTGAGAAAA TTACTGGTGG AGTTCAAACT GATGCTGGAG TGAAGGGGGA CGATACCATG 120
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Nucleotide Fasta Sequence


>IUUC-Cne-026953|ULD,UBQ_Other|Cryptococcus neoformans
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
KEGG cne:CNL05330
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 55.34 3.00e-23 97.80
IUUC-Atr-003089 Amborella trichopoda 53.40 1.00e-22 95.50
IUUC-Apl-003382 Anas platyrhynchos 57.73 5.00e-23 96.70
IUUC-Aca-004981 Anolis carolinensis 56.31 8.00e-25 102.00
IUUC-Aly-005517 Arabidopsis lyrata 48.96 4.00e-18 80.50
IUUC-Ath-006718 Arabidopsis thaliana 57.97 2.00e-17 78.20
IUUC-Ago-007917 Ashbya gossypii 42.86 3.00e-12 61.20
IUUC-Acl-008054 Aspergillus clavatus 70.00 2.00e-10 54.70
IUUC-Afl-008704 Aspergillus flavus 54.35 1.00e-15 72.00
IUUC-Aor-009890 Aspergillus oryzae 53.33 7.00e-19 84.00
IUUC-Bta-012448 Bos taurus 55.34 2.00e-23 98.20
IUUC-Bci-013865 Botrytis cinerea 47.17 3.00e-18 81.60
IUUC-Bdi-014980 Brachypodium distachyon 63.08 4.00e-17 77.40
IUUC-Bol-016055 Brassica oleracea 58.82 3.00e-17 78.20
IUUC-Bra-016845 Brassica rapa 58.82 3.00e-17 78.20
IUUC-Cel-018485 Caenorhabditis elegans 31.48 7.00e-08 46.60
IUUC-Cja-019587 Callithrix jacchus 56.31 2.00e-23 98.60
IUUC-Cfa-020653 Canis familiaris 56.31 1.00e-23 99.00
IUUC-Cpo-021622 Cavia porcellus 56.31 2.00e-23 98.60
IUUC-Cre-023015 Chlamydomonas reinhardtii 46.60 4.00e-20 87.40
IUUC-Csa-023756 Chlorocebus sabaeus 53.85 4.00e-17 78.20
IUUC-Cgl-026518 Colletotrichum gloeosporioides 41.88 1.00e-16 76.30
IUUC-Cme-027314 Cyanidioschyzon merolae 49.02 1.00e-16 75.90
IUUC-Dre-027884 Danio rerio 53.47 1.00e-21 92.40
IUUC-Dno-029262 Dasypus novemcinctus 52.56 5.00e-17 78.20
IUUC-Dor-030601 Dipodomys ordii 55.38 5.00e-10 53.50
IUUC-Dme-031893 Drosophila melanogaster 45.79 1.00e-16 75.90
IUUC-Ete-032773 Echinops telfairi 55.10 4.00e-21 90.50
IUUC-Eca-034187 Equus caballus 57.28 1.00e-23 99.00
IUUC-Eeu-034808 Erinaceus europaeus 55.34 1.00e-22 95.50
IUUC-Fca-036107 Felis catus 56.31 2.00e-23 98.20
IUUC-Fal-036607 Ficedula albicollis 56.70 8.00e-23 95.90
IUUC-Fox-037698 Fusarium oxysporum 42.31 2.00e-16 75.50
IUUC-Gmo-039492 Gadus morhua 54.37 1.00e-22 96.30
IUUC-Ggr-039965 Gaeumannomyces graminis 42.86 1.00e-13 67.40
IUUC-Gga-041268 Gallus gallus 56.31 5.00e-25 103.00
IUUC-Gac-042111 Gasterosteus aculeatus 54.37 3.00e-23 97.80
IUUC-Gma-043240 Glycine max 57.35 7.00e-17 76.60
IUUC-Ggo-045176 Gorilla gorilla 52.56 6.00e-12 61.20
IUUC-Hsa-046077 Homo sapiens 56.31 3.00e-18 81.30
IUUC-Itr-048111 Ictidomys tridecemlineatus 56.84 5.00e-16 73.20
IUUC-Kpa-049157 Komagataella pastoris 44.76 6.00e-13 63.50
IUUC-Lch-049889 Latimeria chalumnae 52.43 1.00e-22 95.90
IUUC-Lpe-050783 Leersia perrieri 59.70 4.00e-16 74.30
IUUC-Loc-052400 Lepisosteus oculatus 54.37 2.00e-22 95.10
IUUC-Lma-053259 Leptosphaeria maculans 44.86 4.00e-16 74.70
IUUC-Laf-053596 Loxodonta africana 53.33 3.00e-22 94.40
IUUC-Mcc-054845 Macaca mulatta 55.79 2.00e-20 88.20
IUUC-Meu-055968 Macropus eugenii 56.31 7.00e-24 99.80
IUUC-Mor-057126 Magnaporthe oryzae 35.71 1.00e-12 63.20
IUUC-Mpo-057311 Magnaporthe poae 43.81 2.00e-15 72.80
IUUC-Mtr-058266 Medicago truncatula 55.88 9.00e-17 76.30
IUUC-Mla-058847 Melampsora laricipopulina 31.67 1.00e-08 49.70
IUUC-Mga-059468 Meleagris gallopavo 57.73 2.00e-23 97.80
IUUC-Mvi-060235 Microbotryum violaceum 36.24 8.00e-14 67.40
IUUC-Mdo-061948 Monodelphis domestica 56.31 8.00e-24 99.80
IUUC-Mmu-063946 Mus musculus 57.28 7.00e-24 99.80
IUUC-Mac-064812 Musa acuminata 60.29 3.00e-17 77.80
IUUC-Mpu-066763 Mustela putorius furo 57.28 4.00e-23 97.40
IUUC-Mlu-066970 Myotis lucifugus 52.56 1.00e-17 79.00
IUUC-Ncr-068824 Neurospora crassa 40.37 1.00e-16 75.90
IUUC-Nle-069849 Nomascus leucogenys 53.85 5.00e-17 78.20
IUUC-Opr-070227 Ochotona princeps 56.31 2.00e-23 98.60
IUUC-Ont-072530 Oreochromis niloticus 54.81 3.00e-24 100.00
IUUC-Oan-073191 Ornithorhynchus anatinus 53.40 2.00e-22 95.10
IUUC-Ocu-074460 Oryctolagus cuniculus 56.31 2.00e-23 98.20
IUUC-Oba-075499 Oryza barthii 62.50 5.00e-16 75.10
IUUC-Obr-076896 Oryza brachyantha 59.38 2.00e-15 73.60
IUUC-Ogl-077834 Oryza glaberrima 62.50 2.00e-16 75.10
IUUC-Ogu-078622 Oryza glumaepatula 62.50 2.00e-16 75.10
IUUC-Oin-079358 Oryza indica 62.50 4.00e-16 75.50
IUUC-Olo-081035 Oryza longistaminata 48.00 2.00e-16 76.30
IUUC-Oni-082425 Oryza nivara 62.50 2.00e-16 75.10
IUUC-Opu-083461 Oryza punctata 61.90 1.00e-15 73.60
IUUC-Oru-084875 Oryza rufipogon 56.34 2.00e-14 67.80
IUUC-Oga-089128 Otolemur garnettii 57.28 1.00e-23 99.00
IUUC-Oar-089896 Ovis aries 55.34 2.00e-23 98.20
IUUC-Ptr-091618 Pan troglodytes 52.56 7.00e-12 61.20
IUUC-Pan-092238 Papio anubis 53.85 4.00e-17 78.20
IUUC-Psi-093879 Pelodiscus sinensis 58.25 4.00e-25 103.00
IUUC-Pma-094484 Petromyzon marinus 63.24 2.00e-17 78.60
IUUC-Ppa-095801 Physcomitrella patens 50.00 3.00e-16 74.70
IUUC-Pfo-097192 Poecilia formosa 57.43 6.00e-23 97.10
IUUC-Pab-098203 Pongo abelii 56.31 4.00e-18 80.90
IUUC-Pop-099614 Populus trichocarpa 52.94 3.00e-15 71.20
IUUC-Pca-100507 Procavia capensis 51.28 1.00e-17 78.20
IUUC-Ppe-101174 Prunus persica 48.54 5.00e-21 90.50
IUUC-Pva-102735 Pteropus vampyrus 55.34 2.00e-20 88.20
IUUC-Pgr-103510 Puccinia graminis 34.45 2.00e-11 59.30
IUUC-Ptt-103918 Puccinia triticina 33.05 1.00e-08 49.70
IUUC-Pte-104173 Pyrenophora teres 46.23 2.00e-17 78.60
IUUC-Pyt-104806 Pyrenophora triticirepentis 44.86 7.00e-18 80.10
IUUC-Rno-105820 Rattus norvegicus 58.42 3.00e-23 98.20
IUUC-Sce-106366 Saccharomyces cerevisiae 42.72 6.00e-11 56.60
IUUC-Sja-107727 Schizosaccharomyces japonicus 36.27 7.00e-12 60.50
IUUC-Spo-108074 Schizosaccharomyces pombe 39.81 4.00e-10 54.30
IUUC-Smo-108944 Selaginella moellendorffii 50.53 1.00e-18 82.40
IUUC-Sit-110277 Setaria italica 62.50 2.00e-16 75.10
IUUC-Sly-111505 Solanum lycopersicum 55.88 1.00e-16 75.90
IUUC-Stu-112076 Solanum tuberosum 57.35 4.00e-17 77.40
IUUC-Sbi-114274 Sorghum bicolor 57.33 8.00e-18 80.10
IUUC-Sre-114953 Sporisorium reilianum 51.89 5.00e-22 94.00
IUUC-Ssc-115418 Sus scrofa 57.28 1.00e-23 99.00
IUUC-Tgu-117311 Taeniopygia guttata 56.70 1.00e-22 95.90
IUUC-Tru-118598 Takifugu rubripes 55.79 5.00e-21 90.10
IUUC-Tni-120109 Tetraodon nigroviridis 53.92 2.00e-19 85.50
IUUC-Tca-120942 Theobroma cacao 55.88 2.00e-17 78.60
IUUC-Tre-122099 Trichoderma reesei 49.48 5.00e-15 70.10
IUUC-Tvi-122285 Trichoderma virens 48.08 1.00e-16 76.30
IUUC-Tae-125193 Triticum aestivum 61.54 4.00e-16 73.90
IUUC-Tur-126677 Triticum urartu 51.95 2.00e-13 65.50
IUUC-Tme-127120 Tuber melanosporum 46.22 6.00e-19 84.00
IUUC-Tbe-128050 Tupaia belangeri 43.69 1.00e-11 59.70
IUUC-Ttr-129019 Tursiops truncatus 56.31 5.00e-22 93.60
IUUC-Uma-129483 Ustilago maydis 53.27 1.00e-22 96.30
IUUC-Vda-129690 Verticillium dahliae 36.52 3.00e-09 51.60
IUUC-Vvi-131174 Vitis vinifera 58.82 2.00e-17 78.60
IUUC-Xma-133862 Xiphophorus maculatus 57.43 6.00e-23 97.10
IUUC-Yli-134398 Yarrowia lipolytica 44.44 1.00e-13 66.20
IUUC-Zma-134964 Zea mays 56.41 6.00e-18 80.10
Created Date 25-Jun-2017

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