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Tag Content
iUUCD ID IUUC-Mga-059468
Ensembl Protein ID ENSMGAP00000003555.2
UniProt Accession G1MXI4; G1MXI4_MELGA
Protein Name Ubiquitin-related modifier 1
Gene Name URM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMGAG00000003812.2 ENSMGAT00000004259.2 ENSMGAP00000003555.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 38.71 1.00e-14 72.40 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Meleagris gallopavo
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
FRGGAELLFD GVKKHQVTLP SQPEPWDIRN LLKWIKQNLL KERPELFMQG ESVRPGILVL 60
INDADWELMG ELDYKLQDQD NVLFISTLHG G 91
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Protein Fasta Sequence


>IUUC-Mga-059468|ULD,UBQ_Other|Meleagris gallopavo
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Nucleotide Sequence
(Fasta)
TTCAGAGGTG GTGCAGAACT CTTGTTCGAT GGTGTAAAAA AGCATCAGGT GACTTTGCCT 60
TCTCAGCCAG AGCCTTGTGA GTATCTGAAT CTGCTGGATA ACTTGAAAGA ATGGCAGCAA 120
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Nucleotide Fasta Sequence


>IUUC-Mga-059468|ULD,UBQ_Other|Meleagris gallopavo
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 86.81 2.00e-43 166.00
IUUC-Atr-003089 Amborella trichopoda 59.14 7.00e-29 117.00
IUUC-Apl-003382 Anas platyrhynchos 98.90 9.00e-49 183.00
IUUC-Aca-004981 Anolis carolinensis 86.81 4.00e-44 168.00
IUUC-Aly-005517 Arabidopsis lyrata 54.95 6.00e-28 114.00
IUUC-Ath-006718 Arabidopsis thaliana 54.76 2.00e-24 103.00
IUUC-Ago-007917 Ashbya gossypii 41.94 2.00e-18 83.20
IUUC-Acl-008054 Aspergillus clavatus 66.00 4.00e-15 72.00
IUUC-Afl-008704 Aspergillus flavus 55.06 2.00e-21 92.40
IUUC-Aor-009890 Aspergillus oryzae 55.79 1.00e-23 101.00
IUUC-Bta-012448 Bos taurus 86.81 5.00e-43 164.00
IUUC-Bci-013865 Botrytis cinerea 46.32 2.00e-20 90.10
IUUC-Bdi-014980 Brachypodium distachyon 67.19 2.00e-23 99.80
IUUC-Bol-016055 Brassica oleracea 51.25 2.00e-23 99.40
IUUC-Bra-016845 Brassica rapa 51.25 2.00e-23 99.40
IUUC-Cel-018485 Caenorhabditis elegans 34.74 2.00e-11 60.10
IUUC-Cja-019587 Callithrix jacchus 89.01 1.00e-43 167.00
IUUC-Cfa-020653 Canis familiaris 85.71 6.00e-43 164.00
IUUC-Cpo-021622 Cavia porcellus 89.01 1.00e-43 167.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 53.26 1.00e-23 100.00
IUUC-Csa-023756 Chlorocebus sabaeus 86.96 5.00e-31 126.00
IUUC-Cgl-026518 Colletotrichum gloeosporioides 46.32 2.00e-20 90.10
IUUC-Cne-026953 Cryptococcus neoformans 57.73 1.00e-27 114.00
IUUC-Cme-027314 Cyanidioschyzon merolae 40.22 1.00e-16 77.00
IUUC-Dre-027884 Danio rerio 80.22 2.00e-40 156.00
IUUC-Dno-029262 Dasypus novemcinctus 84.29 1.00e-30 125.00
IUUC-Dor-030601 Dipodomys ordii 76.92 8.00e-22 94.40
IUUC-Dme-031893 Drosophila melanogaster 65.93 4.00e-31 125.00
IUUC-Ete-032773 Echinops telfairi 83.52 4.00e-41 158.00
IUUC-Eca-034187 Equus caballus 87.91 2.00e-43 166.00
IUUC-Eeu-034808 Erinaceus europaeus 83.52 3.00e-42 162.00
IUUC-Fca-036107 Felis catus 86.81 1.00e-43 166.00
IUUC-Fal-036607 Ficedula albicollis 97.80 2.00e-48 182.00
IUUC-Fox-037698 Fusarium oxysporum 49.47 1.00e-21 94.40
IUUC-Gmo-039492 Gadus morhua 81.32 2.00e-40 156.00
IUUC-Ggr-039965 Gaeumannomyces graminis 49.47 1.00e-19 88.20
IUUC-Gga-041268 Gallus gallus 98.90 1.00e-48 183.00
IUUC-Gac-042111 Gasterosteus aculeatus 82.42 3.00e-41 159.00
IUUC-Gma-043240 Glycine max 52.38 1.00e-22 97.10
IUUC-Ggo-045176 Gorilla gorilla 85.51 2.00e-23 100.00
IUUC-Hsa-046077 Homo sapiens 86.81 4.00e-36 141.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 89.89 4.00e-36 141.00
IUUC-Kpa-049157 Komagataella pastoris 46.24 4.00e-18 81.60
IUUC-Lch-049889 Latimeria chalumnae 81.32 3.00e-41 158.00
IUUC-Lpe-050783 Leersia perrieri 55.95 4.00e-22 95.50
IUUC-Loc-052400 Lepisosteus oculatus 81.32 1.00e-40 156.00
IUUC-Lma-053259 Leptosphaeria maculans 47.37 4.00e-20 89.00
IUUC-Laf-053596 Loxodonta africana 86.02 1.00e-41 160.00
IUUC-Mcc-054845 Macaca mulatta 87.64 3.00e-42 162.00
IUUC-Meu-055968 Macropus eugenii 89.01 6.00e-44 167.00
IUUC-Mor-057126 Magnaporthe oryzae 48.42 1.00e-18 84.70
IUUC-Mpo-057311 Magnaporthe poae 50.53 6.00e-21 92.40
IUUC-Mtr-058266 Medicago truncatula 50.00 4.00e-22 95.50
IUUC-Mla-058847 Melampsora laricipopulina 41.05 9.00e-11 58.20
IUUC-Mvi-060235 Microbotryum violaceum 61.19 5.00e-18 83.20
IUUC-Mdo-061948 Monodelphis domestica 86.81 3.00e-43 165.00
IUUC-Mmu-063946 Mus musculus 86.81 6.00e-43 164.00
IUUC-Mac-064812 Musa acuminata 57.83 6.00e-25 104.00
IUUC-Mpu-066763 Mustela putorius furo 85.71 5.00e-42 161.00
IUUC-Mlu-066970 Myotis lucifugus 88.41 2.00e-31 125.00
IUUC-Ncr-068824 Neurospora crassa 48.42 7.00e-20 88.20
IUUC-Nle-069849 Nomascus leucogenys 85.51 2.00e-30 124.00
IUUC-Opr-070227 Ochotona princeps 89.01 1.00e-43 167.00
IUUC-Ont-072530 Oreochromis niloticus 84.62 6.00e-42 161.00
IUUC-Oan-073191 Ornithorhynchus anatinus 84.44 1.00e-41 160.00
IUUC-Ocu-074460 Oryctolagus cuniculus 87.91 1.00e-43 166.00
IUUC-Oba-075499 Oryza barthii 58.33 2.00e-22 98.20
IUUC-Obr-076896 Oryza brachyantha 64.06 5.00e-22 97.10
IUUC-Ogl-077834 Oryza glaberrima 58.33 4.00e-23 98.60
IUUC-Ogu-078622 Oryza glumaepatula 58.33 4.00e-23 98.60
IUUC-Oin-079358 Oryza indica 58.33 1.00e-22 98.60
IUUC-Olo-081035 Oryza longistaminata 55.21 5.00e-24 103.00
IUUC-Oni-082425 Oryza nivara 58.33 4.00e-23 98.60
IUUC-Opu-083461 Oryza punctata 56.63 5.00e-22 96.30
IUUC-Oru-084875 Oryza rufipogon 59.15 1.00e-20 90.10
IUUC-Oga-089128 Otolemur garnettii 87.91 2.00e-43 166.00
IUUC-Oar-089896 Ovis aries 86.81 5.00e-43 164.00
IUUC-Ptr-091618 Pan troglodytes 85.51 2.00e-23 100.00
IUUC-Pan-092238 Papio anubis 86.96 5.00e-31 125.00
IUUC-Psi-093879 Pelodiscus sinensis 91.21 4.00e-46 175.00
IUUC-Pma-094484 Petromyzon marinus 74.68 9.00e-32 127.00
IUUC-Ppa-095801 Physcomitrella patens 58.02 9.00e-23 97.40
IUUC-Pfo-097192 Poecilia formosa 81.32 6.00e-41 157.00
IUUC-Pab-098203 Pongo abelii 86.81 4.00e-36 141.00
IUUC-Pop-099614 Populus trichocarpa 54.76 4.00e-23 98.60
IUUC-Pca-100507 Procavia capensis 86.96 2.00e-31 125.00
IUUC-Ppe-101174 Prunus persica 56.99 3.00e-27 112.00
IUUC-Pva-102735 Pteropus vampyrus 86.81 8.00e-40 154.00
IUUC-Pgr-103510 Puccinia graminis 39.18 2.00e-10 57.00
IUUC-Ptt-103918 Puccinia triticina 36.08 3.00e-09 53.10
IUUC-Pte-104173 Pyrenophora teres 47.37 4.00e-21 92.40
IUUC-Pyt-104806 Pyrenophora triticirepentis 47.37 4.00e-21 92.40
IUUC-Rno-105820 Rattus norvegicus 87.91 2.00e-43 166.00
IUUC-Sce-106366 Saccharomyces cerevisiae 38.71 3.00e-15 72.40
IUUC-Sja-107727 Schizosaccharomyces japonicus 42.05 2.00e-15 73.90
IUUC-Spo-108074 Schizosaccharomyces pombe 41.11 3.00e-09 52.40
IUUC-Smo-108944 Selaginella moellendorffii 60.67 3.00e-26 108.00
IUUC-Sit-110277 Setaria italica 54.76 6.00e-23 98.20
IUUC-Sly-111505 Solanum lycopersicum 54.76 1.00e-24 103.00
IUUC-Stu-112076 Solanum tuberosum 55.95 3.00e-25 105.00
IUUC-Sbi-114274 Sorghum bicolor 57.14 5.00e-23 98.60
IUUC-Sre-114953 Sporisorium reilianum 57.29 6.00e-25 105.00
IUUC-Ssc-115418 Sus scrofa 86.81 2.00e-43 165.00
IUUC-Tgu-117311 Taeniopygia guttata 96.70 5.00e-48 181.00
IUUC-Tru-118598 Takifugu rubripes 83.15 2.00e-40 155.00
IUUC-Tni-120109 Tetraodon nigroviridis 79.35 3.00e-38 148.00
IUUC-Tca-120942 Theobroma cacao 57.83 2.00e-24 103.00
IUUC-Tre-122099 Trichoderma reesei 48.39 4.00e-16 75.10
IUUC-Tvi-122285 Trichoderma virens 50.53 1.00e-17 81.30
IUUC-Tae-125193 Triticum aestivum 65.62 2.00e-22 95.90
IUUC-Tur-126677 Triticum urartu 55.26 1.00e-19 87.80
IUUC-Tme-127120 Tuber melanosporum 48.42 4.00e-21 92.40
IUUC-Tbe-128050 Tupaia belangeri 62.64 8.00e-26 107.00
IUUC-Ttr-129019 Tursiops truncatus 84.62 5.00e-40 154.00
IUUC-Uma-129483 Ustilago maydis 56.25 8.00e-23 97.80
IUUC-Vda-129690 Verticillium dahliae 41.07 7.00e-17 78.20
IUUC-Vvi-131174 Vitis vinifera 55.42 6.00e-24 101.00
IUUC-Xma-133862 Xiphophorus maculatus 81.32 6.00e-41 157.00
IUUC-Yli-134398 Yarrowia lipolytica 48.96 4.00e-18 82.00
IUUC-Zma-134964 Zea mays 56.79 1.00e-22 97.10
Created Date 25-Jun-2017

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