iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-066970

Ensembl Protein ID

ENSMLUP00000006632.2

UniProt Accession

G1P8W4; G1P8W4_MYOLU

Genbank Protein ID

ENSMLUP00000006632

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

AAPE02046828

Gene Name

URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000007275.2	ENSMLUT00000007267.2	ENSMLUP00000006632.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	36.84	2.00e-09	55.10	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Myotis lucifugus

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPLSVEVE FGGGAELLFD GVKKHQVTLP GQEEPWDIRN LLVWIKKNLL KERPELFIQG 60
DSVRPGILVL INDADWELL 79

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Nucleotide Sequence
(Fasta)

ATGGCAGCGC CCTTATCAGT GGAGGTGGAG TTCGGGTGAG TCACAGAGTT GGGGGCGCCG 60
TGGGGATGGA TTGAAGTCTT CAGGCCCAGA ACTCCTCTCC CTCTGCTTTG GGGCCTGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	97.47	9.00e-41	157.00
IUUC-Atr-003089	Amborella trichopoda	57.89	2.00e-21	93.60
IUUC-Apl-003382	Anas platyrhynchos	88.41	3.00e-31	125.00
IUUC-Aca-004981	Anolis carolinensis	82.28	7.00e-36	141.00
IUUC-Aly-005517	Arabidopsis lyrata	52.17	2.00e-18	83.20
IUUC-Ath-006718	Arabidopsis thaliana	52.46	4.00e-15	72.40
IUUC-Ago-007917	Ashbya gossypii	38.16	6.00e-13	65.10
IUUC-Acl-008054	Aspergillus clavatus	77.78	3.00e-07	46.20
IUUC-Afl-008704	Aspergillus flavus	54.55	3.00e-12	62.80
IUUC-Aor-009890	Aspergillus oryzae	57.69	8.00e-17	78.60
IUUC-Bta-012448	Bos taurus	97.47	2.00e-40	156.00
IUUC-Bci-013865	Botrytis cinerea	41.77	2.00e-12	63.90
IUUC-Bdi-014980	Brachypodium distachyon	61.82	3.00e-15	72.80
IUUC-Bol-016055	Brassica oleracea	54.39	2.00e-15	73.20
IUUC-Bra-016845	Brassica rapa	54.39	2.00e-15	73.20
IUUC-Cel-018485	Caenorhabditis elegans	30.86	1.00e-05	40.80
IUUC-Cja-019587	Callithrix jacchus	100.00	4.00e-41	158.00
IUUC-Cfa-020653	Canis familiaris	97.47	2.00e-40	156.00
IUUC-Cpo-021622	Cavia porcellus	100.00	4.00e-41	158.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	53.33	1.00e-18	84.00
IUUC-Csa-023756	Chlorocebus sabaeus	98.73	1.00e-40	158.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	43.59	5.00e-13	65.90
IUUC-Cne-026953	Cryptococcus neoformans	53.75	1.00e-17	82.00
IUUC-Cme-027314	Cyanidioschyzon merolae	38.36	1.00e-09	53.90
IUUC-Dre-027884	Danio rerio	75.95	6.00e-33	131.00
IUUC-Dno-029262	Dasypus novemcinctus	94.94	1.00e-38	152.00
IUUC-Dor-030601	Dipodomys ordii	58.23	4.00e-15	72.40
IUUC-Dme-031893	Drosophila melanogaster	58.75	1.00e-21	94.00
IUUC-Ete-032773	Echinops telfairi	89.87	1.00e-35	140.00
IUUC-Eca-034187	Equus caballus	100.00	4.00e-41	158.00
IUUC-Eeu-034808	Erinaceus europaeus	93.67	2.00e-39	153.00
IUUC-Fca-036107	Felis catus	97.47	1.00e-40	157.00
IUUC-Fal-036607	Ficedula albicollis	86.96	1.00e-30	124.00
IUUC-Fox-037698	Fusarium oxysporum	44.44	5.00e-15	72.40
IUUC-Gmo-039492	Gadus morhua	75.95	6.00e-33	131.00
IUUC-Ggr-039965	Gaeumannomyces graminis	45.68	7.00e-13	66.20
IUUC-Gga-041268	Gallus gallus	87.34	1.00e-36	144.00
IUUC-Gac-042111	Gasterosteus aculeatus	77.22	3.00e-34	135.00
IUUC-Gma-043240	Glycine max	50.82	3.00e-14	69.70
IUUC-Ggo-045176	Gorilla gorilla	96.20	5.00e-32	129.00
IUUC-Hsa-046077	Homo sapiens	96.20	2.00e-32	129.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	97.01	7.00e-26	107.00
IUUC-Kpa-049157	Komagataella pastoris	44.74	8.00e-12	61.60
IUUC-Lch-049889	Latimeria chalumnae	78.48	6.00e-34	135.00
IUUC-Lpe-050783	Leersia perrieri	56.45	4.00e-15	72.40
IUUC-Loc-052400	Lepisosteus oculatus	79.75	3.00e-34	136.00
IUUC-Lma-053259	Leptosphaeria maculans	43.59	5.00e-13	65.90
IUUC-Laf-053596	Loxodonta africana	98.73	1.00e-40	157.00
IUUC-Mcc-054845	Macaca mulatta	90.79	1.00e-34	137.00
IUUC-Meu-055968	Macropus eugenii	93.59	4.00e-39	152.00
IUUC-Mor-057126	Magnaporthe oryzae	41.98	3.00e-11	60.10
IUUC-Mpo-057311	Magnaporthe poae	47.44	4.00e-14	70.10
IUUC-Mtr-058266	Medicago truncatula	49.21	1.00e-14	70.90
IUUC-Mla-058847	Melampsora laricipopulina	36.71	2.00e-06	43.90
IUUC-Mga-059468	Meleagris gallopavo	88.41	2.00e-31	125.00
IUUC-Mvi-060235	Microbotryum violaceum	30.47	7.00e-10	56.20
IUUC-Mdo-061948	Monodelphis domestica	91.03	1.00e-38	150.00
IUUC-Mmu-063946	Mus musculus	96.20	1.00e-39	153.00
IUUC-Mac-064812	Musa acuminata	58.06	1.00e-15	73.90
IUUC-Mpu-066763	Mustela putorius furo	97.47	2.00e-39	153.00
IUUC-Ncr-068824	Neurospora crassa	39.74	6.00e-13	65.50
IUUC-Nle-069849	Nomascus leucogenys	97.47	4.00e-40	156.00
IUUC-Opr-070227	Ochotona princeps	100.00	4.00e-41	158.00
IUUC-Ont-072530	Oreochromis niloticus	78.48	5.00e-34	135.00
IUUC-Oan-073191	Ornithorhynchus anatinus	89.55	4.00e-30	122.00
IUUC-Ocu-074460	Oryctolagus cuniculus	98.68	6.00e-39	151.00
IUUC-Oba-075499	Oryza barthii	69.05	5.00e-14	70.10
IUUC-Obr-076896	Oryza brachyantha	56.90	2.00e-13	68.90
IUUC-Ogl-077834	Oryza glaberrima	69.05	2.00e-14	70.50
IUUC-Ogu-078622	Oryza glumaepatula	69.05	2.00e-14	70.50
IUUC-Oin-079358	Oryza indica	69.05	6.00e-14	70.50
IUUC-Olo-081035	Oryza longistaminata	48.05	5.00e-15	73.90
IUUC-Oni-082425	Oryza nivara	69.05	2.00e-14	70.50
IUUC-Opu-083461	Oryza punctata	69.05	3.00e-14	70.90
IUUC-Oru-084875	Oryza rufipogon	59.18	2.00e-12	63.20
IUUC-Oga-089128	Otolemur garnettii	100.00	4.00e-41	158.00
IUUC-Oar-089896	Ovis aries	97.47	2.00e-40	156.00
IUUC-Ptr-091618	Pan troglodytes	96.20	5.00e-32	129.00
IUUC-Pan-092238	Papio anubis	98.73	1.00e-40	158.00
IUUC-Psi-093879	Pelodiscus sinensis	87.34	1.00e-36	143.00
IUUC-Pma-094484	Petromyzon marinus	81.01	2.00e-24	103.00
IUUC-Ppa-095801	Physcomitrella patens	57.63	2.00e-14	70.10
IUUC-Pfo-097192	Poecilia formosa	79.75	6.00e-35	138.00
IUUC-Pab-098203	Pongo abelii	94.94	5.00e-32	128.00
IUUC-Pop-099614	Populus trichocarpa	55.74	2.00e-15	73.60
IUUC-Pca-100507	Procavia capensis	98.73	1.00e-40	157.00
IUUC-Ppe-101174	Prunus persica	53.95	5.00e-20	88.60
IUUC-Pva-102735	Pteropus vampyrus	97.47	3.00e-37	145.00
IUUC-Pgr-103510	Puccinia graminis	37.97	2.00e-07	47.80
IUUC-Ptt-103918	Puccinia triticina	32.91	2.00e-05	41.20
IUUC-Pte-104173	Pyrenophora teres	45.00	1.00e-14	70.90
IUUC-Pyt-104806	Pyrenophora triticirepentis	45.00	1.00e-14	71.20
IUUC-Rno-105820	Rattus norvegicus	97.47	4.00e-40	155.00
IUUC-Sce-106366	Saccharomyces cerevisiae	36.84	7.00e-10	55.10
IUUC-Sja-107727	Schizosaccharomyces japonicus	39.47	3.00e-10	57.00
IUUC-Spo-108074	Schizosaccharomyces pombe	34.25	3.00e-06	42.70
IUUC-Smo-108944	Selaginella moellendorffii	61.19	9.00e-18	80.90
IUUC-Sit-110277	Setaria italica	54.84	3.00e-15	72.80
IUUC-Sly-111505	Solanum lycopersicum	54.10	3.00e-16	76.30
IUUC-Stu-112076	Solanum tuberosum	55.74	1.00e-16	77.80
IUUC-Sbi-114274	Sorghum bicolor	56.36	3.00e-15	73.20
IUUC-Sre-114953	Sporisorium reilianum	55.70	2.00e-18	83.60
IUUC-Ssc-115418	Sus scrofa	97.47	2.00e-40	156.00
IUUC-Tgu-117311	Taeniopygia guttata	86.96	1.00e-30	123.00
IUUC-Tru-118598	Takifugu rubripes	83.58	8.00e-30	120.00
IUUC-Tni-120109	Tetraodon nigroviridis	76.25	1.00e-31	127.00
IUUC-Tca-120942	Theobroma cacao	53.33	2.00e-14	69.70
IUUC-Tre-122099	Trichoderma reesei	43.48	4.00e-11	58.90
IUUC-Tvi-122285	Trichoderma virens	49.37	8.00e-16	75.10
IUUC-Tae-125193	Triticum aestivum	54.10	3.00e-14	69.30
IUUC-Tur-126677	Triticum urartu	45.21	1.00e-11	61.20
IUUC-Tme-127120	Tuber melanosporum	44.44	3.00e-15	73.20
IUUC-Tbe-128050	Tupaia belangeri	64.56	3.00e-21	92.40
IUUC-Ttr-129019	Tursiops truncatus	96.20	4.00e-38	148.00
IUUC-Uma-129483	Ustilago maydis	53.16	3.00e-16	76.60
IUUC-Vda-129690	Verticillium dahliae	37.08	8.00e-09	52.00
IUUC-Vvi-131174	Vitis vinifera	56.67	1.00e-15	74.30
IUUC-Xma-133862	Xiphophorus maculatus	79.75	6.00e-35	138.00
IUUC-Yli-134398	Yarrowia lipolytica	43.42	3.00e-12	63.20
IUUC-Zma-134964	Zea mays	58.33	5.00e-14	68.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence