iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012909

Ensembl Protein ID

ENSBTAP00000041340.3

UniProt Accession

A6QLK6; GRAP_BOVIN

Genbank Protein ID

AAI47999.1

Protein Name

GRB2-related adapter protein

Genbank Nucleotide ID

BC147998

Gene Name

GRAP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000003707.4	ENSBTAT00000043796.3	ENSBTAP00000041340.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.30e-30	102.7	4	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            +ly+++a+++deL ++kGd+++++ + e d++W k+  el+g +G++P+n+++
   Q: 4    VALYSFQATESDELAFNKGDTLKIL-NMEDDQNWYKA--ELRGAEGFVPKNYIR 54
           58***********************.99*******99..9************97 PP

Organism

Bos taurus

Functional Description
(View)

Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.

Protein Sequence
(Fasta)

MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGAEGFVPK NYIRLKPHPW 60
YSGRISRQLA EEILMKRNHQ GAFLIRESES SPGEFSVSVN YGDQVQHFKV LRDPSGKYYL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACTGCGGA GGAAGCAGGA AGCTGCCGGC CCTGCTAGCA GCCCAGCTGC CGGGGCGCGG 60
GGACGGCGGT ATGGAGTCTG TGGCCCTGTA CAGCTTCCAG GCCACGGAGA GTGACGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

bta:534491

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001277	Ailuropoda melanoleuca	90.78	4.00e-117	413.00
IUUC-Apl-003499	Anas platyrhynchos	62.21	3.00e-74	271.00
IUUC-Aca-004922	Anolis carolinensis	65.90	7.00e-87	313.00
IUUC-Acl-008379	Aspergillus clavatus	47.54	3.00e-11	64.70
IUUC-Afu-009104	Aspergillus fumigatus	45.90	5.00e-11	63.90
IUUC-Cja-018796	Callithrix jacchus	89.40	2.00e-115	407.00
IUUC-Cfa-021023	Canis familiaris	91.24	4.00e-117	413.00
IUUC-Cpo-021502	Cavia porcellus	91.24	1.00e-117	415.00
IUUC-Csa-024099	Chlorocebus sabaeus	89.86	4.00e-115	406.00
IUUC-Dno-029057	Dasypus novemcinctus	85.03	1.00e-82	298.00
IUUC-Eca-033722	Equus caballus	78.14	3.00e-99	353.00
IUUC-Eeu-035125	Erinaceus europaeus	76.92	1.00e-43	167.00
IUUC-Fca-036087	Felis catus	92.17	1.00e-118	418.00
IUUC-Fal-037633	Ficedula albicollis	74.88	6.00e-94	336.00
IUUC-Gga-041204	Gallus gallus	75.35	2.00e-96	344.00
IUUC-Ggo-044579	Gorilla gorilla	91.24	2.00e-117	414.00
IUUC-Hsa-045927	Homo sapiens	91.24	2.00e-117	414.00
IUUC-Laf-053794	Loxodonta africana	90.78	1.00e-118	418.00
IUUC-Mcc-055527	Macaca mulatta	90.32	2.00e-116	410.00
IUUC-Meu-056608	Macropus eugenii	81.68	8.00e-87	312.00
IUUC-Mmr-060743	Microcebus murinus	82.03	5.00e-102	363.00
IUUC-Mdo-063025	Monodelphis domestica	83.41	1.00e-109	388.00
IUUC-Mmu-064395	Mus musculus	89.86	2.00e-116	411.00
IUUC-Mpu-066088	Mustela putorius furo	90.32	2.00e-115	408.00
IUUC-Mlu-067003	Myotis lucifugus	89.86	1.00e-115	408.00
IUUC-Nfi-068248	Neosartorya fischeri	45.90	5.00e-11	63.90
IUUC-Opr-071051	Ochotona princeps	67.28	9.00e-78	282.00
IUUC-Ont-071576	Oreochromis niloticus	62.50	5.00e-79	286.00
IUUC-Oan-073107	Ornithorhynchus anatinus	67.25	9.00e-83	299.00
IUUC-Ocu-074963	Oryctolagus cuniculus	88.53	1.00e-102	366.00
IUUC-Ola-086725	Oryzias latipes	59.46	1.00e-73	268.00
IUUC-Oga-088158	Otolemur garnettii	90.32	2.00e-117	414.00
IUUC-Oar-090223	Ovis aries	93.55	9.00e-121	426.00
IUUC-Pan-092422	Papio anubis	90.78	4.00e-117	413.00
IUUC-Psi-093655	Pelodiscus sinensis	76.58	2.00e-99	354.00
IUUC-Pfo-096278	Poecilia formosa	61.11	2.00e-75	275.00
IUUC-Pca-100573	Procavia capensis	87.85	4.00e-95	340.00
IUUC-Pva-102471	Pteropus vampyrus	89.01	8.00e-101	358.00
IUUC-Rno-105932	Rattus norvegicus	88.48	2.00e-115	407.00
IUUC-Sha-107209	Sarcophilus harrisii	82.03	3.00e-100	357.00
IUUC-Tru-118065	Takifugu rubripes	61.11	1.00e-75	275.00
IUUC-Tni-120563	Tetraodon nigroviridis	57.87	6.00e-70	256.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence