iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067755

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39

Genbank Nucleotide ID

AAPE02045610

Gene Name

CIAO1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000010473.2	ENSMLUT00000010470.2	ENSMLUP00000009543.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-44	146.6	192	222
UBD/Beta-Prp	6.50e-61	206.1	13	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v++laf ++  +l+s+sdD t+++W+
   Q: 192  GHESTVWSLAFdPSgQRLASCSDDRTVRIWR 222
           8***********6669**************8 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrsl.sgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtl 90
           +h++s++  +++ p ++lla+ + d+++++w ++  +    + l +gh+ +v+ v +sp g++l+++s D+t ++w  + ++++cv tl
   Q: 13   AHPDSRCWFLAWNPTGTLLASCGGDRRVRIWGTEGDNWicKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTL 101
           688999999999*********************9877653566689******************************99999******** PP
   S: 91   kghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk..llrtl 175
           +ghe++v s+++ psg+ l++ s+d+ + vw+++++ ++e   +l+ h++ v +vv+hp++ ll+s+s+D tv+l++ + ++  +  tl
   Q: 102  EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECvsVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDwvCCATL 190
           *********************************9987776566*********************************99777544999** PP
   S: 176  tgghtdsvyslsfdsngkelvsgsldgtvklw 207
           +g h++ v sl+fd++g++l+s+s+d+tv++w
   Q: 191  EG-HESTVWSLAFDPSGQRLASCSDDRTVRIW 221
           *9.***************************** PP

Organism

Myotis lucifugus

Functional Description
(View)

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Protein Sequence
(Fasta)

MKDSLVLLGR VPAHPDSRCW FLAWNPTGTL LASCGGDRRV RIWGTEGDNW ICKSVLSEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGGACT CGCTGGTGCT GCTGGGCCGT GTCCCGGCGC ACCCGGACTC GCGCTGCTGG 60
TTCCTGGCCT GGAACCCCAC GGGAACCCTG CTAGCCTCGT GCGGGGGCGA CCGTAGAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000874	Aegilops tauschii	48.36	7.00e-67	248.00
IUUC-Aml-001317	Ailuropoda melanoleuca	95.87	0.00e+00	630.00
IUUC-Atr-003029	Amborella trichopoda	51.90	6.00e-93	333.00
IUUC-Apl-004042	Anas platyrhynchos	77.27	9.00e-57	211.00
IUUC-Aly-006458	Arabidopsis lyrata	48.12	3.00e-84	305.00
IUUC-Ath-006671	Arabidopsis thaliana	48.12	4.00e-84	304.00
IUUC-Ago-007820	Ashbya gossypii	40.59	2.00e-60	225.00
IUUC-Acl-008042	Aspergillus clavatus	32.49	3.00e-51	196.00
IUUC-Afl-008639	Aspergillus flavus	33.57	5.00e-55	208.00
IUUC-Afu-008899	Aspergillus fumigatus	36.65	1.00e-50	193.00
IUUC-Ani-009453	Aspergillus nidulans	32.86	3.00e-51	195.00
IUUC-Ang-009758	Aspergillus niger	35.41	2.00e-53	202.00
IUUC-Aor-010212	Aspergillus oryzae	33.57	5.00e-55	208.00
IUUC-Ate-010314	Aspergillus terreus	33.33	2.00e-53	203.00
IUUC-Ame-010676	Astyanax mexicanus	77.25	3.00e-157	547.00
IUUC-Bgr-012095	Blumeria graminis	30.33	4.00e-38	152.00
IUUC-Bta-012884	Bos taurus	93.81	1.00e-178	618.00
IUUC-Bci-013622	Botrytis cinerea	32.04	7.00e-39	154.00
IUUC-Bdi-014614	Brachypodium distachyon	48.52	5.00e-84	304.00
IUUC-Bol-016439	Brassica oleracea	47.08	1.00e-82	299.00
IUUC-Bra-016830	Brassica rapa	46.04	3.00e-81	295.00
IUUC-Cel-018709	Caenorhabditis elegans	39.76	2.00e-63	235.00
IUUC-Cja-019822	Callithrix jacchus	95.87	0.00e+00	627.00
IUUC-Cfa-020823	Canis familiaris	97.05	0.00e+00	637.00
IUUC-Cre-022811	Chlamydomonas reinhardtii	47.55	8.00e-80	290.00
IUUC-Csa-023754	Chlorocebus sabaeus	96.76	0.00e+00	633.00
IUUC-Cin-025395	Ciona intestinalis	56.72	2.00e-114	405.00
IUUC-Csv-025943	Ciona savignyi	54.95	1.00e-111	395.00
IUUC-Cgl-026435	Colletotrichum gloeosporioides	30.61	2.00e-37	150.00
IUUC-Cne-026939	Cryptococcus neoformans	31.92	1.00e-48	187.00
IUUC-Cme-027239	Cyanidioschyzon merolae	41.35	9.00e-45	174.00
IUUC-Dre-028172	Danio rerio	76.05	4.00e-155	540.00
IUUC-Dno-029472	Dasypus novemcinctus	94.54	3.00e-152	530.00
IUUC-Dor-031134	Dipodomys ordii	83.78	7.00e-151	526.00
IUUC-Dse-031535	Dothistroma septosporum	30.33	3.00e-47	182.00
IUUC-Dme-032020	Drosophila melanogaster	58.79	8.00e-117	413.00
IUUC-Eca-033700	Equus caballus	96.76	0.00e+00	633.00
IUUC-Eeu-035010	Erinaceus europaeus	94.10	1.00e-176	611.00
IUUC-Fca-036309	Felis catus	87.94	7.00e-171	592.00
IUUC-Fal-037243	Ficedula albicollis	73.95	2.00e-86	311.00
IUUC-Fox-038058	Fusarium oxysporum	33.33	4.00e-45	176.00
IUUC-Fso-038459	Fusarium solani	33.25	2.00e-40	160.00
IUUC-Gmo-039375	Gadus morhua	74.93	2.00e-139	488.00
IUUC-Ggr-040002	Gaeumannomyces graminis	36.24	2.00e-41	163.00
IUUC-Gga-040294	Gallus gallus	82.71	6.00e-128	450.00
IUUC-Gac-042499	Gasterosteus aculeatus	74.55	2.00e-137	481.00
IUUC-Gma-043543	Glycine max	48.67	6.00e-87	313.00
IUUC-Ggo-045181	Gorilla gorilla	96.76	0.00e+00	633.00
IUUC-Hsa-046528	Homo sapiens	96.76	0.00e+00	633.00
IUUC-Hvu-047341	Hordeum vulgare	57.45	1.00e-55	208.00
IUUC-Itr-048790	Ictidomys tridecemlineatus	95.87	0.00e+00	627.00
IUUC-Kpa-049353	Komagataella pastoris	35.88	2.00e-56	213.00
IUUC-Lch-049763	Latimeria chalumnae	80.84	5.00e-163	566.00
IUUC-Lpe-051500	Leersia perrieri	44.47	5.00e-80	291.00
IUUC-Loc-052021	Lepisosteus oculatus	80.24	1.00e-152	532.00
IUUC-Lma-053331	Leptosphaeria maculans	34.57	1.00e-54	208.00
IUUC-Laf-054558	Loxodonta africana	94.69	2.00e-179	621.00
IUUC-Mcc-055374	Macaca mulatta	96.46	0.00e+00	630.00
IUUC-Meu-056042	Macropus eugenii	76.55	7.00e-111	392.00
IUUC-Mor-057187	Magnaporthe oryzae	34.63	3.00e-39	155.00
IUUC-Mtr-058072	Medicago truncatula	49.11	8.00e-86	310.00
IUUC-Mla-059108	Melampsora laricipopulina	31.59	6.00e-52	198.00
IUUC-Mga-059370	Meleagris gallopavo	63.74	1.00e-99	355.00
IUUC-Mvi-060495	Microbotryum violaceum	36.83	1.00e-56	213.00
IUUC-Mmr-060902	Microcebus murinus	96.17	0.00e+00	630.00
IUUC-Mdo-062510	Monodelphis domestica	92.92	2.00e-170	591.00
IUUC-Mmu-063575	Mus musculus	93.51	1.00e-177	615.00
IUUC-Mac-065322	Musa acuminata	50.15	1.00e-88	319.00
IUUC-Mpu-065925	Mustela putorius furo	95.87	0.00e+00	629.00
IUUC-Nfi-068327	Neosartorya fischeri	32.81	2.00e-50	192.00
IUUC-Ncr-068845	Neurospora crassa	32.92	1.00e-32	134.00
IUUC-Nle-069406	Nomascus leucogenys	94.69	1.00e-177	615.00
IUUC-Opr-070416	Ochotona princeps	74.93	2.00e-131	461.00
IUUC-Ont-071936	Oreochromis niloticus	74.48	8.00e-141	493.00
IUUC-Oan-073452	Ornithorhynchus anatinus	92.73	2.00e-76	277.00
IUUC-Ocu-074791	Oryctolagus cuniculus	94.40	2.00e-179	620.00
IUUC-Oba-075636	Oryza barthii	49.26	5.00e-87	314.00
IUUC-Obr-076742	Oryza brachyantha	48.25	9.00e-76	276.00
IUUC-Ogl-077766	Oryza glaberrima	49.26	5.00e-87	314.00
IUUC-Ogu-079039	Oryza glumaepatula	49.26	2.00e-87	315.00
IUUC-Oin-079315	Oryza indica	49.14	2.00e-76	279.00
IUUC-Olo-080669	Oryza longistaminata	43.75	3.00e-79	288.00
IUUC-Ome-081490	Oryza meridionalis	49.26	3.00e-87	315.00
IUUC-Oni-082572	Oryza nivara	49.26	5.00e-87	314.00
IUUC-Opu-083732	Oryza punctata	49.11	5.00e-87	314.00
IUUC-Oru-084763	Oryza rufipogon	49.26	5.00e-87	314.00
IUUC-Osa-085372	Oryza sativa	49.26	5.00e-87	314.00
IUUC-Ola-087379	Oryzias latipes	72.65	4.00e-137	480.00
IUUC-Olu-087801	Ostreococcus lucimarinus	36.01	7.00e-45	174.00
IUUC-Oga-089076	Otolemur garnettii	95.58	0.00e+00	627.00
IUUC-Oar-090022	Ovis aries	93.22	1.00e-176	611.00
IUUC-Ptr-090809	Pan troglodytes	96.76	0.00e+00	633.00
IUUC-Pan-091685	Papio anubis	96.76	0.00e+00	639.00
IUUC-Psi-093046	Pelodiscus sinensis	87.54	2.00e-167	582.00
IUUC-Pma-094181	Petromyzon marinus	63.80	6.00e-130	456.00
IUUC-Pno-094882	Phaeosphaeria nodorum	35.04	2.00e-55	210.00
IUUC-Ppa-095172	Physcomitrella patens	47.67	3.00e-84	305.00
IUUC-Pfo-096396	Poecilia formosa	70.92	6.00e-137	479.00
IUUC-Pab-098427	Pongo abelii	96.76	0.00e+00	627.00
IUUC-Pop-100016	Populus trichocarpa	52.06	9.00e-91	326.00
IUUC-Pca-101048	Procavia capensis	94.99	6.00e-180	622.00
IUUC-Ppe-102050	Prunus persica	46.86	2.00e-85	308.00
IUUC-Pva-103117	Pteropus vampyrus	95.58	0.00e+00	628.00
IUUC-Pgr-103307	Puccinia graminis	34.25	2.00e-56	213.00
IUUC-Ptt-103938	Puccinia triticina	38.06	9.00e-49	187.00
IUUC-Pte-104315	Pyrenophora teres	33.81	1.00e-55	210.00
IUUC-Pyt-104825	Pyrenophora triticirepentis	33.57	4.00e-55	208.00
IUUC-Rno-105523	Rattus norvegicus	93.51	2.00e-178	617.00
IUUC-Sce-106297	Saccharomyces cerevisiae	41.77	1.00e-64	239.00
IUUC-Sha-106981	Sarcophilus harrisii	92.15	8.00e-142	496.00
IUUC-Sja-107715	Schizosaccharomyces japonicus	40.06	1.00e-56	214.00
IUUC-Spo-108214	Schizosaccharomyces pombe	42.12	7.00e-58	218.00
IUUC-Smo-109034	Selaginella moellendorffii	45.05	6.00e-81	294.00
IUUC-Sit-110663	Setaria italica	50.15	2.00e-88	318.00
IUUC-Sly-110898	Solanum lycopersicum	48.84	1.00e-82	299.00
IUUC-Stu-112647	Solanum tuberosum	51.13	2.00e-69	254.00
IUUC-Sbi-114288	Sorghum bicolor	47.80	6.00e-84	303.00
IUUC-Sre-115065	Sporisorium reilianum	43.54	1.00e-74	273.00
IUUC-Ssc-115960	Sus scrofa	89.61	5.00e-180	623.00
IUUC-Tru-118382	Takifugu rubripes	71.34	1.00e-146	512.00
IUUC-Tsy-119585	Tarsius syrichta	87.32	2.00e-160	558.00
IUUC-Tni-120133	Tetraodon nigroviridis	73.94	4.00e-142	497.00
IUUC-Tca-121167	Theobroma cacao	48.97	1.00e-80	293.00
IUUC-Tre-122119	Trichoderma reesei	29.33	5.00e-41	162.00
IUUC-Tvi-122407	Trichoderma virens	30.07	1.00e-41	163.00
IUUC-Tae-125748	Triticum aestivum	48.66	8.00e-81	293.00
IUUC-Tur-126682	Triticum urartu	48.89	1.00e-67	249.00
IUUC-Tme-127095	Tuber melanosporum	37.03	3.00e-62	232.00
IUUC-Tbe-128004	Tupaia belangeri	96.46	0.00e+00	633.00
IUUC-Ttr-129284	Tursiops truncatus	91.81	5.00e-172	596.00
IUUC-Uma-129527	Ustilago maydis	43.05	2.00e-74	272.00
IUUC-Vda-129854	Verticillium dahliae	32.14	6.00e-39	154.00
IUUC-Vpa-130681	Vicugna pacos	96.55	2.00e-49	189.00
IUUC-Vvi-131004	Vitis vinifera	53.12	3.00e-87	315.00
IUUC-Xtr-131928	Xenopus tropicalis	81.60	8.00e-156	542.00
IUUC-Xma-134290	Xiphophorus maculatus	70.62	5.00e-134	470.00
IUUC-Yli-134364	Yarrowia lipolytica	44.19	2.00e-68	252.00
IUUC-Zma-135658	Zea mays	49.55	1.00e-85	309.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence