iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045373

UUCD1 version

UUC-GoG-00309

Ensembl Protein ID

ENSGGOP00000007381.2

UniProt Accession

G3QX50; G3QX50_GORGO

Protein Name

Uncharacterized protein

Gene Name

TBL1X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000007537.2	ENSGGOT00000007577.2	ENSGGOP00000007381.2
ENSGGOG00000007537.2	ENSGGOT00000031813.1	ENSGGOP00000019811.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-53	176.9	504	542
UBD/Beta-Prp	1.50e-63	215.2	376	575

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g+l++s
   Q: 504  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGNLVHS 542
           9**********999********************99886 PP

UBD/Beta-Prp

   S: 15   cvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfs 103
           +v++ ++++ +a+ s+d +i v ++     +++++gh++ev+a+k++p+g +l+++s+D+t+k+w++++  c+h l++h+++++++++s
   Q: 376  DVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 463
           3333.444445555555555555555555555555555555555555555555555555555555555555555555555555555554 PP
   S: 104  p.........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsv 183
           p         s+  l+s+s d+t+r+wd+e g c + tl++h++ v +v+++pdg++l+sGs D++v +W+ ++g+l++  +g  t+ +
   Q: 464  PtgpatsnpnSNIMLASASFDSTVRLWDIERGVCTH-TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG--TGGI 549
           444433333222345555555555555555555555.5555555555555555555555555555555555555555555554..5555 PP
   S: 184  yslsfdsngkelvsgsldgtvklwdl 209
             + ++  g  + + + dg+v + dl
   Q: 550  FEVCWNARGDKVGASASDGSVCVLDL 575
           55555555555555555555554444 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MTELAGASSS CCHRPAGRGA MQSVLHHFQR LRGREGGSHF NTSSPRGEAK MSITSDEVNF 60
LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI SILQKGLQYV EAEISINEDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTGCATGTA ATACCTCAGC ATCAGTCTGC ACAAGCCCAG GGAGCCCAGG AGCAACGAAG 60
GGCAGGCTCA AGGGAAGGCC CCACCATGTC CTTCTGGGGG GCCTTGAATG GCAACTGATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0005667--C:transcription factor complex
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0045444--P:fat cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone
GO:0007605--P:sensory perception of sound

KEGG

ggo:101139589

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001450	Ailuropoda melanoleuca	89.40	0.00e+00	993.00
IUUC-Apl-003232	Anas platyrhynchos	92.98	0.00e+00	974.00
IUUC-Aca-005035	Anolis carolinensis	92.47	0.00e+00	992.00
IUUC-Bta-013202	Bos taurus	93.94	0.00e+00	989.00
IUUC-Cja-019281	Callithrix jacchus	91.52	0.00e+00	1060.00
IUUC-Cfa-020929	Canis familiaris	93.36	0.00e+00	981.00
IUUC-Csa-023943	Chlorocebus sabaeus	97.06	0.00e+00	1112.00
IUUC-Dno-028926	Dasypus novemcinctus	93.36	0.00e+00	975.00
IUUC-Dme-031939	Drosophila melanogaster	80.38	2.00e-174	605.00
IUUC-Ete-032822	Echinops telfairi	82.95	0.00e+00	838.00
IUUC-Eca-033897	Equus caballus	94.69	0.00e+00	984.00
IUUC-Fca-036462	Felis catus	94.50	0.00e+00	987.00
IUUC-Fal-037388	Ficedula albicollis	93.17	0.00e+00	984.00
IUUC-Gga-040671	Gallus gallus	93.36	0.00e+00	984.00
IUUC-Gac-041851	Gasterosteus aculeatus	88.24	0.00e+00	925.00
IUUC-Hsa-045841	Homo sapiens	98.44	0.00e+00	1129.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	95.97	0.00e+00	760.00
IUUC-Lch-050535	Latimeria chalumnae	89.94	0.00e+00	961.00
IUUC-Laf-054071	Loxodonta africana	93.38	0.00e+00	986.00
IUUC-Mcc-055233	Macaca mulatta	97.02	0.00e+00	1097.00
IUUC-Mga-059895	Meleagris gallopavo	93.55	0.00e+00	984.00
IUUC-Mvi-060557	Microbotryum violaceum	37.30	2.00e-70	260.00
IUUC-Mmr-061286	Microcebus murinus	93.96	0.00e+00	993.00
IUUC-Mmu-063447	Mus musculus	94.31	0.00e+00	991.00
IUUC-Nle-069151	Nomascus leucogenys	97.40	0.00e+00	1120.00
IUUC-Ont-072252	Oreochromis niloticus	87.86	0.00e+00	943.00
IUUC-Oan-073562	Ornithorhynchus anatinus	94.12	0.00e+00	993.00
IUUC-Oba-075618	Oryza barthii	48.21	8.00e-144	503.00
IUUC-Ogl-077302	Oryza glaberrima	50.00	3.00e-155	541.00
IUUC-Ogu-078718	Oryza glumaepatula	50.00	3.00e-155	541.00
IUUC-Oin-079515	Oryza indica	44.30	3.00e-95	342.00
IUUC-Ome-081696	Oryza meridionalis	48.93	6.00e-150	524.00
IUUC-Oni-082137	Oryza nivara	50.00	3.00e-155	541.00
IUUC-Opu-083505	Oryza punctata	48.29	1.00e-143	503.00
IUUC-Oru-085276	Oryza rufipogon	50.00	2.00e-155	542.00
IUUC-Osa-085791	Oryza sativa	50.00	3.00e-155	541.00
IUUC-Oar-089506	Ovis aries	92.22	0.00e+00	985.00
IUUC-Ptr-090793	Pan troglodytes	89.75	0.00e+00	937.00
IUUC-Pan-091909	Papio anubis	97.07	0.00e+00	1117.00
IUUC-Psi-093358	Pelodiscus sinensis	89.02	0.00e+00	943.00
IUUC-Pfo-097214	Poecilia formosa	86.34	0.00e+00	909.00
IUUC-Pab-098317	Pongo abelii	97.89	0.00e+00	1104.00
IUUC-Rno-105857	Rattus norvegicus	94.31	0.00e+00	991.00
IUUC-Sha-107326	Sarcophilus harrisii	91.27	0.00e+00	991.00
IUUC-Stu-112786	Solanum tuberosum	47.76	1.00e-141	496.00
IUUC-Ssc-115646	Sus scrofa	93.57	0.00e+00	1008.00
IUUC-Tgu-116898	Taeniopygia guttata	93.17	0.00e+00	976.00
IUUC-Tru-117862	Takifugu rubripes	88.28	0.00e+00	937.00
IUUC-Tni-119656	Tetraodon nigroviridis	88.18	0.00e+00	937.00
IUUC-Tae-125368	Triticum aestivum	50.54	2.00e-154	539.00
IUUC-Tur-126856	Triticum urartu	55.56	6.00e-63	234.00
IUUC-Ttr-128826	Tursiops truncatus	91.93	0.00e+00	920.00
IUUC-Uma-129469	Ustilago maydis	43.14	9.00e-59	221.00
IUUC-Vvi-131193	Vitis vinifera	59.26	2.00e-129	456.00
IUUC-Xma-133591	Xiphophorus maculatus	86.58	0.00e+00	916.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence