iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098304

Ensembl Protein ID

ENSPPYP00000023858.1

UniProt Accession

K7ETI7; K7ETI7_PONAB

Genbank Protein ID

ENSPPYP00000023858

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01101166

Gene Name

RFFL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000008177.2	ENSPPYT00000033123.1	ENSPPYP00000023858.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.17	0.00e+00	749.00	IUUC-Hsa-045798

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pongo abelii

Protein Sequence
(Fasta)

MNKDFIMWAT CCNWFCLDGQ PEEVPPPQGA RMQAYSNPGY SSFPSPTGLE PSCKSCGAHF 60
ANTARKQTCL DCKKNFCMTC SSQVGNGPRL CLLCQRFRAT AFQREELMKM KVKDLRDYLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCAGTTGAA ATAAGGTTTT AGCTTTATTT GTGAGTAAAT CAGTAGAATA CTGGATGTTA 60
GGATGCATCT ATCCACTTTA TTATAAATAA TGCAAGGCTG ATTTTATGAT GTGATCTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0002947--C:tumor necrosis factor receptor superfamily complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001630	Ailuropoda melanoleuca	89.70	0.00e+00	642.00
IUUC-Apl-004124	Anas platyrhynchos	66.03	2.00e-124	438.00
IUUC-Aly-005548	Arabidopsis lyrata	47.06	1.00e-08	55.50
IUUC-Ame-011616	Astyanax mexicanus	59.02	1.00e-104	373.00
IUUC-Bta-012374	Bos taurus	85.79	0.00e+00	637.00
IUUC-Cja-019780	Callithrix jacchus	95.88	0.00e+00	689.00
IUUC-Cfa-021252	Canis familiaris	92.35	0.00e+00	651.00
IUUC-Cpo-022047	Cavia porcellus	90.71	0.00e+00	662.00
IUUC-Csa-023161	Chlorocebus sabaeus	98.90	0.00e+00	743.00
IUUC-Cho-024316	Choloepus hoffmanni	91.42	7.00e-158	549.00
IUUC-Cne-026858	Cryptococcus neoformans	25.15	7.00e-07	48.50
IUUC-Dre-028596	Danio rerio	55.92	3.00e-109	388.00
IUUC-Dno-029333	Dasypus novemcinctus	92.01	0.00e+00	663.00
IUUC-Ete-033163	Echinops telfairi	83.47	6.00e-165	573.00
IUUC-Eca-033994	Equus caballus	92.35	0.00e+00	682.00
IUUC-Eeu-035162	Erinaceus europaeus	87.00	3.00e-131	460.00
IUUC-Fca-036418	Felis catus	91.26	0.00e+00	699.00
IUUC-Fal-037427	Ficedula albicollis	65.40	3.00e-132	464.00
IUUC-Gga-041053	Gallus gallus	67.49	7.00e-131	459.00
IUUC-Ggo-045436	Gorilla gorilla	99.17	0.00e+00	749.00
IUUC-Hsa-045798	Homo sapiens	99.17	0.00e+00	749.00
IUUC-Itr-048077	Ictidomys tridecemlineatus	92.08	0.00e+00	656.00
IUUC-Lch-050639	Latimeria chalumnae	62.53	1.00e-125	442.00
IUUC-Laf-053355	Loxodonta africana	89.16	0.00e+00	630.00
IUUC-Mcc-055222	Macaca mulatta	98.35	0.00e+00	687.00
IUUC-Meu-056692	Macropus eugenii	78.24	4.00e-161	560.00
IUUC-Mga-059298	Meleagris gallopavo	66.30	2.00e-130	458.00
IUUC-Mmr-061792	Microcebus murinus	90.91	0.00e+00	648.00
IUUC-Mdo-062986	Monodelphis domestica	81.10	6.00e-171	593.00
IUUC-Mmu-063356	Mus musculus	88.80	0.00e+00	651.00
IUUC-Mpu-066273	Mustela putorius furo	91.53	0.00e+00	698.00
IUUC-Mlu-066953	Myotis lucifugus	91.26	0.00e+00	685.00
IUUC-Nle-070075	Nomascus leucogenys	98.92	0.00e+00	759.00
IUUC-Opr-070838	Ochotona princeps	89.53	0.00e+00	639.00
IUUC-Ont-071967	Oreochromis niloticus	74.83	1.00e-56	213.00
IUUC-Ocu-074807	Oryctolagus cuniculus	90.98	0.00e+00	686.00
IUUC-Obr-076159	Oryza brachyantha	41.07	3.00e-08	50.80
IUUC-Ola-086903	Oryzias latipes	68.21	8.00e-56	211.00
IUUC-Oga-088536	Otolemur garnettii	90.91	0.00e+00	627.00
IUUC-Oar-089838	Ovis aries	86.34	5.00e-180	623.00
IUUC-Ptr-090962	Pan troglodytes	98.90	0.00e+00	748.00
IUUC-Pan-092853	Papio anubis	98.35	0.00e+00	740.00
IUUC-Psi-093164	Pelodiscus sinensis	65.21	6.00e-126	443.00
IUUC-Pma-094104	Petromyzon marinus	44.65	7.00e-57	214.00
IUUC-Pno-094968	Phaeosphaeria nodorum	36.73	2.00e-08	55.80
IUUC-Pca-100316	Procavia capensis	89.53	2.00e-177	614.00
IUUC-Ppe-101490	Prunus persica	37.80	1.00e-09	57.40
IUUC-Pva-102612	Pteropus vampyrus	77.69	1.00e-157	548.00
IUUC-Rno-105449	Rattus norvegicus	89.53	0.00e+00	643.00
IUUC-Sha-107578	Sarcophilus harrisii	80.55	2.00e-160	558.00
IUUC-Sar-113638	Sorex araneus	86.23	4.00e-175	607.00
IUUC-Ssc-116401	Sus scrofa	89.40	0.00e+00	687.00
IUUC-Tru-118765	Takifugu rubripes	49.59	8.00e-83	300.00
IUUC-Tsy-118850	Tarsius syrichta	90.10	1.00e-153	535.00
IUUC-Tbe-128086	Tupaia belangeri	84.57	2.00e-180	624.00
IUUC-Ttr-128249	Tursiops truncatus	69.15	1.00e-138	485.00
IUUC-Vpa-130816	Vicugna pacos	87.21	5.00e-41	160.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence