• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046178
UUCD1 version UUC-HoS-00565
Ensembl Protein ID ENSP00000355636.1
UniProt Accession O75529; Q5TDI5; Q5TDI6; Q8IW31; TAF5L_HUMAN
Genbank Protein ID AAC39906.1; CAI22015.1; CAI22016.1; EAW69902.1; EAW69903.1; AAH41094.1; CAA08816.1
Protein Name TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; PCAF-associated factor 65 beta
Genbank Nucleotide ID AF069736; AL121990; AL121990; CH471098; CH471098; BC041094; AJ009770
Gene Name TAF5L; PAF65B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000135801.9 ENST00000366676.5 ENSP00000355636.1
ENSG00000135801.9 ENST00000366675.3 ENSP00000355635.3
ENSG00000135801.9 ENST00000366674.1 ENSP00000355634.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.60e-41 139.0 508 540
UBD/Beta-Prp 1.90e-67 229.2 271 564
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gHtd +t+l f +d +l++s+s D++++vWD+r
   Q: 508  GHTDNITSLTFsPDsGLIASASMDNSVRVWDIR 540
           8***********999****************76 PP
   

   UBD/Beta-Prp
   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkl................................lrslsgheaevtavkfspdgkilvtgse 72
           ++   +spd++lla+g+++++ik+w+++++kl                                ++ l gh ++v++++f  d++ l+++se
   Q: 271  LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLksephqvdvsrihlacdileeeddeddnagteMKILRGHCGPVYSTRFLADSSGLLSCSE 362
           5667889************************************************************************************* PP
   S: 73   DrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlW 164
           D+ i+ wdl +++ ++ ++gh + v++l++sp++ +++sGshdrt+r+w  +  + l+ + +gh + v cv++hp++n+l++Gs+D+tvrlW
   Q: 363  DMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLR-IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLW 453
           **********************************************************.********************************* PP
   S: 165  dlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdl 256
           + ++g+ +r +tg h ++v sl+f++ngk+l+s+++d+++klwdl +g+  ++l+ghtdn++s+ fsp++ +++s+s+D+s+r+Wd+r+  +
   Q: 454  SAQQGNSVRLFTG-HRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544
           ************9.***********************************************************************9999999 PP
   S: 257  lktlqlhnssvisvavlsfg 276
                ++ s ++ v + +++
   Q: 545  SAPADGSSSELVGVYTGQMS 564
           88888888666666663333 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
 The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
Protein Sequence
(Fasta)
MKRVRTEQIQ MAVSCYLKRR QYVDSDGPLK QGLRLSQTAE EMAANLTVQS ESGCANIVSA 60
APCQAEPQQY EVQFGRLRNF LTDSDSQHSH EVMPLLYPLF VYLHLNLVQN SPKSTVESFY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046178|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGCCGCCC AGAGCGGCGG CGGGGGCGGC GGGGCGCGGG GCGCGGGGGC CCAGCTGAGC 60
CGGCCGTCGG AGTGAGACCC TGCGGCAGAG ACGACGGAGG CGGAAGCAAC CCGATCCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046178|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR007582--TFIID_NTD2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF04494--TFIID_NTD2
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0016607--C:nuclear speck
GO:0000932--C:P-body
GO:0030914--C:STAGA complex
GO:0033276--C:transcription factor TFTC complex
GO:0003713--F:transcription coactivator activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0043966--P:histone H3 acetylation
GO:0006366--P:transcription from RNA polymerase II promoter
KEGG hsa:27097
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002016 Ailuropoda melanoleuca 98.47 0.00e+00 1115.00
IUUC-Apl-003636 Anas platyrhynchos 92.72 0.00e+00 1132.00
IUUC-Aca-004229 Anolis carolinensis 91.85 0.00e+00 1102.00
IUUC-Ame-010599 Astyanax mexicanus 66.89 0.00e+00 823.00
IUUC-Bta-013404 Bos taurus 93.21 0.00e+00 1057.00
IUUC-Cja-019643 Callithrix jacchus 99.83 0.00e+00 1151.00
IUUC-Cfa-020913 Canis familiaris 98.98 0.00e+00 1139.00
IUUC-Cpo-021777 Cavia porcellus 95.25 0.00e+00 1087.00
IUUC-Csa-024184 Chlorocebus sabaeus 99.83 0.00e+00 1152.00
IUUC-Cho-024638 Choloepus hoffmanni 98.13 0.00e+00 1108.00
IUUC-Cin-025618 Ciona intestinalis 35.13 3.00e-91 329.00
IUUC-Csv-025874 Ciona savignyi 33.96 2.00e-90 326.00
IUUC-Dre-028817 Danio rerio 66.94 0.00e+00 811.00
IUUC-Dno-029969 Dasypus novemcinctus 88.96 0.00e+00 1059.00
IUUC-Dor-031117 Dipodomys ordii 96.10 0.00e+00 1123.00
IUUC-Ete-032712 Echinops telfairi 89.81 0.00e+00 996.00
IUUC-Eca-033742 Equus caballus 98.98 0.00e+00 1139.00
IUUC-Eeu-035096 Erinaceus europaeus 95.93 0.00e+00 1136.00
IUUC-Fca-035769 Felis catus 97.97 0.00e+00 1155.00
IUUC-Fal-036645 Ficedula albicollis 92.27 0.00e+00 1068.00
IUUC-Fso-038302 Fusarium solani 33.24 2.00e-40 160.00
IUUC-Gmo-038636 Gadus morhua 64.00 0.00e+00 777.00
IUUC-Gga-040144 Gallus gallus 92.53 0.00e+00 1103.00
IUUC-Gac-041716 Gasterosteus aculeatus 68.06 0.00e+00 815.00
IUUC-Ggo-044568 Gorilla gorilla 100.00 0.00e+00 1153.00
IUUC-Itr-048967 Ictidomys tridecemlineatus 90.49 0.00e+00 1097.00
IUUC-Lch-050501 Latimeria chalumnae 78.19 0.00e+00 879.00
IUUC-Loc-052895 Lepisosteus oculatus 82.48 0.00e+00 647.00
IUUC-Laf-053950 Loxodonta africana 93.72 0.00e+00 1080.00
IUUC-Mcc-055450 Macaca mulatta 99.83 0.00e+00 1148.00
IUUC-Meu-056182 Macropus eugenii 89.47 0.00e+00 1028.00
IUUC-Mga-059619 Meleagris gallopavo 92.70 0.00e+00 1106.00
IUUC-Mmr-061074 Microcebus murinus 97.80 0.00e+00 1155.00
IUUC-Mdo-062307 Monodelphis domestica 94.38 0.00e+00 904.00
IUUC-Mmu-063226 Mus musculus 93.38 0.00e+00 1075.00
IUUC-Mpu-066016 Mustela putorius furo 98.30 0.00e+00 1110.00
IUUC-Mlu-067257 Myotis lucifugus 88.31 0.00e+00 1086.00
IUUC-Nle-070139 Nomascus leucogenys 99.83 0.00e+00 1150.00
IUUC-Opr-070243 Ochotona princeps 93.21 0.00e+00 1093.00
IUUC-Ont-072686 Oreochromis niloticus 69.00 0.00e+00 838.00
IUUC-Oan-073670 Ornithorhynchus anatinus 82.70 0.00e+00 845.00
IUUC-Ocu-074525 Oryctolagus cuniculus 98.64 0.00e+00 1148.00
IUUC-Ola-086524 Oryzias latipes 68.50 0.00e+00 855.00
IUUC-Oga-088540 Otolemur garnettii 98.30 0.00e+00 1134.00
IUUC-Oar-089793 Ovis aries 90.15 0.00e+00 990.00
IUUC-Ptr-091154 Pan troglodytes 100.00 0.00e+00 1153.00
IUUC-Pan-092759 Papio anubis 99.83 0.00e+00 1148.00
IUUC-Psi-094008 Pelodiscus sinensis 89.81 0.00e+00 1097.00
IUUC-Pma-094593 Petromyzon marinus 46.23 4.00e-134 471.00
IUUC-Pfo-097409 Poecilia formosa 67.39 0.00e+00 811.00
IUUC-Pab-097946 Pongo abelii 87.78 0.00e+00 993.00
IUUC-Pca-100727 Procavia capensis 90.32 0.00e+00 1004.00
IUUC-Pva-103211 Pteropus vampyrus 84.55 0.00e+00 1014.00
IUUC-Ptt-103995 Puccinia triticina 43.83 4.00e-70 260.00
IUUC-Rno-105236 Rattus norvegicus 93.55 0.00e+00 1059.00
IUUC-Sha-106833 Sarcophilus harrisii 94.26 0.00e+00 1101.00
IUUC-Sar-113381 Sorex araneus 98.81 0.00e+00 1167.00
IUUC-Ssc-116421 Sus scrofa 95.25 0.00e+00 1140.00
IUUC-Tgu-117143 Taeniopygia guttata 93.21 0.00e+00 1139.00
IUUC-Tru-118680 Takifugu rubripes 68.00 0.00e+00 836.00
IUUC-Tsy-119622 Tarsius syrichta 83.02 0.00e+00 867.00
IUUC-Tni-120131 Tetraodon nigroviridis 67.50 0.00e+00 840.00
IUUC-Tbe-127656 Tupaia belangeri 95.45 3.00e-89 322.00
IUUC-Ttr-129171 Tursiops truncatus 94.74 0.00e+00 1078.00
IUUC-Xtr-132241 Xenopus tropicalis 81.36 0.00e+00 967.00
IUUC-Xma-133554 Xiphophorus maculatus 67.98 0.00e+00 749.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved