iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	19158078

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	3.80e-20	72.3	148	212
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	8.00e-08	31.5	247	278

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +Dv l v+g++++ah+++Laa+S++F+a+f++++ e+k kl++e++d+  e++r +++++Yt+k+ 
   Q: 148  CDVELLVAGSVIRAHRYILAAASPYFKAMFTNGMVEMK-KLTIELQDIPEESVRIIVDYIYTDKIA 212
           8*************************************.************************986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Nc+++++f+d+y+c+ L ++ +df++++F+
   Q: 247  SHNCMSLYHFSDIYNCTNLISSIEDFASSQFR 278
           69****************************97 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates degradation of glutamate receptors in neurons. The BCR(kel-8) ubiquitin ligase complex mediates ubiquitination and subsequent degradation of rpy-1. Indirectly regulates the protein turnover of glr-1, possibly via ubiquitination and degradation of rpy-1.

Protein Sequence
(Fasta)

MWTFNRSTAE APTMPSSSNT LPASSISINT TSTVTLHMPV YAKAIFGSFP SVQQVRVENG 60
ERCLIEAMDE LNKNEKGLYR PVRLENGDQI STTDDVLNGK LARVSYTPFE EFELVSNSKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGACCT TCAACAGATC TACCGCGGAG GCGCCAACTA TGCCGTCAAG CTCTAATACG 60
GTAGGTGGTA ACTATTTTAC TTTTTCTGGA ATTTCATTTT GTAAGCTACC ACGGATTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030605--KLHL8
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0030054--C:cell junction
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0014069--C:postsynaptic density
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001443	Ailuropoda melanoleuca	41.64	1.00e-131	462.00
IUUC-Apl-003978	Anas platyrhynchos	39.90	1.00e-132	465.00
IUUC-Aca-004958	Anolis carolinensis	37.09	3.00e-122	431.00
IUUC-Ame-011139	Astyanax mexicanus	39.79	1.00e-135	475.00
IUUC-Bta-013142	Bos taurus	39.14	1.00e-132	465.00
IUUC-Bdi-014143	Brachypodium distachyon	36.44	9.00e-40	157.00
IUUC-Cja-019650	Callithrix jacchus	41.25	3.00e-135	474.00
IUUC-Cfa-021046	Canis familiaris	41.82	5.00e-132	463.00
IUUC-Cpo-022445	Cavia porcellus	39.93	1.00e-124	438.00
IUUC-Csa-023642	Chlorocebus sabaeus	42.45	2.00e-135	474.00
IUUC-Dre-027723	Danio rerio	39.59	2.00e-132	464.00
IUUC-Dno-028964	Dasypus novemcinctus	38.34	6.00e-106	376.00
IUUC-Ete-032815	Echinops telfairi	38.56	1.00e-128	452.00
IUUC-Eca-034162	Equus caballus	40.46	1.00e-132	465.00
IUUC-Eeu-034660	Erinaceus europaeus	41.45	2.00e-131	461.00
IUUC-Fca-035659	Felis catus	41.64	9.00e-132	462.00
IUUC-Fal-037619	Ficedula albicollis	40.51	2.00e-134	471.00
IUUC-Gmo-038546	Gadus morhua	39.20	4.00e-133	467.00
IUUC-Ggr-039827	Gaeumannomyces graminis	25.83	5.00e-05	39.70
IUUC-Gga-040770	Gallus gallus	39.44	1.00e-130	458.00
IUUC-Gac-042557	Gasterosteus aculeatus	38.42	7.00e-131	459.00
IUUC-Ggo-044741	Gorilla gorilla	42.22	2.00e-135	474.00
IUUC-Hsa-046025	Homo sapiens	41.25	2.00e-135	474.00
IUUC-Itr-048541	Ictidomys tridecemlineatus	41.51	1.00e-129	455.00
IUUC-Loc-052834	Lepisosteus oculatus	40.48	5.00e-126	443.00
IUUC-Laf-054513	Loxodonta africana	40.90	7.00e-135	473.00
IUUC-Mcc-054707	Macaca mulatta	41.07	2.00e-135	474.00
IUUC-Meu-056779	Macropus eugenii	40.24	1.00e-134	472.00
IUUC-Mor-057181	Magnaporthe oryzae	28.48	2.00e-07	48.90
IUUC-Mga-059676	Meleagris gallopavo	39.26	1.00e-130	458.00
IUUC-Mmr-061359	Microcebus murinus	38.63	2.00e-129	454.00
IUUC-Mdo-062527	Monodelphis domestica	40.21	1.00e-133	469.00
IUUC-Mmu-063112	Mus musculus	40.10	2.00e-133	468.00
IUUC-Mpu-065800	Mustela putorius furo	41.82	1.00e-131	462.00
IUUC-Mlu-067536	Myotis lucifugus	40.70	3.00e-131	460.00
IUUC-Ncr-068884	Neurospora crassa	28.77	2.00e-05	42.70
IUUC-Nle-069397	Nomascus leucogenys	40.52	1.00e-135	475.00
IUUC-Opr-070599	Ochotona princeps	39.92	5.00e-106	377.00
IUUC-Ont-072580	Oreochromis niloticus	39.11	3.00e-134	470.00
IUUC-Oan-073180	Ornithorhynchus anatinus	41.35	3.00e-134	470.00
IUUC-Ocu-074026	Oryctolagus cuniculus	40.63	2.00e-132	464.00
IUUC-Obr-076181	Oryza brachyantha	35.96	7.00e-34	138.00
IUUC-Ogl-077595	Oryza glaberrima	32.74	4.00e-31	128.00
IUUC-Olo-080536	Oryza longistaminata	32.29	1.00e-29	124.00
IUUC-Osa-085891	Oryza sativa	32.74	9.00e-32	130.00
IUUC-Ola-086776	Oryzias latipes	39.66	4.00e-125	440.00
IUUC-Olu-087696	Ostreococcus lucimarinus	33.19	1.00e-25	108.00
IUUC-Oga-088651	Otolemur garnettii	39.22	2.00e-132	464.00
IUUC-Oar-089567	Ovis aries	38.65	1.00e-126	445.00
IUUC-Ptr-091564	Pan troglodytes	42.22	2.00e-135	474.00
IUUC-Pan-092578	Papio anubis	42.45	2.00e-135	474.00
IUUC-Psi-093635	Pelodiscus sinensis	39.58	3.00e-129	454.00
IUUC-Pma-094660	Petromyzon marinus	39.83	2.00e-132	464.00
IUUC-Pfo-097507	Poecilia formosa	39.07	2.00e-125	441.00
IUUC-Pab-098025	Pongo abelii	42.22	2.00e-135	474.00
IUUC-Ppe-101154	Prunus persica	36.28	8.00e-37	147.00
IUUC-Pva-102359	Pteropus vampyrus	39.52	3.00e-102	364.00
IUUC-Rno-105750	Rattus norvegicus	40.44	3.00e-133	467.00
IUUC-Sha-107513	Sarcophilus harrisii	41.16	3.00e-132	464.00
IUUC-Stu-112032	Solanum tuberosum	33.91	2.00e-37	149.00
IUUC-Ssc-116205	Sus scrofa	38.54	5.00e-106	376.00
IUUC-Tgu-117435	Taeniopygia guttata	40.42	7.00e-134	469.00
IUUC-Tru-118709	Takifugu rubripes	38.77	3.00e-132	464.00
IUUC-Tsy-119466	Tarsius syrichta	40.96	3.00e-128	451.00
IUUC-Tni-119988	Tetraodon nigroviridis	38.70	2.00e-131	461.00
IUUC-Tvi-122406	Trichoderma virens	33.33	1.00e-05	41.60
IUUC-Tme-127039	Tuber melanosporum	38.75	1.00e-10	60.80
IUUC-Tbe-127704	Tupaia belangeri	38.60	2.00e-120	424.00
IUUC-Ttr-128892	Tursiops truncatus	42.23	3.00e-106	377.00
IUUC-Xtr-132289	Xenopus tropicalis	39.36	1.00e-123	435.00
IUUC-Xma-133419	Xiphophorus maculatus	39.39	8.00e-122	429.00
IUUC-Yli-134409	Yarrowia lipolytica	25.34	8.00e-11	62.40
IUUC-Zma-134695	Zea mays	34.88	9.00e-34	137.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence