iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035919

Ensembl Protein ID

ENSFCAP00000022034.1

UniProt Accession

M3X5Y3; M3X5Y3_FELCA

Genbank Protein ID

ENSFCAP00000022034

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AANG02026247

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000022369.1	ENSFCAT00000027119.1	ENSFCAP00000022034.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.80e-82	275.2	202	515

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 36   klneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedks 124
            +++++p++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++++
   Q: 202  LIQNKEPSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGTTRR 281
           567888999***************************************************************.........66888889 PP
   S: 125  elsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeelege 203
            l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e leg+
   Q: 282  ILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCVSCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALEGR 370
           99999***************************************************998879*************************96 PP
   S: 204  nkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYe 279
             y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  Y+
   Q: 371  I-YACDQCNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLNMEPYCCRDMLSSLDkeTFAYD 457
           5.*******9999999*******************************997.8889********************876654433999** PP
   S: 280  LiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++r
   Q: 458  LSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQR 515
           ***********************9999********************...********985 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWCCRECA TTESVWACLK CSHVACGRYI EDHALKHFEE 60
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDPP LRRGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAACATGT CGGGCGGTTG CGGCTCGCCC AGGACCACTC CATCCTGAAC 60
CCGCAGAAGT GGTGCTGCAG GGAGTGCGCC ACCACCGAGT CGGTGTGGGC TTGTCTCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	98.25	0.00e+00	815.00
IUUC-Bta-012911	Bos taurus	95.02	0.00e+00	777.00
IUUC-Cfa-020408	Canis familiaris	97.24	0.00e+00	802.00
IUUC-Cpo-022233	Cavia porcellus	91.45	0.00e+00	740.00
IUUC-Cho-025051	Choloepus hoffmanni	90.38	0.00e+00	642.00
IUUC-Eca-033851	Equus caballus	94.59	0.00e+00	693.00
IUUC-Gmo-039249	Gadus morhua	77.99	6.00e-146	511.00
IUUC-Gga-040383	Gallus gallus	85.61	0.00e+00	703.00
IUUC-Gac-042371	Gasterosteus aculeatus	62.98	4.00e-169	587.00
IUUC-Ggo-044979	Gorilla gorilla	94.75	0.00e+00	792.00
IUUC-Hsa-046743	Homo sapiens	94.50	0.00e+00	789.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	95.99	0.00e+00	802.00
IUUC-Loc-051961	Lepisosteus oculatus	78.28	2.00e-171	596.00
IUUC-Laf-053819	Loxodonta africana	94.51	0.00e+00	799.00
IUUC-Mcc-055048	Macaca mulatta	95.00	0.00e+00	794.00
IUUC-Meu-055971	Macropus eugenii	94.01	4.00e-93	335.00
IUUC-Mga-059720	Meleagris gallopavo	85.82	0.00e+00	703.00
IUUC-Mmr-061253	Microcebus murinus	86.98	1.00e-156	546.00
IUUC-Mpu-066318	Mustela putorius furo	96.99	0.00e+00	805.00
IUUC-Mlu-067090	Myotis lucifugus	92.52	0.00e+00	775.00
IUUC-Nle-069486	Nomascus leucogenys	95.00	0.00e+00	793.00
IUUC-Oan-073245	Ornithorhynchus anatinus	89.14	5.00e-180	623.00
IUUC-Ocu-074851	Oryctolagus cuniculus	95.10	7.00e-162	563.00
IUUC-Oar-089462	Ovis aries	96.15	0.00e+00	777.00
IUUC-Pva-102868	Pteropus vampyrus	95.76	0.00e+00	801.00
IUUC-Sar-113561	Sorex araneus	95.21	2.00e-94	339.00
IUUC-Ssc-115735	Sus scrofa	95.01	0.00e+00	796.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence