iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036283

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02071008

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000008727.3	ENSFCAT00000008728.3	ENSFCAP00000008090.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.70e-85	285.4	704	1024

Active Site

Position(s)	Description	Evidence
994	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            dl k l +ef +E +   +Gv++ef++++++e+ ++++g+f y e+++++++p + ++    e+ ++F  +G+l+g++l++ ++ +
   Q: 704  TDLCKLLVIEFIKEICSVGEGVKSEFFHCIFEEMTKTEYGMFIYPEEGSYMWFPVSPKF----EKKRYFL-FGMLCGLSLYNLNVAN 785
           57888899*******99999*************************************99....6789995.5*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           lp++ +++k+ll++k sl+dl+e+ p l k+l+ei++n+ +di e+ l + fs++     + ++++L+p+G ++pV ++Nk+eYv+ 
   Q: 786  LPFPLALFKKLLDQKASLQDLKELSPLLGKNLQEILNNEADDIGEE-LYIYFSIHW----DKNDVDLIPNGISVPVDQTNKKEYVSV 867
           **************************************88888887.999998555....779999********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
            v+y++++++k  +e+f++Gf++v+++e+l++F++eel + + G++++d+++++k+ +y +gy++++p+i +Fw+++++++ ee+++
   Q: 868  CVDYIFNTSVKAVYEEFQRGFYKVCDKEMLKIFQPEELMTAVVGNTDYDWKQFEKNSQYGQGYHKSHPTILMFWKAFHKLTLEEKRK 954
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           fL F+ g++rl ++G +e+   lf ++k  s+++ P++ TC n L+LP+Ys++e ++e L++Ai+++kgF 
   Q: 955  FLFFLKGNDRLHARGKQEMG-ILFRCPKTFSERDNPRALTCHNILDLPKYSTMERVEEALQVAINSNKGFA 1024
           ********************.99***********************************************6 PP

Organism

Felis catus

Protein Sequence
(Fasta)

FCITSAKNSL ENASRTSAPE ACGPGGPELR QAASGERHSL LLLSDGAVHS CGDNSRGQLG 60
RRGLQREEQP KEPIQALETL RVELVSCGKE HSLAVCYKGR VFAWGAGSEG QLGIGEFKEI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTGCATTA CCAGTGCCAA AAACAGCTTA GAAAATGCTT CGGATGCTTT TATTAAGCAT 60
CCTAGGCATT ATTCTAACAT TATGTATTAT CTGTTAAATT ACCCTAACAT TAGATTTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	83.38	0.00e+00	1596.00
IUUC-Aca-004663	Anolis carolinensis	46.20	0.00e+00	845.00
IUUC-Bta-013080	Bos taurus	74.73	0.00e+00	1459.00
IUUC-Cja-018891	Callithrix jacchus	72.15	0.00e+00	1428.00
IUUC-Cfa-020763	Canis familiaris	80.08	0.00e+00	1520.00
IUUC-Cpo-022346	Cavia porcellus	70.47	0.00e+00	1432.00
IUUC-Csa-023049	Chlorocebus sabaeus	73.93	0.00e+00	1545.00
IUUC-Dno-029093	Dasypus novemcinctus	74.31	0.00e+00	1500.00
IUUC-Eca-034098	Equus caballus	77.75	0.00e+00	1485.00
IUUC-Eeu-035028	Erinaceus europaeus	67.25	2.00e-150	526.00
IUUC-Ggo-045553	Gorilla gorilla	72.18	0.00e+00	1451.00
IUUC-Hsa-046396	Homo sapiens	74.52	0.00e+00	1516.00
IUUC-Loc-052700	Lepisosteus oculatus	40.95	0.00e+00	778.00
IUUC-Laf-054433	Loxodonta africana	71.50	0.00e+00	1509.00
IUUC-Mcc-055014	Macaca mulatta	70.15	0.00e+00	1472.00
IUUC-Mdo-061839	Monodelphis domestica	56.68	0.00e+00	1025.00
IUUC-Mmu-064378	Mus musculus	63.19	0.00e+00	1231.00
IUUC-Mpu-066293	Mustela putorius furo	79.12	0.00e+00	1488.00
IUUC-Mlu-067407	Myotis lucifugus	75.22	0.00e+00	1492.00
IUUC-Nle-069978	Nomascus leucogenys	75.05	0.00e+00	1537.00
IUUC-Opr-070190	Ochotona princeps	59.55	0.00e+00	669.00
IUUC-Oga-088780	Otolemur garnettii	67.51	0.00e+00	1364.00
IUUC-Oar-090307	Ovis aries	76.48	0.00e+00	1532.00
IUUC-Ptr-091567	Pan troglodytes	74.52	0.00e+00	1512.00
IUUC-Pan-091802	Papio anubis	69.75	0.00e+00	1437.00
IUUC-Pab-098024	Pongo abelii	58.76	0.00e+00	1124.00
IUUC-Pva-102382	Pteropus vampyrus	72.01	0.00e+00	1384.00
IUUC-Rno-105768	Rattus norvegicus	61.69	0.00e+00	1201.00
IUUC-Sha-106525	Sarcophilus harrisii	54.50	0.00e+00	1078.00
IUUC-Sar-113014	Sorex araneus	59.57	5.00e-154	538.00
IUUC-Vpa-130214	Vicugna pacos	71.95	0.00e+00	1311.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence