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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108222
UUCD1 version UUC-ScP-00208
Ensembl Protein ID SPAC328.02.1:pep
UniProt Accession Q9P3U4; HEL1_SCHPO
Genbank Protein ID CAB95997.1
Protein Name E3 ubiquitin-protein ligase dbl4; DNA-break-localizing protein 4; Histone E3 ligase 1; RING-type E3 ubiquitin transferase dbl4
Genbank Nucleotide ID CU329670
Gene Name dbl4; SPAC328.02
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC328.02 SPAC328.02.1 SPAC328.02.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics
Status
Classification
Family E-Value Score Start End
E3 activity/RBR 3.90e-43 148.3 131 320
Active Site
Position(s) Description Evidence
304 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++C+ e        ++eC h+fC +C++qyl  +i+eg+ + i+cp+ +c++ ++ ++i++ +++e+  +ry++ll +++v+ + +l+w
   Q: 131  CEICYDEGCLP--FFSAECDHEFCLACYRQYLDSRISEGE-SVIQCPEESCTQIVSIQSITK-VLDEKSLDRYHRLLDRSFVDDNDHLRW 216
           99999887773..34689**********************.99*******************.79999********************** PP
   S: 91   cpapdCslvvllekea.....eklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyiekne 175
           cpapdC++++  + ++        +v+c +cgk+fC+ C +  H+++ C  +k +l+k++   +++e++++++an+k+CpkC+++iekn+
   Q: 217  CPAPDCEFAIECHVTQaslssVVPTVTC-NCGKQFCFGCGHDNHQPTICPLVKIWLQKCQ---DDSETANWIHANTKECPKCSTTIEKNG 302
           ********99887766555533345557.9******************************...99************************* PP
   S: 176  gCnhmtCakCkaefCwlC 193
           gCnhmtC+kCk+efCw+C
   Q: 303  GCNHMTCKKCKYEFCWVC 320
           ****************** PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
 Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
Protein Sequence
(Fasta)
MSDLLDDEFY EEEFENDLLD ASEFEDEFDE DAEIDDDGFT VERKRRRAHS VSYRVVSVRD 60
LRASLNEKIN QLTSIIDLTR EQVLGLYRYF KWNRERLLER YIDAPEESLQ KAGVGLSGSK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Spo-108222|E3,RBR;E3,RING|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATCCATCTCC CGTACACTTC GTTAAAACAT TTTTGATTTG GAAAGCAGGA GGGCAATTGT 60
CTTGCTCATT TCATAAAGGC CAAAGCCGAA GTATTTTACC TTTTGCATAC ATCTGGCTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108222|E3,RBR;E3,RING|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF01485--IBR
PF00097--zf-C3HC4
SMART

SM00647--IBR
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0036205--P:histone catabolic process
GO:0016574--P:histone ubiquitination
GO:0007127--P:meiosis I
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG spo:SPAC328.02
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000970 Aegilops tauschii 33.33 2.00e-61 228.00
IUUC-Aml-001385 Ailuropoda melanoleuca 44.73 4.00e-105 372.00
IUUC-Atr-002495 Amborella trichopoda 32.32 6.00e-65 239.00
IUUC-Apl-004184 Anas platyrhynchos 46.99 2.00e-103 367.00
IUUC-Aca-004976 Anolis carolinensis 46.99 9.00e-104 368.00
IUUC-Aly-006224 Arabidopsis lyrata 32.94 2.00e-66 244.00
IUUC-Ath-006859 Arabidopsis thaliana 31.36 1.00e-67 248.00
IUUC-Ago-007926 Ashbya gossypii 32.30 1.00e-66 245.00
IUUC-Acl-008252 Aspergillus clavatus 55.39 4.00e-153 532.00
IUUC-Afl-008468 Aspergillus flavus 56.37 1.00e-155 541.00
IUUC-Afu-009062 Aspergillus fumigatus 55.14 4.00e-151 525.00
IUUC-Ani-009219 Aspergillus nidulans 55.94 8.00e-155 538.00
IUUC-Ang-009538 Aspergillus niger 55.17 6.00e-147 511.00
IUUC-Aor-010009 Aspergillus oryzae 56.37 2.00e-154 536.00
IUUC-Ate-010497 Aspergillus terreus 56.36 6.00e-146 508.00
IUUC-Ame-011264 Astyanax mexicanus 42.71 2.00e-111 393.00
IUUC-Bgr-012016 Blumeria graminis 52.94 9.00e-147 511.00
IUUC-Bta-013518 Bos taurus 44.73 5.00e-105 372.00
IUUC-Bci-013819 Botrytis cinerea 53.35 7.00e-151 525.00
IUUC-Bdi-014096 Brachypodium distachyon 32.05 2.00e-71 261.00
IUUC-Bol-015971 Brassica oleracea 33.03 7.00e-67 246.00
IUUC-Bra-017081 Brassica rapa 31.63 2.00e-67 248.00
IUUC-Cel-018521 Caenorhabditis elegans 41.18 6.00e-103 365.00
IUUC-Cja-019869 Callithrix jacchus 39.83 2.00e-83 301.00
IUUC-Cfa-020812 Canis familiaris 44.73 6.00e-104 369.00
IUUC-Cpo-021627 Cavia porcellus 44.73 5.00e-105 372.00
IUUC-Cre-022815 Chlamydomonas reinhardtii 33.87 5.00e-69 253.00
IUUC-Csa-023034 Chlorocebus sabaeus 46.99 3.00e-103 367.00
IUUC-Cho-024444 Choloepus hoffmanni 43.75 1.00e-101 361.00
IUUC-Cin-025135 Ciona intestinalis 43.93 2.00e-103 367.00
IUUC-Csv-026243 Ciona savignyi 42.19 8.00e-99 352.00
IUUC-Cgl-026434 Colletotrichum gloeosporioides 53.63 5.00e-156 542.00
IUUC-Cne-026861 Cryptococcus neoformans 49.05 8.00e-133 465.00
IUUC-Dre-027785 Danio rerio 44.30 2.00e-110 390.00
IUUC-Dno-029205 Dasypus novemcinctus 44.73 5.00e-105 372.00
IUUC-Dor-030769 Dipodomys ordii 37.50 2.00e-78 284.00
IUUC-Dse-031171 Dothistroma septosporum 53.53 2.00e-151 526.00
IUUC-Dme-031903 Drosophila melanogaster 44.49 5.00e-110 389.00
IUUC-Ete-032355 Echinops telfairi 32.77 3.00e-58 217.00
IUUC-Eca-033431 Equus caballus 45.68 4.00e-104 369.00
IUUC-Eeu-034838 Erinaceus europaeus 37.73 3.00e-72 263.00
IUUC-Fca-035882 Felis catus 46.01 1.00e-94 338.00
IUUC-Fal-037068 Ficedula albicollis 45.68 3.00e-104 369.00
IUUC-Fox-037790 Fusarium oxysporum 65.70 4.00e-114 402.00
IUUC-Fso-038125 Fusarium solani 55.13 1.00e-158 550.00
IUUC-Gmo-038703 Gadus morhua 44.42 1.00e-110 391.00
IUUC-Ggr-039722 Gaeumannomyces graminis 53.96 1.00e-153 533.00
IUUC-Gga-040319 Gallus gallus 50.42 2.00e-93 333.00
IUUC-Gac-041708 Gasterosteus aculeatus 44.52 2.00e-110 390.00
IUUC-Gma-042954 Glycine max 31.12 2.00e-64 238.00
IUUC-Ggo-045178 Gorilla gorilla 44.73 5.00e-105 372.00
IUUC-Hsa-045718 Homo sapiens 44.73 5.00e-105 372.00
IUUC-Hvu-047322 Hordeum vulgare 32.26 2.00e-70 258.00
IUUC-Itr-048934 Ictidomys tridecemlineatus 53.48 5.00e-89 318.00
IUUC-Kpa-049350 Komagataella pastoris 35.06 1.00e-84 304.00
IUUC-Lch-049584 Latimeria chalumnae 33.89 1.00e-64 238.00
IUUC-Lpe-051080 Leersia perrieri 34.35 3.00e-71 260.00
IUUC-Loc-052442 Lepisosteus oculatus 42.71 5.00e-112 395.00
IUUC-Lma-053253 Leptosphaeria maculans 53.56 1.00e-151 527.00
IUUC-Laf-054351 Loxodonta africana 46.99 1.00e-103 367.00
IUUC-Mcc-054670 Macaca mulatta 43.01 3.00e-102 363.00
IUUC-Meu-056335 Macropus eugenii 49.65 2.00e-69 254.00
IUUC-Mor-057179 Magnaporthe oryzae 54.08 9.00e-155 538.00
IUUC-Mpo-057553 Magnaporthe poae 53.52 5.00e-155 538.00
IUUC-Mtr-058263 Medicago truncatula 32.34 1.00e-64 239.00
IUUC-Mla-058889 Melampsora laricipopulina 42.74 1.00e-113 401.00
IUUC-Mga-059385 Meleagris gallopavo 46.99 1.00e-103 367.00
IUUC-Mvi-060517 Microbotryum violaceum 52.97 1.00e-145 507.00
IUUC-Mmr-061439 Microcebus murinus 41.72 2.00e-91 327.00
IUUC-Mdo-062890 Monodelphis domestica 44.73 5.00e-105 372.00
IUUC-Mmu-063433 Mus musculus 44.73 5.00e-105 372.00
IUUC-Mac-065341 Musa acuminata 35.33 7.00e-76 276.00
IUUC-Mpu-066288 Mustela putorius furo 44.73 5.00e-105 372.00
IUUC-Mlu-067187 Myotis lucifugus 45.04 2.00e-105 374.00
IUUC-Nfi-068339 Neosartorya fischeri 54.55 1.00e-151 527.00
IUUC-Ncr-068947 Neurospora crassa 52.03 1.00e-141 494.00
IUUC-Nle-069263 Nomascus leucogenys 44.73 5.00e-105 372.00
IUUC-Opr-070518 Ochotona princeps 34.95 1.00e-67 248.00
IUUC-Ont-072309 Oreochromis niloticus 44.42 6.00e-111 392.00
IUUC-Oan-073731 Ornithorhynchus anatinus 47.17 2.00e-100 356.00
IUUC-Ocu-074000 Oryctolagus cuniculus 46.99 1.00e-103 367.00
IUUC-Oba-075918 Oryza barthii 33.57 1.00e-66 245.00
IUUC-Obr-076705 Oryza brachyantha 33.63 7.00e-71 259.00
IUUC-Ogl-077640 Oryza glaberrima 34.52 1.00e-72 265.00
IUUC-Ogu-079025 Oryza glumaepatula 33.93 4.00e-71 260.00
IUUC-Oin-079448 Oryza indica 34.67 1.00e-71 262.00
IUUC-Olo-080626 Oryza longistaminata 37.46 1.00e-59 222.00
IUUC-Ome-081470 Oryza meridionalis 34.67 2.00e-71 261.00
IUUC-Oni-082202 Oryza nivara 34.36 2.00e-68 251.00
IUUC-Opu-084059 Oryza punctata 33.63 4.00e-71 260.00
IUUC-Oru-084181 Oryza rufipogon 33.93 3.00e-71 260.00
IUUC-Osa-086069 Oryza sativa 33.93 2.00e-71 261.00
IUUC-Ola-086792 Oryzias latipes 44.42 8.00e-111 391.00
IUUC-Olu-087826 Ostreococcus lucimarinus 30.33 7.00e-51 192.00
IUUC-Oga-088706 Otolemur garnettii 44.73 5.00e-105 372.00
IUUC-Oar-089354 Ovis aries 44.73 7.00e-105 372.00
IUUC-Ptr-091287 Pan troglodytes 44.73 5.00e-105 372.00
IUUC-Pan-091701 Papio anubis 46.99 2.00e-103 367.00
IUUC-Psi-093814 Pelodiscus sinensis 46.99 1.00e-103 367.00
IUUC-Pma-094243 Petromyzon marinus 31.45 4.00e-59 221.00
IUUC-Pno-095124 Phaeosphaeria nodorum 44.72 4.00e-117 412.00
IUUC-Ppa-095554 Physcomitrella patens 34.50 1.00e-70 258.00
IUUC-Pfo-096449 Poecilia formosa 44.42 6.00e-111 392.00
IUUC-Pab-098132 Pongo abelii 44.73 5.00e-105 372.00
IUUC-Pop-099195 Populus trichocarpa 31.88 1.00e-63 235.00
IUUC-Pca-100303 Procavia capensis 51.34 1.00e-89 321.00
IUUC-Ppe-101468 Prunus persica 32.08 2.00e-67 248.00
IUUC-Pva-102457 Pteropus vampyrus 44.73 5.00e-105 372.00
IUUC-Pgr-103443 Puccinia graminis 49.59 5.00e-140 489.00
IUUC-Ptt-103795 Puccinia triticina 51.60 1.00e-126 444.00
IUUC-Pte-104022 Pyrenophora teres 51.47 3.00e-142 496.00
IUUC-Pyt-104643 Pyrenophora triticirepentis 51.97 2.00e-153 533.00
IUUC-Rno-106083 Rattus norvegicus 44.73 5.00e-105 372.00
IUUC-Sce-106154 Saccharomyces cerevisiae 34.06 2.00e-78 284.00
IUUC-Sha-106765 Sarcophilus harrisii 46.99 2.00e-103 367.00
IUUC-Sja-107977 Schizosaccharomyces japonicus 67.98 0.00e+00 668.00
IUUC-Ssl-108406 Sclerotinia sclerotiorum 25.79 8.00e-09 53.10
IUUC-Smo-109424 Selaginella moellendorffii 30.72 3.00e-71 260.00
IUUC-Sit-110645 Setaria italica 34.43 7.00e-72 263.00
IUUC-Sly-111226 Solanum lycopersicum 33.95 3.00e-69 254.00
IUUC-Stu-112533 Solanum tuberosum 31.43 8.00e-68 249.00
IUUC-Sar-113023 Sorex araneus 46.76 1.00e-101 361.00
IUUC-Sbi-114839 Sorghum bicolor 34.67 2.00e-71 261.00
IUUC-Sre-115120 Sporisorium reilianum 53.94 9.00e-157 544.00
IUUC-Ssc-115667 Sus scrofa 43.48 1.00e-75 274.00
IUUC-Tgu-117273 Taeniopygia guttata 46.99 8.00e-104 368.00
IUUC-Tru-118338 Takifugu rubripes 44.14 2.00e-109 387.00
IUUC-Tsy-119096 Tarsius syrichta 42.59 4.00e-87 313.00
IUUC-Tni-120238 Tetraodon nigroviridis 44.64 3.00e-111 393.00
IUUC-Tca-121539 Theobroma cacao 31.94 9.00e-66 242.00
IUUC-Tre-121902 Trichoderma reesei 54.88 2.00e-156 543.00
IUUC-Tvi-122474 Trichoderma virens 54.27 3.00e-158 549.00
IUUC-Tae-123155 Triticum aestivum 34.12 8.00e-69 252.00
IUUC-Tur-126546 Triticum urartu 27.16 1.00e-50 192.00
IUUC-Tme-127089 Tuber melanosporum 54.94 1.00e-151 527.00
IUUC-Tbe-127647 Tupaia belangeri 27.90 2.00e-44 172.00
IUUC-Ttr-128909 Tursiops truncatus 38.49 1.00e-77 281.00
IUUC-Uma-129487 Ustilago maydis 52.30 1.00e-158 551.00
IUUC-Vda-129939 Verticillium dahliae 53.94 2.00e-156 543.00
IUUC-Vpa-130259 Vicugna pacos 43.44 2.00e-97 347.00
IUUC-Vvi-131543 Vitis vinifera 33.10 2.00e-65 241.00
IUUC-Xtr-132219 Xenopus tropicalis 44.73 1.00e-104 371.00
IUUC-Xma-133423 Xiphophorus maculatus 44.42 6.00e-111 392.00
IUUC-Yli-134622 Yarrowia lipolytica 35.56 2.00e-87 314.00
IUUC-Zma-134901 Zea mays 34.43 8.00e-71 259.00
Created Date 25-Jun-2017

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