iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001816

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01138589

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000012193.1	ENSAMET00000013469.1	ENSAMEP00000012926.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.70e-199	662.2	457	931

Active Site

Position(s)	Description	Evidence
641	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  q+kl+++++llvGag++GcEllK ++l+G+     g +tv Dmd++e snl+rqFLfr +d+g++KAevaaea ++l
   Q: 457  YDGQIAVFGIGFQRKLSQQHYLLVGAGAIGCELLKGFALVGLgaaasGGVTVADMDHIERSNLSRQFLFRTQDIGRPKAEVAAEATHRL 545
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           n+d +v++ ++++++++e+i+   Ff+ +d+V++ald+++ar +v+ +c+++ +pl+e+gt G+ G+++v+++++te+y+++     p+
   Q: 546  NSDLKVTPFTYPLDPTTEHIYdddFFSHVDGVAAALDSFQARHYVAARCTHYLKPLLEAGTQGTSGHASVFVPHVTEAYRAPAsglAPE 634
           ***************************************************************************************** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           +  +P+ctl+++p+++eht++wa        +l +++++ +++  + l++ d  + ++ +++v   l++ +++++++++++a+ +++++
   Q: 635  DAAYPVCTLRHFPSTVEHTLQWArdefdglfRLSAETINRHQEVLTSLAEADGPQVLTLLQEVLGVLRE-RPRTWQDCVAWALGHWQRR 722
           ***************************************************************766555.7****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv..................................................sfcsnaealqvpe 287
           ++++i+qll+ f++d+v ++++ fw+                                                      + + +   +
   Q: 723  FHYDITQLLSRFPPDKVLEDGTLFWSgpkqcpqplefdasqdvhllyvltaanlyaqmhglpgsrdqtalrellklL--LLPRPQPLAP 809
           ****************************9999999999999999988888888888888877777666666655332..2222222334 PP
   S: 288  kvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipai 369
               d e   asa+     l+ l ++le ++  + ++p  l+fekd ds  +vd+v+aaa+lra+++gi+p +++++ k+i+g+iipai
   Q: 810  VFPNDLELAGASAEfgpeqLKKLHQVLEVWSGSPPLEP--LKFEKDNDSnfHVDFVAAAASLRAQNYGIPP-ANRNQSKRIVGQIIPAI 895
           55555555555555566669999999**********99..9*******99*********************.***************** PP
   S: 370  attnavvgGlaaqEviKvvsg..kfeplknfflfda 403
           att+a+v+Gl+ +E++Kvv g  +  ++++ +l++a
   Q: 896  ATTTAAVAGLVGLELYKVVGGprPLGAFRHSYLHLA 931
           *******************99555556777666655 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

TPGNPVPLRA SCSGALASAG LARPAATLSV SAAACHPAAG LKMDVLETTK WLDEELYSRQ 60
LYVLDLPAMQ RIQGAKVLLS GLQGLGAEVA KNLVLMGVGS LTLHDPQPAC WSDLAAQFFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTCCCGGAA ACCCGGTGCC TCTTCGAGCT AGCTGCAGTG GGGCACTGGC CTCTGCTGGC 60
CTAGCCCGCC CCGCAGCAAC CCTGTCTGTA AGCGCTGCAG CCTGCCATCC CGCCGCCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-012665	Bos taurus	75.52	0.00e+00	1346.00
IUUC-Cja-019047	Callithrix jacchus	77.39	0.00e+00	1459.00
IUUC-Cfa-021225	Canis familiaris	84.44	0.00e+00	1617.00
IUUC-Cpo-022336	Cavia porcellus	69.84	0.00e+00	1278.00
IUUC-Csa-023462	Chlorocebus sabaeus	80.87	0.00e+00	1460.00
IUUC-Cho-024436	Choloepus hoffmanni	77.97	6.00e-99	355.00
IUUC-Dno-029347	Dasypus novemcinctus	78.79	0.00e+00	1439.00
IUUC-Dor-030997	Dipodomys ordii	72.64	0.00e+00	1324.00
IUUC-Ete-033124	Echinops telfairi	72.35	0.00e+00	931.00
IUUC-Eca-033929	Equus caballus	81.67	0.00e+00	1596.00
IUUC-Eeu-034717	Erinaceus europaeus	69.38	0.00e+00	963.00
IUUC-Fca-036564	Felis catus	85.13	0.00e+00	1587.00
IUUC-Ggo-044480	Gorilla gorilla	79.98	0.00e+00	1457.00
IUUC-Hsa-046498	Homo sapiens	79.58	0.00e+00	1422.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	73.54	0.00e+00	1354.00
IUUC-Laf-054119	Loxodonta africana	76.71	0.00e+00	1461.00
IUUC-Mcc-055597	Macaca mulatta	78.09	0.00e+00	1382.00
IUUC-Mdo-063058	Monodelphis domestica	55.77	0.00e+00	1003.00
IUUC-Mmu-063578	Mus musculus	70.10	0.00e+00	1340.00
IUUC-Mpu-066255	Mustela putorius furo	85.93	0.00e+00	1633.00
IUUC-Mlu-067814	Myotis lucifugus	75.74	0.00e+00	1321.00
IUUC-Nle-069193	Nomascus leucogenys	79.19	0.00e+00	1433.00
IUUC-Opr-070715	Ochotona princeps	70.56	0.00e+00	1298.00
IUUC-Ocu-074162	Oryctolagus cuniculus	75.99	0.00e+00	1395.00
IUUC-Oga-088895	Otolemur garnettii	75.60	0.00e+00	1362.00
IUUC-Oar-089579	Ovis aries	75.15	0.00e+00	1340.00
IUUC-Ptr-090581	Pan troglodytes	79.80	0.00e+00	1396.00
IUUC-Pan-092458	Papio anubis	80.67	0.00e+00	1449.00
IUUC-Pab-098653	Pongo abelii	74.13	0.00e+00	1358.00
IUUC-Pca-100578	Procavia capensis	72.60	0.00e+00	840.00
IUUC-Pva-102914	Pteropus vampyrus	78.64	0.00e+00	1189.00
IUUC-Rno-106066	Rattus norvegicus	71.63	0.00e+00	1384.00
IUUC-Sha-107368	Sarcophilus harrisii	59.55	0.00e+00	1102.00
IUUC-Ssc-115743	Sus scrofa	80.68	0.00e+00	1520.00
IUUC-Tbe-127587	Tupaia belangeri	73.58	0.00e+00	1219.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence