iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000000634.5	ENSPTRT00000001202.5	ENSPTRP00000001089.5
ENSPTRG00000000634.5	ENSPTRT00000076084.1	ENSPTRP00000060653.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-28	97.9	293	322
E3 adaptor/Cullin RING/APC_C/CDC20	5.90e-148	492.1	158	465

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvW 28
           gH+ +v++l++ +d ++l+sG++D+ + vW
   Q: 293  GHSQEVCGLRWaPDgRHLASGGNDNLVNVW 322
           8***********999*************** PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkk 88
           p+++ldape+r+d+ylnL+dWss nvlavaL++svylwsa++gd+ +l ++ +++++++sv+wi+eg++lavGt+++ev+++Dv+++k+
   Q: 158  PDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMeQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKR 246
           689************************************************899*********************************** PP
   S: 89   vrtltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse....Plk 173
           +r++t+hsarvg+LsWn+++lssGsr+g+i+h+dvrv+e++++tl++h+qevCGl+w+ d+++LasGGnDn v+vw ++  e    Pl+
   Q: 247  LRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggwvPLQ 335
           ********************************************************************************9999***** PP
   S: 174  kfkehkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvae 262
           +f++h++avka+aw+Pwq+++La+GGGt+Dr+i++wn+++ga+l+++d++sqvcs+lws+++kel+s+hGfa+n++++wkyp+++kvae
   Q: 336  TFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 424
           ***************************************************************************************** PP
   S: 263  lkgheaRvlslalspdgeaivtaagDetlrfwklfdkkkak 303
           lkgh++Rvlsl++spdg+++++aa+Detlr+w++f+ ++a+
   Q: 425  LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPAR 465
           ***********************************998765 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

SLLLDAPIPA PPARWQRKVE AAGPAPSPMR AANRSHSAGR TPGRTPGKSS SKVQTTPSNP 60
GGDRYIPHRS AAQMRVASFL XSKENQPENS QTPTKKEHQK AWALNLNGFD VEEAKILRLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCCTCACTG CTTTAGCTGG ATGCACCCAT CCCCATGCAC CCCCTGCGCG CTGGCAGCGC 60
AAAGTTTAGG AAGCCGCAGG CCCGGCCCCC TCACCCATGC GGGCCGCCAA CCGATCCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033187--CDC20
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0007064--P:mitotic sister chromatid cohesion
GO:0090307--P:mitotic spindle assembly
GO:0090129--P:positive regulation of synapse maturation
GO:0031915--P:positive regulation of synaptic plasticity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0040020--P:regulation of meiotic nuclear division

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000974	Aegilops tauschii	48.00	3.00e-110	392.00
IUUC-Aml-001545	Ailuropoda melanoleuca	96.09	0.00e+00	897.00
IUUC-Atr-003103	Amborella trichopoda	47.91	4.00e-108	384.00
IUUC-Apl-003255	Anas platyrhynchos	79.77	0.00e+00	748.00
IUUC-Aca-004920	Anolis carolinensis	74.60	0.00e+00	732.00
IUUC-Aly-006012	Arabidopsis lyrata	48.54	1.00e-108	386.00
IUUC-Ath-006795	Arabidopsis thaliana	46.24	3.00e-106	378.00
IUUC-Ago-007784	Ashbya gossypii	48.23	1.00e-84	306.00
IUUC-Acl-008269	Aspergillus clavatus	48.18	2.00e-96	346.00
IUUC-Afl-008432	Aspergillus flavus	47.51	6.00e-97	348.00
IUUC-Afu-008829	Aspergillus fumigatus	47.21	5.00e-97	348.00
IUUC-Ani-009471	Aspergillus nidulans	47.51	1.00e-98	353.00
IUUC-Ang-009711	Aspergillus niger	48.63	4.00e-97	348.00
IUUC-Aor-010118	Aspergillus oryzae	47.51	6.00e-97	348.00
IUUC-Ate-010479	Aspergillus terreus	50.78	4.00e-92	332.00
IUUC-Bgr-012059	Blumeria graminis	49.84	2.00e-95	343.00
IUUC-Bta-012625	Bos taurus	96.30	0.00e+00	901.00
IUUC-Bci-013607	Botrytis cinerea	47.95	8.00e-99	354.00
IUUC-Bdi-014344	Brachypodium distachyon	48.66	5.00e-109	387.00
IUUC-Bol-015368	Brassica oleracea	45.71	6.00e-105	375.00
IUUC-Bra-016738	Brassica rapa	46.44	2.00e-104	373.00
IUUC-Cel-018472	Caenorhabditis elegans	48.57	3.00e-89	322.00
IUUC-Cja-019132	Callithrix jacchus	97.33	0.00e+00	911.00
IUUC-Cfa-020780	Canis familiaris	96.50	0.00e+00	897.00
IUUC-Cpo-022223	Cavia porcellus	95.88	0.00e+00	850.00
IUUC-Cre-022701	Chlamydomonas reinhardtii	49.77	1.00e-115	409.00
IUUC-Csa-023666	Chlorocebus sabaeus	98.15	0.00e+00	915.00
IUUC-Cho-024920	Choloepus hoffmanni	94.42	4.00e-146	511.00
IUUC-Cin-025675	Ciona intestinalis	51.43	1.00e-127	450.00
IUUC-Csv-026019	Ciona savignyi	50.97	4.00e-123	434.00
IUUC-Cgl-026465	Colletotrichum gloeosporioides	41.00	8.00e-98	351.00
IUUC-Cne-026933	Cryptococcus neoformans	40.35	4.00e-89	322.00
IUUC-Cme-027234	Cyanidioschyzon merolae	51.91	1.00e-105	376.00
IUUC-Dre-028026	Danio rerio	59.51	8.00e-172	596.00
IUUC-Dno-028865	Dasypus novemcinctus	95.28	0.00e+00	884.00
IUUC-Dor-030958	Dipodomys ordii	94.86	0.00e+00	893.00
IUUC-Dse-031391	Dothistroma septosporum	50.15	5.00e-97	348.00
IUUC-Dme-031905	Drosophila melanogaster	49.33	1.00e-140	493.00
IUUC-Ete-032387	Echinops telfairi	90.74	0.00e+00	855.00
IUUC-Eca-033522	Equus caballus	86.01	0.00e+00	802.00
IUUC-Eeu-035059	Erinaceus europaeus	83.57	0.00e+00	751.00
IUUC-Fca-036346	Felis catus	96.73	0.00e+00	818.00
IUUC-Fal-037558	Ficedula albicollis	79.43	0.00e+00	758.00
IUUC-Fox-037850	Fusarium oxysporum	45.43	3.00e-98	352.00
IUUC-Fso-038375	Fusarium solani	45.69	1.00e-98	353.00
IUUC-Gmo-039284	Gadus morhua	61.71	1.00e-172	599.00
IUUC-Ggr-039864	Gaeumannomyces graminis	48.55	6.00e-99	354.00
IUUC-Gga-040790	Gallus gallus	78.43	0.00e+00	774.00
IUUC-Gac-041431	Gasterosteus aculeatus	60.20	1.00e-168	585.00
IUUC-Gma-043489	Glycine max	46.49	2.00e-105	375.00
IUUC-Ggo-045052	Gorilla gorilla	98.56	0.00e+00	916.00
IUUC-Hsa-046305	Homo sapiens	98.56	0.00e+00	916.00
IUUC-Hvu-047476	Hordeum vulgare	45.58	1.00e-109	389.00
IUUC-Itr-048461	Ictidomys tridecemlineatus	96.30	0.00e+00	854.00
IUUC-Kpa-049239	Komagataella pastoris	52.70	1.00e-95	343.00
IUUC-Lch-050174	Latimeria chalumnae	60.79	1.00e-163	569.00
IUUC-Lpe-050954	Leersia perrieri	48.28	1.00e-100	359.00
IUUC-Loc-052638	Lepisosteus oculatus	62.75	9.00e-173	599.00
IUUC-Lma-052998	Leptosphaeria maculans	43.50	4.00e-100	358.00
IUUC-Laf-053742	Loxodonta africana	96.71	0.00e+00	901.00
IUUC-Mcc-054948	Macaca mulatta	98.15	0.00e+00	915.00
IUUC-Meu-056013	Macropus eugenii	83.70	7.00e-128	450.00
IUUC-Mor-057277	Magnaporthe oryzae	45.93	2.00e-96	346.00
IUUC-Mpo-057624	Magnaporthe poae	51.47	5.00e-97	348.00
IUUC-Mtr-057725	Medicago truncatula	46.05	4.00e-99	354.00
IUUC-Mla-059048	Melampsora laricipopulina	49.07	2.00e-83	303.00
IUUC-Mga-060102	Meleagris gallopavo	79.07	0.00e+00	776.00
IUUC-Mvi-060465	Microbotryum violaceum	47.63	1.00e-92	333.00
IUUC-Mmr-061615	Microcebus murinus	97.43	0.00e+00	905.00
IUUC-Mdo-061982	Monodelphis domestica	87.62	0.00e+00	729.00
IUUC-Mmu-063864	Mus musculus	93.42	0.00e+00	883.00
IUUC-Mac-064861	Musa acuminata	46.92	9.00e-110	390.00
IUUC-Mpu-066502	Mustela putorius furo	96.30	0.00e+00	890.00
IUUC-Mlu-067277	Myotis lucifugus	88.32	0.00e+00	834.00
IUUC-Nfi-068536	Neosartorya fischeri	47.21	5.00e-97	348.00
IUUC-Ncr-068951	Neurospora crassa	45.87	1.00e-95	343.00
IUUC-Nle-070149	Nomascus leucogenys	98.15	0.00e+00	909.00
IUUC-Opr-070778	Ochotona princeps	93.93	0.00e+00	639.00
IUUC-Ont-071660	Oreochromis niloticus	61.59	5.00e-167	580.00
IUUC-Oan-073677	Ornithorhynchus anatinus	76.64	0.00e+00	671.00
IUUC-Ocu-073797	Oryctolagus cuniculus	96.09	0.00e+00	899.00
IUUC-Oba-075514	Oryza barthii	48.28	3.00e-100	358.00
IUUC-Obr-076018	Oryza brachyantha	48.16	7.00e-108	384.00
IUUC-Ogl-077254	Oryza glaberrima	48.28	9.00e-101	360.00
IUUC-Ogu-078521	Oryza glumaepatula	48.16	1.00e-107	384.00
IUUC-Oin-080094	Oryza indica	48.28	9.00e-101	360.00
IUUC-Olo-080449	Oryza longistaminata	48.28	8.00e-101	360.00
IUUC-Ome-081186	Oryza meridionalis	47.91	1.00e-107	384.00
IUUC-Oni-082243	Oryza nivara	48.28	9.00e-101	360.00
IUUC-Opu-084007	Oryza punctata	48.28	2.00e-100	358.00
IUUC-Oru-084357	Oryza rufipogon	48.28	2.00e-100	359.00
IUUC-Osa-086094	Oryza sativa	48.28	2.00e-100	359.00
IUUC-Ola-086907	Oryzias latipes	60.29	1.00e-157	549.00
IUUC-Olu-087647	Ostreococcus lucimarinus	49.07	2.00e-118	419.00
IUUC-Oga-088184	Otolemur garnettii	96.10	0.00e+00	894.00
IUUC-Oar-090023	Ovis aries	90.85	0.00e+00	799.00
IUUC-Pan-091845	Papio anubis	98.15	0.00e+00	915.00
IUUC-Psi-093188	Pelodiscus sinensis	79.24	0.00e+00	798.00
IUUC-Pma-094187	Petromyzon marinus	53.75	1.00e-139	489.00
IUUC-Pno-094809	Phaeosphaeria nodorum	42.04	2.00e-101	362.00
IUUC-Ppa-095457	Physcomitrella patens	46.99	4.00e-110	391.00
IUUC-Pfo-097429	Poecilia formosa	57.73	6.00e-151	526.00
IUUC-Pab-098603	Pongo abelii	98.35	0.00e+00	915.00
IUUC-Pop-099654	Populus trichocarpa	46.23	1.00e-101	363.00
IUUC-Pca-101062	Procavia capensis	95.68	0.00e+00	878.00
IUUC-Ppe-101865	Prunus persica	46.53	1.00e-95	343.00
IUUC-Pva-102925	Pteropus vampyrus	94.65	0.00e+00	919.00
IUUC-Pgr-103466	Puccinia graminis	49.38	2.00e-85	309.00
IUUC-Ptt-103888	Puccinia triticina	46.53	6.00e-78	285.00
IUUC-Pte-104142	Pyrenophora teres	42.38	6.00e-99	354.00
IUUC-Pyt-104693	Pyrenophora triticirepentis	42.38	8.00e-99	354.00
IUUC-Rno-106005	Rattus norvegicus	93.62	0.00e+00	882.00
IUUC-Sce-106240	Saccharomyces cerevisiae	43.75	1.00e-82	300.00
IUUC-Sha-107472	Sarcophilus harrisii	88.50	0.00e+00	845.00
IUUC-Sja-107919	Schizosaccharomyces japonicus	42.82	2.00e-94	339.00
IUUC-Spo-108075	Schizosaccharomyces pombe	45.34	4.00e-97	348.00
IUUC-Ssl-108507	Sclerotinia sclerotiorum	49.27	5.00e-98	351.00
IUUC-Smo-108922	Selaginella moellendorffii	49.03	2.00e-122	432.00
IUUC-Sit-110032	Setaria italica	46.70	1.00e-108	386.00
IUUC-Sly-111202	Solanum lycopersicum	44.42	1.00e-104	373.00
IUUC-Stu-112024	Solanum tuberosum	43.01	5.00e-105	374.00
IUUC-Sar-113092	Sorex araneus	89.92	0.00e+00	832.00
IUUC-Sbi-114558	Sorghum bicolor	48.52	2.00e-108	385.00
IUUC-Sre-115222	Sporisorium reilianum	49.10	3.00e-92	332.00
IUUC-Ssc-115710	Sus scrofa	96.91	0.00e+00	905.00
IUUC-Tgu-117100	Taeniopygia guttata	78.62	0.00e+00	757.00
IUUC-Tru-118184	Takifugu rubripes	57.11	1.00e-138	485.00
IUUC-Tsy-118892	Tarsius syrichta	95.54	5.00e-149	519.00
IUUC-Tni-120474	Tetraodon nigroviridis	59.80	4.00e-157	547.00
IUUC-Tca-120949	Theobroma cacao	46.02	3.00e-105	375.00
IUUC-Tre-122211	Trichoderma reesei	41.16	2.00e-98	352.00
IUUC-Tvi-122531	Trichoderma virens	41.24	5.00e-98	351.00
IUUC-Tae-123765	Triticum aestivum	48.00	2.00e-110	392.00
IUUC-Tur-126018	Triticum urartu	46.10	7.00e-103	367.00
IUUC-Tme-127151	Tuber melanosporum	38.99	1.00e-94	340.00
IUUC-Tbe-127384	Tupaia belangeri	98.99	2.00e-177	614.00
IUUC-Ttr-128511	Tursiops truncatus	96.30	0.00e+00	895.00
IUUC-Uma-129555	Ustilago maydis	48.80	3.00e-92	332.00
IUUC-Vda-129993	Verticillium dahliae	41.25	3.00e-99	355.00
IUUC-Vvi-131245	Vitis vinifera	46.93	1.00e-93	336.00
IUUC-Xtr-131993	Xenopus tropicalis	72.80	0.00e+00	719.00
IUUC-Xma-133332	Xiphophorus maculatus	61.02	2.00e-167	582.00
IUUC-Yli-134584	Yarrowia lipolytica	50.16	5.00e-100	358.00
IUUC-Zma-135135	Zea mays	47.16	2.00e-107	382.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence