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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045677
UUCD1 version UUC-HoS-00134
Ensembl Protein ID ENSP00000369427.2
UniProt Accession Q16576; Q5JP00; RBBP7_HUMAN
Genbank Protein ID AAC50231.1; CAA51360.1; BAG52439.1; ENSP00000369424
Protein Name Histone-binding protein RBBP7; Histone acetyltransferase type B subunit 2; Nucleosome-remodeling factor subunit RBAP46; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46
Genbank Nucleotide ID U35143; X72841; AK091911; AL929302
Gene Name RBBP7; RBAP46
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000102054.17 ENST00000380087.6 ENSP00000369427.2
ENSG00000102054.17 ENST00000380084.8 ENSP00000369424.4
ENSG00000102054.17 ENST00000404022.5 ENSP00000386068.1
ENSG00000102054.17 ENST00000444437.5 ENSP00000402796.1
ENSG00000102054.17 ENST00000416035.1 ENSP00000392714.1
ENSG00000102054.17 ENST00000493145.1 ENSP00000417507.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.80e-37 126.7 271 305
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtg 33
           Ht++v+cl+f   s+ +l++Gs D+t+ +WDlr  
   Q: 271  HTAEVNCLSFnpySEFILATGSADKTVALWDLRNL 305
           **********96554568*************9875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
 Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Protein Sequence
(Fasta)
MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP EVTKPEGKDY 60
ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSD KGEFGGFGSV TGKIECEIKI 120
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Protein Fasta Sequence


>IUUC-Hsa-045677|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGTCTCGGCG CCGGAGCCGT TGGCTCCCAG ACCCGCCTCT CCGCCTCCTC TCACTTTTCC 60
CAGGGCGGAT GCGCCTGCGC TCAGCTGCCT GGGCGGGCTG GGAGGCGCGG GTTGAAAAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045677|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0235--DNA replication
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0035098--C:ESC/E(Z) complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0004407--F:histone deacetylase activity
GO:0003723--F:RNA binding
GO:0008283--P:cell proliferation
GO:0070370--P:cellular heat acclimation
GO:0034080--P:CENP-A containing nucleosome assembly
GO:0006260--P:DNA replication
GO:0007275--P:multicellular organism development
GO:0030308--P:negative regulation of cell growth
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0048545--P:response to steroid hormone
GO:0006351--P:transcription, DNA-templated
KEGG hsa:5931
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001256 Ailuropoda melanoleuca 99.05 0.00e+00 867.00
IUUC-Apl-003357 Anas platyrhynchos 92.07 0.00e+00 809.00
IUUC-Bta-013455 Bos taurus 99.53 0.00e+00 877.00
IUUC-Cja-019957 Callithrix jacchus 99.29 0.00e+00 868.00
IUUC-Cfa-020917 Canis familiaris 99.05 0.00e+00 869.00
IUUC-Cpo-022173 Cavia porcellus 100.00 0.00e+00 881.00
IUUC-Csa-023738 Chlorocebus sabaeus 100.00 0.00e+00 881.00
IUUC-Dno-029206 Dasypus novemcinctus 99.76 0.00e+00 879.00
IUUC-Dor-030733 Dipodomys ordii 86.02 0.00e+00 737.00
IUUC-Eca-034138 Equus caballus 99.05 0.00e+00 868.00
IUUC-Fca-035977 Felis catus 99.05 0.00e+00 868.00
IUUC-Fal-037538 Ficedula albicollis 90.05 0.00e+00 797.00
IUUC-Gga-040764 Gallus gallus 93.65 0.00e+00 828.00
IUUC-Itr-048060 Ictidomys tridecemlineatus 100.00 0.00e+00 868.00
IUUC-Kpa-049258 Komagataella pastoris 36.65 9.00e-71 260.00
IUUC-Laf-053973 Loxodonta africana 98.83 0.00e+00 869.00
IUUC-Mcc-055687 Macaca mulatta 100.00 0.00e+00 881.00
IUUC-Mga-059209 Meleagris gallopavo 90.82 0.00e+00 795.00
IUUC-Mmr-061008 Microcebus murinus 99.29 0.00e+00 870.00
IUUC-Mdo-062817 Monodelphis domestica 96.24 0.00e+00 850.00
IUUC-Mmu-063773 Mus musculus 99.76 0.00e+00 879.00
IUUC-Mpu-066722 Mustela putorius furo 99.05 0.00e+00 867.00
IUUC-Mlu-067813 Myotis lucifugus 99.05 0.00e+00 868.00
IUUC-Nle-070023 Nomascus leucogenys 99.29 0.00e+00 869.00
IUUC-Oan-073579 Ornithorhynchus anatinus 95.29 0.00e+00 842.00
IUUC-Ocu-074778 Oryctolagus cuniculus 99.76 0.00e+00 879.00
IUUC-Oga-088987 Otolemur garnettii 92.20 0.00e+00 785.00
IUUC-Oar-090250 Ovis aries 98.82 0.00e+00 862.00
IUUC-Ptr-091598 Pan troglodytes 99.76 0.00e+00 869.00
IUUC-Pan-092412 Papio anubis 100.00 0.00e+00 881.00
IUUC-Psi-093162 Pelodiscus sinensis 95.13 0.00e+00 773.00
IUUC-Pab-097865 Pongo abelii 100.00 0.00e+00 881.00
IUUC-Pva-102369 Pteropus vampyrus 99.05 0.00e+00 869.00
IUUC-Rno-105892 Rattus norvegicus 100.00 0.00e+00 881.00
IUUC-Sha-107575 Sarcophilus harrisii 95.29 0.00e+00 840.00
IUUC-Sar-113236 Sorex araneus 90.84 0.00e+00 768.00
IUUC-Ssc-116352 Sus scrofa 99.05 0.00e+00 870.00
IUUC-Tsy-118854 Tarsius syrichta 99.29 0.00e+00 869.00
IUUC-Tbe-128010 Tupaia belangeri 88.15 0.00e+00 762.00
IUUC-Ttr-128558 Tursiops truncatus 87.38 0.00e+00 743.00
IUUC-Vpa-130664 Vicugna pacos 99.29 0.00e+00 865.00
Created Date 25-Jun-2017

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