iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-60	201.2	1150	1202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +v+++ydy a+n+deL++ kG  + v+  ++ d +W++g  e +g  GlfP+n+v+ 
   Q: 1150 QVIAMYDYIANNEDELNFSKGQLINVM--NKDDPDWWQG--EINGVTGLFPSNYVKM 1202
           6899**********************9..8899******..9*************85 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MMAQFPTAMN GGPNMWAITS EERTKHDKQF DNLKPSGGYI TGDQARTFFL QSGLPAPVLA 60
EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP PIMKQPPMFS PLISARFGMG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTGAGAGC TGCAAGAAGT CAGGACCATG ATGGCTCAGT TTCCCACAGC TATGAATGGT 60
GAGTAACTTT GTGCATGGTA GGGTGGGCTT TTGTTGTGGT GGTAAGCCTA TCGTTGTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR000008--C2_dom
IPR000219--DH-domain
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000261--EH_dom
IPR027029--Intersectin-2
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS50010--DH_2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50031--EH
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00168--C2
PF12763--EF-hand_4
PF16652--PH_13
PF00621--RhoGEF
PF00018--SH3_1
PF07653--SH3_2
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00054--EFh
SM00027--EH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005813--C:centrosome
GO:0070062--C:extracellular exosome
GO:0005509--F:calcium ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0006897--P:endocytosis
GO:1903861--P:positive regulation of dendrite extension
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001455	Ailuropoda melanoleuca	90.77	0.00e+00	2128.00
IUUC-Apl-004205	Anas platyrhynchos	81.35	0.00e+00	1982.00
IUUC-Aca-004287	Anolis carolinensis	83.28	0.00e+00	1658.00
IUUC-Ame-011759	Astyanax mexicanus	64.78	0.00e+00	1248.00
IUUC-Bta-013248	Bos taurus	91.16	0.00e+00	2070.00
IUUC-Cel-018490	Caenorhabditis elegans	32.74	2.00e-53	204.00
IUUC-Cfa-020628	Canis familiaris	91.13	0.00e+00	2151.00
IUUC-Cpo-022427	Cavia porcellus	82.45	0.00e+00	2024.00
IUUC-Csa-023122	Chlorocebus sabaeus	92.83	0.00e+00	2134.00
IUUC-Cne-026918	Cryptococcus neoformans	34.98	3.00e-38	155.00
IUUC-Dno-029419	Dasypus novemcinctus	92.98	0.00e+00	2157.00
IUUC-Dor-030504	Dipodomys ordii	77.96	0.00e+00	1741.00
IUUC-Dme-032099	Drosophila melanogaster	32.83	1.00e-56	215.00
IUUC-Eca-034196	Equus caballus	88.56	0.00e+00	2025.00
IUUC-Eeu-034972	Erinaceus europaeus	66.10	2.00e-177	617.00
IUUC-Fca-035757	Felis catus	91.09	0.00e+00	2137.00
IUUC-Fal-037531	Ficedula albicollis	87.00	0.00e+00	1745.00
IUUC-Gga-041012	Gallus gallus	79.08	0.00e+00	1909.00
IUUC-Ggo-045405	Gorilla gorilla	88.37	0.00e+00	2092.00
IUUC-Hsa-046833	Homo sapiens	92.01	0.00e+00	2110.00
IUUC-Kpa-049215	Komagataella pastoris	34.75	6.00e-15	75.90
IUUC-Lch-050094	Latimeria chalumnae	72.14	0.00e+00	1675.00
IUUC-Loc-052646	Lepisosteus oculatus	72.28	0.00e+00	1438.00
IUUC-Mcc-054709	Macaca mulatta	91.76	0.00e+00	2135.00
IUUC-Meu-056396	Macropus eugenii	80.66	0.00e+00	1539.00
IUUC-Mga-059997	Meleagris gallopavo	82.98	0.00e+00	2037.00
IUUC-Mvi-060268	Microbotryum violaceum	30.85	4.00e-47	184.00
IUUC-Mmr-060891	Microcebus murinus	93.39	0.00e+00	2183.00
IUUC-Mmu-064226	Mus musculus	92.12	0.00e+00	2220.00
IUUC-Mpu-066431	Mustela putorius furo	92.07	0.00e+00	2131.00
IUUC-Mlu-068190	Myotis lucifugus	90.77	0.00e+00	2129.00
IUUC-Nle-070116	Nomascus leucogenys	88.81	0.00e+00	1676.00
IUUC-Opr-070815	Ochotona princeps	78.21	0.00e+00	1756.00
IUUC-Ont-072464	Oreochromis niloticus	64.04	0.00e+00	1231.00
IUUC-Ola-086482	Oryzias latipes	60.34	0.00e+00	1225.00
IUUC-Oga-088449	Otolemur garnettii	90.02	0.00e+00	2078.00
IUUC-Oar-090275	Ovis aries	91.74	0.00e+00	2108.00
IUUC-Ptr-091667	Pan troglodytes	91.76	0.00e+00	2097.00
IUUC-Pan-091723	Papio anubis	89.50	0.00e+00	1811.00
IUUC-Psi-093136	Pelodiscus sinensis	81.14	0.00e+00	1942.00
IUUC-Pab-098755	Pongo abelii	89.64	0.00e+00	2034.00
IUUC-Pca-101134	Procavia capensis	84.35	0.00e+00	1479.00
IUUC-Pva-102433	Pteropus vampyrus	83.06	0.00e+00	1867.00
IUUC-Pgr-103473	Puccinia graminis	29.38	1.00e-36	149.00
IUUC-Sar-112978	Sorex araneus	87.51	0.00e+00	1392.00
IUUC-Ssc-115562	Sus scrofa	83.25	0.00e+00	1904.00
IUUC-Tgu-116758	Taeniopygia guttata	82.72	0.00e+00	2011.00
IUUC-Tni-119958	Tetraodon nigroviridis	57.61	0.00e+00	1358.00
IUUC-Tbe-127477	Tupaia belangeri	89.00	0.00e+00	742.00
IUUC-Ttr-129196	Tursiops truncatus	88.74	0.00e+00	2026.00
IUUC-Vpa-130035	Vicugna pacos	79.37	2.00e-180	627.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence