iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-044812

Ensembl Protein ID

ENSGGOP00000027941.1

UniProt Accession

G3SIK1; G3SIK1_GORGO

Protein Name

Histone-lysine N-methyltransferase

Gene Name

KMT2C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000025173.1	ENSGGOT00000028111.1	ENSGGOP00000027941.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	8.20e-23	80.8	840	890

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedek.slveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C vCg+ g++ +  l+ C++C +++Hp C++++  + l+ s+ w C +C+
   Q: 840  DMCVVCGSFGQGAEgRLLACSQCGQCYHPYCVSIK-VNILKLSKGWRCLECT 890
           79*********9999********************.556666666******6 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

EIKEQSAEED AEAEVDNSKQ LIPTLQRSVS EESANSLVSV GVEAKISEQL CAFCYCGEKS 60
SLGQGDLKQF RITPGFILPW RNQPSNKKDI DDNSNGTYEK MQNSAPRKQR GQRKERSPQQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAATCAAAG AACAATCTGC AGAAGAGGAT GCTGAAGCAG AAGTGGATAA CAGCAAACAG 60
CTAATTCCAA CTCTTCAGCG ATCTGTGTCT GAGGAATCGG CAAACTCCCT GGTCTCTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002314	Ailuropoda melanoleuca	85.68	0.00e+00	7126.00
IUUC-Apl-003311	Anas platyrhynchos	71.84	0.00e+00	5642.00
IUUC-Aca-004705	Anolis carolinensis	65.09	0.00e+00	5126.00
IUUC-Bta-012322	Bos taurus	81.38	0.00e+00	6610.00
IUUC-Cel-018354	Caenorhabditis elegans	35.38	1.00e-64	243.00
IUUC-Cja-019983	Callithrix jacchus	92.92	0.00e+00	7885.00
IUUC-Cfa-020903	Canis familiaris	84.99	0.00e+00	7178.00
IUUC-Cpo-021732	Cavia porcellus	82.82	0.00e+00	6865.00
IUUC-Csa-023083	Chlorocebus sabaeus	93.37	0.00e+00	6068.00
IUUC-Cho-024469	Choloepus hoffmanni	83.01	0.00e+00	2307.00
IUUC-Dre-028110	Danio rerio	64.04	0.00e+00	1245.00
IUUC-Dor-030569	Dipodomys ordii	80.53	0.00e+00	4589.00
IUUC-Dme-031590	Drosophila melanogaster	32.16	1.00e-58	222.00
IUUC-Eca-033945	Equus caballus	84.55	0.00e+00	5002.00
IUUC-Fca-035922	Felis catus	83.36	0.00e+00	6834.00
IUUC-Gac-041896	Gasterosteus aculeatus	43.19	0.00e+00	1739.00
IUUC-Hsa-046595	Homo sapiens	96.17	0.00e+00	8183.00
IUUC-Itr-048303	Ictidomys tridecemlineatus	84.94	0.00e+00	6943.00
IUUC-Lch-050086	Latimeria chalumnae	55.80	0.00e+00	2571.00
IUUC-Loc-052891	Lepisosteus oculatus	49.95	0.00e+00	2040.00
IUUC-Laf-054348	Loxodonta africana	82.20	0.00e+00	3033.00
IUUC-Mcc-054868	Macaca mulatta	94.48	0.00e+00	7982.00
IUUC-Meu-056322	Macropus eugenii	66.93	0.00e+00	1210.00
IUUC-Mga-059541	Meleagris gallopavo	70.92	0.00e+00	5509.00
IUUC-Mmr-061092	Microcebus murinus	85.63	0.00e+00	5578.00
IUUC-Mdo-062610	Monodelphis domestica	71.37	0.00e+00	1856.00
IUUC-Mmu-063666	Mus musculus	82.50	0.00e+00	6802.00
IUUC-Mpu-066366	Mustela putorius furo	82.83	0.00e+00	6512.00
IUUC-Mlu-068201	Myotis lucifugus	79.76	0.00e+00	3983.00
IUUC-Nle-069232	Nomascus leucogenys	93.42	0.00e+00	6102.00
IUUC-Opr-070625	Ochotona princeps	72.41	0.00e+00	1217.00
IUUC-Ont-072401	Oreochromis niloticus	56.96	0.00e+00	1053.00
IUUC-Oan-072945	Ornithorhynchus anatinus	70.47	0.00e+00	4056.00
IUUC-Ocu-074920	Oryctolagus cuniculus	82.00	0.00e+00	5237.00
IUUC-Ola-086436	Oryzias latipes	44.12	0.00e+00	1744.00
IUUC-Oga-088637	Otolemur garnettii	83.27	0.00e+00	4384.00
IUUC-Oar-089363	Ovis aries	79.82	0.00e+00	6434.00
IUUC-Ptr-091527	Pan troglodytes	96.19	0.00e+00	8241.00
IUUC-Pan-092102	Papio anubis	92.54	0.00e+00	7699.00
IUUC-Pma-094252	Petromyzon marinus	40.51	7.00e-146	512.00
IUUC-Pfo-096288	Poecilia formosa	61.18	0.00e+00	1168.00
IUUC-Pab-098241	Pongo abelii	96.86	0.00e+00	5444.00
IUUC-Pca-100103	Procavia capensis	76.58	0.00e+00	1507.00
IUUC-Pva-102238	Pteropus vampyrus	75.85	0.00e+00	2532.00
IUUC-Rno-105395	Rattus norvegicus	71.74	0.00e+00	1062.00
IUUC-Sha-106550	Sarcophilus harrisii	71.05	0.00e+00	4308.00
IUUC-Sar-113183	Sorex araneus	83.97	1.00e-122	436.00
IUUC-Tgu-116677	Taeniopygia guttata	70.15	0.00e+00	5323.00
IUUC-Tru-118037	Takifugu rubripes	46.52	0.00e+00	1388.00
IUUC-Tsy-118932	Tarsius syrichta	90.14	0.00e+00	5555.00
IUUC-Tni-119970	Tetraodon nigroviridis	45.13	0.00e+00	1734.00
IUUC-Ttr-129051	Tursiops truncatus	82.20	0.00e+00	6553.00
IUUC-Vpa-130236	Vicugna pacos	83.53	0.00e+00	1959.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence