iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	37.63	1.00e-113	405.00	IUUC-Sce-106413

Active Site

Position(s)	Description	Evidence
567	Glycyl thioester intermediate	{ECO:0000250}

Organism

Rattus norvegicus

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation (By similarity).

Protein Sequence
(Fasta)

MGDPGLSKLQ FAPFNSALDV GFWHELTQKK LNEYRLDEAP KDIKGYYYNG DSAGLPTRLT 60
LEFSAFDMSA PTPARCCPAM GTLHNTNTLE AFKTADKKLL LEQSANEIWE AIKSGAALEN 120

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Nucleotide Sequence
(Fasta)

CTGGTAAGAG CAGTGGCCAT GGGGGACCCT GGACTGTCCA AGCTGCAGTT TGCCCCCTTT 60
AATAGTGCCC TGGACGTTGG CTTCTGGCAC GAACTGACCC AGAAGAAGTT GAACGAGTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0030424--C:axon
GO:0005930--C:axoneme
GO:0005737--C:cytoplasm
GO:0000407--C:pre-autophagosomal structure
GO:0019778--F:Atg12 activating enzyme activity
GO:0007568--P:aging
GO:0071455--P:cellular response to hyperoxia
GO:0071315--P:cellular response to morphine
GO:0009267--P:cellular response to starvation
GO:0051607--P:defense response to virus
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0060548--P:negative regulation of cell death
GO:0090298--P:negative regulation of mitochondrial DNA replication
GO:1903204--P:negative regulation of oxidative stress-induced neuron death
GO:0043065--P:positive regulation of apoptotic process
GO:0010508--P:positive regulation of autophagy
GO:0045732--P:positive regulation of protein catabolic process
GO:0031401--P:positive regulation of protein modification process
GO:0006497--P:protein lipidation
GO:0015031--P:protein transport
GO:1901214--P:regulation of neuron death
GO:1902617--P:response to fluoride
GO:0009749--P:response to glucose
GO:0031667--P:response to nutrient levels
GO:0039521--P:suppression by virus of host autophagy

KEGG

rno:312647

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	34.89	7.00e-99	355.00
IUUC-Aml-002316	Ailuropoda melanoleuca	92.60	0.00e+00	1178.00
IUUC-Atr-002579	Amborella trichopoda	44.92	9.00e-163	566.00
IUUC-Apl-003805	Anas platyrhynchos	82.05	0.00e+00	1191.00
IUUC-Aca-004618	Anolis carolinensis	82.94	0.00e+00	999.00
IUUC-Aly-005670	Arabidopsis lyrata	44.78	2.00e-141	495.00
IUUC-Ath-007499	Arabidopsis thaliana	45.49	2.00e-145	509.00
IUUC-Ago-007838	Ashbya gossypii	39.51	3.00e-118	419.00
IUUC-Acl-008093	Aspergillus clavatus	42.29	3.00e-146	512.00
IUUC-Afl-008663	Aspergillus flavus	45.12	5.00e-140	491.00
IUUC-Afu-008926	Aspergillus fumigatus	40.06	1.00e-136	480.00
IUUC-Ani-009156	Aspergillus nidulans	43.55	5.00e-147	514.00
IUUC-Ang-009853	Aspergillus niger	47.10	9.00e-57	213.00
IUUC-Aor-010055	Aspergillus oryzae	41.85	4.00e-149	521.00
IUUC-Ate-010281	Aspergillus terreus	44.01	4.00e-107	382.00
IUUC-Ame-010939	Astyanax mexicanus	77.07	0.00e+00	1140.00
IUUC-Bgr-012006	Blumeria graminis	41.06	4.00e-141	494.00
IUUC-Bta-012336	Bos taurus	91.42	0.00e+00	1268.00
IUUC-Bci-013598	Botrytis cinerea	41.39	2.00e-140	493.00
IUUC-Bdi-014170	Brachypodium distachyon	35.42	2.00e-98	354.00
IUUC-Bol-015357	Brassica oleracea	45.83	2.00e-152	533.00
IUUC-Bra-016835	Brassica rapa	46.12	1.00e-152	533.00
IUUC-Cel-018172	Caenorhabditis elegans	40.06	8.00e-134	471.00
IUUC-Cja-019544	Callithrix jacchus	92.96	0.00e+00	1322.00
IUUC-Cfa-021043	Canis familiaris	92.56	0.00e+00	1328.00
IUUC-Cpo-022366	Cavia porcellus	91.42	0.00e+00	1308.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	44.28	4.00e-112	398.00
IUUC-Csa-023373	Chlorocebus sabaeus	93.27	0.00e+00	1337.00
IUUC-Cho-024965	Choloepus hoffmanni	73.38	0.00e+00	638.00
IUUC-Cin-025710	Ciona intestinalis	50.50	0.00e+00	694.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	40.34	9.00e-142	497.00
IUUC-Cne-027083	Cryptococcus neoformans	41.23	3.00e-131	462.00
IUUC-Dre-028740	Danio rerio	70.09	0.00e+00	992.00
IUUC-Dno-029637	Dasypus novemcinctus	92.25	0.00e+00	1191.00
IUUC-Dor-030492	Dipodomys ordii	93.42	0.00e+00	1332.00
IUUC-Dse-031267	Dothistroma septosporum	37.41	4.00e-133	469.00
IUUC-Dme-032084	Drosophila melanogaster	40.76	1.00e-140	493.00
IUUC-Ete-032616	Echinops telfairi	85.39	0.00e+00	1207.00
IUUC-Eca-033991	Equus caballus	92.55	0.00e+00	1318.00
IUUC-Eeu-035126	Erinaceus europaeus	88.19	6.00e-121	428.00
IUUC-Fca-035472	Felis catus	92.41	0.00e+00	1328.00
IUUC-Fal-037178	Ficedula albicollis	81.87	0.00e+00	1161.00
IUUC-Fox-037901	Fusarium oxysporum	41.82	1.00e-143	503.00
IUUC-Fso-038279	Fusarium solani	41.69	3.00e-143	502.00
IUUC-Gmo-039329	Gadus morhua	70.32	0.00e+00	969.00
IUUC-Ggr-040061	Gaeumannomyces graminis	43.45	1.00e-140	493.00
IUUC-Gga-040244	Gallus gallus	83.64	0.00e+00	1229.00
IUUC-Gac-041880	Gasterosteus aculeatus	67.31	0.00e+00	937.00
IUUC-Gma-043235	Glycine max	44.03	4.00e-153	535.00
IUUC-Ggo-045428	Gorilla gorilla	93.27	0.00e+00	1342.00
IUUC-Hsa-046183	Homo sapiens	93.27	0.00e+00	1338.00
IUUC-Hvu-047509	Hordeum vulgare	35.33	7.00e-96	345.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	93.06	0.00e+00	1235.00
IUUC-Kpa-049142	Komagataella pastoris	38.71	5.00e-128	451.00
IUUC-Lch-049601	Latimeria chalumnae	66.83	0.00e+00	826.00
IUUC-Lpe-051496	Leersia perrieri	35.16	1.00e-96	348.00
IUUC-Loc-051751	Lepisosteus oculatus	77.34	0.00e+00	1130.00
IUUC-Lma-053203	Leptosphaeria maculans	41.19	4.00e-117	414.00
IUUC-Laf-053424	Loxodonta africana	92.12	0.00e+00	1322.00
IUUC-Mcc-054633	Macaca mulatta	93.12	0.00e+00	1336.00
IUUC-Meu-056523	Macropus eugenii	79.83	0.00e+00	1102.00
IUUC-Mor-056983	Magnaporthe oryzae	41.90	7.00e-147	514.00
IUUC-Mpo-057615	Magnaporthe poae	43.41	4.00e-147	515.00
IUUC-Mtr-058366	Medicago truncatula	44.35	8.00e-148	517.00
IUUC-Mla-058826	Melampsora laricipopulina	43.19	1.00e-160	560.00
IUUC-Mga-059447	Meleagris gallopavo	83.93	0.00e+00	1235.00
IUUC-Mvi-060537	Microbotryum violaceum	43.18	3.00e-153	535.00
IUUC-Mmr-060676	Microcebus murinus	93.40	0.00e+00	1332.00
IUUC-Mdo-062967	Monodelphis domestica	87.48	0.00e+00	1246.00
IUUC-Mmu-063217	Mus musculus	98.14	0.00e+00	1400.00
IUUC-Mac-065527	Musa acuminata	40.89	2.00e-136	479.00
IUUC-Mpu-066417	Mustela putorius furo	92.15	0.00e+00	1299.00
IUUC-Mlu-067195	Myotis lucifugus	92.11	0.00e+00	1344.00
IUUC-Nfi-068576	Neosartorya fischeri	40.76	3.00e-145	509.00
IUUC-Ncr-068867	Neurospora crassa	41.94	3.00e-143	502.00
IUUC-Nle-069447	Nomascus leucogenys	95.05	0.00e+00	689.00
IUUC-Opr-070737	Ochotona princeps	79.80	0.00e+00	1147.00
IUUC-Ont-071260	Oreochromis niloticus	74.75	0.00e+00	1071.00
IUUC-Oan-073622	Ornithorhynchus anatinus	85.69	0.00e+00	862.00
IUUC-Ocu-074584	Oryctolagus cuniculus	92.12	0.00e+00	1348.00
IUUC-Oba-075483	Oryza barthii	35.21	6.00e-94	338.00
IUUC-Obr-076786	Oryza brachyantha	36.21	3.00e-102	366.00
IUUC-Ogl-077388	Oryza glaberrima	35.00	3.00e-92	333.00
IUUC-Ogu-078618	Oryza glumaepatula	35.36	3.00e-98	353.00
IUUC-Oin-080007	Oryza indica	35.36	1.00e-94	341.00
IUUC-Olo-080994	Oryza longistaminata	35.99	1.00e-90	328.00
IUUC-Ome-081735	Oryza meridionalis	35.21	3.00e-94	340.00
IUUC-Oni-082153	Oryza nivara	35.05	5.00e-94	339.00
IUUC-Opu-083146	Oryza punctata	35.43	2.00e-93	337.00
IUUC-Oru-084919	Oryza rufipogon	35.05	5.00e-94	339.00
IUUC-Osa-086182	Oryza sativa	35.30	1.00e-94	341.00
IUUC-Ola-086441	Oryzias latipes	75.75	0.00e+00	1089.00
IUUC-Olu-087664	Ostreococcus lucimarinus	42.92	4.00e-138	485.00
IUUC-Oga-089074	Otolemur garnettii	93.04	0.00e+00	1234.00
IUUC-Oar-090159	Ovis aries	91.88	0.00e+00	1256.00
IUUC-Ptr-091105	Pan troglodytes	93.09	0.00e+00	1130.00
IUUC-Pan-092446	Papio anubis	93.27	0.00e+00	1336.00
IUUC-Psi-093372	Pelodiscus sinensis	81.97	0.00e+00	1097.00
IUUC-Pma-094661	Petromyzon marinus	60.45	0.00e+00	710.00
IUUC-Pno-094813	Phaeosphaeria nodorum	38.62	3.00e-116	412.00
IUUC-Ppa-095224	Physcomitrella patens	43.58	2.00e-148	520.00
IUUC-Pfo-096565	Poecilia formosa	76.59	0.00e+00	1061.00
IUUC-Pop-099702	Populus trichocarpa	45.51	1.00e-166	580.00
IUUC-Pca-100324	Procavia capensis	69.62	0.00e+00	929.00
IUUC-Ppe-101416	Prunus persica	45.40	1.00e-158	553.00
IUUC-Pva-102589	Pteropus vampyrus	86.53	0.00e+00	1214.00
IUUC-Pgr-103497	Puccinia graminis	42.70	6.00e-156	544.00
IUUC-Ptt-103718	Puccinia triticina	43.55	6.00e-154	538.00
IUUC-Pte-104206	Pyrenophora teres	39.93	2.00e-109	389.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	38.63	6.00e-120	424.00
IUUC-Sce-106413	Saccharomyces cerevisiae	38.34	8.00e-119	421.00
IUUC-Sha-106679	Sarcophilus harrisii	87.61	0.00e+00	1266.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	36.15	2.00e-120	426.00
IUUC-Spo-108107	Schizosaccharomyces pombe	40.09	2.00e-124	439.00
IUUC-Ssl-108570	Sclerotinia sclerotiorum	42.23	2.00e-147	516.00
IUUC-Smo-109677	Selaginella moellendorffii	42.07	3.00e-136	478.00
IUUC-Sit-110319	Setaria italica	46.02	3.00e-80	293.00
IUUC-Sly-111215	Solanum lycopersicum	44.73	1.00e-152	533.00
IUUC-Stu-112442	Solanum tuberosum	45.36	1.00e-149	523.00
IUUC-Sar-113370	Sorex araneus	86.08	0.00e+00	678.00
IUUC-Sbi-114261	Sorghum bicolor	32.60	8.00e-87	315.00
IUUC-Sre-114997	Sporisorium reilianum	40.40	2.00e-145	509.00
IUUC-Ssc-115304	Sus scrofa	91.67	0.00e+00	1248.00
IUUC-Tgu-117235	Taeniopygia guttata	81.75	0.00e+00	1165.00
IUUC-Tru-118374	Takifugu rubripes	76.09	0.00e+00	1061.00
IUUC-Tsy-118966	Tarsius syrichta	81.51	0.00e+00	1107.00
IUUC-Tni-120269	Tetraodon nigroviridis	70.05	0.00e+00	905.00
IUUC-Tca-121245	Theobroma cacao	45.07	9.00e-159	553.00
IUUC-Tre-121966	Trichoderma reesei	41.48	4.00e-141	494.00
IUUC-Tvi-122360	Trichoderma virens	41.82	8.00e-139	487.00
IUUC-Tae-125251	Triticum aestivum	34.50	4.00e-98	352.00
IUUC-Tur-126294	Triticum urartu	34.60	3.00e-93	336.00
IUUC-Tme-127117	Tuber melanosporum	40.89	2.00e-141	496.00
IUUC-Tbe-127662	Tupaia belangeri	66.04	5.00e-137	481.00
IUUC-Ttr-129054	Tursiops truncatus	92.42	0.00e+00	1325.00
IUUC-Uma-129526	Ustilago maydis	41.10	7.00e-155	541.00
IUUC-Vda-129878	Verticillium dahliae	40.50	1.00e-139	490.00
IUUC-Vpa-130264	Vicugna pacos	73.07	0.00e+00	1001.00
IUUC-Vvi-131163	Vitis vinifera	44.51	7.00e-159	554.00
IUUC-Xtr-132328	Xenopus tropicalis	54.38	0.00e+00	678.00
IUUC-Xma-133015	Xiphophorus maculatus	73.30	0.00e+00	1025.00
IUUC-Yli-134468	Yarrowia lipolytica	38.17	1.00e-117	416.00
IUUC-Zma-134871	Zea mays	33.33	8.00e-96	345.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence