iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-026233

UUCD1 version

UUC-CiS-00176

Ensembl Protein ID

ENSCSAVP00000019809.1

UniProt Accession

H2ZQE3; H2ZQE3_CIOSA

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000011632.1	ENSCSAVT00000020022.1	ENSCSAVP00000019809.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	34.54	1.00e-37	153.00	IUUC-Ath-007192
E3 activity/RING/RING	80.24	4.00e-122	434.00	IUUC-Dme-031700
E3 activity/RING/RING	84.25	9.00e-131	463.00	IUUC-Hsa-046357

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ciona savignyi

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

SGNDLDLASL FECPVCFDYV LPPILQCQSG HLVCSNCRPK LTCCPTCRGT LGNIRNLGME 60
KVAMTVDFPC KYAASGCEVT LRYIQKPEHE ETCEYRPYSC PCPGASCKWQ GSLDQVMPHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTAAAACA GGAATGGATT ATCACTCTAA TCACATACTC ATTGAAATGT AAAGATGAGT 60
CGACAGTCAT CTAACATTGG AAATGACAGG TAAGCTGTAT TTCTATCATT TGATAGATGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	36.40	3.00e-42	163.00
IUUC-Aml-001186	Ailuropoda melanoleuca	84.25	1.00e-132	463.00
IUUC-Atr-002857	Amborella trichopoda	37.30	5.00e-45	172.00
IUUC-Apl-003813	Anas platyrhynchos	84.25	2.00e-132	463.00
IUUC-Aca-005014	Anolis carolinensis	84.25	1.00e-132	463.00
IUUC-Aly-006522	Arabidopsis lyrata	34.94	1.00e-39	154.00
IUUC-Ath-007192	Arabidopsis thaliana	34.54	4.00e-39	153.00
IUUC-Ame-011196	Astyanax mexicanus	84.65	5.00e-133	465.00
IUUC-Bta-012887	Bos taurus	84.25	1.00e-132	464.00
IUUC-Bdi-014200	Brachypodium distachyon	36.80	5.00e-43	166.00
IUUC-Bol-016263	Brassica oleracea	34.14	8.00e-40	155.00
IUUC-Bra-017336	Brassica rapa	35.20	4.00e-41	160.00
IUUC-Cel-018320	Caenorhabditis elegans	68.80	8.00e-107	378.00
IUUC-Cja-019796	Callithrix jacchus	84.25	2.00e-132	463.00
IUUC-Cfa-020642	Canis familiaris	84.25	3.00e-133	466.00
IUUC-Cpo-022348	Cavia porcellus	84.25	2.00e-132	463.00
IUUC-Csa-023974	Chlorocebus sabaeus	84.25	2.00e-132	463.00
IUUC-Cho-024933	Choloepus hoffmanni	82.80	1.00e-126	444.00
IUUC-Cin-025674	Ciona intestinalis	98.03	2.00e-152	530.00
IUUC-Dre-028041	Danio rerio	84.65	7.00e-133	464.00
IUUC-Dno-029764	Dasypus novemcinctus	84.25	2.00e-132	463.00
IUUC-Dor-030489	Dipodomys ordii	82.51	4.00e-94	335.00
IUUC-Dme-031700	Drosophila melanogaster	81.45	8.00e-117	411.00
IUUC-Ete-032946	Echinops telfairi	83.20	4.00e-127	445.00
IUUC-Eca-033536	Equus caballus	84.25	2.00e-132	463.00
IUUC-Eeu-034861	Erinaceus europaeus	81.60	3.00e-123	432.00
IUUC-Fca-035362	Felis catus	84.25	1.00e-132	464.00
IUUC-Fal-037487	Ficedula albicollis	84.25	2.00e-132	462.00
IUUC-Gmo-039091	Gadus morhua	77.56	6.00e-123	431.00
IUUC-Gga-040269	Gallus gallus	84.25	2.00e-132	463.00
IUUC-Gac-042282	Gasterosteus aculeatus	85.04	7.00e-133	464.00
IUUC-Gma-042926	Glycine max	34.94	1.00e-41	161.00
IUUC-Ggo-045444	Gorilla gorilla	84.25	2.00e-132	463.00
IUUC-Hsa-046357	Homo sapiens	84.25	2.00e-132	463.00
IUUC-Hvu-047574	Hordeum vulgare	36.40	3.00e-42	164.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	84.25	2.00e-132	463.00
IUUC-Lch-049504	Latimeria chalumnae	84.25	2.00e-132	463.00
IUUC-Lpe-050879	Leersia perrieri	36.03	4.00e-41	160.00
IUUC-Loc-052191	Lepisosteus oculatus	84.65	8.00e-133	464.00
IUUC-Laf-053668	Loxodonta africana	84.25	2.00e-132	463.00
IUUC-Mcc-054640	Macaca mulatta	84.25	2.00e-132	463.00
IUUC-Meu-055922	Macropus eugenii	81.60	3.00e-124	436.00
IUUC-Mtr-058747	Medicago truncatula	36.55	8.00e-44	169.00
IUUC-Mga-059503	Meleagris gallopavo	84.25	2.00e-132	463.00
IUUC-Mvi-060329	Microbotryum violaceum	34.38	6.70e-01	27.70
IUUC-Mmr-060794	Microcebus murinus	84.25	2.00e-132	463.00
IUUC-Mdo-061971	Monodelphis domestica	82.00	6.00e-126	441.00
IUUC-Mmu-063876	Mus musculus	84.65	4.00e-133	465.00
IUUC-Mac-065014	Musa acuminata	36.55	1.00e-41	161.00
IUUC-Mpu-066488	Mustela putorius furo	84.25	1.00e-132	463.00
IUUC-Mlu-067207	Myotis lucifugus	84.25	8.00e-133	464.00
IUUC-Nle-069706	Nomascus leucogenys	84.25	1.00e-132	463.00
IUUC-Opr-070341	Ochotona princeps	54.90	1.00e-48	184.00
IUUC-Ont-071849	Oreochromis niloticus	85.04	6.00e-133	464.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	1.00e-48	184.00
IUUC-Ocu-074876	Oryctolagus cuniculus	84.25	3.00e-132	462.00
IUUC-Oba-075789	Oryza barthii	36.08	6.00e-43	166.00
IUUC-Obr-076037	Oryza brachyantha	36.08	7.00e-43	166.00
IUUC-Ogl-077148	Oryza glaberrima	36.08	6.00e-43	166.00
IUUC-Ogu-078042	Oryza glumaepatula	36.08	6.00e-43	166.00
IUUC-Oin-079325	Oryza indica	36.08	5.00e-43	166.00
IUUC-Olo-080244	Oryza longistaminata	36.08	1.00e-42	166.00
IUUC-Ome-081318	Oryza meridionalis	36.44	2.00e-41	160.00
IUUC-Oni-082163	Oryza nivara	36.08	6.00e-43	166.00
IUUC-Opu-084065	Oryza punctata	36.84	1.00e-41	161.00
IUUC-Oru-084833	Oryza rufipogon	36.08	5.00e-43	166.00
IUUC-Osa-085316	Oryza sativa	36.08	5.00e-43	166.00
IUUC-Ola-086814	Oryzias latipes	85.04	7.00e-133	464.00
IUUC-Oga-088399	Otolemur garnettii	84.25	2.00e-132	463.00
IUUC-Oar-089323	Ovis aries	84.25	2.00e-132	463.00
IUUC-Ptr-090692	Pan troglodytes	84.25	2.00e-132	463.00
IUUC-Pan-092012	Papio anubis	84.25	2.00e-132	463.00
IUUC-Psi-093687	Pelodiscus sinensis	84.25	1.00e-132	464.00
IUUC-Pma-094387	Petromyzon marinus	82.75	1.00e-129	454.00
IUUC-Ppa-095212	Physcomitrella patens	35.34	2.00e-41	161.00
IUUC-Pfo-097134	Poecilia formosa	85.04	7.00e-133	464.00
IUUC-Pab-097555	Pongo abelii	84.25	2.00e-132	463.00
IUUC-Pop-099563	Populus trichocarpa	35.60	5.00e-45	172.00
IUUC-Pca-100328	Procavia capensis	82.40	6.00e-124	435.00
IUUC-Ppe-101760	Prunus persica	35.57	3.00e-42	164.00
IUUC-Pva-102368	Pteropus vampyrus	89.09	4.00e-57	213.00
IUUC-Rno-104866	Rattus norvegicus	84.65	7.00e-133	464.00
IUUC-Sha-106547	Sarcophilus harrisii	84.25	9.00e-133	464.00
IUUC-Smo-109412	Selaginella moellendorffii	34.55	2.00e-39	154.00
IUUC-Sit-110245	Setaria italica	35.18	4.00e-42	163.00
IUUC-Sly-111117	Solanum lycopersicum	32.02	2.00e-40	157.00
IUUC-Stu-112474	Solanum tuberosum	35.34	5.00e-42	162.00
IUUC-Sbi-114035	Sorghum bicolor	35.60	3.00e-42	163.00
IUUC-Ssc-116441	Sus scrofa	83.20	5.00e-127	445.00
IUUC-Tgu-116579	Taeniopygia guttata	84.25	2.00e-132	463.00
IUUC-Tru-118250	Takifugu rubripes	84.65	3.00e-131	459.00
IUUC-Tsy-119548	Tarsius syrichta	81.68	5.00e-61	225.00
IUUC-Tni-120488	Tetraodon nigroviridis	84.25	2.00e-129	452.00
IUUC-Tca-121228	Theobroma cacao	36.14	5.00e-43	166.00
IUUC-Tae-123647	Triticum aestivum	36.40	3.00e-42	163.00
IUUC-Tur-126049	Triticum urartu	34.80	9.00e-41	158.00
IUUC-Ttr-129166	Tursiops truncatus	84.03	7.00e-121	425.00
IUUC-Vpa-130799	Vicugna pacos	88.24	2.00e-91	325.00
IUUC-Vvi-131451	Vitis vinifera	34.82	2.00e-41	160.00
IUUC-Xtr-132553	Xenopus tropicalis	84.65	1.00e-132	463.00
IUUC-Xma-133670	Xiphophorus maculatus	85.04	7.00e-133	464.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence