iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045563

UUCD1 version

UUC-GoG-00351

Ensembl Protein ID

ENSGGOP00000008216.2

UniProt Accession

G3QZB0; G3QZB0_GORGO

Protein Name

Apoptotic protease-activating factor 1

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000008401.2	ENSGGOT00000008444.2	ENSGGOP00000008216.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.40e-61	199.4	743	778
UBD/Beta-Prp	1.40e-100	336.8	616	804

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD+++ +
   Q: 743  GHTNSVNHCRFsPDdKLLASCSADGTLKLWDVTSAN 778
           8***********777*****************9876 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h++ ++  +fs+d++ +a+ ++d+t++v++++tg +l +++ he+ev ++ fs d+ +++t+s D+ +k+w+  tg+ vht+ +h+++v
   Q: 616  HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQV 704
           44444445666666666666666666666666666666666666666666666666666666666666666666666666666666666 PP
   S: 98   lslsfspsg..dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
            +++f  s+    l++Gs+d  +++wdl++++c + t  gh+ +vn+ +++pd++ll+s+s+D+t++lWd+                  
   Q: 705  NCCHFTNSShhLLLATGSSDCFLKLWDLNQKECRN-TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDV------------------ 774
           66666663312344556666666666666666665.66666666666666666666666666666666666.................. PP
   S: 185  slsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn......... 264
                                                                              +s +  k+++ ++         
   Q: 775  -------------------------------------------------------------------TSANERKSINVKQfflnsedpq 796
           ...................................................................4444444444444333333333 PP
   S: 265  .ssvisva 271
            +  + v+
   Q: 797  eDMEVIVK 804
           32222222 PP

Organism

Gorilla gorilla

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

GKMDAKARNC LLQHREALEK DIKTSYIMDH MISDGFLTIS EEEKVRNEPT QQQRAAMLIK 60
MILKKDNDSY VSFYNALLHE GYKDLAALLH DGIPVVSSSS GKDSVSGITS YVRTVLCEGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCGGTGGA AAACTCCTGT TGCCGTTTCC CTCCACCGGC CTGGAGTCCC CCAGTCTTGT 60
CCCGGCAGTG CCGCCCTTCC CAGTAAGACC TAGGCGCAAA GGTTTGGGTA AGTTGACCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	91.47	0.00e+00	2321.00
IUUC-Apl-004201	Anas platyrhynchos	70.90	0.00e+00	1831.00
IUUC-Aca-004638	Anolis carolinensis	68.95	0.00e+00	1811.00
IUUC-Ani-009285	Aspergillus nidulans	25.75	2.00e-66	248.00
IUUC-Ame-011062	Astyanax mexicanus	54.99	0.00e+00	1379.00
IUUC-Bta-012865	Bos taurus	90.81	0.00e+00	2343.00
IUUC-Cja-018815	Callithrix jacchus	84.90	0.00e+00	2135.00
IUUC-Cfa-020222	Canis familiaris	87.08	0.00e+00	2185.00
IUUC-Cpo-021524	Cavia porcellus	88.47	0.00e+00	2276.00
IUUC-Csa-023861	Chlorocebus sabaeus	97.68	0.00e+00	2501.00
IUUC-Cho-024484	Choloepus hoffmanni	79.87	0.00e+00	1214.00
IUUC-Dre-028006	Danio rerio	53.58	0.00e+00	1271.00
IUUC-Dno-029591	Dasypus novemcinctus	90.79	0.00e+00	2340.00
IUUC-Dor-030237	Dipodomys ordii	76.38	0.00e+00	1093.00
IUUC-Ete-032620	Echinops telfairi	85.65	0.00e+00	1095.00
IUUC-Eca-033569	Equus caballus	90.72	0.00e+00	2321.00
IUUC-Eeu-035354	Erinaceus europaeus	64.79	1.00e-177	617.00
IUUC-Fca-036337	Felis catus	91.60	0.00e+00	2352.00
IUUC-Fal-037077	Ficedula albicollis	71.10	0.00e+00	1830.00
IUUC-Gmo-039687	Gadus morhua	51.01	0.00e+00	940.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.45	7.00e-41	163.00
IUUC-Gga-040299	Gallus gallus	69.86	0.00e+00	1848.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.08	0.00e+00	1281.00
IUUC-Hsa-046771	Homo sapiens	99.44	0.00e+00	2554.00
IUUC-Lch-050200	Latimeria chalumnae	65.31	0.00e+00	1642.00
IUUC-Loc-052090	Lepisosteus oculatus	59.64	0.00e+00	1519.00
IUUC-Laf-053861	Loxodonta africana	91.19	0.00e+00	2337.00
IUUC-Mcc-055543	Macaca mulatta	98.08	0.00e+00	2511.00
IUUC-Meu-056688	Macropus eugenii	80.51	0.00e+00	2049.00
IUUC-Mga-059243	Meleagris gallopavo	70.55	0.00e+00	1858.00
IUUC-Mmr-061134	Microcebus murinus	86.90	0.00e+00	2029.00
IUUC-Mdo-062913	Monodelphis domestica	79.15	0.00e+00	2057.00
IUUC-Mmu-063811	Mus musculus	87.83	0.00e+00	2283.00
IUUC-Mpu-066780	Mustela putorius furo	91.44	0.00e+00	2316.00
IUUC-Mlu-067276	Myotis lucifugus	90.42	0.00e+00	2327.00
IUUC-Nle-069129	Nomascus leucogenys	98.48	0.00e+00	2517.00
IUUC-Opr-071007	Ochotona princeps	67.25	0.00e+00	1124.00
IUUC-Ont-071348	Oreochromis niloticus	55.09	0.00e+00	1412.00
IUUC-Oan-072717	Ornithorhynchus anatinus	81.37	0.00e+00	2113.00
IUUC-Ocu-074286	Oryctolagus cuniculus	91.45	0.00e+00	1998.00
IUUC-Ola-086895	Oryzias latipes	50.58	0.00e+00	1194.00
IUUC-Oga-088678	Otolemur garnettii	91.59	0.00e+00	2351.00
IUUC-Oar-089359	Ovis aries	90.49	0.00e+00	2340.00
IUUC-Ptr-091062	Pan troglodytes	99.52	0.00e+00	2557.00
IUUC-Pan-092528	Papio anubis	98.90	0.00e+00	1461.00
IUUC-Psi-093430	Pelodiscus sinensis	73.94	0.00e+00	1922.00
IUUC-Pma-094690	Petromyzon marinus	39.08	3.00e-153	535.00
IUUC-Pfo-097204	Poecilia formosa	54.88	0.00e+00	1387.00
IUUC-Pab-097690	Pongo abelii	99.44	0.00e+00	2549.00
IUUC-Pca-100778	Procavia capensis	71.16	0.00e+00	1185.00
IUUC-Pva-102870	Pteropus vampyrus	88.67	0.00e+00	2110.00
IUUC-Pyt-104620	Pyrenophora triticirepentis	26.40	5.00e-59	223.00
IUUC-Rno-104889	Rattus norvegicus	87.83	0.00e+00	2249.00
IUUC-Sha-107465	Sarcophilus harrisii	79.38	0.00e+00	2095.00
IUUC-Ssl-108421	Sclerotinia sclerotiorum	29.05	1.00e-64	240.00
IUUC-Sar-113268	Sorex araneus	91.74	0.00e+00	680.00
IUUC-Ssc-115654	Sus scrofa	90.15	0.00e+00	2324.00
IUUC-Tgu-117302	Taeniopygia guttata	71.10	0.00e+00	1839.00
IUUC-Tru-118363	Takifugu rubripes	54.53	0.00e+00	1386.00
IUUC-Tsy-119007	Tarsius syrichta	88.54	0.00e+00	2252.00
IUUC-Tni-120910	Tetraodon nigroviridis	53.28	0.00e+00	1340.00
IUUC-Tbe-127413	Tupaia belangeri	77.56	0.00e+00	1409.00
IUUC-Ttr-129213	Tursiops truncatus	85.02	0.00e+00	2140.00
IUUC-Vpa-130146	Vicugna pacos	85.48	0.00e+00	1624.00
IUUC-Xtr-132559	Xenopus tropicalis	61.45	0.00e+00	1553.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence