iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020938

Ensembl Protein ID

ENSCAFP00000025203.3

UniProt Accession

E2QSZ5; E2QSZ5_CANLF

Genbank Protein ID

ENSCAFP00000025203

Protein Name

Coronin

Genbank Nucleotide ID

AAEX03004406

Gene Name

CORO1A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000017110.3	ENSCAFT00000027103.3	ENSCAFP00000025203.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.80e-20	70.5	79	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgvl 35
           gHt++v ++a+   +d+ ++sGs D+t++vW++ +g l
   Q: 79   GHTAPVLDIAWcphNDNVIASGSEDCTVMVWEIPDGGL 116
           8***********9877****************998875 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFMALI CEASGGGAFL 60
VLPLGKTGRV DKNAPTVCGH TAPVLDIAWC PHNDNVIASG SEDCTVMVWE IPDGGLTLPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGAAGCCT CCAGAATGCC AGAGTAATTC ATTTGTTCCC TGTGAGGTAG GCGAGGCAGA 60
GGTGCTCCAG GGTGAAGACC TGAGATGGCA GAGAAGTGAC TCTCCCGAGG CCACGGTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR029508--CORO1A
IPR015505--Coronin
IPR015048--DUF1899
IPR015049--Trimer_CC
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF08954--Trimer_CC
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005884--C:actin filament
GO:0030424--C:axon
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0030027--C:lamellipodium
GO:0001891--C:phagocytic cup
GO:0045335--C:phagocytic vesicle
GO:0043234--C:protein complex
GO:0051015--F:actin filament binding
GO:0003723--F:RNA binding
GO:0030036--P:actin cytoskeleton organization
GO:0007015--P:actin filament organization
GO:0006816--P:calcium ion transport
GO:0031589--P:cell-substrate adhesion
GO:0071353--P:cellular response to interleukin-4
GO:0061502--P:early endosome to recycling endosome transport
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0030595--P:leukocyte chemotaxis
GO:0043320--P:natural killer cell degranulation
GO:0051126--P:negative regulation of actin nucleation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0031339--P:negative regulation of vesicle fusion
GO:0038180--P:nerve growth factor signaling pathway
GO:0001845--P:phagolysosome assembly
GO:0050918--P:positive chemotaxis
GO:0030335--P:positive regulation of cell migration
GO:0042102--P:positive regulation of T cell proliferation
GO:0008360--P:regulation of cell shape
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0043029--P:T cell homeostasis
GO:0032796--P:uropod organization

KEGG

cfa:489949

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002012	Ailuropoda melanoleuca	98.05	0.00e+00	936.00
IUUC-Aca-005048	Anolis carolinensis	66.60	0.00e+00	676.00
IUUC-Ame-011101	Astyanax mexicanus	68.86	0.00e+00	685.00
IUUC-Bta-013168	Bos taurus	97.40	0.00e+00	933.00
IUUC-Cja-019660	Callithrix jacchus	96.96	0.00e+00	927.00
IUUC-Cpo-022056	Cavia porcellus	94.36	0.00e+00	908.00
IUUC-Csa-023193	Chlorocebus sabaeus	97.40	0.00e+00	928.00
IUUC-Cne-026773	Cryptococcus neoformans	38.94	9.00e-87	314.00
IUUC-Dno-029363	Dasypus novemcinctus	96.75	0.00e+00	922.00
IUUC-Dor-030426	Dipodomys ordii	95.88	0.00e+00	914.00
IUUC-Eca-034229	Equus caballus	96.96	0.00e+00	929.00
IUUC-Eeu-034499	Erinaceus europaeus	95.06	0.00e+00	795.00
IUUC-Fca-036472	Felis catus	96.96	0.00e+00	926.00
IUUC-Gmo-039519	Gadus morhua	66.01	0.00e+00	654.00
IUUC-Gac-042545	Gasterosteus aculeatus	68.56	0.00e+00	683.00
IUUC-Ggo-045162	Gorilla gorilla	97.18	0.00e+00	927.00
IUUC-Hsa-046874	Homo sapiens	97.18	0.00e+00	927.00
IUUC-Itr-048911	Ictidomys tridecemlineatus	96.10	0.00e+00	922.00
IUUC-Lch-050582	Latimeria chalumnae	66.74	0.00e+00	690.00
IUUC-Laf-053427	Loxodonta africana	96.53	0.00e+00	913.00
IUUC-Mcc-055750	Macaca mulatta	97.42	0.00e+00	862.00
IUUC-Meu-056083	Macropus eugenii	89.15	0.00e+00	855.00
IUUC-Mla-058883	Melampsora laricipopulina	43.07	4.00e-87	315.00
IUUC-Mvi-060569	Microbotryum violaceum	40.99	7.00e-89	321.00
IUUC-Mmr-060858	Microcebus murinus	97.40	0.00e+00	931.00
IUUC-Mdo-062469	Monodelphis domestica	90.83	0.00e+00	859.00
IUUC-Mmu-063583	Mus musculus	94.79	0.00e+00	910.00
IUUC-Mpu-066451	Mustela putorius furo	97.51	0.00e+00	899.00
IUUC-Mlu-066978	Myotis lucifugus	96.31	0.00e+00	924.00
IUUC-Nle-069815	Nomascus leucogenys	97.40	0.00e+00	929.00
IUUC-Opr-070911	Ochotona princeps	94.36	0.00e+00	899.00
IUUC-Ont-072391	Oreochromis niloticus	68.83	0.00e+00	687.00
IUUC-Ocu-074429	Oryctolagus cuniculus	86.55	0.00e+00	795.00
IUUC-Oga-089072	Otolemur garnettii	95.46	0.00e+00	913.00
IUUC-Oar-089676	Ovis aries	97.40	0.00e+00	933.00
IUUC-Ptr-091647	Pan troglodytes	97.18	0.00e+00	927.00
IUUC-Pan-092672	Papio anubis	97.40	0.00e+00	928.00
IUUC-Pab-098348	Pongo abelii	91.97	0.00e+00	859.00
IUUC-Pva-102668	Pteropus vampyrus	97.18	0.00e+00	929.00
IUUC-Pgr-103354	Puccinia graminis	41.98	4.00e-91	328.00
IUUC-Rno-105604	Rattus norvegicus	94.14	0.00e+00	902.00
IUUC-Sha-107210	Sarcophilus harrisii	90.89	0.00e+00	884.00
IUUC-Sar-113292	Sorex araneus	96.49	0.00e+00	742.00
IUUC-Sre-114911	Sporisorium reilianum	39.61	5.00e-81	295.00
IUUC-Tme-126924	Tuber melanosporum	42.11	1.00e-93	337.00
IUUC-Tbe-128025	Tupaia belangeri	96.65	1.00e-152	531.00
IUUC-Ttr-128689	Tursiops truncatus	96.75	0.00e+00	929.00
IUUC-Uma-129489	Ustilago maydis	39.56	4.00e-85	308.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence