iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-047015

UUCD1 version

UUC-HoS-00002

Ensembl Protein ID

ENSP00000333181.7

UniProt Accession

A6NNE9; A7E2S6; MARHB_HUMAN

Genbank Protein ID

AAI50514.1; AAI50515.1; ENSP00000333181

Protein Name

E3 ubiquitin-protein ligase MARCH11; Membrane-associated RING finger protein 11; Membrane-associated RING-CH protein XI; RING-type E3 ubiquitin transferase MARCH11

Genbank Nucleotide ID

AC092335; BC150514; CR590337

Gene Name

11-Mar

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000183654.8	ENST00000332432.8	ENSP00000333181.7
ENSG00000183654.8	ENST00000507111.1	ENSP00000424425.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17604280

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.23	13.6	170	215

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHv.....f.hadClqkwpglknssskefrCPlC 45
           C iC++  ++g l++pC  +     + h+ Cl kw     s++++++C lC
   Q: 170  CKICFQGAEQGELLNPCR-CdgsvrYtHQLCLLKW----ISERGSWTCELC 215
           99******999999**96.22455645********....9*********** PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.

Protein Sequence
(Fasta)

MSFEGGHGGS RCRGAESGDA EPPPQPPPPP PPTPPPGEPA PVPAAPRYLP PLPASPETPE 60
RAAGPSEPLG EVAPRCRGAD ELPPPPLPLQ PAGQEVAAAG DSGEGPRRLP EAAAAKGGPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTCCCTGC AGGTGAGGGA TTTTTTTTTT TTTCCAGAAA GAAAACTGTT AGCTCTGCCC 60
TGAAGATGAG TCCCACAGAG GTTTTGCAGG GTGGAGTTAC CGAGAAATTG ACTTCGGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0016021--C:integral component of membrane
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

hsa:441061

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001530	Ailuropoda melanoleuca	94.93	5.00e-139	486.00
IUUC-Apl-003523	Anas platyrhynchos	94.47	6.00e-135	473.00
IUUC-Aca-004368	Anolis carolinensis	90.71	2.00e-124	437.00
IUUC-Acl-008264	Aspergillus clavatus	30.69	6.00e-08	51.60
IUUC-Ang-009870	Aspergillus niger	27.84	7.00e-07	48.10
IUUC-Bta-013095	Bos taurus	85.89	2.00e-135	475.00
IUUC-Bdi-014187	Brachypodium distachyon	34.00	7.00e-09	54.30
IUUC-Cja-019775	Callithrix jacchus	91.29	5.00e-172	597.00
IUUC-Cfa-020770	Canis familiaris	98.67	4.00e-125	440.00
IUUC-Cpo-021621	Cavia porcellus	99.11	6.00e-125	439.00
IUUC-Csa-023832	Chlorocebus sabaeus	93.03	9.00e-155	539.00
IUUC-Dno-028992	Dasypus novemcinctus	99.44	1.00e-95	341.00
IUUC-Dor-030131	Dipodomys ordii	98.65	8.00e-124	435.00
IUUC-Ete-032224	Echinops telfairi	95.88	8.00e-87	312.00
IUUC-Eca-034327	Equus caballus	100.00	5.00e-96	342.00
IUUC-Fca-036285	Felis catus	99.44	1.00e-95	341.00
IUUC-Fal-037405	Ficedula albicollis	94.04	7.00e-134	470.00
IUUC-Gga-040712	Gallus gallus	87.55	9.00e-136	476.00
IUUC-Ggo-044816	Gorilla gorilla	98.78	3.00e-137	480.00
IUUC-Hvu-047417	Hordeum vulgare	38.00	2.00e-09	56.60
IUUC-Itr-049040	Ictidomys tridecemlineatus	99.19	2.00e-139	487.00
IUUC-Lch-049580	Latimeria chalumnae	81.33	1.00e-104	372.00
IUUC-Loc-052242	Lepisosteus oculatus	60.41	3.00e-107	381.00
IUUC-Laf-054493	Loxodonta africana	99.41	6.00e-90	322.00
IUUC-Mcc-054837	Macaca mulatta	99.58	2.00e-134	471.00
IUUC-Mga-059607	Meleagris gallopavo	91.96	9.00e-124	435.00
IUUC-Mdo-062949	Monodelphis domestica	85.85	1.00e-138	486.00
IUUC-Mmu-063350	Mus musculus	84.30	1.00e-154	539.00
IUUC-Mpu-066267	Mustela putorius furo	98.89	2.00e-137	481.00
IUUC-Mlu-067169	Myotis lucifugus	91.01	2.00e-132	465.00
IUUC-Nle-070005	Nomascus leucogenys	98.81	1.00e-159	555.00
IUUC-Opr-070775	Ochotona princeps	98.25	1.00e-90	324.00
IUUC-Oan-073458	Ornithorhynchus anatinus	86.07	7.00e-100	356.00
IUUC-Ocu-074189	Oryctolagus cuniculus	83.70	4.00e-152	530.00
IUUC-Oba-075206	Oryza barthii	38.00	9.00e-09	53.90
IUUC-Ogl-077791	Oryza glaberrima	38.00	9.00e-09	53.90
IUUC-Oni-082903	Oryza nivara	38.00	9.00e-09	53.90
IUUC-Opu-084009	Oryza punctata	38.00	9.00e-09	53.90
IUUC-Osa-085810	Oryza sativa	38.00	9.00e-09	53.90
IUUC-Ola-086995	Oryzias latipes	68.89	2.00e-88	318.00
IUUC-Oga-088747	Otolemur garnettii	97.57	5.00e-146	509.00
IUUC-Oar-090370	Ovis aries	99.44	3.00e-95	340.00
IUUC-Ptr-091675	Pan troglodytes	94.09	4.00e-168	583.00
IUUC-Pan-092898	Papio anubis	91.54	2.00e-157	548.00
IUUC-Psi-093400	Pelodiscus sinensis	95.07	2.00e-128	451.00
IUUC-Pfo-097096	Poecilia formosa	71.73	6.00e-87	313.00
IUUC-Pab-098715	Pongo abelii	95.99	3.00e-156	544.00
IUUC-Rno-105703	Rattus norvegicus	84.25	2.00e-143	502.00
IUUC-Sha-107351	Sarcophilus harrisii	100.00	7.00e-92	328.00
IUUC-Sar-113347	Sorex araneus	95.42	8.00e-77	278.00
IUUC-Tgu-116459	Taeniopygia guttata	92.34	3.00e-132	464.00
IUUC-Tru-118083	Takifugu rubripes	68.22	1.00e-84	305.00
IUUC-Tsy-119273	Tarsius syrichta	97.98	2.00e-135	474.00
IUUC-Tae-123878	Triticum aestivum	36.00	4.00e-09	55.50
IUUC-Tbe-127966	Tupaia belangeri	100.00	6.00e-91	325.00
IUUC-Ttr-128836	Tursiops truncatus	99.57	2.00e-132	464.00
IUUC-Vpa-130196	Vicugna pacos	100.00	7.00e-133	466.00
IUUC-Xtr-132468	Xenopus tropicalis	85.78	1.00e-111	395.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence