iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033546

Ensembl Protein ID

ENSECAP00000022724.1

UniProt Accession

F6SNK9; F6SNK9_HORSE

Protein Name

E3 ubiquitin-protein ligase

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000025153.1	ENSECAT00000027159.1	ENSECAP00000022724.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.61	1.00e-154	542.00	IUUC-Hsa-046179
E3 activity/RING/RING	99.61	7.00e-154	540.00	IUUC-Mmu-063206
E3 activity/RING/RING	99.61	5.00e-154	540.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Equus caballus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

SRVTSAAAVI SADGGSVAGP LSPQHHELTS LFECPVCFDY VLPPILQCQA GHLVCNQCRQ 60
KLSCCPTCRG ALTPSIRNLA MEKVASAVLF PCKYATTGCS LTLHHTEKPE HEDICEYRPY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTCGGGTAA CCTCCGCAGC GGCGGTGATA TCGGCGGACG GCGGCAGCGT GGCTGGCCCG 60
TTGTCCCCGC AGCACCACGA GCTGACTTCG CTCTTCGAGT GCCCGGTCTG CTTTGACTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	99.61	1.00e-155	542.00
IUUC-Ame-011678	Astyanax mexicanus	92.09	4.00e-142	497.00
IUUC-Bta-012750	Bos taurus	99.61	3.00e-154	537.00
IUUC-Cja-019800	Callithrix jacchus	100.00	2.00e-154	538.00
IUUC-Cfa-020505	Canis familiaris	99.61	7.00e-154	536.00
IUUC-Cpo-021394	Cavia porcellus	98.84	4.00e-154	536.00
IUUC-Csa-023374	Chlorocebus sabaeus	100.00	2.00e-154	538.00
IUUC-Cho-024933	Choloepus hoffmanni	100.00	3.00e-154	537.00
IUUC-Dre-027711	Danio rerio	91.70	9.00e-142	495.00
IUUC-Dno-029260	Dasypus novemcinctus	91.34	3.00e-149	520.00
IUUC-Dor-030489	Dipodomys ordii	96.22	7.00e-108	382.00
IUUC-Ete-032946	Echinops telfairi	98.84	4.00e-156	543.00
IUUC-Eeu-034861	Erinaceus europaeus	95.75	1.00e-149	522.00
IUUC-Fal-037160	Ficedula albicollis	88.05	3.00e-133	467.00
IUUC-Gmo-039091	Gadus morhua	89.06	6.00e-140	489.00
IUUC-Gga-040252	Gallus gallus	97.67	3.00e-152	530.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.72	3.00e-140	490.00
IUUC-Ggo-044618	Gorilla gorilla	100.00	2.00e-154	538.00
IUUC-Hsa-046179	Homo sapiens	100.00	2.00e-154	538.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	98.06	2.00e-153	533.00
IUUC-Lch-049496	Latimeria chalumnae	91.94	2.00e-151	527.00
IUUC-Loc-052107	Lepisosteus oculatus	92.80	4.00e-142	496.00
IUUC-Laf-054257	Loxodonta africana	98.85	4.00e-155	540.00
IUUC-Mcc-055023	Macaca mulatta	100.00	2.00e-154	538.00
IUUC-Meu-055922	Macropus eugenii	97.25	5.00e-150	523.00
IUUC-Mga-060070	Meleagris gallopavo	92.34	5.00e-150	523.00
IUUC-Mmr-061494	Microcebus murinus	100.00	2.00e-154	538.00
IUUC-Mdo-061971	Monodelphis domestica	98.82	4.00e-153	533.00
IUUC-Mmu-063206	Mus musculus	100.00	9.00e-154	535.00
IUUC-Mpu-066597	Mustela putorius furo	100.00	2.00e-154	538.00
IUUC-Mlu-067199	Myotis lucifugus	99.61	1.00e-153	535.00
IUUC-Nle-069342	Nomascus leucogenys	100.00	2.00e-154	538.00
IUUC-Opr-070341	Ochotona princeps	56.86	3.00e-50	191.00
IUUC-Ont-071906	Oreochromis niloticus	89.45	2.00e-141	494.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	4.00e-50	191.00
IUUC-Ocu-073950	Oryctolagus cuniculus	99.23	4.00e-156	543.00
IUUC-Oga-089154	Otolemur garnettii	100.00	2.00e-154	538.00
IUUC-Oar-089446	Ovis aries	98.10	6.00e-157	546.00
IUUC-Ptr-091088	Pan troglodytes	100.00	2.00e-154	538.00
IUUC-Psi-093079	Pelodiscus sinensis	98.11	5.00e-157	546.00
IUUC-Pfo-097007	Poecilia formosa	85.38	9.00e-134	469.00
IUUC-Pab-098092	Pongo abelii	100.00	2.00e-154	538.00
IUUC-Pca-100328	Procavia capensis	96.86	5.00e-149	520.00
IUUC-Pva-102368	Pteropus vampyrus	100.00	2.00e-64	238.00
IUUC-Rno-105477	Rattus norvegicus	100.00	9.00e-154	535.00
IUUC-Sha-107630	Sarcophilus harrisii	97.73	1.00e-156	545.00
IUUC-Ssc-116441	Sus scrofa	99.61	4.00e-154	536.00
IUUC-Tru-118004	Takifugu rubripes	86.72	1.00e-135	475.00
IUUC-Tsy-119548	Tarsius syrichta	89.47	9.00e-68	249.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.93	5.00e-138	483.00
IUUC-Vpa-130799	Vicugna pacos	99.42	2.00e-103	367.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence