iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	JASPAR	miRTarBase	microRNA
TRANSFAC	RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.80e-14	54.3	32	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.dvqpevfrallkFlYtgklden 68
           +Dv++vv +e+f+ahk vL+a+S  Fy+ f+ +l+ +   + ++++ +++pe f  ll+F+Yt++l++ 
   Q: 32   TDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCN--LSVINLDpEISPEGFCILLDFMYTSRLNLR 98
           7**********************************76..699999988*****************9875 PP

Organism

Mus musculus

Functional Description
(View)

Functional Description

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

Protein Sequence
(Fasta)

MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 60
FTDQLKCNLS VINLDPEISP EGFCILLDFM YTSRLNLREG NIMAVMTTAM YLQMEHVVDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAGCCGCGC GCGCCCGCCT CGGGACCCCC GGTGTTCCGG GCGGCGGTGC TGCGGGAACC 60
ACGATCCGCA CTATAGGGCG GCGAGCGGCG CGGCCCCGAG GCATTCTGCC GGCCGGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005657--C:replication fork
GO:0003682--F:chromatin binding
GO:0031490--F:chromatin DNA binding
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0001161--F:intronic transcription regulatory region sequence-specific DNA binding
GO:0046872--F:metal ion binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0030036--P:actin cytoskeleton organization
GO:0030183--P:B cell differentiation
GO:0000902--P:cell morphogenesis
GO:0006974--P:cellular response to DNA damage stimulus
GO:0048821--P:erythrocyte development
GO:0002467--P:germinal center formation
GO:0006954--P:inflammatory response
GO:0043066--P:negative regulation of apoptotic process
GO:0045596--P:negative regulation of cell differentiation
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0001953--P:negative regulation of cell-matrix adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:0048294--P:negative regulation of isotype switching to IgE isotypes
GO:0032764--P:negative regulation of mast cell cytokine production
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0002829--P:negative regulation of type 2 immune response
GO:0043065--P:positive regulation of apoptotic process
GO:0030890--P:positive regulation of B cell proliferation
GO:0051272--P:positive regulation of cellular component movement
GO:0031065--P:positive regulation of histone deacetylation
GO:0045666--P:positive regulation of neuron differentiation
GO:0000060--P:protein import into nucleus, translocation
GO:0008104--P:protein localization
GO:0042127--P:regulation of cell proliferation
GO:0043087--P:regulation of GTPase activity
GO:0050727--P:regulation of inflammatory response
GO:0043380--P:regulation of memory T cell differentiation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0007266--P:Rho protein signal transduction
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
GO:0042092--P:type 2 immune response

KEGG

mmu:12053

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001625	Ailuropoda melanoleuca	94.08	0.00e+00	1338.00
IUUC-Apl-003263	Anas platyrhynchos	78.09	0.00e+00	1121.00
IUUC-Ame-010714	Astyanax mexicanus	59.59	0.00e+00	802.00
IUUC-Bta-012576	Bos taurus	93.78	0.00e+00	1317.00
IUUC-Cja-018906	Callithrix jacchus	94.34	0.00e+00	1357.00
IUUC-Cfa-021058	Canis familiaris	92.76	0.00e+00	1317.00
IUUC-Cpo-022328	Cavia porcellus	94.77	0.00e+00	1363.00
IUUC-Csa-023942	Chlorocebus sabaeus	94.78	0.00e+00	1363.00
IUUC-Cho-024599	Choloepus hoffmanni	89.59	0.00e+00	763.00
IUUC-Cin-025470	Ciona intestinalis	80.99	9.00e-60	225.00
IUUC-Csv-025860	Ciona savignyi	82.11	1.00e-59	224.00
IUUC-Dre-027605	Danio rerio	59.89	0.00e+00	823.00
IUUC-Dno-029476	Dasypus novemcinctus	87.26	0.00e+00	1267.00
IUUC-Dor-030724	Dipodomys ordii	94.20	0.00e+00	1320.00
IUUC-Dme-031902	Drosophila melanogaster	42.39	7.00e-14	72.40
IUUC-Ete-032678	Echinops telfairi	89.53	0.00e+00	1258.00
IUUC-Eca-034377	Equus caballus	94.63	0.00e+00	1347.00
IUUC-Eeu-034532	Erinaceus europaeus	89.21	0.00e+00	827.00
IUUC-Fca-036465	Felis catus	94.63	0.00e+00	1348.00
IUUC-Fal-036977	Ficedula albicollis	78.04	0.00e+00	1142.00
IUUC-Gmo-039515	Gadus morhua	80.08	6.00e-113	400.00
IUUC-Gga-040505	Gallus gallus	78.65	0.00e+00	1129.00
IUUC-Gac-041393	Gasterosteus aculeatus	58.86	0.00e+00	802.00
IUUC-Gma-043945	Glycine max	32.58	1.00e-04	42.40
IUUC-Ggo-044500	Gorilla gorilla	94.64	0.00e+00	1364.00
IUUC-Hsa-046648	Homo sapiens	94.63	0.00e+00	1366.00
IUUC-Itr-048732	Ictidomys tridecemlineatus	90.96	0.00e+00	1293.00
IUUC-Lch-050387	Latimeria chalumnae	58.47	0.00e+00	759.00
IUUC-Loc-052103	Lepisosteus oculatus	61.91	0.00e+00	857.00
IUUC-Laf-053636	Loxodonta africana	93.37	0.00e+00	1349.00
IUUC-Mcc-055290	Macaca mulatta	94.77	0.00e+00	1366.00
IUUC-Meu-055910	Macropus eugenii	78.81	0.00e+00	1148.00
IUUC-Mga-059925	Meleagris gallopavo	78.37	0.00e+00	1119.00
IUUC-Mvi-060431	Microbotryum violaceum	28.57	7.70e-02	32.00
IUUC-Mmr-060855	Microcebus murinus	94.77	0.00e+00	1347.00
IUUC-Mpu-066598	Mustela putorius furo	93.78	0.00e+00	1315.00
IUUC-Mlu-067370	Myotis lucifugus	93.37	0.00e+00	1300.00
IUUC-Nle-069870	Nomascus leucogenys	95.05	0.00e+00	1369.00
IUUC-Opr-070986	Ochotona princeps	91.23	0.00e+00	1276.00
IUUC-Ont-072475	Oreochromis niloticus	59.69	0.00e+00	767.00
IUUC-Oan-073596	Ornithorhynchus anatinus	84.01	0.00e+00	1176.00
IUUC-Ocu-073970	Oryctolagus cuniculus	93.51	0.00e+00	1356.00
IUUC-Ola-087102	Oryzias latipes	59.50	0.00e+00	808.00
IUUC-Oga-088873	Otolemur garnettii	93.79	0.00e+00	1350.00
IUUC-Oar-090083	Ovis aries	88.40	0.00e+00	1221.00
IUUC-Ptr-090628	Pan troglodytes	94.91	0.00e+00	1369.00
IUUC-Pan-092324	Papio anubis	94.36	0.00e+00	1352.00
IUUC-Psi-093695	Pelodiscus sinensis	79.49	0.00e+00	1103.00
IUUC-Pfo-096460	Poecilia formosa	58.30	0.00e+00	788.00
IUUC-Pab-098012	Pongo abelii	94.77	0.00e+00	1367.00
IUUC-Pca-100127	Procavia capensis	91.97	0.00e+00	1230.00
IUUC-Pva-102830	Pteropus vampyrus	93.07	0.00e+00	1319.00
IUUC-Rno-105752	Rattus norvegicus	98.30	0.00e+00	1372.00
IUUC-Sha-107259	Sarcophilus harrisii	82.52	0.00e+00	1184.00
IUUC-Sar-113610	Sorex araneus	90.72	0.00e+00	1047.00
IUUC-Ssc-115327	Sus scrofa	93.78	0.00e+00	1338.00
IUUC-Tgu-116457	Taeniopygia guttata	79.07	0.00e+00	1156.00
IUUC-Tru-118520	Takifugu rubripes	58.81	0.00e+00	788.00
IUUC-Tni-119969	Tetraodon nigroviridis	58.67	0.00e+00	784.00
IUUC-Tbe-127327	Tupaia belangeri	88.83	0.00e+00	1249.00
IUUC-Ttr-129204	Tursiops truncatus	91.37	0.00e+00	1283.00
IUUC-Xtr-132937	Xenopus tropicalis	67.14	0.00e+00	902.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence