iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089196

Ensembl Protein ID

ENSOARP00000002444.1

UniProt Accession

W5NW97; W5NW97_SHEEP

Genbank Protein ID

ENSOARP00000002444

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AMGL01028264

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000002298.1	ENSOART00000002496.1	ENSOARP00000002444.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.80e-131	439.3	13	528

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv...gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnp 86
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G    gs+t++D+++v+ ++ +++F+++++++gk++A++a+e+l+eln 
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGMigiGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAQAAMEFLQELNN 101
           **************************************9887777******************************************** PP
   S: 87   dvnveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqkti 171
           dv+++++ees+++l ++++ Ff++f++Vv+++ ++++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++
   Q: 102  DVSGSFVEESPENLLDNDPsFFCRFTIVVATQLSESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDK 190
           ***************************************************************************************** PP
   S: 172  Pfctlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkaf 245
           Pf++l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+
   Q: 191  PFPELREHFQsydldhmekKDHSHTPWIVIVAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTAL 279
           ********99999999998***********************************************9********************** PP
   S: 246  akttins.ikqllksfecdivtkskspfwv........................................................... 274
           ++t+i+s i++++++++c ++tk+++ fw+                                                           
   Q: 280  NTTQIPSsIEDIFNDDRCINITKQTPTFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakll 368
           ***************************************************************************************** PP
   S: 275  ................sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds 331
                            +csn++ l+v            ++v+kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d+
   Q: 369  qsigqapesisekelkLLCSNSAFLRVVrcrslaeeyslDTVNKDEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDI 457
           ****************99*****9996667777777777*************************************************9 PP
   S: 332  ..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
             + +++t+++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  gkLKSCLTSFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 528
           99999***999....********************************************************9776 PP

Organism

Ovis aries

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQPGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGMIGIGSF 60
TIIDGNQVSG EDAGNNFFLQ RSSIGKNRAQ AAMEFLQELN NDVSGSFVEE SPENLLDNDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCAGC CGGGGAAGCT GCTAAAGGAG CAGAAGTACG ACCGGCAGCT GAGGGGGGGG 60
CGGGCGGCAC CCGTCGTGGG GGGGGCGGGG NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.48	4.00e-125	441.00
IUUC-Aml-002333	Ailuropoda melanoleuca	96.66	0.00e+00	1082.00
IUUC-Atr-002644	Amborella trichopoda	40.71	6.00e-113	400.00
IUUC-Apl-003446	Anas platyrhynchos	83.91	0.00e+00	915.00
IUUC-Aca-004450	Anolis carolinensis	80.22	0.00e+00	916.00
IUUC-Aly-006187	Arabidopsis lyrata	40.15	2.00e-125	442.00
IUUC-Ath-007600	Arabidopsis thaliana	40.71	1.00e-126	446.00
IUUC-Ago-007900	Ashbya gossypii	25.78	6.00e-38	151.00
IUUC-Acl-008333	Aspergillus clavatus	34.16	1.00e-79	290.00
IUUC-Afl-008529	Aspergillus flavus	35.42	9.00e-86	310.00
IUUC-Afu-009071	Aspergillus fumigatus	33.51	2.00e-80	293.00
IUUC-Ani-009443	Aspergillus nidulans	33.33	1.00e-76	280.00
IUUC-Ang-009669	Aspergillus niger	33.15	7.00e-81	294.00
IUUC-Aor-009914	Aspergillus oryzae	34.75	2.00e-82	299.00
IUUC-Ate-010450	Aspergillus terreus	34.53	2.00e-83	303.00
IUUC-Ame-011183	Astyanax mexicanus	71.80	0.00e+00	825.00
IUUC-Bgr-012111	Blumeria graminis	32.73	3.00e-64	239.00
IUUC-Bta-012583	Bos taurus	99.07	0.00e+00	1106.00
IUUC-Bci-013892	Botrytis cinerea	32.72	3.00e-64	239.00
IUUC-Bdi-014592	Brachypodium distachyon	43.07	2.00e-127	449.00
IUUC-Bol-016399	Brassica oleracea	40.42	9.00e-124	437.00
IUUC-Bra-017506	Brassica rapa	38.96	6.00e-120	424.00
IUUC-Cel-018456	Caenorhabditis elegans	35.41	3.00e-92	332.00
IUUC-Cja-020007	Callithrix jacchus	97.39	0.00e+00	1100.00
IUUC-Cfa-020324	Canis familiaris	97.21	0.00e+00	1087.00
IUUC-Cpo-022248	Cavia porcellus	66.36	0.00e+00	647.00
IUUC-Csa-023149	Chlorocebus sabaeus	97.79	0.00e+00	929.00
IUUC-Cho-024537	Choloepus hoffmanni	85.68	0.00e+00	808.00
IUUC-Cin-025763	Ciona intestinalis	49.44	1.00e-154	539.00
IUUC-Csv-026113	Ciona savignyi	46.04	4.00e-145	508.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.83	8.00e-65	241.00
IUUC-Cne-026884	Cryptococcus neoformans	30.09	7.00e-71	261.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.19	5.00e-18	85.90
IUUC-Dre-028140	Danio rerio	73.00	0.00e+00	847.00
IUUC-Dno-030033	Dasypus novemcinctus	97.06	0.00e+00	957.00
IUUC-Dor-030513	Dipodomys ordii	69.01	1.00e-116	413.00
IUUC-Dse-031536	Dothistroma septosporum	34.93	1.00e-84	307.00
IUUC-Dme-031683	Drosophila melanogaster	44.59	1.00e-126	446.00
IUUC-Ete-032420	Echinops telfairi	83.24	0.00e+00	889.00
IUUC-Eca-033992	Equus caballus	98.43	0.00e+00	917.00
IUUC-Eeu-034713	Erinaceus europaeus	79.92	3.00e-117	415.00
IUUC-Fca-036548	Felis catus	96.46	0.00e+00	1076.00
IUUC-Fal-037600	Ficedula albicollis	80.38	0.00e+00	882.00
IUUC-Fox-038037	Fusarium oxysporum	33.63	2.00e-74	273.00
IUUC-Fso-038387	Fusarium solani	34.84	7.00e-77	281.00
IUUC-Gmo-038562	Gadus morhua	71.56	0.00e+00	823.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.42	2.00e-72	266.00
IUUC-Gga-041129	Gallus gallus	84.57	0.00e+00	945.00
IUUC-Gac-042558	Gasterosteus aculeatus	72.85	0.00e+00	831.00
IUUC-Gma-043610	Glycine max	40.93	5.00e-120	424.00
IUUC-Ggo-045611	Gorilla gorilla	97.39	0.00e+00	1095.00
IUUC-Hsa-046563	Homo sapiens	97.21	0.00e+00	1087.00
IUUC-Hvu-047790	Hordeum vulgare	38.62	6.00e-78	284.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	97.39	0.00e+00	1092.00
IUUC-Kpa-049309	Komagataella pastoris	35.58	8.00e-82	297.00
IUUC-Lch-050038	Latimeria chalumnae	76.17	0.00e+00	852.00
IUUC-Lpe-051535	Leersia perrieri	41.00	3.00e-109	389.00
IUUC-Loc-051917	Lepisosteus oculatus	69.93	0.00e+00	803.00
IUUC-Lma-053112	Leptosphaeria maculans	34.57	2.00e-86	313.00
IUUC-Laf-053690	Loxodonta africana	95.90	0.00e+00	1078.00
IUUC-Mcc-055117	Macaca mulatta	95.38	0.00e+00	1069.00
IUUC-Meu-056761	Macropus eugenii	77.18	0.00e+00	833.00
IUUC-Mor-057230	Magnaporthe oryzae	33.99	1.00e-77	283.00
IUUC-Mpo-057514	Magnaporthe poae	33.82	4.00e-71	262.00
IUUC-Mtr-058551	Medicago truncatula	40.43	3.00e-117	415.00
IUUC-Mla-059183	Melampsora laricipopulina	36.58	4.00e-96	345.00
IUUC-Mga-060144	Meleagris gallopavo	82.86	0.00e+00	915.00
IUUC-Mvi-060221	Microbotryum violaceum	35.79	3.00e-82	299.00
IUUC-Mmr-061325	Microcebus murinus	94.44	0.00e+00	1058.00
IUUC-Mdo-062532	Monodelphis domestica	91.04	0.00e+00	1023.00
IUUC-Mmu-063956	Mus musculus	97.02	0.00e+00	1085.00
IUUC-Mac-064521	Musa acuminata	40.52	7.00e-122	430.00
IUUC-Mpu-066716	Mustela putorius furo	96.63	0.00e+00	1021.00
IUUC-Mlu-067459	Myotis lucifugus	95.36	0.00e+00	1063.00
IUUC-Nfi-068245	Neosartorya fischeri	33.87	2.00e-80	293.00
IUUC-Ncr-068910	Neurospora crassa	34.54	3.00e-77	282.00
IUUC-Nle-070034	Nomascus leucogenys	94.70	0.00e+00	1041.00
IUUC-Opr-070552	Ochotona princeps	87.43	0.00e+00	897.00
IUUC-Ont-071426	Oreochromis niloticus	73.68	0.00e+00	850.00
IUUC-Oan-073389	Ornithorhynchus anatinus	83.82	0.00e+00	778.00
IUUC-Ocu-074911	Oryctolagus cuniculus	96.09	0.00e+00	1081.00
IUUC-Oba-075437	Oryza barthii	41.94	2.00e-118	419.00
IUUC-Obr-076684	Oryza brachyantha	42.88	8.00e-113	400.00
IUUC-Ogl-077170	Oryza glaberrima	41.94	2.00e-118	419.00
IUUC-Ogu-078844	Oryza glumaepatula	42.66	2.00e-111	396.00
IUUC-Oin-079105	Oryza indica	41.94	7.00e-118	417.00
IUUC-Olo-080943	Oryza longistaminata	40.40	9.00e-107	380.00
IUUC-Oni-082891	Oryza nivara	40.04	3.00e-112	398.00
IUUC-Opu-083457	Oryza punctata	42.69	3.00e-117	415.00
IUUC-Oru-084960	Oryza rufipogon	40.40	7.00e-107	380.00
IUUC-Osa-085358	Oryza sativa	42.13	2.00e-118	419.00
IUUC-Ola-086420	Oryzias latipes	72.39	8.00e-170	589.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.90	1.00e-60	227.00
IUUC-Oga-088810	Otolemur garnettii	95.90	0.00e+00	1075.00
IUUC-Ptr-090617	Pan troglodytes	97.39	0.00e+00	1089.00
IUUC-Pan-092761	Papio anubis	97.39	0.00e+00	1092.00
IUUC-Psi-093191	Pelodiscus sinensis	86.35	0.00e+00	957.00
IUUC-Pma-094380	Petromyzon marinus	61.29	0.00e+00	656.00
IUUC-Pno-095084	Phaeosphaeria nodorum	33.03	5.00e-75	276.00
IUUC-Ppa-095875	Physcomitrella patens	40.00	4.00e-119	421.00
IUUC-Pfo-096467	Poecilia formosa	72.56	0.00e+00	829.00
IUUC-Pab-098255	Pongo abelii	96.87	0.00e+00	908.00
IUUC-Pop-099722	Populus trichocarpa	40.71	5.00e-124	437.00
IUUC-Pca-100807	Procavia capensis	79.62	2.00e-121	429.00
IUUC-Ppe-101280	Prunus persica	40.00	4.00e-122	431.00
IUUC-Pva-102333	Pteropus vampyrus	93.30	0.00e+00	1037.00
IUUC-Pgr-103401	Puccinia graminis	31.79	3.00e-80	292.00
IUUC-Ptt-103889	Puccinia triticina	27.35	2.00e-57	216.00
IUUC-Pte-104355	Pyrenophora teres	35.22	5.00e-89	321.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.82	1.00e-90	327.00
IUUC-Rno-105810	Rattus norvegicus	95.90	0.00e+00	1074.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.25	3.00e-36	145.00
IUUC-Sha-106770	Sarcophilus harrisii	89.51	1.00e-153	535.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.39	3.00e-75	275.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.70	1.00e-82	300.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.73	4.00e-67	249.00
IUUC-Smo-109296	Selaginella moellendorffii	42.37	1.00e-122	433.00
IUUC-Sit-110157	Setaria italica	44.53	2.00e-134	472.00
IUUC-Sly-111105	Solanum lycopersicum	40.22	1.00e-121	430.00
IUUC-Stu-112469	Solanum tuberosum	40.04	2.00e-122	432.00
IUUC-Sar-113083	Sorex araneus	73.22	0.00e+00	751.00
IUUC-Sbi-113813	Sorghum bicolor	44.53	1.00e-133	469.00
IUUC-Sre-115058	Sporisorium reilianum	38.85	2.00e-84	306.00
IUUC-Tgu-116772	Taeniopygia guttata	80.19	0.00e+00	882.00
IUUC-Tru-118686	Takifugu rubripes	71.80	0.00e+00	833.00
IUUC-Tsy-119111	Tarsius syrichta	90.81	3.00e-153	535.00
IUUC-Tni-120231	Tetraodon nigroviridis	66.79	0.00e+00	751.00
IUUC-Tca-121491	Theobroma cacao	40.19	2.00e-115	409.00
IUUC-Tre-122103	Trichoderma reesei	36.01	1.00e-80	293.00
IUUC-Tvi-122672	Trichoderma virens	36.63	1.00e-74	273.00
IUUC-Tae-125679	Triticum aestivum	43.07	2.00e-127	449.00
IUUC-Tur-126487	Triticum urartu	41.75	9.00e-121	427.00
IUUC-Tme-127097	Tuber melanosporum	38.70	7.00e-94	337.00
IUUC-Ttr-128465	Tursiops truncatus	91.06	0.00e+00	1010.00
IUUC-Uma-129645	Ustilago maydis	34.16	2.00e-90	326.00
IUUC-Vda-129989	Verticillium dahliae	30.93	5.00e-56	211.00
IUUC-Vpa-130529	Vicugna pacos	94.04	0.00e+00	1046.00
IUUC-Vvi-131059	Vitis vinifera	41.30	4.00e-122	431.00
IUUC-Xtr-132002	Xenopus tropicalis	78.30	0.00e+00	899.00
IUUC-Xma-133930	Xiphophorus maculatus	72.97	0.00e+00	834.00
IUUC-Yli-134505	Yarrowia lipolytica	35.80	1.00e-86	313.00
IUUC-Zma-135895	Zea mays	44.78	1.00e-132	466.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence