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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045997
UUCD1 version UUC-HoS-00630
Ensembl Protein ID ENSP00000451998.1
UniProt Accession Q05BV3; B9EK59; Q5H9N6; Q6UYC9; Q6ZRP3; Q6ZT03; EMAL5_HUMAN
Genbank Protein ID BAC86793.1; BAC87266.1; AAH32685.1; AAI50640.1; AAQ62653.1; CAI46257.1
Protein Name Echinoderm microtubule-associated protein-like 5
Genbank Nucleotide ID AK127024; AK128086; AL121768; BC150639; AY357725; CR933726
Gene Name EML5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000165521.15 ENST00000554922.5 ENSP00000451998.1
ENSG00000165521.15 ENST00000553526.5 ENSP00000450965.1
ENSG00000165521.15 ENST00000380664.9 ENSP00000370039.5
ENSG00000165521.15 ENST00000555823.1 ENSP00000452030.1
ENSG00000165521.15 ENST00000553281.5 ENSP00000452360.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDHINTMenthaInWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-56 187.9 1700 1732
UBD/Beta-Prp 2.80e-138 461.8 726 940
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htd.svtclaf.sd.tllvsGsdDgtikvWDlr 31
           H d ++++la  ++ ++++s++ Dgt+++WD+ 
   Q: 1700 HVDgPIWGLAThPSrDFFLSAAEDGTVRLWDIA 1732
           5553699999898889***************75 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatg..srdgtikvwdvttgkllrslsgh.eaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkghed 95
           h++ i c++++p k+++atg  +rd +i +wd++t k l+ l+gh + +v+av+fs dgk l++++ D  +t+ +wd ++g+ +++ +g +d
   Q: 726  HDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHhQYGVSAVDFSADGKRLASVGIDdsHTVVLWDWKKGEKLSIARGSKD 817
           4555566************95569******************7651669***************9999999********************* PP
   S: 96   svlslsfspsg.dklvsGshdrtirvwdletgqclee....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           ++  ++++p+  dkl++++  +  + w    g  +         g++++ +c+v+  ++ + +sG+  + v +W  +  +l++t +  h+++
   Q: 818  KIFVVKMNPYVpDKLITAG-IKHMKFWRKAGGGLIGRkgyiGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW--RDIFLVKTVKA-HDGP 905
           *********9978888887.9999***88888888779998455677799************************..889******98.**** PP
   S: 183  vyslsfdsngkelvsgsldgtvklwdlqtgecvrtln 219
           v s+   +  k +v+g++dg v lwd + ++c++t+ 
   Q: 906  VFSMHALE--KGFVTGGKDGIVALWDDSFERCLKTYA 940
           ****9888..67**********************996 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
 May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
Protein Sequence
(Fasta)
MAARSAPSCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR EHRQKFYRGH 60
SDDIISLALH PERVLVATGQ VGKEPYICIW DSYTVQTISV LKDVHTHGIA CLAFDLDGQR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045997|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGGGCATCC ACTTGACAGC CGGCGGCGCT CGCGGCCCTC AGCATGTTCC GCGAGGCGAG 60
GGTTTTCCTC CCGCCTGTGG GCTGAGGCGG CGGCGGCCCC CGAAACGAGA TGCACCTGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045997|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR005108--HELP
IPR011041--Quinoprot_gluc/sorb_DH
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF03451--HELP
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0003824--F:catalytic activity
GO:0008017--F:microtubule binding
KEGG hsa:161436
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002225 Ailuropoda melanoleuca 96.47 0.00e+00 3844.00
IUUC-Apl-003360 Anas platyrhynchos 91.17 0.00e+00 3560.00
IUUC-Ame-011681 Astyanax mexicanus 84.97 0.00e+00 3512.00
IUUC-Bta-012838 Bos taurus 96.36 0.00e+00 3881.00
IUUC-Cja-019068 Callithrix jacchus 98.84 0.00e+00 3930.00
IUUC-Cfa-020531 Canis familiaris 96.46 0.00e+00 3907.00
IUUC-Cpo-022304 Cavia porcellus 93.05 0.00e+00 3634.00
IUUC-Csa-023621 Chlorocebus sabaeus 98.42 0.00e+00 3589.00
IUUC-Cho-024944 Choloepus hoffmanni 77.14 0.00e+00 1509.00
IUUC-Dre-028772 Danio rerio 84.72 0.00e+00 3510.00
IUUC-Dno-030063 Dasypus novemcinctus 95.31 0.00e+00 3820.00
IUUC-Dor-030980 Dipodomys ordii 86.98 0.00e+00 1579.00
IUUC-Ete-032554 Echinops telfairi 93.38 0.00e+00 1050.00
IUUC-Eca-033909 Equus caballus 97.00 0.00e+00 3585.00
IUUC-Eeu-035180 Erinaceus europaeus 79.00 0.00e+00 1465.00
IUUC-Fal-037219 Ficedula albicollis 91.59 0.00e+00 3686.00
IUUC-Gmo-039146 Gadus morhua 80.54 0.00e+00 3313.00
IUUC-Gga-041095 Gallus gallus 90.93 0.00e+00 2655.00
IUUC-Gac-041341 Gasterosteus aculeatus 83.12 0.00e+00 3405.00
IUUC-Lch-050306 Latimeria chalumnae 84.70 0.00e+00 3180.00
IUUC-Loc-052215 Lepisosteus oculatus 85.18 0.00e+00 3558.00
IUUC-Laf-054044 Loxodonta africana 95.45 0.00e+00 3847.00
IUUC-Mcc-054733 Macaca mulatta 99.39 0.00e+00 3943.00
IUUC-Mga-059666 Meleagris gallopavo 89.94 0.00e+00 3518.00
IUUC-Mmr-060995 Microcebus murinus 97.93 0.00e+00 3902.00
IUUC-Mdo-062482 Monodelphis domestica 93.27 0.00e+00 3776.00
IUUC-Mmu-063533 Mus musculus 95.80 0.00e+00 3822.00
IUUC-Mpu-066704 Mustela putorius furo 96.46 0.00e+00 3894.00
IUUC-Mlu-067592 Myotis lucifugus 96.05 0.00e+00 3847.00
IUUC-Nle-069911 Nomascus leucogenys 99.19 0.00e+00 3932.00
IUUC-Ont-071966 Oreochromis niloticus 84.70 0.00e+00 3511.00
IUUC-Ola-086738 Oryzias latipes 84.06 0.00e+00 3460.00
IUUC-Oga-088436 Otolemur garnettii 95.06 0.00e+00 3798.00
IUUC-Oar-090153 Ovis aries 95.99 0.00e+00 3734.00
IUUC-Ptr-091008 Pan troglodytes 99.70 0.00e+00 3937.00
IUUC-Pan-092404 Papio anubis 98.94 0.00e+00 3915.00
IUUC-Psi-093417 Pelodiscus sinensis 90.76 0.00e+00 3545.00
IUUC-Pfo-096073 Poecilia formosa 84.93 0.00e+00 3518.00
IUUC-Pab-097900 Pongo abelii 99.19 0.00e+00 3932.00
IUUC-Pca-100107 Procavia capensis 81.19 0.00e+00 2555.00
IUUC-Pva-102880 Pteropus vampyrus 92.47 0.00e+00 3519.00
IUUC-Rno-106084 Rattus norvegicus 95.90 0.00e+00 3889.00
IUUC-Sha-106974 Sarcophilus harrisii 93.03 0.00e+00 3767.00
IUUC-Sar-113401 Sorex araneus 84.71 0.00e+00 1827.00
IUUC-Ssc-116057 Sus scrofa 96.30 0.00e+00 3790.00
IUUC-Tru-118444 Takifugu rubripes 83.40 0.00e+00 3429.00
IUUC-Tsy-118941 Tarsius syrichta 85.45 0.00e+00 2859.00
IUUC-Tni-120683 Tetraodon nigroviridis 83.01 0.00e+00 3281.00
IUUC-Tbe-127467 Tupaia belangeri 89.11 0.00e+00 1870.00
IUUC-Ttr-129138 Tursiops truncatus 92.15 0.00e+00 3539.00
IUUC-Vpa-130083 Vicugna pacos 90.84 0.00e+00 3454.00
IUUC-Xtr-131835 Xenopus tropicalis 88.44 0.00e+00 3660.00
Created Date 25-Jun-2017

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