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Tag Content
UUCD2 ID IUUC-Gga-040530
UUCD1 version UUC-GaG-00386
Ensembl Protein ID ENSGALP00000013362.3
UniProt Accession Q5ZJL7; DDB2_CHICK
Genbank Protein ID CAG32076.1
Protein Name DNA damage-binding protein 2; Damage-specific DNA-binding protein 2
Genbank Nucleotide ID AJ720417
Gene Name DDB2; RCJMB04_17d21
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000008218.4 ENSGALT00000013377.3 ENSGALP00000013362.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.50e-10 41.3 261 295
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtg 33
           H+ +vt ++f   + +ll+++s D t+k+WDlr  
   Q: 261  HKKKVTHVEFnsRCeWLLATASVDQTVKIWDLRNI 295
           8899******98446****************9875 PP
   
Organism Gallus gallus
Functional Description
(View)

Functional Description


     Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity).
 Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity).
Protein Sequence
(Fasta)
MAPVNQPKDK KHEKAHEHRS EEAKSAGKRK LDYEGLENEP LAKKLFLRKT SKAQEKIGWN 60
RGGTVMRNTR ALFHQPKWQC SIVHYVYQNM LGGSIRAQLR QCLQLPFLRS LTSYRLFRTA 120
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Protein Fasta Sequence


>IUUC-Gga-040530|E3,WD_repeat|Gallus gallus
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Nucleotide Sequence
(Fasta)
GACACCGAGG AGCGGAGGCC TGGGGAGCGC AGGTGAGAGT GGGCGGCCCT TCCCGCCGGG 60
CCGGGGCCGG GGGGCTGTCC CTGGGGAAGC CGGGCGGTGC GGGGATGGGA AATGGGAACA 120
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Nucleotide Fasta Sequence


>IUUC-Gga-040530|E3,WD_repeat|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR033312--DDB2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0030054--C:cell junction
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0003684--F:damaged DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035518--P:histone H2A monoubiquitination
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006290--P:pyrimidine dimer repair
GO:0070914--P:UV-damage excision repair
KEGG gga:423185
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000470 Aegilops tauschii 30.81 1.00e-37 150.00
IUUC-Aml-002203 Ailuropoda melanoleuca 53.72 3.00e-133 468.00
IUUC-Atr-002957 Amborella trichopoda 34.91 6.00e-43 168.00
IUUC-Apl-003832 Anas platyrhynchos 94.08 0.00e+00 930.00
IUUC-Aca-004358 Anolis carolinensis 75.47 0.00e+00 758.00
IUUC-Aly-006296 Arabidopsis lyrata 33.93 8.00e-43 167.00
IUUC-Ath-007115 Arabidopsis thaliana 34.40 1.00e-44 174.00
IUUC-Ame-010817 Astyanax mexicanus 52.25 2.00e-142 498.00
IUUC-Bta-012914 Bos taurus 52.01 2.00e-132 465.00
IUUC-Bdi-014261 Brachypodium distachyon 32.16 3.00e-38 153.00
IUUC-Bol-015317 Brassica oleracea 34.35 9.00e-43 167.00
IUUC-Bra-016848 Brassica rapa 34.35 2.00e-42 166.00
IUUC-Cja-018967 Callithrix jacchus 59.24 9.00e-132 462.00
IUUC-Cfa-021238 Canis familiaris 59.95 5.00e-126 444.00
IUUC-Cpo-022063 Cavia porcellus 56.13 1.00e-131 462.00
IUUC-Csa-023382 Chlorocebus sabaeus 59.78 4.00e-132 464.00
IUUC-Cho-024805 Choloepus hoffmanni 45.53 5.00e-52 197.00
IUUC-Dre-028732 Danio rerio 66.21 4.00e-151 527.00
IUUC-Dor-030461 Dipodomys ordii 68.47 2.00e-94 338.00
IUUC-Ete-033038 Echinops telfairi 54.26 1.00e-122 432.00
IUUC-Eca-033772 Equus caballus 59.26 6.00e-126 443.00
IUUC-Eeu-034662 Erinaceus europaeus 52.68 7.00e-32 131.00
IUUC-Fca-036095 Felis catus 58.36 2.00e-126 445.00
IUUC-Gmo-039683 Gadus morhua 57.14 1.00e-144 505.00
IUUC-Gac-041517 Gasterosteus aculeatus 62.26 3.00e-138 484.00
IUUC-Gma-043378 Glycine max 33.92 2.00e-42 167.00
IUUC-Ggo-045364 Gorilla gorilla 52.98 3.00e-133 468.00
IUUC-Hsa-046354 Homo sapiens 60.33 5.00e-133 467.00
IUUC-Hvu-047151 Hordeum vulgare 31.89 6.00e-31 127.00
IUUC-Itr-048304 Ictidomys tridecemlineatus 56.51 6.00e-133 466.00
IUUC-Lpe-051256 Leersia perrieri 32.07 2.00e-37 149.00
IUUC-Loc-052398 Lepisosteus oculatus 63.27 1.00e-150 525.00
IUUC-Laf-053562 Loxodonta africana 53.76 6.00e-127 447.00
IUUC-Mcc-055197 Macaca mulatta 60.99 8.00e-104 370.00
IUUC-Meu-056151 Macropus eugenii 61.48 2.00e-103 367.00
IUUC-Mtr-057940 Medicago truncatula 31.76 4.00e-43 169.00
IUUC-Mga-059923 Meleagris gallopavo 97.83 0.00e+00 1003.00
IUUC-Mmr-061465 Microcebus murinus 63.54 1.00e-104 372.00
IUUC-Mdo-063063 Monodelphis domestica 60.42 7.00e-146 509.00
IUUC-Mmu-064294 Mus musculus 59.56 7.00e-129 453.00
IUUC-Mac-065598 Musa acuminata 32.94 1.00e-36 147.00
IUUC-Mpu-066831 Mustela putorius furo 53.69 3.00e-129 454.00
IUUC-Mlu-067222 Myotis lucifugus 52.25 5.00e-128 450.00
IUUC-Nle-069581 Nomascus leucogenys 59.78 1.00e-132 466.00
IUUC-Opr-070644 Ochotona princeps 52.90 1.00e-128 452.00
IUUC-Ont-072605 Oreochromis niloticus 56.17 4.00e-137 481.00
IUUC-Oan-072973 Ornithorhynchus anatinus 69.49 4.00e-145 507.00
IUUC-Ocu-074615 Oryctolagus cuniculus 58.24 6.00e-131 460.00
IUUC-Oba-075283 Oryza barthii 30.22 4.00e-36 145.00
IUUC-Obr-076605 Oryza brachyantha 31.30 8.00e-39 154.00
IUUC-Ogl-077512 Oryza glaberrima 30.22 4.00e-36 145.00
IUUC-Ogu-078329 Oryza glumaepatula 30.22 4.00e-36 145.00
IUUC-Oin-079980 Oryza indica 30.22 5.00e-36 145.00
IUUC-Olo-080516 Oryza longistaminata 29.95 9.00e-36 144.00
IUUC-Ome-081415 Oryza meridionalis 30.22 6.00e-36 145.00
IUUC-Oni-082985 Oryza nivara 30.22 5.00e-36 145.00
IUUC-Opu-084159 Oryza punctata 32.07 2.00e-37 149.00
IUUC-Oru-085137 Oryza rufipogon 30.22 3.00e-36 146.00
IUUC-Osa-085614 Oryza sativa 30.22 3.00e-36 146.00
IUUC-Ola-087044 Oryzias latipes 57.72 7.00e-139 486.00
IUUC-Oga-088274 Otolemur garnettii 62.23 1.00e-135 475.00
IUUC-Oar-089826 Ovis aries 51.79 2.00e-131 462.00
IUUC-Ptr-091631 Pan troglodytes 60.33 5.00e-133 467.00
IUUC-Pan-092535 Papio anubis 59.78 6.00e-133 467.00
IUUC-Psi-093815 Pelodiscus sinensis 84.63 0.00e+00 799.00
IUUC-Pma-094474 Petromyzon marinus 55.98 1.00e-122 432.00
IUUC-Ppa-095414 Physcomitrella patens 33.43 7.00e-40 158.00
IUUC-Pfo-096559 Poecilia formosa 55.29 2.00e-140 492.00
IUUC-Pab-098528 Pongo abelii 60.05 7.00e-133 466.00
IUUC-Pop-100064 Populus trichocarpa 32.57 6.00e-41 161.00
IUUC-Pca-100803 Procavia capensis 59.89 1.00e-125 442.00
IUUC-Ppe-101966 Prunus persica 35.56 4.00e-44 172.00
IUUC-Pva-103213 Pteropus vampyrus 59.24 1.00e-125 442.00
IUUC-Rno-105087 Rattus norvegicus 54.55 5.00e-128 450.00
IUUC-Sha-107466 Sarcophilus harrisii 64.06 1.00e-145 509.00
IUUC-Smo-108958 Selaginella moellendorffii 31.30 2.00e-37 149.00
IUUC-Sit-109968 Setaria italica 31.62 7.00e-35 141.00
IUUC-Sly-111495 Solanum lycopersicum 32.45 2.00e-39 156.00
IUUC-Sar-113272 Sorex araneus 58.94 1.00e-121 429.00
IUUC-Sbi-114706 Sorghum bicolor 28.22 5.00e-31 129.00
IUUC-Ssc-115437 Sus scrofa 52.01 2.00e-126 445.00
IUUC-Tgu-116602 Taeniopygia guttata 85.56 0.00e+00 787.00
IUUC-Tru-118698 Takifugu rubripes 60.54 1.00e-124 439.00
IUUC-Tsy-119027 Tarsius syrichta 57.94 1.00e-111 395.00
IUUC-Tni-119787 Tetraodon nigroviridis 61.00 2.00e-135 475.00
IUUC-Tca-121447 Theobroma cacao 34.55 8.00e-43 167.00
IUUC-Tae-123253 Triticum aestivum 31.31 1.00e-38 154.00
IUUC-Tur-126724 Triticum urartu 32.87 6.00e-38 151.00
IUUC-Tbe-127680 Tupaia belangeri 57.45 5.00e-94 337.00
IUUC-Ttr-128201 Tursiops truncatus 45.09 3.00e-101 361.00
IUUC-Vpa-130451 Vicugna pacos 72.86 1.00e-27 117.00
IUUC-Vvi-131001 Vitis vinifera 36.15 1.00e-46 180.00
IUUC-Xtr-132266 Xenopus tropicalis 68.41 2.00e-158 551.00
IUUC-Xma-133034 Xiphophorus maculatus 58.47 5.00e-131 461.00
Created Date 25-Jun-2017

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