iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132655

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

F-box and WD repeat domain-containing 4

Genbank Nucleotide ID

AAMC01062444

Gene Name

fbxw4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000021190.3	ENSXETT00000045813.3	ENSXETP00000045813.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-18	65.4	201	230
E3 adaptor/Cullin RING/SCF/F-box	5.80e-06	26.6	27	71

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDlr 31
           H  +v+c++    +++vsGs+D t kvW+l+
   Q: 201  HDQDVNCVDChR-GIIVSGSRDRTAKVWSLT 230
           9999*****944.9***************97 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           +l +lpeeil+  +++ld++ l+r+a+vcr++q+++s++a+w+++
   Q: 27   HLLHLPEEILLLLFSYLDTQALGRLAQVCRKLQHFTSKDAVWRKI 71
           45789*************************************987 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

EQTLARVLPD WERPAPGEQL RSAMWPHLLH LPEEILLLLF SYLDTQALGR LAQVCRKLQH 60
FTSKDAVWRK IAKKCLNSGF VQQGTDVASW ISVKERVRVS QNWKNGRCRR NILLKWKRNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCAGACAC TGGCTAGAGT ACTGCCAGAC TGGGAACGTC CGGCCCCGGG AGAGCAGCTC 60
CGCTCCGCTA TGTGGCCCCA CTTGCTGCAC TTGCCCGAGG AAATCCTTCT GCTCCTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002129	Ailuropoda melanoleuca	66.94	1.00e-148	519.00
IUUC-Apl-003837	Anas platyrhynchos	75.24	6.00e-145	506.00
IUUC-Aca-004776	Anolis carolinensis	70.54	1.00e-145	509.00
IUUC-Ame-010651	Astyanax mexicanus	62.62	7.00e-113	400.00
IUUC-Bta-013495	Bos taurus	67.12	4.00e-141	494.00
IUUC-Cja-018901	Callithrix jacchus	66.67	2.00e-138	485.00
IUUC-Cfa-021251	Canis familiaris	66.94	4.00e-148	518.00
IUUC-Cpo-021750	Cavia porcellus	67.40	3.00e-129	454.00
IUUC-Csa-024026	Chlorocebus sabaeus	66.39	4.00e-147	514.00
IUUC-Cho-024496	Choloepus hoffmanni	50.27	1.00e-97	349.00
IUUC-Cin-025142	Ciona intestinalis	31.89	8.00e-28	117.00
IUUC-Csv-025883	Ciona savignyi	38.13	2.00e-66	246.00
IUUC-Dre-027447	Danio rerio	60.10	1.00e-133	469.00
IUUC-Dno-029572	Dasypus novemcinctus	58.26	9.00e-112	397.00
IUUC-Dor-030982	Dipodomys ordii	61.48	6.00e-130	457.00
IUUC-Ete-032917	Echinops telfairi	67.71	2.00e-130	457.00
IUUC-Eca-033969	Equus caballus	67.49	5.00e-140	490.00
IUUC-Eeu-034850	Erinaceus europaeus	62.84	2.00e-130	458.00
IUUC-Fca-036182	Felis catus	64.23	2.00e-135	475.00
IUUC-Fal-037391	Ficedula albicollis	71.31	2.00e-152	531.00
IUUC-Gmo-038632	Gadus morhua	57.14	5.00e-128	450.00
IUUC-Gga-040783	Gallus gallus	72.90	3.00e-159	554.00
IUUC-Gac-042314	Gasterosteus aculeatus	56.28	6.00e-113	400.00
IUUC-Ggo-044739	Gorilla gorilla	66.12	6.00e-146	510.00
IUUC-Hsa-046705	Homo sapiens	66.39	2.00e-138	484.00
IUUC-Itr-048014	Ictidomys tridecemlineatus	68.18	5.00e-116	410.00
IUUC-Loc-052397	Lepisosteus oculatus	66.67	2.00e-140	491.00
IUUC-Laf-054544	Loxodonta africana	67.60	2.00e-129	454.00
IUUC-Meu-056363	Macropus eugenii	57.19	5.00e-90	324.00
IUUC-Mga-059275	Meleagris gallopavo	74.92	5.00e-144	503.00
IUUC-Mmr-060906	Microcebus murinus	65.57	3.00e-145	508.00
IUUC-Mdo-062400	Monodelphis domestica	72.43	8.00e-162	563.00
IUUC-Mmu-063556	Mus musculus	66.94	7.00e-146	509.00
IUUC-Mpu-066500	Mustela putorius furo	66.67	5.00e-148	516.00
IUUC-Mlu-068074	Myotis lucifugus	67.71	2.00e-131	461.00
IUUC-Nle-069601	Nomascus leucogenys	66.12	4.00e-146	510.00
IUUC-Opr-070904	Ochotona princeps	61.21	3.00e-100	358.00
IUUC-Ont-072679	Oreochromis niloticus	57.81	6.00e-125	440.00
IUUC-Oan-073434	Ornithorhynchus anatinus	65.58	1.00e-78	285.00
IUUC-Ocu-074649	Oryctolagus cuniculus	66.39	5.00e-142	496.00
IUUC-Ola-087336	Oryzias latipes	51.57	3.00e-106	378.00
IUUC-Oga-088590	Otolemur garnettii	65.57	2.00e-135	475.00
IUUC-Oar-090178	Ovis aries	65.05	7.00e-131	460.00
IUUC-Pan-092881	Papio anubis	66.39	3.00e-146	511.00
IUUC-Pfo-096176	Poecilia formosa	55.79	3.00e-117	415.00
IUUC-Pab-098285	Pongo abelii	66.12	3.00e-146	511.00
IUUC-Pca-100888	Procavia capensis	62.87	7.00e-133	466.00
IUUC-Pva-102184	Pteropus vampyrus	56.83	2.00e-114	405.00
IUUC-Rno-105668	Rattus norvegicus	66.39	2.00e-145	508.00
IUUC-Sha-106629	Sarcophilus harrisii	73.44	2.00e-142	498.00
IUUC-Ssc-116183	Sus scrofa	67.48	3.00e-149	521.00
IUUC-Tgu-116630	Taeniopygia guttata	72.63	2.00e-167	581.00
IUUC-Tru-118761	Takifugu rubripes	54.05	2.00e-118	419.00
IUUC-Tni-120651	Tetraodon nigroviridis	53.96	6.00e-64	236.00
IUUC-Ttr-128582	Tursiops truncatus	67.12	2.00e-138	484.00
IUUC-Vpa-130431	Vicugna pacos	55.70	6.00e-67	247.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence