iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000001786.14	ENSMUST00000130320.7	ENSMUSP00000120840.1
ENSMUSG00000001786.14	ENSMUST00000001837.13	ENSMUSP00000001837.7
ENSMUSG00000001786.14	ENSMUST00000147168.1	ENSMUSP00000119334.1
ENSMUSG00000001786.14	ENSMUST00000120344.7	ENSMUSP00000113222.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	UniProt	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	72.90	0.00e+00	773.00	IUUC-Hsa-046348

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity).

Protein Sequence
(Fasta)

MKLRVRLQKR TQPLEVPESE PTLGQLRAHL SQVLLPTLGF SSDTRFAITL NNKDALTGDE 60
ETLASYGIVS GDLICLVLED DMPAPNLPSS TDTEHSSLQD NDQPSLAATP SQTNIPDEQG 120

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Nucleotide Sequence
(Fasta)

GCTTTCGGTT TCTTCCCGGG GCCGACCGAA GCTTGCGGTC CGACTCTCGC CATGAAGCTG 60
CGCGTGCGGC TTCAGAAGCG GACCCAGCCG CTCGAGGTGC CGGAGTCGGA GCCAACGCTC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0496--Mitochondrion
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR021625--PI31_Prot_N
IPR029071--Ubiquitin-rel_dom

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF11566--PI31_Prot_N

Gene Ontology

GO:0097414--C:classical Lewy body
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0097409--C:glial cytoplasmic inclusion
GO:1990037--C:Lewy body core
GO:1990038--C:Lewy body corona
GO:0097462--C:Lewy neurite
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0046982--F:protein heterodimerization activity
GO:0019901--F:protein kinase binding
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000422--P:mitophagy
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000134--P:negative regulation of G1/S transition of mitotic cell cycle
GO:0045620--P:negative regulation of lymphocyte differentiation
GO:1903204--P:negative regulation of oxidative stress-induced neuron death
GO:1903599--P:positive regulation of mitophagy
GO:0006626--P:protein targeting to mitochondrion
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0040012--P:regulation of locomotion
GO:0010975--P:regulation of neuron projection development
GO:0031647--P:regulation of protein stability

KEGG

mmu:69754

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000290	Aegilops tauschii	23.01	4.00e-04	38.90
IUUC-Aml-001880	Ailuropoda melanoleuca	74.43	3.00e-171	594.00
IUUC-Atr-003003	Amborella trichopoda	25.64	9.00e-08	52.00
IUUC-Apl-003234	Anas platyrhynchos	59.55	1.00e-147	516.00
IUUC-Aca-004673	Anolis carolinensis	56.36	1.00e-138	486.00
IUUC-Ath-007055	Arabidopsis thaliana	24.07	3.00e-11	63.20
IUUC-Ang-009828	Aspergillus niger	33.93	1.60e-01	30.40
IUUC-Ame-011733	Astyanax mexicanus	40.77	1.00e-68	253.00
IUUC-Bta-013386	Bos taurus	72.33	0.00e+00	668.00
IUUC-Bdi-014029	Brachypodium distachyon	18.92	7.00e-04	38.90
IUUC-Bol-015733	Brassica oleracea	25.52	1.00e-11	64.30
IUUC-Bra-016639	Brassica rapa	24.25	1.00e-06	47.80
IUUC-Cja-019301	Callithrix jacchus	75.38	0.00e+00	778.00
IUUC-Cfa-020474	Canis familiaris	74.24	0.00e+00	694.00
IUUC-Cpo-021958	Cavia porcellus	69.01	0.00e+00	725.00
IUUC-Csa-023971	Chlorocebus sabaeus	73.85	0.00e+00	727.00
IUUC-Cho-024677	Choloepus hoffmanni	71.63	1.00e-114	406.00
IUUC-Cin-025781	Ciona intestinalis	30.68	1.00e-44	174.00
IUUC-Csv-025989	Ciona savignyi	29.07	2.00e-23	102.00
IUUC-Dre-027820	Danio rerio	42.49	5.00e-34	138.00
IUUC-Dno-029936	Dasypus novemcinctus	68.55	0.00e+00	679.00
IUUC-Dor-030716	Dipodomys ordii	75.93	0.00e+00	667.00
IUUC-Ete-032853	Echinops telfairi	58.31	1.00e-110	393.00
IUUC-Eca-034267	Equus caballus	76.45	0.00e+00	632.00
IUUC-Eeu-035344	Erinaceus europaeus	71.43	6.00e-92	331.00
IUUC-Fca-035849	Felis catus	72.16	0.00e+00	660.00
IUUC-Fal-037612	Ficedula albicollis	57.64	3.00e-137	481.00
IUUC-Gmo-039634	Gadus morhua	51.22	4.00e-20	91.70
IUUC-Gga-041190	Gallus gallus	57.84	5.00e-149	521.00
IUUC-Gac-042001	Gasterosteus aculeatus	39.19	1.00e-70	260.00
IUUC-Ggo-044544	Gorilla gorilla	72.90	0.00e+00	717.00
IUUC-Hsa-046348	Homo sapiens	72.90	0.00e+00	717.00
IUUC-Itr-048160	Ictidomys tridecemlineatus	78.38	0.00e+00	660.00
IUUC-Lch-049937	Latimeria chalumnae	48.78	2.00e-99	356.00
IUUC-Loc-052097	Lepisosteus oculatus	46.64	5.00e-88	318.00
IUUC-Lma-052967	Leptosphaeria maculans	30.43	4.00e-04	39.70
IUUC-Laf-053445	Loxodonta africana	72.85	0.00e+00	684.00
IUUC-Meu-055942	Macropus eugenii	54.13	3.00e-115	408.00
IUUC-Mtr-058475	Medicago truncatula	26.02	1.00e-08	54.30
IUUC-Mga-059897	Meleagris gallopavo	60.64	3.00e-111	395.00
IUUC-Mmr-061491	Microcebus murinus	77.10	0.00e+00	725.00
IUUC-Mdo-062549	Monodelphis domestica	64.72	4.00e-180	624.00
IUUC-Mac-064591	Musa acuminata	25.45	1.00e-08	54.70
IUUC-Mlu-067947	Myotis lucifugus	74.80	0.00e+00	635.00
IUUC-Nle-069189	Nomascus leucogenys	73.47	0.00e+00	720.00
IUUC-Opr-070340	Ochotona princeps	56.36	4.00e-54	205.00
IUUC-Ont-071633	Oreochromis niloticus	42.69	1.00e-80	294.00
IUUC-Oan-073153	Ornithorhynchus anatinus	63.86	7.00e-134	470.00
IUUC-Ocu-074367	Oryctolagus cuniculus	78.83	0.00e+00	629.00
IUUC-Oba-075835	Oryza barthii	20.15	3.00e-05	43.90
IUUC-Obr-076729	Oryza brachyantha	22.50	6.00e-07	48.90
IUUC-Ome-081758	Oryza meridionalis	20.45	1.00e-04	42.40
IUUC-Opu-083777	Oryza punctata	23.14	6.00e-06	46.60
IUUC-Oru-084872	Oryza rufipogon	19.39	9.00e-04	39.70
IUUC-Osa-086001	Oryza sativa	19.77	3.00e-04	40.00
IUUC-Ola-087349	Oryzias latipes	40.34	7.00e-67	248.00
IUUC-Oga-088097	Otolemur garnettii	75.72	0.00e+00	712.00
IUUC-Oar-089633	Ovis aries	73.43	0.00e+00	676.00
IUUC-Ptr-091253	Pan troglodytes	72.71	0.00e+00	714.00
IUUC-Pan-092709	Papio anubis	73.66	0.00e+00	724.00
IUUC-Pma-094225	Petromyzon marinus	36.85	1.00e-73	270.00
IUUC-Ppa-095848	Physcomitrella patens	23.53	1.00e-06	48.10
IUUC-Pfo-096303	Poecilia formosa	43.46	2.00e-65	243.00
IUUC-Pab-098160	Pongo abelii	73.08	0.00e+00	657.00
IUUC-Pop-099047	Populus trichocarpa	25.94	1.00e-13	71.60
IUUC-Pca-100918	Procavia capensis	71.35	1.00e-118	419.00
IUUC-Ppe-101570	Prunus persica	22.82	5.00e-09	55.80
IUUC-Pva-103142	Pteropus vampyrus	75.98	0.00e+00	660.00
IUUC-Rno-105527	Rattus norvegicus	90.25	0.00e+00	937.00
IUUC-Sha-106501	Sarcophilus harrisii	60.48	8.00e-147	513.00
IUUC-Smo-108975	Selaginella moellendorffii	26.16	1.00e-06	45.80
IUUC-Sly-111386	Solanum lycopersicum	25.10	8.00e-10	58.50
IUUC-Stu-112530	Solanum tuberosum	26.03	4.00e-20	92.80
IUUC-Sar-113529	Sorex araneus	71.90	0.00e+00	641.00
IUUC-Ssc-116130	Sus scrofa	76.28	0.00e+00	726.00
IUUC-Tgu-116850	Taeniopygia guttata	56.33	2.00e-137	482.00
IUUC-Tru-117759	Takifugu rubripes	39.44	4.00e-67	248.00
IUUC-Tni-120308	Tetraodon nigroviridis	38.88	1.00e-55	210.00
IUUC-Tca-120980	Theobroma cacao	25.11	2.00e-11	64.30
IUUC-Tae-123742	Triticum aestivum	23.91	1.00e-05	44.70
IUUC-Tbe-127805	Tupaia belangeri	73.55	8.00e-134	470.00
IUUC-Ttr-129004	Tursiops truncatus	75.57	0.00e+00	663.00
IUUC-Vpa-130452	Vicugna pacos	77.85	0.00e+00	648.00
IUUC-Vvi-131289	Vitis vinifera	23.64	2.00e-12	67.40
IUUC-Xtr-132447	Xenopus tropicalis	46.08	4.00e-111	395.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence