iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089797

Ensembl Protein ID

ENSOARP00000022451.1

UniProt Accession

W5QI99; W5QI99_SHEEP

Genbank Protein ID

ENSOARP00000022451

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01103363

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000020889.1	ENSOART00000022759.1	ENSOARP00000022451.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.00e-135	450.7	518	847

Active Site

Position(s)	Description	Evidence
817	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld ++
   Q: 518  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 606
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk+gG++i Vtn+Nk+eY+ lv+++r
   Q: 607  IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFVIDEELFGQTHQHELKSGGSEIVVTNKNKKEYIYLVIQWR 690
           *********************************99...6666..79******************************************* PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy+ ++++iqwFw+++ +++se+r ++LqFvTg
   Q: 691  FVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSINHQVIQWFWKAVLMMDSEKRIRLLQFVTG 779
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 780  TSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 847
           *******************************************************************8 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MNGIFTSVQT KTIKKTLNPK WNEEILFRVH PQQHRLLFEV FDENRLTRDD FLGQVDVPLY 60
PLPTENPRME RPYTFKDFVL HPRSHKSRVK GYLRLKMTYL PKTSGSEDDN TEQAEELEPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAAAATTC CCGAATTGTG AGGGTAAAAG TTATAGCTGG AATAGGCCTT GCCAAAAAGG 60
ATATCTTGGG AGCTAGGTAA GTATAATAAG TTGGGATGCA ATTTTAAAAC TTTGTATTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0016020--C:membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0003197--P:endocardial cushion development
GO:0010766--P:negative regulation of sodium ion transport
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0003151--P:outflow tract morphogenesis
GO:0045732--P:positive regulation of protein catabolic process
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0048814--P:regulation of dendrite morphogenesis
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	95.52	0.00e+00	1551.00
IUUC-Apl-003886	Anas platyrhynchos	76.29	0.00e+00	1354.00
IUUC-Ame-011138	Astyanax mexicanus	83.75	0.00e+00	844.00
IUUC-Bta-012453	Bos taurus	97.40	0.00e+00	1517.00
IUUC-Bci-013785	Botrytis cinerea	47.08	6.00e-157	548.00
IUUC-Cja-019034	Callithrix jacchus	93.14	0.00e+00	1404.00
IUUC-Cfa-020258	Canis familiaris	94.78	0.00e+00	1478.00
IUUC-Cpo-021648	Cavia porcellus	90.00	0.00e+00	1534.00
IUUC-Csa-023334	Chlorocebus sabaeus	94.82	0.00e+00	1573.00
IUUC-Cin-025157	Ciona intestinalis	56.07	0.00e+00	929.00
IUUC-Dre-027924	Danio rerio	67.62	0.00e+00	971.00
IUUC-Dno-029159	Dasypus novemcinctus	89.81	0.00e+00	1336.00
IUUC-Ete-032409	Echinops telfairi	86.08	0.00e+00	1176.00
IUUC-Eca-033441	Equus caballus	95.41	0.00e+00	1550.00
IUUC-Eeu-034546	Erinaceus europaeus	74.97	0.00e+00	1181.00
IUUC-Fca-036384	Felis catus	95.16	0.00e+00	1532.00
IUUC-Fal-037547	Ficedula albicollis	80.99	0.00e+00	1390.00
IUUC-Gmo-039679	Gadus morhua	68.43	0.00e+00	1153.00
IUUC-Gga-040524	Gallus gallus	82.63	0.00e+00	1402.00
IUUC-Gac-042607	Gasterosteus aculeatus	66.67	0.00e+00	1163.00
IUUC-Hsa-046479	Homo sapiens	95.02	0.00e+00	1532.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	82.10	0.00e+00	1194.00
IUUC-Lch-050445	Latimeria chalumnae	72.84	0.00e+00	1196.00
IUUC-Loc-052645	Lepisosteus oculatus	73.60	0.00e+00	1266.00
IUUC-Laf-053638	Loxodonta africana	85.12	0.00e+00	1347.00
IUUC-Mcc-055585	Macaca mulatta	94.28	0.00e+00	1500.00
IUUC-Meu-056897	Macropus eugenii	95.12	8.00e-170	591.00
IUUC-Mla-058996	Melampsora laricipopulina	46.94	7.00e-154	537.00
IUUC-Mga-059362	Meleagris gallopavo	76.67	0.00e+00	1373.00
IUUC-Mmr-061061	Microcebus murinus	94.78	0.00e+00	1564.00
IUUC-Mdo-062178	Monodelphis domestica	69.32	0.00e+00	1213.00
IUUC-Mmu-063318	Mus musculus	80.24	0.00e+00	1343.00
IUUC-Mpu-066567	Mustela putorius furo	95.08	0.00e+00	1634.00
IUUC-Mlu-068148	Myotis lucifugus	95.02	0.00e+00	1502.00
IUUC-Nle-069225	Nomascus leucogenys	95.27	0.00e+00	1546.00
IUUC-Oan-073019	Ornithorhynchus anatinus	85.31	0.00e+00	1454.00
IUUC-Ocu-074409	Oryctolagus cuniculus	93.91	0.00e+00	1509.00
IUUC-Oga-088241	Otolemur garnettii	87.84	0.00e+00	1343.00
IUUC-Ptr-091629	Pan troglodytes	93.41	0.00e+00	1373.00
IUUC-Psi-093618	Pelodiscus sinensis	84.10	0.00e+00	1335.00
IUUC-Pfo-097145	Poecilia formosa	67.88	0.00e+00	1137.00
IUUC-Pab-098394	Pongo abelii	94.35	0.00e+00	1582.00
IUUC-Pca-100568	Procavia capensis	78.58	0.00e+00	1156.00
IUUC-Rno-106095	Rattus norvegicus	80.12	0.00e+00	1347.00
IUUC-Sha-107370	Sarcophilus harrisii	79.38	0.00e+00	1346.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.54	1.00e-156	546.00
IUUC-Tgu-117474	Taeniopygia guttata	82.28	0.00e+00	1399.00
IUUC-Tru-117675	Takifugu rubripes	65.72	0.00e+00	1135.00
IUUC-Tni-119993	Tetraodon nigroviridis	65.30	0.00e+00	1127.00
IUUC-Tre-122203	Trichoderma reesei	46.70	9.00e-152	530.00
IUUC-Tbe-127408	Tupaia belangeri	86.83	0.00e+00	1158.00
IUUC-Ttr-128437	Tursiops truncatus	87.57	0.00e+00	1231.00
IUUC-Vpa-130503	Vicugna pacos	91.46	0.00e+00	1305.00
IUUC-Xtr-132431	Xenopus tropicalis	71.46	0.00e+00	1274.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence