iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.40e-16	59.1	80	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgv 34
           gH + v ++++   +d  ++s+s D tik+W++ ++ 
   Q: 80   GHRGNVLDVKWnpfDDFEIASCSEDATIKIWSIPKQL 116
           8**********99665779************987665 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSWHPQYRSS KFRHVFGKPA SKENCYDSVP ITRSVHDNHF CAVNPHFIAV VTECAGGGAF 60
LVIPLHQTGK LDPHYPKVCG HRGNVLDVKW NPFDDFEIAS CSEDATIKIW SIPKQLLTRN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGAGTCGG CGGGCGGCGA GGAGCGCGGA GCCGGAGCTG GACGCCGCCG CCGCCACCGC 60
CACCTGCGCG GCAGTCATCA AGGTAGGGCG GCCCTGCGCC GCCGGCCGTG CCTTCCCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR027335--CORO2A
IPR015505--Coronin
IPR015048--DUF1899
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0017053--C:transcriptional repressor complex
GO:0051015--F:actin filament binding
GO:0030036--P:actin cytoskeleton organization
GO:0035556--P:intracellular signal transduction

KEGG

hsa:7464

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001912	Ailuropoda melanoleuca	80.99	0.00e+00	887.00
IUUC-Aca-005075	Anolis carolinensis	73.47	0.00e+00	777.00
IUUC-Bta-012783	Bos taurus	86.86	0.00e+00	973.00
IUUC-Cja-019159	Callithrix jacchus	89.92	0.00e+00	892.00
IUUC-Cfa-020284	Canis familiaris	83.43	0.00e+00	853.00
IUUC-Cpo-021367	Cavia porcellus	88.38	0.00e+00	897.00
IUUC-Csa-023565	Chlorocebus sabaeus	97.71	0.00e+00	1031.00
IUUC-Dre-028349	Danio rerio	65.15	0.00e+00	718.00
IUUC-Dor-030775	Dipodomys ordii	81.11	0.00e+00	806.00
IUUC-Ete-032668	Echinops telfairi	82.31	0.00e+00	683.00
IUUC-Eca-034079	Equus caballus	89.29	0.00e+00	947.00
IUUC-Eeu-034643	Erinaceus europaeus	68.63	7.00e-129	454.00
IUUC-Fca-036478	Felis catus	86.10	0.00e+00	917.00
IUUC-Fal-037451	Ficedula albicollis	71.24	0.00e+00	746.00
IUUC-Gmo-039434	Gadus morhua	63.58	0.00e+00	699.00
IUUC-Gga-040488	Gallus gallus	72.50	0.00e+00	774.00
IUUC-Gac-041523	Gasterosteus aculeatus	63.01	0.00e+00	702.00
IUUC-Ggo-045423	Gorilla gorilla	98.48	0.00e+00	1039.00
IUUC-Itr-048854	Ictidomys tridecemlineatus	86.12	0.00e+00	769.00
IUUC-Lch-050184	Latimeria chalumnae	70.13	0.00e+00	778.00
IUUC-Loc-052734	Lepisosteus oculatus	67.69	0.00e+00	725.00
IUUC-Laf-054380	Loxodonta africana	87.43	0.00e+00	921.00
IUUC-Mcc-054684	Macaca mulatta	97.71	0.00e+00	1032.00
IUUC-Meu-056001	Macropus eugenii	59.08	1.00e-161	563.00
IUUC-Mmr-061399	Microcebus murinus	90.86	0.00e+00	979.00
IUUC-Mdo-062623	Monodelphis domestica	80.69	0.00e+00	866.00
IUUC-Mmu-064299	Mus musculus	85.74	0.00e+00	909.00
IUUC-Mpu-065745	Mustela putorius furo	81.56	0.00e+00	834.00
IUUC-Mlu-068024	Myotis lucifugus	90.44	0.00e+00	927.00
IUUC-Nle-069335	Nomascus leucogenys	98.10	0.00e+00	1033.00
IUUC-Opr-070973	Ochotona princeps	81.91	0.00e+00	665.00
IUUC-Ont-072630	Oreochromis niloticus	62.01	0.00e+00	703.00
IUUC-Ocu-074195	Oryctolagus cuniculus	88.74	0.00e+00	935.00
IUUC-Ola-087230	Oryzias latipes	64.37	0.00e+00	712.00
IUUC-Oga-088250	Otolemur garnettii	88.57	0.00e+00	951.00
IUUC-Oar-089411	Ovis aries	86.67	0.00e+00	971.00
IUUC-Ptr-090596	Pan troglodytes	99.62	0.00e+00	1050.00
IUUC-Pan-092015	Papio anubis	97.52	0.00e+00	1029.00
IUUC-Psi-094029	Pelodiscus sinensis	73.28	0.00e+00	788.00
IUUC-Pfo-097349	Poecilia formosa	62.78	0.00e+00	705.00
IUUC-Pab-098296	Pongo abelii	98.29	0.00e+00	1038.00
IUUC-Pca-100626	Procavia capensis	78.85	0.00e+00	671.00
IUUC-Pgr-103354	Puccinia graminis	41.59	8.00e-93	334.00
IUUC-Ptt-103735	Puccinia triticina	35.36	2.00e-70	260.00
IUUC-Rno-105241	Rattus norvegicus	86.76	0.00e+00	915.00
IUUC-Sar-113419	Sorex araneus	68.21	6.00e-152	530.00
IUUC-Ssc-115919	Sus scrofa	90.10	0.00e+00	919.00
IUUC-Tgu-116680	Taeniopygia guttata	67.30	0.00e+00	724.00
IUUC-Tru-118719	Takifugu rubripes	64.74	0.00e+00	714.00
IUUC-Tni-120171	Tetraodon nigroviridis	65.70	0.00e+00	717.00
IUUC-Tbe-127845	Tupaia belangeri	93.17	2.00e-178	619.00
IUUC-Ttr-129217	Tursiops truncatus	80.57	0.00e+00	849.00
IUUC-Vpa-130161	Vicugna pacos	66.87	2.00e-121	429.00
IUUC-Xtr-132099	Xenopus tropicalis	68.39	0.00e+00	761.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence