iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033391

Ensembl Protein ID

ENSECAP00000003149.1

UniProt Accession

F6SAM1; F6SAM1_HORSE

Protein Name

Uncharacterized protein

Gene Name

PSEN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000004387.1	ENSECAT00000004545.1	ENSECAP00000003149.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	8.30e-09	35.5	185	223

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e+++++FP+l+ys+++v+L++++  +++a+ +  
   Q: 185  VETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRKVS 223
           89****************************999998876 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MTILLVVLYK YRCYKVIHAW LIISSLLLLF FFSIIYLGEV FKTYNVAMDY ITVALLIWNF 60
GVVGMIAIHW KGPLRLQQAY LIMISALMAL VFIKYLPEWT AWLILAVISI YERSIFIHGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATGAGCACA GTAGCGAAAG GCGGAGGCGT GGCAACCCTG AGCCATTATC TAATGGACGA 60
CCCCAGAGTA ACTCTAACTC ACAGCAGGTG GTGGAGCAAG ATGAAGAAGA AGATGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

SMART

SM00730--PSN

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0030054--C:cell junction
GO:0005813--C:centrosome
GO:0035253--C:ciliary rootlet
GO:0031410--C:cytoplasmic vesicle
GO:0043198--C:dendritic shaft
GO:0005783--C:endoplasmic reticulum
GO:0070765--C:gamma-secretase complex
GO:0005794--C:Golgi apparatus
GO:0030426--C:growth cone
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0045121--C:membrane raft
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005640--C:nuclear outer membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0098793--C:presynapse
GO:0005791--C:rough endoplasmic reticulum
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0042500--F:aspartic endopeptidase activity, intramembrane cleaving
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0005262--F:calcium channel activity
GO:0004175--F:endopeptidase activity
GO:0000186--P:activation of MAPKK activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0000045--P:autophagosome assembly
GO:0034205--P:beta-amyloid formation
GO:0050435--P:beta-amyloid metabolic process
GO:0001568--P:blood vessel development
GO:0048854--P:brain morphogenesis
GO:0021870--P:Cajal-Retzius cell differentiation
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0001708--P:cell fate specification
GO:0006974--P:cellular response to DNA damage stimulus
GO:0021795--P:cerebral cortex cell migration
GO:0015871--P:choline transport
GO:0021904--P:dorsal/ventral neural tube patterning
GO:0030326--P:embryonic limb morphogenesis
GO:0050673--P:epithelial cell proliferation
GO:0001947--P:heart looping
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0015813--P:L-glutamate transport
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007613--P:memory
GO:0006839--P:mitochondrial transport
GO:0043011--P:myeloid dendritic cell differentiation
GO:0043066--P:negative regulation of apoptotic process
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0050771--P:negative regulation of axonogenesis
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0051402--P:neuron apoptotic process
GO:0048666--P:neuron development
GO:0001764--P:neuron migration
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0050820--P:positive regulation of coagulation
GO:0060999--P:positive regulation of dendritic spine development
GO:0043406--P:positive regulation of MAP kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001921--P:positive regulation of receptor recycling
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0009791--P:post-embryonic development
GO:0006486--P:protein glycosylation
GO:0016485--P:protein processing
GO:0015031--P:protein transport
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0043393--P:regulation of protein binding
GO:0060075--P:regulation of resting membrane potential
GO:0048167--P:regulation of synaptic plasticity
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0006979--P:response to oxidative stress
GO:0016337--P:single organismal cell-cell adhesion
GO:0048705--P:skeletal system morphogenesis
GO:0043589--P:skin morphogenesis
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis
GO:0001756--P:somitogenesis
GO:0016080--P:synaptic vesicle targeting
GO:0002286--P:T cell activation involved in immune response
GO:0050852--P:T cell receptor signaling pathway
GO:0048538--P:thymus development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001648	Ailuropoda melanoleuca	72.02	7.00e-123	433.00
IUUC-Aly-005455	Arabidopsis lyrata	32.81	2.00e-19	90.10
IUUC-Ath-006730	Arabidopsis thaliana	34.38	3.00e-19	89.40
IUUC-Bdi-014196	Brachypodium distachyon	26.63	1.00e-20	94.40
IUUC-Bol-015841	Brassica oleracea	34.19	2.00e-20	93.20
IUUC-Bra-017580	Brassica rapa	47.93	2.00e-17	83.60
IUUC-Cpo-022237	Cavia porcellus	73.92	9.00e-128	449.00
IUUC-Ete-032487	Echinops telfairi	79.52	2.00e-77	282.00
IUUC-Eeu-035134	Erinaceus europaeus	70.96	3.00e-114	404.00
IUUC-Hvu-047141	Hordeum vulgare	36.89	4.00e-18	85.90
IUUC-Itr-048420	Ictidomys tridecemlineatus	73.16	1.00e-126	445.00
IUUC-Oan-072783	Ornithorhynchus anatinus	67.85	7.00e-108	383.00
IUUC-Opu-084176	Oryza punctata	32.68	6.00e-18	85.10
IUUC-Pva-102244	Pteropus vampyrus	65.79	3.00e-102	365.00
IUUC-Sit-110624	Setaria italica	34.24	4.00e-18	85.90
IUUC-Sar-113169	Sorex araneus	67.19	2.00e-103	369.00
IUUC-Sbi-114305	Sorghum bicolor	30.95	2.00e-17	83.20
IUUC-Tgu-116469	Taeniopygia guttata	67.74	3.00e-110	391.00
IUUC-Tae-125925	Triticum aestivum	35.22	8.00e-19	88.20
IUUC-Tur-126237	Triticum urartu	34.98	3.00e-18	85.90
IUUC-Ttr-128793	Tursiops truncatus	73.39	2.00e-122	432.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence