iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mac-065544

Ensembl Protein ID

GSMUA_Achr6P05400_001

UniProt Accession

M0T4D8; M0T4D8_MUSAM

Protein Name

Coatomer subunit beta'

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
GSMUA_Achr6G05400_001	GSMUA_Achr6T05400_001	GSMUA_Achr6P05400_001

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-30	104.7	266	306
UBD/Beta-Prp	6.10e-58	197.2	127	371

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+ +v+c+++    d ++l++GsdD t kvWD+ t  ++++
   Q: 266  HSKGVNCVDYftgGDrPYLITGSDDQTAKVWDYQTKSCVQT 306
           999*****966*9778*******************999986 PP

UBD/Beta-Prp

   S: 40   ttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgq 127
           ++ ++++s++  e +v++ kf+ ++++ v g++D++i+v++++t + + ++++h+d++++++++p+   ++s s+d  i++wd+++g+
   Q: 127  ENSTMVKSFEVTELPVRSAKFIARKQWVVAGADDMFIRVYNYNTMDKIKVFEAHTDYIRCVAVHPTLPCVLSSSDDMLIKLWDWDKGW 214
           566779999******************************************************************************* PP
   S: 128  cleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvysls..fdsngkelvsgsldgtvklwdlqtg 212
              ++++gh++ v+ v+++p++ n ++s+slDrtv++W+l + +   tl   h + v++++     ++++l++gs+d+t k+wd+qt+
   Q: 215  MCTQIFEGHSHYVMQVTFNPKDtNTFASASLDRTVKIWNLGSPDPNFTLDA-HSKGVNCVDyfTGGDRPYLITGSDDQTAKVWDYQTK 301
           9999*********************************************98.*********7445566******************** PP
   S: 213  ecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvl 282
           +cv+tl+ght nv+ v f+p+  ++++gs+Dg++riW  ++  l +tl++  ++v++v +++ +++v++ 
   Q: 302  SCVQTLEGHTHNVSAVCFHPELPIIITGSEDGTVRIWHATTYRLENTLNYGLERVWAVGYMKGSRRVVIG 371
           **********************************************************997766666654 PP

Organism

Musa acuminata

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

Protein Sequence
(Fasta)

MLGGPTQPTE IAISRFYMSS LLMVSRDPVE PKPSSSSRSI LSDGSGSLIR RFTPLRDFVL 60
RLRSKDASET GNQEETFSKV GKGEIGRSTS NRAMDSCESL FWYCLYLELS VTGKSLVLDM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTAGGAG GCCCAACACA GCCCACGGAA ATAGCAATCT CCCGATTCTA TATGTCCTCG 60
CTCTTGATGG TGTCTCGAGA TCCCGTAGAG CCAAAACCAT CCTCCTCGTC CCGATCCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030663--C:COPI-coated vesicle membrane
GO:0000139--C:Golgi membrane
GO:0030117--C:membrane coat
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Afl-008535	Aspergillus flavus	53.47	0.00e+00	862.00
IUUC-Bdi-014102	Brachypodium distachyon	84.06	0.00e+00	1508.00
IUUC-Eeu-035086	Erinaceus europaeus	49.79	2.00e-127	449.00
IUUC-Meu-056174	Macropus eugenii	51.46	2.00e-111	396.00
IUUC-Opu-083433	Oryza punctata	84.09	0.00e+00	1491.00
IUUC-Pno-094785	Phaeosphaeria nodorum	59.45	6.00e-104	370.00
IUUC-Stu-112906	Solanum tuberosum	81.28	0.00e+00	1431.00
IUUC-Sar-113472	Sorex araneus	57.10	0.00e+00	760.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence