iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066573

Ensembl Protein ID

ENSMPUP00000005434.1

UniProt Accession

M3Y283; M3Y283_MUSPF

Genbank Protein ID

ENSMPUP00000005434

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01026883

Gene Name

USP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000005475.1	ENSMPUT00000005525.1	ENSMPUP00000005434.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-98	330.4	269	598

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           Gl+NlgNtC+mNS+LQcLsn++elr+++l+  + ++l+++  ++ +++l+++++kl++ +w +s + +vsp+e++++++++a++f gy+
   Q: 269  GLRNLGNTCFMNSILQCLSNTRELRDYCLQrLYMRDLSHS--SSAHTALMEEFAKLIQTIWtSSPNDVVSPSEFKTQIQRYAPRFVGYN 355
           9*****************************7788888877..789****************889999********************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqDaqEfl+flld+l++e+++ +  pk++ e+ d+  l+d+      ++k  ++++s i dlF gqlks+++c +c+  s+ ++pf+dl
   Q: 356  QQDAQEFLRFLLDGLHNEVNRVTVRPKSNPENLDH--LPDDekgrqMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDL 442
           *******************9955555554444443..2222335559****************************************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ld 260
           slp+ ++    + +l dc++ ftke+ l+g++k  c +c++++++ kk++++++P++L+lhLkRf  se++ + +k+++ v+fpl+ Ld
   Q: 443  SLPIAKRGYP-EVTLMDCMRLFTKEDVLDGDEKPTCCRCRARKRCIKKFSIQRFPKILVLHLKRF--SESRIRTSKLTTFVNFPLRdLD 528
           ******9976.779***************************************************..88899***************** PP
   S: 261  lspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           l++f +++++    +  Y+L+av +HsG++ +GHY+ay+++  +g+W +f+Ds+Vt+++ ++v +   s+aY+lfY+
   Q: 529  LREFASENTN----HAVYNLYAVSNHSGTTMGGHYTAYCRSpVTGEWHTFNDSSVTPMSSSQVRT---SDAYLLFYE 598
           ******9553....78*************************44666*******************...********8 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MSQLSSTLKR YTESAHYADA PYAKSGYGTY TPSSYGANLA ASFLEKEKLG FKPGPPTSFL 60
TRPRTYGPSS ILDYDRGRPL LRPDIIGGGK RAESQTRGTE RPSGSGLSGG SGFPYGVTNN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTAAATCAC TAAGGTTCCG ATGGCTTACA TGACTTTCCC ACTGTCTGAG AGCCAATAAA 60
AGGGAAAGAA CAGGAATACA TGCCCAGGCC TAGAAGTCCA TTAGAAAAGA GTTTGGACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005938--C:cell cortex
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0032922--P:circadian regulation of gene expression
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0045475--P:locomotor rhythm
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001988	Ailuropoda melanoleuca	96.53	0.00e+00	1123.00
IUUC-Aca-005132	Anolis carolinensis	60.84	0.00e+00	687.00
IUUC-Ame-011102	Astyanax mexicanus	75.50	3.00e-145	508.00
IUUC-Bta-012529	Bos taurus	93.40	0.00e+00	1026.00
IUUC-Bra-016678	Brassica rapa	35.67	6.00e-47	181.00
IUUC-Cja-019016	Callithrix jacchus	90.66	0.00e+00	1027.00
IUUC-Cfa-020714	Canis familiaris	96.20	0.00e+00	1125.00
IUUC-Cpo-021727	Cavia porcellus	91.09	0.00e+00	1046.00
IUUC-Csa-023071	Chlorocebus sabaeus	98.56	0.00e+00	686.00
IUUC-Cin-025797	Ciona intestinalis	50.43	1.00e-95	342.00
IUUC-Csv-026132	Ciona savignyi	51.48	6.00e-98	351.00
IUUC-Dre-027872	Danio rerio	81.82	1.00e-163	569.00
IUUC-Dno-029329	Dasypus novemcinctus	94.22	0.00e+00	1090.00
IUUC-Dor-030574	Dipodomys ordii	93.40	0.00e+00	1041.00
IUUC-Dme-032208	Drosophila melanogaster	47.63	7.00e-83	302.00
IUUC-Ete-032725	Echinops telfairi	82.81	1.00e-179	622.00
IUUC-Eca-033361	Equus caballus	96.86	0.00e+00	1125.00
IUUC-Eeu-035272	Erinaceus europaeus	79.13	0.00e+00	713.00
IUUC-Fca-036497	Felis catus	97.52	0.00e+00	1136.00
IUUC-Fal-036766	Ficedula albicollis	64.44	0.00e+00	680.00
IUUC-Gmo-039129	Gadus morhua	66.77	3.00e-123	434.00
IUUC-Gga-040889	Gallus gallus	84.16	2.00e-148	519.00
IUUC-Gac-042475	Gasterosteus aculeatus	70.40	1.00e-137	483.00
IUUC-Ggo-044814	Gorilla gorilla	92.53	8.00e-178	615.00
IUUC-Hsa-045937	Homo sapiens	92.90	0.00e+00	1047.00
IUUC-Itr-048171	Ictidomys tridecemlineatus	94.28	0.00e+00	1104.00
IUUC-Lch-050527	Latimeria chalumnae	61.52	0.00e+00	639.00
IUUC-Loc-052697	Lepisosteus oculatus	79.43	2.00e-162	565.00
IUUC-Laf-054167	Loxodonta africana	88.34	0.00e+00	1033.00
IUUC-Mcc-055584	Macaca mulatta	93.40	0.00e+00	1086.00
IUUC-Meu-056542	Macropus eugenii	86.49	0.00e+00	959.00
IUUC-Mga-060020	Meleagris gallopavo	60.32	0.00e+00	644.00
IUUC-Mmr-060989	Microcebus murinus	95.54	0.00e+00	1110.00
IUUC-Mdo-062761	Monodelphis domestica	86.33	0.00e+00	962.00
IUUC-Mmu-063710	Mus musculus	91.11	0.00e+00	1066.00
IUUC-Nle-070013	Nomascus leucogenys	92.89	0.00e+00	1020.00
IUUC-Opr-070907	Ochotona princeps	91.93	0.00e+00	1028.00
IUUC-Ont-071944	Oreochromis niloticus	82.13	3.00e-165	573.00
IUUC-Oan-073105	Ornithorhynchus anatinus	83.02	4.00e-147	513.00
IUUC-Ocu-073941	Oryctolagus cuniculus	93.74	0.00e+00	1075.00
IUUC-Ola-087412	Oryzias latipes	78.06	2.00e-151	529.00
IUUC-Oga-088973	Otolemur garnettii	95.05	0.00e+00	1107.00
IUUC-Oar-089916	Ovis aries	94.06	0.00e+00	1073.00
IUUC-Ptr-090998	Pan troglodytes	93.23	0.00e+00	1055.00
IUUC-Pan-092686	Papio anubis	93.56	0.00e+00	1087.00
IUUC-Psi-093284	Pelodiscus sinensis	72.01	6.00e-125	439.00
IUUC-Pma-094462	Petromyzon marinus	64.71	5.00e-74	270.00
IUUC-Pno-094986	Phaeosphaeria nodorum	32.11	1.00e-39	158.00
IUUC-Pfo-097352	Poecilia formosa	80.00	3.00e-167	581.00
IUUC-Pab-098688	Pongo abelii	86.96	0.00e+00	946.00
IUUC-Pca-100205	Procavia capensis	94.52	0.00e+00	649.00
IUUC-Pva-103188	Pteropus vampyrus	95.38	0.00e+00	1081.00
IUUC-Rno-105853	Rattus norvegicus	91.91	0.00e+00	1085.00
IUUC-Sha-107237	Sarcophilus harrisii	86.00	0.00e+00	956.00
IUUC-Sar-113103	Sorex araneus	91.64	0.00e+00	630.00
IUUC-Ssc-115955	Sus scrofa	96.20	0.00e+00	1092.00
IUUC-Tgu-116894	Taeniopygia guttata	69.28	2.00e-177	614.00
IUUC-Tru-117703	Takifugu rubripes	66.37	2.00e-134	471.00
IUUC-Tsy-118879	Tarsius syrichta	96.41	0.00e+00	838.00
IUUC-Tni-119866	Tetraodon nigroviridis	78.93	7.00e-154	536.00
IUUC-Tbe-127367	Tupaia belangeri	87.50	0.00e+00	694.00
IUUC-Ttr-128773	Tursiops truncatus	92.24	0.00e+00	1067.00
IUUC-Vpa-130402	Vicugna pacos	85.66	0.00e+00	810.00
IUUC-Xtr-132658	Xenopus tropicalis	57.84	1.00e-180	626.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence