iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048323

Ensembl Protein ID

ENSSTOP00000000574.2

UniProt Accession

I3LX27; I3LX27_ICTTR

Genbank Protein ID

ENSSTOP00000000574

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AGTP01092106

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000000630.2	ENSSTOT00000000630.2	ENSSTOP00000000574.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.80e-14	52.4	54	111

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++ v +lydy a+nd +L++ kG++++v+   ++ ++W+ +++  +g++G +P+nFv+ le
   Q: 54   EHFVVALYDYAAVNDRDLQMLKGEKLQVL---KETGDWWLAKSLVTGREGYVPSNFVAPLE 111
           57799************************...88899********************9986 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MGLLSSKRQV TEKGKGWSPL KIGTQSKDPP PLPPLVVFNH LTPPPPEEHP DREEHFVVAL 60
YDYAAVNDRD LQMLKGEKLQ VLKETGDWWL AKSLVTGREG YVPSNFVAPL ETLEVEKWFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTCTGC TCAGCAGCAA GAGGCAGGTC ACTGAGAAGG GCAAGGGCTG GAGCCCCTTG 60
AAGATCGGCA CCCAGAGCAA AGACCCCCCA CCACTGCCAC CCCTGGTGAG TGCCCAGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0050853--P:B cell receptor signaling pathway
GO:0032024--P:positive regulation of insulin secretion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	90.27	0.00e+00	905.00
IUUC-Apl-003307	Anas platyrhynchos	75.45	0.00e+00	732.00
IUUC-Aca-004357	Anolis carolinensis	68.83	0.00e+00	665.00
IUUC-Ame-010642	Astyanax mexicanus	70.67	0.00e+00	686.00
IUUC-Bta-012400	Bos taurus	88.02	0.00e+00	887.00
IUUC-Cja-019717	Callithrix jacchus	86.07	0.00e+00	691.00
IUUC-Cfa-021056	Canis familiaris	88.80	0.00e+00	910.00
IUUC-Cpo-021779	Cavia porcellus	88.98	0.00e+00	891.00
IUUC-Csa-023557	Chlorocebus sabaeus	91.51	0.00e+00	914.00
IUUC-Dre-027517	Danio rerio	68.40	0.00e+00	687.00
IUUC-Eca-034218	Equus caballus	89.03	0.00e+00	885.00
IUUC-Eeu-035095	Erinaceus europaeus	66.80	0.00e+00	657.00
IUUC-Fca-036015	Felis catus	88.80	0.00e+00	919.00
IUUC-Fal-036946	Ficedula albicollis	75.28	0.00e+00	725.00
IUUC-Gga-040822	Gallus gallus	74.83	0.00e+00	734.00
IUUC-Ggo-044608	Gorilla gorilla	91.78	0.00e+00	832.00
IUUC-Hsa-046719	Homo sapiens	90.48	0.00e+00	905.00
IUUC-Lch-050114	Latimeria chalumnae	72.87	0.00e+00	698.00
IUUC-Loc-052326	Lepisosteus oculatus	72.83	0.00e+00	711.00
IUUC-Laf-053387	Loxodonta africana	87.00	0.00e+00	888.00
IUUC-Mcc-055026	Macaca mulatta	91.30	0.00e+00	911.00
IUUC-Mga-059427	Meleagris gallopavo	74.83	0.00e+00	725.00
IUUC-Mmr-061660	Microcebus murinus	89.80	0.00e+00	887.00
IUUC-Mdo-062318	Monodelphis domestica	76.49	0.00e+00	791.00
IUUC-Mmu-063325	Mus musculus	88.98	0.00e+00	916.00
IUUC-Mpu-066582	Mustela putorius furo	90.06	0.00e+00	903.00
IUUC-Nle-069624	Nomascus leucogenys	91.29	0.00e+00	885.00
IUUC-Opr-070656	Ochotona princeps	83.37	0.00e+00	817.00
IUUC-Ont-072266	Oreochromis niloticus	69.47	0.00e+00	674.00
IUUC-Ocu-073907	Oryctolagus cuniculus	87.00	0.00e+00	874.00
IUUC-Oga-088057	Otolemur garnettii	89.02	0.00e+00	897.00
IUUC-Oar-089332	Ovis aries	83.43	0.00e+00	849.00
IUUC-Ptr-091551	Pan troglodytes	89.22	0.00e+00	863.00
IUUC-Pan-092173	Papio anubis	91.10	0.00e+00	885.00
IUUC-Psi-093895	Pelodiscus sinensis	74.33	0.00e+00	727.00
IUUC-Pab-097598	Pongo abelii	90.89	0.00e+00	870.00
IUUC-Pva-102135	Pteropus vampyrus	89.61	0.00e+00	876.00
IUUC-Rno-104891	Rattus norvegicus	89.38	0.00e+00	907.00
IUUC-Sha-107192	Sarcophilus harrisii	78.13	0.00e+00	813.00
IUUC-Ssc-115696	Sus scrofa	88.62	0.00e+00	908.00
IUUC-Tgu-117056	Taeniopygia guttata	74.55	0.00e+00	720.00
IUUC-Tru-117621	Takifugu rubripes	68.82	0.00e+00	656.00
IUUC-Tbe-127520	Tupaia belangeri	88.65	0.00e+00	677.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence