iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000015492.2	ENSCJAT00000030193.2	ENSCJAP00000028572.2
ENSCJAG00000015492.2	ENSCJAT00000030184.2	ENSCJAP00000028563.2
ENSCJAG00000015492.2	ENSCJAT00000030194.2	ENSCJAP00000028573.2
ENSCJAG00000015492.2	ENSCJAT00000020673.2	ENSCJAP00000019560.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	9.10e-52	175.5	8	142
UBD/UBC-like/UBD_UBC	1.20e-80	269.3	10	146

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPk..vkfltkifhPnvyenGkvClsilke 88
           l  el++l++dpp+++sa+pv + d+++w+++i+Gp+d+pY+ggvF l+i+fp+dYPfkPPk  v f+t+i+hPn+++nG++Cl+il+ 
   Q: 8    LSDELSDLARDPPAQCSAGPVGD-DMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKasVAFTTRIYHPNINSNGSICLDILR- 94
           5689*******************.9************************************855789********************9. PP
   S: 89   eekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkv 137
            ++Wspal++++vllsi+sll++pnp++pl  e+a+++k++r +y+++ 
   Q: 95   -SQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRIS 142
           .********************************************9876 PP

UBD/UBC-like/UBD_UBC

   S: 4    kelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppk..vafitkiyhpninsngsicldilrsqws 90
            el+dl+rd++aq+sa++v+dd+f+++ati+gp+dspy+ggvfflti++ptdypfkppk  vaf+t+iyhpninsngsicldilrsqws
   Q: 10   DELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKasVAFTTRIYHPNINSNGSICLDILRSQWS 98
           79********************************************************97789************************** PP
   S: 91   aaltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           +alt+skvlls+csll+d++pddplv+eiariyktd++ky+ri+rewt
   Q: 99   PALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRISREWT 146
           ***********************************************8 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

VLGIFKCLSD ELSDLARDPP AQCSAGPVGD DMFHWQATIM GPNDSPYQGG VFFLTIHFPT 60
DYPFKPPKAS VAFTTRIYHP NINSNGSICL DILRSQWSPA LTISKVLLSI CSLLCDPNPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAACGGGC GGGTAGCTAG GCCCTCCTCG TAATCTGGTG TGAAGGTGGC CCTCCTGTTG 60
GGCCTTTAAG GTCTGTAGAT GCTGCAGGCC AGCACAAAGG ATACTGTGTG AGATAAGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0006513--P:protein monoubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Eeu-034766	Erinaceus europaeus	97.16	5.00e-79	285.00
IUUC-Ggo-045076	Gorilla gorilla	94.04	1.00e-80	291.00
IUUC-Laf-054461	Loxodonta africana	99.29	2.00e-81	293.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence