iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062848

UUCD1 version

UUC-MoD-00171

Ensembl Protein ID

ENSMODP00000017283.2

UniProt Accession

F6SEC3; F6SEC3_MONDO

Protein Name

Uncharacterized protein

Gene Name

TRIM24

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000013826.3	ENSMODT00000017602.2	ENSMODP00000017283.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.00e-09	37.1	812	856
E3 activity/RING/RING	6.70e-06	26.7	30	111

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C+vC++gge    l++CekC ++fH +C+ ++   ++p+ e wiC+ Cr
   Q: 812  DWCAVCQNGGE----LLCCEKCPKVFHLTCHVPT-LMNFPSGE-WICTFCR 856
           79*********....*******************.*******8.******8 PP

E3 activity/RING/RING

   S: 1    CaiCledf.kdgplvlpCgHvfhadCl...qkw...................................pglknssskefrCPlC 45
           Ca+C++ + ++ p++lpC H f++ Cl   q++                                   p++   + + +rCP+C
   Q: 30   CAVCHQNIqSRVPKLLPCLHSFCQRCLpapQRYlmlpapllgaaetpppaataaattappgspisatpPYST--QVGVIRCPVC 111
           ****99887888*********************999999999999999999999988887777777444444..777778**** PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

PSGENEAESR QGPDSERGGE AARLNLLDTC AVCHQNIQSR VPKLLPCLHS FCQRCLPAPQ 60
RYLMLPAPLL GAAETPPPAA TAAATTAPPG SPISATPPYS TQVGVIRCPV CSQECAERHI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGAGTGGGG AGAATGAGGC CGAGAGCCGG CAGGGCCCGG ACTCGGAGCG CGGCGGGGAG 60
GCGGCCCGCC TCAACCTGTT GGACACTTGC GCCGTCTGTC ACCAGAACAT CCAGAGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR019786--Zinc_finger_PHD-type_CS
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box

PRINTS

PR00503--BROMODOMAIN

SMART

SM00502--BBC
SM00336--BBOX
SM00297--BROMO
SM00249--PHD
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005719--C:nuclear euchromatin
GO:0005654--C:nucleoplasm
GO:0005726--C:perichromatin fibrils
GO:0003682--F:chromatin binding
GO:0034056--F:estrogen response element binding
GO:0004672--F:protein kinase activity
GO:0043565--F:sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0055074--P:calcium ion homeostasis
GO:0071391--P:cellular response to estrogen stimulus
GO:0008285--P:negative regulation of cell proliferation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0046777--P:protein autophosphorylation
GO:0030163--P:protein catabolic process
GO:0042981--P:regulation of apoptotic process
GO:0031647--P:regulation of protein stability
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0070562--P:regulation of vitamin D receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001838	Ailuropoda melanoleuca	88.47	0.00e+00	1583.00
IUUC-Apl-003697	Anas platyrhynchos	81.70	0.00e+00	1331.00
IUUC-Bta-013282	Bos taurus	88.71	0.00e+00	1621.00
IUUC-Cja-018920	Callithrix jacchus	88.29	0.00e+00	1633.00
IUUC-Cfa-020984	Canis familiaris	89.45	0.00e+00	1635.00
IUUC-Cpo-022035	Cavia porcellus	89.08	0.00e+00	1531.00
IUUC-Csa-024208	Chlorocebus sabaeus	88.87	0.00e+00	1647.00
IUUC-Dno-029145	Dasypus novemcinctus	90.36	0.00e+00	1552.00
IUUC-Dor-030396	Dipodomys ordii	87.12	0.00e+00	1165.00
IUUC-Ete-032414	Echinops telfairi	83.78	0.00e+00	878.00
IUUC-Eca-033489	Equus caballus	90.69	0.00e+00	1503.00
IUUC-Eeu-034654	Erinaceus europaeus	83.70	0.00e+00	679.00
IUUC-Fca-035844	Felis catus	87.83	0.00e+00	1389.00
IUUC-Fal-036735	Ficedula albicollis	81.53	0.00e+00	1358.00
IUUC-Gga-041124	Gallus gallus	78.78	0.00e+00	1402.00
IUUC-Ggo-044542	Gorilla gorilla	88.96	0.00e+00	1647.00
IUUC-Hsa-046785	Homo sapiens	88.95	0.00e+00	1644.00
IUUC-Itr-048262	Ictidomys tridecemlineatus	88.79	0.00e+00	1588.00
IUUC-Laf-054279	Loxodonta africana	86.77	0.00e+00	1612.00
IUUC-Mcc-055668	Macaca mulatta	88.96	0.00e+00	1648.00
IUUC-Meu-056195	Macropus eugenii	86.98	0.00e+00	912.00
IUUC-Mga-059272	Meleagris gallopavo	80.96	0.00e+00	1319.00
IUUC-Mmr-060936	Microcebus murinus	88.87	0.00e+00	1626.00
IUUC-Mmu-063598	Mus musculus	87.84	0.00e+00	1597.00
IUUC-Mpu-066272	Mustela putorius furo	88.49	0.00e+00	1498.00
IUUC-Mlu-067958	Myotis lucifugus	88.57	0.00e+00	1498.00
IUUC-Nle-069375	Nomascus leucogenys	88.96	0.00e+00	1648.00
IUUC-Opr-070836	Ochotona princeps	74.72	9.00e-173	600.00
IUUC-Oan-073393	Ornithorhynchus anatinus	84.51	0.00e+00	1047.00
IUUC-Ocu-074873	Oryctolagus cuniculus	88.89	0.00e+00	1514.00
IUUC-Oga-088692	Otolemur garnettii	88.19	0.00e+00	1596.00
IUUC-Oar-090160	Ovis aries	90.15	0.00e+00	1492.00
IUUC-Ptr-090756	Pan troglodytes	88.95	0.00e+00	1644.00
IUUC-Pan-091719	Papio anubis	88.87	0.00e+00	1645.00
IUUC-Psi-093433	Pelodiscus sinensis	83.74	0.00e+00	1389.00
IUUC-Pab-098599	Pongo abelii	87.80	0.00e+00	1617.00
IUUC-Pca-100540	Procavia capensis	83.81	0.00e+00	928.00
IUUC-Pva-102478	Pteropus vampyrus	83.35	0.00e+00	1464.00
IUUC-Rno-105478	Rattus norvegicus	69.86	8.00e-166	577.00
IUUC-Sha-106740	Sarcophilus harrisii	89.91	0.00e+00	1497.00
IUUC-Sar-113615	Sorex araneus	88.39	0.00e+00	1308.00
IUUC-Tgu-117368	Taeniopygia guttata	79.63	0.00e+00	1430.00
IUUC-Tsy-118904	Tarsius syrichta	88.96	0.00e+00	1511.00
IUUC-Tbe-127354	Tupaia belangeri	76.94	0.00e+00	647.00
IUUC-Ttr-128983	Tursiops truncatus	85.50	0.00e+00	1102.00
IUUC-Vpa-130420	Vicugna pacos	88.10	0.00e+00	1460.00
IUUC-Vvi-131561	Vitis vinifera	47.17	5.00e-12	66.60

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence