iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132111

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Tripartite motif-containing protein 72; Mitsugumin-53

Genbank Nucleotide ID

BC082513

Gene Name

trim72; mg53

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000026752.2	ENSXETT00000056209.2	ENSXETP00000056209.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	5.60e-06	26.5	12	82
E3 activity/RING/RING	2.80e-07	31.1	16	59

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl...asggk....tcPvtrqplteedlvPnltlrrliqawce 70
           +++ Cp+ lel+r Pv+ ++G+t+ + ++       +   +     cP++++p ++e+l  n  l +l+q++ +
   Q: 12   KDLTCPLCLELFRAPVTPECGHTFCQGCLTGAPknqD---QngstPCPTCQTPSRPETLQINRQLEHLVQSFKQ 82
           5789************************988664431...345569************************9965 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle f+  p++  CgH+f++ Cl     +++ ++++  CP+C+
   Q: 16   CPLCLELFRA-PVTPECGHTFCQGCLTGA-PKNQDQNGSTPCPTCQ 59
           ********88.99777**********666.7778899********7 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity).

Protein Sequence
(Fasta)

MSTPQLMQGM QKDLTCPLCL ELFRAPVTPE CGHTFCQGCL TGAPKNQDQN GSTPCPTCQT 60
PSRPETLQIN RQLEHLVQSF KQVPKGHCLE HLDPLSVYCE QDKELICGVC ASLGKHKGHN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCAGATCG TTCTGTTTGG ATTCTCTGAC ATCTCTGCAG GTAACAAACC TTGATTTGCC 60
ACTCACTCTG GGATAGGATG GGGGAGATCA TTAGAGTGGG ATTTCACCAC ACAGGGCTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-1015--Disulfide bond
KW-0268--Exocytosis
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0042383--C:sarcolemma
GO:0001786--F:phosphatidylserine binding
GO:0008270--F:zinc ion binding
GO:0006887--P:exocytosis
GO:0007517--P:muscle organ development
GO:0003012--P:muscle system process
GO:0001778--P:plasma membrane repair
GO:0051260--P:protein homooligomerization

KEGG

xtr:493550

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004755	Anolis carolinensis	65.97	0.00e+00	647.00
IUUC-Bta-013476	Bos taurus	49.89	3.00e-133	468.00
IUUC-Eeu-034526	Erinaceus europaeus	58.14	2.00e-161	561.00
IUUC-Itr-048959	Ictidomys tridecemlineatus	57.36	3.00e-161	561.00
IUUC-Meu-056767	Macropus eugenii	60.47	8.00e-168	583.00
IUUC-Mmr-061616	Microcebus murinus	58.07	2.00e-164	572.00
IUUC-Mmu-063094	Mus musculus	56.93	2.00e-162	565.00
IUUC-Oan-072738	Ornithorhynchus anatinus	62.90	9.00e-175	606.00
IUUC-Pca-100618	Procavia capensis	50.43	2.00e-133	468.00
IUUC-Pva-102430	Pteropus vampyrus	50.11	1.00e-134	472.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence